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I Wayan Sudarsa
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INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
The Effect of Eight Weeks of Hydrotherapy on Quality Of Life of Elderly Women Residing in Jahrom, Iran: A Quasi-Experimental Study Ehsan Rahmanian
Journal of Global Pharma Technology .
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Abstract

Introduction: Exercise is generally believed to be an effective method in preventing elderly disorders which delays elderly. Exercise programs and regular and continuous physical activities can increase the Quality Of Life (QOL) of elderly people, cause greater independence in daily tasks, and help a more favourable ageing process. Therefore, this research aimed to study the effect of 8 weeks of hydrotherapy on Quality Of Life of elderly women aged over 50 residing in Jerome, Iran. Method this is a quasi-experimental study by pretest-posttest design. A sample of 29 elderly women aged over 50 was selected using convenience sampling. Hydrotherapy was performed for 8 weeks (24 sessions). Quality Of Life was assessed at two stages (before and after hydrotherapy) by SF-36. Descriptive and inferential tests, paired t-test, and Kolmogorov- Smirnov Test were employed to analyze the data. Findings: The mean age of women was 51.04±9.63. No significant difference was found on the QOL before and after the intervention (P-Value>0.05). Paired t-test results showed that a significant difference was found on Role-Playing Limitation due to Emotional Reasons before and after the intervention (P-Value<0.05). A significant difference was also found on Physical Pain before and after the intervention (P-Value<0.05). No significant difference was found on QOL components (general health, physical functioning, role-playing limitations due to physical functioning, social functioning, vitality and mental health) before and after the intervention (P-Value>0.05). Conclusion: Although QOL declined after the intervention, the result was not statistically significant. Therefore, hydrotherapy was not effective in elderly women QOL. Keywords: Exercise, Hydrotherapy, Quality of Life, Elderly Women.
Investigation of Steam Blanching and Infrared Drying in Processing of Chrysanthemum indicum L. Flower Herbal Tea Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In Vietnam, Chrysanthemum indicum has been used as an herb. Its flower has a strong aroma. Chrysanthemum indicum L. flower has a bright yellow color and various functional active compounds. However it’s easily perishable in blooming season, it’s necessary to to dry fresh Chrysanthemum indicum L. flower to extend its shelf‐life for long-term use. Objective of this study penetrated on the effectiveness of various processing variables such as blanching by steaming; infrared drying power, temperature and time on total phenolic, flavonoid, carotenoid and sensory score of dried herbal tea from Chrysanthemum indicum flowers by the infrared irradiation. Our results showed that these flowers should be blanched by steaming within 60s and then being dried at power 200 W, temperature 60oC with air velocity 1.5 m/s in the infrared dryer. From this approach, major phytochemical components such as total phenolic, flavonoid, carotenoid in the dried Chrysanthemum indicum flower could be maintained. Owing to the benefits of the infrared irradiation, it would be an innovative solution for blanching and drying to preserve utmost valuable elements inside as well as good appearance outside of dried Chrysanthemum indicum L. flower.Keywords: Chrysanthemum indicum, Steaming, Drying, Infrared irradiation, Phenolic, flavonoid, Carotenoid.
Association between GNB3 C825T Polymorphism and Sex in Iraqi Patients with Myocardial Infarction Ayat K. Taher
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Objective: The C825T polymorphism of the GNB3 gene is associated with hypertension, obesity and diabetes, while the association between the polymorphism and MI has been poorly explored. The aim of present study was to investigate the frequency distribution of C825T polymorphism of GNB3 gene in three study groups (G1, G2 and healthy controls) and its association with sex in Iraqi patients with myocardial infarction.  Methods: the study consist of 120 subjects (40 healthy individuals, 40 patients with only MI and 40 patients with MI and hypertension); genomic DNA extracted from whole blood, and C825T polymorphism was detected by polymerase chain reaction- Restriction fragment length polymorphism (PCR-RFLP). Results: the results show that most of patients were males it was (77.5 %) in G1 patients, while it was (70 %) in G2 patients, the difference was significant (P < 0.01) between males and females in both groups. the frequency of homozygous (CC) genotype G1 was (19.35 %) in males and (22.22%) in females and it was (28 %) for males, (16.67%) for females in G2. The heterozygous (CT) genotype for G1 in males and females was (61.29 %, 11.11%) respectively, for G2 it was (28 %, 16.67%) respectively. While, homozygous (TT) genotype in G1 was (19.35 %) for males and (66.67%) for females, and for G2 it was (14.29 %, 50.00%) in males, females respectively. The C allele frequency in G1 patients was (0.50) in males much higher than females (0.28), while T allele frequency was higher in females (0.72) than males (0.50). The frequency of C allele in G2 was (0.55, 0.33) for male and female respectively, and T allele frequency was (0.45) in male and it was higher in female (0.67). Odds ratio in both groups (G1and G2) was more than one according to (CT) genotype so it consider as a risk factor to MI for males while, (TT) genotypes consider as a risk factor to MI for females, while (CC) genotype can consider as a protective factor from MI since OR was more than one in both patient groups (G1 and G2). Conclusion: the polymorphism C825T of GNB3 gene in Iraqi population associated with myocardial infarction but more often in females.Keywords: Myocardial Infarction, G protein, GNB3, C825T polymorphism.
Synthesis and Design of New Gemcitabine Derivatives as In Vitro α-Glucosidase Inhibitors Ali J. Radhi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A new series of gemcitabine derivatives containing imine structure have been prepared efficiently by reaction gemcitabine with some aromatic aldehydes. The structures of the imine derivatives were confirmed by many spectroscopic methods such as elemental analysis, FTIR and NMR spectroscopy. The α-glucosidase activity was evaluated of end compounds in vitro. All imine derivatives  were showed α-glucosidase inhibition with IC50 values 223±1.24, 244±2.32, 94±1.01, 268±1.35, 387±2.12, 78±1.42, 145±1.32, 54±2.41 µM respectively, when compared with the control drug (IC50 = 784.35 ± 2.41 µM).Compound (g8) have higher therapeutic indices, representing possible promising roles. Overall result suggests that gemcitabine derivatives containing Schiff base structure (g1-g8) could be lead a new design in this study of novel α-glucosidase inhibitor.Keywords: Gemcitabine, Imine, Diabetes mellitus and α-Glucosidase Inhibitors.
Methylene Blue Reduction by Using Multistage Filtratio Ouhood Hassan Saleh
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Slow sand filtration (SSF) is established and workable equipment for drinking water handling in small societies. However, this technology is sensible to depressed water temperatures which can result in reduced biological treatment, and excessive water turbidity quantities which can result in early plugging of the filters and repeated cleanup necessities, leading to raised danger of-pathogen development. Multistage filtration (MSF), comprising of roughing filtration (RF) tracked by slow sand filtration, can cope these treatment restrictions and give a strong treatment option for surface water resources of changeable water characteristics in northern climates, that normally water temperatures ranging below 2oC. The main objective of this study was to reveal the accuracy of MSF to remove methylene blue (MB) dye from water. In this research, testing was achieved by pilot multistage filtration system and fed with synthetic water polluted with MB dye. A system consisted from roughing filters filled with limestone media with different sizes and slow filter filled with glass media (SGF). The removal of MB of pilot plant was tested at hydraulic loading rates (0.5 and 1) m/h and initial concentration of (10 and 30) mg/L. The percentage reduction of MB dye reduced with increasing the influent MB dye concentration and increasing filtration rate. Limestone roughing filter (LRF) and slow glass filter gave good MB removal with average removal efficiency of 99.20% and 99.85% at least influent MB concentration of 10 mg/L and least velocity of 0.5 m/hr.Keywords: Slow sand filtration, Multistage-filtration (MSF), Roughing-filtration, Methylene Blue, Glass, Limestone.
Synthesis, Physical and Rheological Properties of Troger Base Polymer Sadiq A. Karim
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Tröger base polymer (DM-TB) was synthesised based 4,4`-diamino-3,3`-dimethylphenylmethane (DM) via condensation polymerization for diamine monomer with dimethoxymethane in trifluoroacetic acid at room temperature. The polymerization afforded a high ratio product and white polymer with a good thermal stability.Keywords: Tröger Base Polymer; Physical and Rheological Properties.
Detection of Some Virulence Factors Genes in S. Aureus Isolated From Different Clinical Cases Rawaa M. Mohammed
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

A total of 60 specimens (urine, burn swabs, and wound swabs) from different clinical cases were collected from patients (in different age groups) who admitted to several health centers in Al-Dewaniya General Teaching Hospital, during a period extending from October 2016 to January 2017. Some virulence factors was investigated for 30 isolates only of MRSA using Single and Multiplex PCR For detection virulence factor genes which both coa gene encoding  production of coagulase, clfA gene encoding for clumping factor, spa gene encoding for protein A, fnbA gene encoding for fibronectin binding proteins, luks gene encoding production of Panton Valentine Leukocidin (PVL), Results showed that all 30 isolates (100%) were possescoa, clfA, spaand fnbA genes, 13 (43.3%) were possesluks gene. Nanoparticle represented by gold and silver were tested in this study to defect their effect on viability of S.aureus. The results indicated that? Particle were more effective to inhibit the grow that of this bacterium (data are not showing in this paper).Keywords: virulence factors, MRSA, PVL, S.aureus, Nanoparticles.
Prevalence of Toxoplasmosis among Aborted Women and Immunohistochemical Evaluation of their Placenta Kawther A. M. Al-Mussawi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Toxoplasmosis is one of the zoonotic diseases caused by the obligate intracellular protozoan Toxoplasma gondii, which is associated with spontaneous abortion in infected pregnant women. In the present study, the sera of 228 first-trimester aborted women were screened for anti-Toxoplasma IgG and IgM antibodies, and the infection was further assessed in the blood and placenta of positive and negative cases by molecular methods. The results revealed that 47.4% of aborted women were sero-positive for toxoplasmosis (AT) by the latex agglutination test, while 52.6% were negative (NT). It was also found that 74.1% of AT cases were positive for IgG, while 25.9% were positive for IgM. In addition, the examined AT cases showed the amplified DNA fragment of the parasite, while it was not observed in NT samples. The placenta of molecularly diagnosed AT and NT cases were subjected for immunohistochemical expression evaluation for T-bet, GATA-3, FOXP3, IL-17, CD8, CD68 and perforin. A significant increased expression of T-bet, IL-17, CD8, CD68 and perforin was observed in AT cases compared to NT cases. In contrast, FOXP3 showed a significant decreased expression in AT cases, while no significant difference was observed for GATA-3. In conclusion, toxoplasmosis is an important risk factor for spontaneous abortion, which was associated with abnormal expression of some immunological markers in placenta.Keywords: Toxoplasmosis, Abortion, Prevalence, Immunohistochemical expression.  
Characterization of the Dielectric Barrier Discharge (DBD) Plasma Jet for Staphylococcus Aureus Bacteria Deactivation Mohammed K. Khalaf
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

In this paper, the insulation barrier of the dielectric-barrier discharge (DBD) plasma jet is discharged at atmospheric pressure .Where the degradation efficiency of the DBD plasma jet is evaluated on bacteria of Staphylococcus aureus with different exposure times. The influence of the flow rate and applied voltage of the argon gas used is studied and linked to the temperature and column length of the plasma jet. In addition, the Optical Emission Spectroscopy (OES) is examined to detect plasma parameters such as electron temperature and electron density. OES is also used detect active species within a plasma column such as OI, N2 and OH and other. The percentage of bacteria growth inhibition is increased directly with increased time of exposure from the DBD plasma jet. Keywords: Dielectric barrier discharge, Non-thermal plasma, Bacteria inactivation. Optical Emission Spectroscopy.
Effect of Season on Arabian Camel (Camel us Dromedarius) Semen Parameters Hayder A.N. AL-Zamely
Journal of Global Pharma Technology .
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Abstract

This study was conducted on forty (40) of one- hamped Arabin camels to evaluate the effect of season on semen parameters, therefore the semen was collected from these animals in four seasons which are Winter, Autumn, Spring and Summer, the parameters which are studied include: semen concentration, semen motility, semen volume, the percentage of life sperms and the percentage of abnormal sperms. The results were revealed that, there is significant increase in sperms concentration, semen volume and semen motility during cold seasons (Winter and Autumn) as compared with other seasons also there is increase in percentage of life sperms and decrease in percentage of abnormal sperms in cold seasons (Winter and Autumn) as compared with other seasonsKeywords: Arabian camel, semen, season.

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