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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
Evaluation the Efficacy of Combined Therapy Ketoconazole and Tamsulosinvs Tamsulosin in AUR Followed BPH Iraqi Patients Ali Abdulbaqi Ali Ismael
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

The  Benin prostate hyperplasia symptom may began with 40years and the  incidence increased with  increased age to reach  30% in  men aged above70 years , this associated with   sever complication like AUR which associated with higher morbidity and mortality about 1:7 of patients suffering from AUR dies during the first year, So the study aimed to evaluated the efficacy of mixed therapy versus mono therapy  as well as prolong period ( 5 and 8- days ) in success   TWOC . This study included 100 AUR as complicated to BPA patients which divided into two groups the 1st one 50 patients treated with mixed therapy Ketoconazole and Tamsulosin for 5 Daye (25patients) and 8daye (25 patients)  , While the 2nd groups treated with immunotherapy Tamsulosin for 5 day and 8 day to 25 patient for each one , then evaluate peak flow rate , Residual urine , voided volume and prostate size to determined efficient type  of therapy that gave  successful  treatment . Results clarified  that mixed therapy recorded the best  results than mono-therapy and duration for 8 day revealed  high PFR, voided volume and low residual urine  and prostate size. In conclusion Combination therapy ( Tamsulosin and ketoconazole )augment the prospers rate of treatment without catheter in AUR person this confirmed through that patient  void more successfully after catheter removal , according to  duration  the 8 day revealed high peak flow rate , voided volume and decreased the residual urine also , combination therapy with 8doses recommended to treatment AUR complicated BPH patients Keywords: BPA, AUR, Ketoconazole, Tamsulosin, TWOC, Combined therapy.
Preparation and Characterization of Nanoparticles TiO2 and Its Application for Methylene Blue Dye Degradation under Solar Light Ahmed Hassan Ali
Journal of Global Pharma Technology .
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Abstract

This research paper study, the treatment of m ethylene blue dye was investigated in a photo catalyticsystem under solar irradiation in heterogeneous solution with multi concentrations like (0.3 , 0.8 , 1.3 ,and 2) g/l of commercial TiO2 as a photo catalyst. The optimum value of photo catalyst concentration (0.8mg/l) the nano particles TiO2 was prepared by using sol-gel technique. The properties of the preparedTiO2 were checked with X-ray and transmission electron microscopy technique. Then the treatment ofthe m ethylene blue dye was checked by using synthesis TiO2with same previous conditions. We havecompared the treatment efficiency of solution between the prepared nanoparticles and commercial TiO2.The results shows that the prepared TiO2hasa more efficiency. The practical work also includes therecycled ofTiO2 nano particles.Keywords: Photo catalytic Degradation; Titanium dioxide; Wastewater treatment; Preparation andcharacterization of nano particles.
Growth Performance and Haematological Indices in Calves Fed with Probiotic Supplement 'Bacticor' Almaz Basharov
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The paper presents the study results on the effect of a feed probiotic supplement ‘Bacticor’ on biochemical and morphological parameters of blood, absolute and average daily live weight gains in calves and   economic efficiency of raising the animals.  The farm experiments conducted before showed that 20 g per head was the optimal daily dose of the supplement. The established dose of the feed probiotic supplement increased the final live weight by 1.77 % and absolute live weight gain rose by 8.3 %. The viability of the study calves for all groups was reported 100 % throughout the experiment. The study feed supplement had a positive effect on the formation of specific immunity in calves. A noticeable decrease in the concentration of lymphocytes was observed in the middle of the experiment, where the concentration of these specific cells was 3.6*109/l compared to 8.9*109/l in the control group. The feed supplement ‘Bacticor’ slightly increased the concentration of total protein by 1.73-3.22%, glucose by 7.0-14.5% in the blood serum of calves.  Rearing one calf for three months of the experiment required 3.89-3.93 EFU (Energy Feed Unit); the costs for 1 kg of live weight gain were by 7.2 % lower in the test group than in the control group.Keywords: Probiotic supplement, Bacillus subtilus, Strains, Microorganisms, Lactobacilli, Pre-weaning calves, Haematological parameters, Immune resistance, Feed conversion.
Comparative Study According to Absolute Power and Muscular Activity (EMG) between Leg and Arm Muscles for Weightlifting Trainees Ghassan Adeeb Abdlhassan
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

It is known that inside the exercises of maximum power there are trends and factors influential and for the purpose of verifying the extent of the effects of these factors in the maximum force had to go into these factors and to determine the reality, which comes in the forefront of the area of the cross section of the muscle, so researchers compared between the muscles of the arms and legs in terms of strength the absolute value of these two muscles in order to verify the returns of the maximum power and determine accurately. The main objectives of the research to identify the following:Identify the differences between the muscles of the limbs (legs - arms) according to the absolute power of weightlifters.The researchers selected a random sample of 6 students from the College of Physical Education and Sports Science / University of Baghdad. The researchers conducted tests of the maximum strength of the two men and arms on the research sample. The results were obtained and dealt with statistically using (SPSS).The most important conclusions were as follows:That the muscles of the arms of absolute strength higher than the muscles of the legs.Keywords: Absolute power, Muscular activity, Muscles and weightlifting.
The Effect Of Extra Virgin Olive Oil To Increase Endogeneous Antioxidant And PlGF In Preeclampsia Rat Model Yulia Silvani
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Preeclampsia is a special disease in pregnancy with oxidative stress as one of its pathogenesis pathways, suspected that it can interfere the process of angiogenesis and negatively impacts the fetus and maternal wellbeing. Objective: This study aimed to determine effect of EVOO as a strong exogenous antioxidant to increase SOD activity and GSH level in accordance with improvement on PlGF level as an angiogenesis factor in preeclampsia rat model. Method: This research consisted of five groups; negative control, positive control (preeclampsia rat model), doses 1, 2, and 3 that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure measurements were carried out at the 12th, 15th, and 19th day of pregnancy. After sacrificed, placentas were collected to determine SOD activity and GSH level either maternal plasma to determine PlGF level. Results: Result of this study showed that there was a reduction of GSH (p=0.02) and PlGF (p=0.233) level between negative and positive control group meanwhile SOD activity seem increased (p=0.049). There were significant differences among positive control and dose 1 in SOD activity (p=0.008), dose 3 in GSH level (p=0.000), both dose 1 (p=0.017) and 2 (p=0.000) in PlGF level. Conclussion: Administration of EVOO increased SOD and GSH in all three doses groups, while there was a decrease in PlGF at dose 3. EVOO had been shown to be a potential antioxidant in preeclampsia through increased SOD activity and GSH level, at once modulate angiogenesis through increased PlGF level.Keywords: Preeclampsia, EVOO, SOD, GSH, PlGF, Antioxidant, Oxidative stress, Angiogenesis
Effect of Topical Artemisinin from Artemisia Annua in Comparison with Tacrolimus on Induced Atopic Dermatitis in Mice Mohammed Fareed Hameed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: To evaluate the effectiveness of artemisinin isolated from Artemisia annua terpenes fraction in atopic dermatitis mice model. Methods: This research is a randomized, prospective, placebo and controlled animal study. Thirty two male, albino mice included in this study. The mice were randomly divided into four groups (Each group eight). Group I without treatment (Healthy). Group II only the inducer Phthalic anhydride given. Groups II, III, and IV subjected to 5% phthalic anhydride solution and after three hours of phthalic anhydride application, treatment is used for group III (Tacrolimus 0.03% ointment) , and group IV (Artemisinin 175mg/kg). Artemisinin was extracted from Artemisia annua and isolated by preparative high pressure liquid chromatography. Measurement of serum interleukin 13, interleukin 4, and immunoglobulin E and histopathology were done. Results: When healthy group is compared to atopic dermatitis induced non-treated group, a significant increase (P value ≤ 0.05) in serum IL-13 and IL-4 were found, while high significant increase (P value ≤ 0.001) in serum IgE was recorded. Regarding Histopathology score, high significant decrease in epidermal thickness, hyperkeratosis, parakeratosis, erosion, inflammation and edema after 4 weeks of starting treatment between Tacrolimus and atopic dermatitis induced non-treated groups. When artemisinin and atopic dermatitis induced non-treated groups were compared, a significant decrease was found in serum IgE. Conclusion: Artemisia annua artemisinin has an effect on phthalic anhydride induced atopic dermatitis albino mice like model.Keywords: Atopic dermatitis, Artemisia annua, Artemisinin.
Response of Some Anatomical Properties and Growth of Calotropis Procera (AIT) R.Br to Method Adition of Nano-iron, Zinc and Organic Fertilizer Growth Abdulameer Ali Yaseen
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Pots experiment was conducted in a nursery affiliated to the Al-Qasim town during the spring season of (2016 - 17). The aim of the experiment was to find the effect chelated nano iron and zinc fertilizer(seven concentration) in two application methods: foliar applied  (0 ,1Fe, 2Fe,1Zn, 2Zn, 1Fe +1Zn, 2Fe+2Zn) g.L-1 and fertigation was included (0 ,80Fe, 160Fe,80Zn, 160Zn, 80Fe +80Zn, 160Fe +160Zn) mg.L-1 and organic fertilizer Drin (0.0 , 5) ml.L-1 and their interactions on  growth parameter, and the production of active substances as well as  mineral and organic content of the leaves and some anatomical features of Calotropis procera (Ait.) R.BR. The experiment was designed in a randomized complete blocks (RCBD), in a Factorial arrangement (7*2*2) with three replications. The Least Significant Difference (LSD) at 0.05 probability level was used to compare treatments means, whenever treatment effects were evident. The nano iron and zinc fertilizer and the methods application (first treatment), as well as organic fertilizer Drin, were applied at (6- 8 fully expanded leaves) stage. While the second application of nano fertilizer and organic fertilizer was after three month from the first treatment. The results showed that the use of doubled recommended of nano-iron was recorded the highest leaf area. Doubled concentrations for nano zinc was recorded the highest stem diameter and cortex thickness.Foliar application of nano fertilizer had given highest stem diameter, leaf area, the vessel diameter in the vascular bundles of stem.  Foliar application of organic fertilizer (5ml. L-1) increased all parameters studied except leaf area and cortex thickness, while the negative impaction on the vessel diameter in the vascular bundles of the stem. The interaction between nano fertilizer and application method by combinations significant increased all parameters studied. The interaction between nano fertilizers and organic fertilizer increased all parameters studied. The Interaction between application method and organic fertilizer showed did not reveal a significant difference in all parameters studied except leaf area. And interaction between study factors revealed a significant improvement of the C. procera plant in all parameter studied.Keywords: Nano iron and Zinc, Application method, Calotropis procera.
A Retrospective Study of Erythema Nodosum Leprosum in Dermatology and Venereology Outpatient Clinic of Sanglah General Hospital, Bali-Indonesia I Gusti Nyoman Darmaputra
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Introduction: Erythema nodosum leprosum (ENL) or type II reaction in leprosy is acute inflammation in the chronic disease of multibacillary leprosy. Clinical manifestation of ENL on the skin such as painful cutaneous nodule, commonly found on the face and extremities accompanied by nerve inflammation, systemic involvement, and other extracutaneous symptoms which possibly caused disability if it is not treated appropriately. Aim: To find out the ENL pattern in the Department of Skin and Venereology, Sanglah General Hospital for three years. Methods: This study was a retrospective study from the medical record of ENL new cases treated in the Skin and Venereology Outpatient Clinic, within period January 2013-December 2015 classified by the number of patients, age, sex, and type of leprosy. Result: Starting from January 2013-December 2015 there were about 39 new leprosy patients with ENL (36% of all new patients in the leprosy division), 64% are male, 82% aged 17-45 years, and 69% of patients suffer from borderline lepromatous (BL) leprosy. Conclusion: Most leprosy patients with ENL are male, aged 17-45 years with BL type leprosy. Complications that arise due to ENL or the side effects of corticosteroids could cause a large socio-economic impact.Keywords: Erythema nodosum leprosum, Leprosy reaction, Sanglah General Hospital.
The Usage of Paracetamol and Ibuprofen in Children with Persistent Ductus Arteriosus . Yulistiani
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Backgrounds: Persistent Ductus Arteriosus (PDA) is the structure of the ductus arteriosus that failed to close after the birth of the baby. One of the therapies which are used to overcome the closure of PDA is pharmacological therapy using prostaglandin inhibitors. Aim: to determine usage profiles, including dosage, frequency, route, and duration of paracetamol administration and ibuprofen for DAP. In addition, it also assesses the actual outcomes and side effects of using paracetamol and ibuprofen in children with PDAs. Method: this research was a quantitative research with a retrospective method. The sampling method used random sampling. The total sample was 32 children who were hospitalized with diagnosis of PDA with or without complications. Data was collected by conducting an assessment of the patient's medical record to the documentation sheet.  Results: Based on research in 32 patients, 78% of patients received paracetamol therapy, 16% of patients received ibuprofen, and 6% of patients received replacement therapy for paracetamol to ibuprofen. From 25 patients who received paracetamol therapy, 12 patients (48%) gave the outcome of PDA closure and eliminated patient tachypnea and cyanosis. The average dose of paracetamol used for PDA is 7.5-15 mg / kg every 6 hours for 3-7 days by oral route (9%) and intravenously (63%).While the average dose of ibuprofen for PDAs is 10 mg / kg / day for the first day and 5 mg / kg / day for the second and third days by oral route (100%). Conclusion: the use of paracetamol and ibuprofen for PDAs was in accordance with existing literature relating to the dose, route, frequency, and duration of administration for PDAs. However, there were some patients with special conditions that require adjustment of the second dose of the drug. The use of paracetamol and ibuprofen for PDAs did not cause actual side effects. The use of paracetamol for PDAs needs to be further investigated regarding the effectiveness and drug related problems and the need to consider the use of ibuprofen for PDAs related to potential side effects that can be caused.Keywords: Patent ductus arteriosus, Paracetamol, Ibuprofen, Pediatrics.
Green and Health Constitution of Green Open Space and Its Implementation in Surakarta Absori Absori
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Purpose: to find the essence from 1945 Constitution of the Republic of Indonesia Article 28H Paragraph (1) confirms that the right to obtain a good and healthy environment and good health services is part of human rights. Methods: this reaserch is a normative juridical methods and his research aimed at describing the Green Constitution in government policy regarding green open space and its implementation in Surakarta as an attempt to carry out the development and planning of the city that is environmentally friendly. This research was legal research conducted using a qualitative non-doctrinal approach. The results: showed that the Green Constitution that is friendly and perspective of the environment contained regulations and protections for environmental perspective. Based on data from the Regional Spatial Planning Coordinating Team (called TKPRD) Surakarta has 10% open space and the latest research conducted by the Geographic Information System (2015) of Surakarta has 9.17% green open space. Conclussion: The Municipal Government of Surakarta should provide green open space about what is mandated in Law by 30%.

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