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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Technical Aspects Affecting to Jackfruit (Artocarpus Heterophyllus) Beverage Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Jackfruit (Artocarpus heterophyllus) is a tropical climacteric fruit. It is one of the commonly consumed foods in Vietnam. Its fesh in fully ripen stage can be eaten directly as a fruit. Jackfruit contains a wide range of phytonutrients such as carotenoids that can act as antioxidants. The jackfruit fesh is highly perishable and ofen undergoes favour loss, tissue sofening, and cut surface browning. During the jackfruit havesting season, excessive supply of the fruit causes the price of jackfruit decreasing dramatically. This fruit is underutilized in commercial scale processing. Therefore we have our tried to add value to the jackfruit fruit. One method of adding value to fresh jackfruit is processing it into drink. We carried out the investigation of extraction (ratio of water: jackfruit, temperature and time of blanching); juicy mixture; preservation. Our result showed that the jackfruit drink having the best quality when extracting with water: jackfruit pulp ratio (70:30) at 85 oC in 3 minutes. The sample was then cooled to 37°C before the addition of pectinase enzyme at 0.09%. The juice was then incubated in a water bath at 37°C in 30 minutes. After the incubation process, the juice was heated in a water bath at 100°C for 2 minutes to inactivate all enzymes present. The hydrolyzed jackfruit juice will be formulated with sugar 2.5%, citric acid 5%, carrageenan 0.06%. Jackfruit drink shelf-life could be maintained for 12 months.Keywords: Jackfruit, Artocarpus heterophyllus, Beverage, Carrageenan, Pectinase, shelf-life
Synthesis and Characterization of Heterocyclic Compounds and Polymers with Studying the Biological activity for some of them Dhefaf H. Badri
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This paper deals with the preparation of new monomers and polymers which including heterocyclic unit. The diacid chlorides compounds [1-3] were prepared from the reaction of glutaric acid, adipic acid, terephthalic acid with thionyl chloride.  Succinic acid reacted with ethanol to produce compound [4]. Compound [4] reacted with hydrazine hydrate to obtain succinic hydrazide [5].Compound [5] reaction with CS2 and KOH in absolute ethanol to produce compound [6].The polymers [7-12] have been created by  reacting diacid chlorides compounds [1-3] with compound[5] or [6] in dry pyridine with some drops of DMF. The topology of produced compounds has characterized through their spectral and analytical data as in FT-IR spectra, Thermal analysis [DSC, TGA] and Antibacterial activity investigated using dual bacteria kinds.Keywords: Succinic hydrazides, Oxadiazole, Heterocyclic polymers.
Potential of Quercetin in Bitter Melon (Momordica charantia L) as an Antidiabetic: In Silico Study Roni Yuliwar; I Ketut Sudiana; Kusnanto Kusnanto; Dwi Krihariyanie; Hidayat Arifin
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Purpose: The purpose of this study is to predict the in silico molecular interactions of bitter melon quercetin with GLP-1 receptors using the comparable compounds of myricetin and allosteric modulators. Methods: The in silico test was used to predict the quercetin molecular interactions by docking using the Molegro Virtual Docker computer program. The receptor used was human GLP-1, code PDB: 5VEX with allosteric modulators ligand (97V_1201 [A]). As part from predicting molecular interactions, this study also carried out the prediction of its pharmacokinetic properties (ADME) and the toxicity of quercetin and myricetin using the pkCSM online tool program. The data analysis was performed by comparing the docking bond energies between quercetin, the allosteric modulator ligands and the myricetin comparators at the target receptor. The lower the bond energy of the ligands to the target receptor, the more stable the bonds are. This can be used to predict the biological activity of the compound. Results: The in silico test results showed that the bond energy of quercetin = -70.2678 kcal/mol, myricetin = -105,298 kcal/mol and allosteric modulators = -126,992 kcal/mol. Conclusions: The above test results indicate that quercetin has antidiabetic potential by activating the GLP-1 receptor although it is lower than the myricetin and allosteric modulators. The results of the in silico test using the pkCSM online tool program showed that the quercetin compound had good pharmacokinetic properties and a low toxicity level.
Biological Activities of Red and Green Algae from Visakhapatnam Coast Satyalakshmi Siragam
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Objective: Determination of antibacterial, antioxidant, anti-inflammatory and anti-tumor activity of green and red algae collected from Visakhapatnam sea coast.Methods: In vitro methods are used for determination of biological activities of algal extracts. Diffusion method of microbiological assay was used for estimation of antibacterial activity. Reducing power and free radical scavenging method for determination of antioxidant activity of algae. In vitro anti-inflammatory activity was determined by egg albumin and erythrocyte stabilization. HeLa (Cervical carcinoma) cell lines are used for determination of anti-tumor activity.Results: Red algae Gracilaria corticata exhibited good antibacterial activity against selected test microorganisms. In vitro free radical scavenging method is used for determination of antioxidant activity of Caulerpa taxifolia and exhibited 48.76±0.08% of inhibition at 200 µg/mL. Gracilaria corticata exhibited good anti-inflammatory activity of 58% which was determined by in vitro method of erythrocyte stabilization and 66.75% by egg albumin method. Green algae Caulerpa taxifolia exhibited (IC50 = 32±1.2) remarkable antitumor activity on HeLa cell lines than control.Conclusion: Among two organic solvents used for extraction of active principles from marine algae, methanolic extracts showed better biological activity than the chloroform extract. Green algae Caulerpa taxifolia exhibited significant antioxidant and anti tumor activity than remaining two algal species. Red algae Gracilaria corticata showing remarkable anti-inflammatory activity in both the in vivo methods. This study expands the medicinal importance of marine algae collected from coastal regions like Visakhapatnam.
An Update on Solubility Enhancement Methods for BCS Class -II Drugs Vamshi Krishna Tippavajhala
Journal of Global Pharma Technology Volume 09 Issue 09
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Abstract

Abstract: To attain the anticipated concentration of a drug in the systemic circulation in order to exhibit the pharmacologic response, solubility of the drug plays a critical role. Key research problems faced during formulation development of various drugs owe to their low aqueous solubility. About 40% of NCEs are unsuccessful in reaching their therapeutic range mainly due to their solubility issues. In this context, this review article details various solubility enhancement techniques and their application mainly to address this poor solubility of various BCS class-II drugs. Keywords: Solubility Enhancement Methods, BCS Class-II drugs.
Clinical Study of Phospholipase D1 and Choline Kinase Alpha Enzymes in Women with Breast Cancer in Thi-Qar Governorate-Iraq Husam Mohammed Kredy
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Objective: Breast cancer is the most common cancer among women, comprising 18% of all female cancers, and worldwide, breast cancer is the fifth most common cause of cancer mortality. The study was designed to determine and compare the levels of phospholipase D1 (PLD1) and choline kinase alpha (CHKAα) enzymes in Breast cancer patients and apparently healthy individuals.  Material and Methods: Blood phospholipase D1 (PLD1) and choline kinase alpha (CHKAα) enzymes levels were determined in 85 breast cancer patients and 55 apparently healthy subjects. Histopathological and immunohistochemical analysis done for (50) cases (out of those 85 breast cancer patients), tissue samples are collected from patients with breast cancer who undergoing surgical resection (mastectomy) and normal breast tissues: (control group, which include normal breast tissue from patients with benign lesions, and normal breast tissue from the same women with breast cancer). Results: The levels of serum phospholipase D1 (PLD1) and choline kinase alpha (CHKAα) enzymes were showing significant increase in breast cancer patients as compared to control group (P ≤ 0.05). We found that 82% of breast cancer biopsies were phospholipase D1 positive. There was no expression of phospholipase D1   in all normal breast tissues. Sixty-seven percent of breast cancer biopsies were choline kinase alpha positive. There was no expression of choline kinase alpha in all normal breast tissues. Conclusion: In Breast cancer patients, we found that there is an increase in (PLD1) and (CHKAα) enzymes level both in serum and malignant tissue, and this suggests that the overexpression of PLD1 and CHKAα may play an important role in the human breast tumorigenesis and they are useful markers for breast cancer.Keywords: Breast cancer, Phospholipids, Phospholipase D1 (PLD1), Choline kinase alpha (CHKAα).
Gene Sequencing of Human Toxoplasma Gondii Isolated from Inoculated Sheep Ola Kamal
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

The persistence of nucleotides in precise order within a DNA structure is named DNA sequencing. In the medical diagnosis DNA Sequencing becomes a necessity in biotechnology. The technology of DNA sequencing is considered the most accurate method to complete genomes of many types and species, including the human, animals, plants, and microbial species. Studying new genes is significant in determining and identifying the drug target potential when it accompanied with phenotypes and diseases. Also evolutionary biology DNA sequencing to know how organisms are evolved and how they are differ. The inoculation of 17 samples of aborted females were the subject of the study using T.gondii tachyzoits isolation, it underwent gene sequence work from the period of the 15th September 2015 to 10th may 2016 .Genotyping using the Surface Antigen Glycoproteins (SAG2) gene locus refers to that isolates were (12 types II, 3 types I and 2 types III). All these types were illustrated by genetic map as homologues nucleotides sequencing.Keywords: DNA sequencing, Toxoplasma gondii, Sheep, Genotyping.
Review on Traditional Use of Nephroprotective Plants in Kerala Praseeda KG
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
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Abstract

Our mother nature is an abundant treasure of medicinal plants. Many of the plants have active constituents like alkaloids, benzoquinones, catechols, carotenoids, flavonoids, glycosides, flavanol glycosides, steroid glycosides, glycoalkaloids, terpenoids, monoterpenoids, diterpenoids, triterpene saponins, sterols and polyphenols which are proved to be having tissue rejuvenation property. Which can be made use in critical conditions like nephropathy which can be curable only with kidney transplantation or dialysis, which are even unaffordable to common man. It will be very useful to isolate active ingredients from easily available medicinal plants which can be effectively used for conditions like Chronic Kidney Disease. India is a country which extensively follows different forms of medications like allopathy, Ayurveda, siddha and unani among them traditional system of medicine is considered to be pretty much important. The biodiversity of India helps traditional healers to explore vast possibility of it. Modern medicine gets ample support by evaluating and isolating natural, semisynthetic, and synthetic derivatives of effective phytoconstituents of herbs. The information’s regarding such medicinal plants is exclusively possessed by certain tribal communities all over India. This article also points towards some plants used by traditional healers of different tribal communities of Kerala.Keywords: Nephroprotective, Herbal medicine, Tribal communities.
Jugulo-atrial Bypass Procedure in Malignant Mediastinal Tumor with Superior Vena Cava Syndrome (SVCS) at Sanglah General Hospital, Bali, Indonesia: Case Series I Nyoman Semadi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Superior vena cava syndrome (SVCS) is a collection of symptoms and signs due to obstruction in the superior vena cava (SVC). More than 90% of SVCS cases are caused by malignancy (lung, breast, intra-mediastinal organs) and vascular reconstruction surgery is the last resort in the management of SVCS. Decompression surgery still can be performed on all types of tumours. These case series aim to elaborate on the outcome of the jugulo-atrial bypass procedure in malignant mediastinal tumour with SVCS at Sanglah General Hospital, Bali, Indonesia. Case Description: In Case 1, Male 31-year-old, has chief complaint shortness of breathing accompanied by swelling on face, neck, and chest that has become worse since one month prior to admitted to the Sanglah General Hospital. A similar clinical finding was also found in Case 2, Male 53-year-old, with a productive dry cough and coughing up blood for more than two months and revealed an anterior mediastinal mass on CT-Scan. However, in Case 3 Male 68-year-old, his shortness of breath began after the history of lump on neck since 3 years ago. He was also diagnosed with the antiphospholipid syndrome and received oral anticoagulant therapy for 17 months. The sagittal, coronal, and axial view of chest CT scan with contrast showed an apparent demarcated heterogeneous mass in the anterior mediastinum with central necrosis. The calcification component was also found as a resulted in vena cava superior suppression on each case. The operative procedure was a median sternotomy with jugulo-atrial bypass procedure and followed by chemotherapy. The complete resolution of the anterior mediastinal mass as well as the improvement of clinical outcome were exhibited few weeks after treatment. Conclusion: Two of the three cases of malignant mediastinal tumour have been performed jugulo-atrial bypass surgery to reduce SVCS. From the histopathological examination, these three cases with SVCS were malignant mediastinal tumour. Jugulo-atrial bypass procedure was proven to reduce complaints of shortness of breath and swelling post-surgery. Keywords : SVCS, Malignant Mediastinal Tumor, Jugulo-Atrial By-Pass.
Diagnosis of Pulmonary Cryptococcosis in Respiratory Specimens from Immuno Compromised Iraqi Patients Jabbar Salman Hassan
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Background: Cryptococcus neoformans, the causative agent of cryptococcosis, is a common encapsulated fungus that can cause a scope of sicknesses. Inhalation of organisms is the standard course of the disease that may stay spread to the lungs or experience hematogenous disseminations and reach to any organ through the body. Objective: The goal of this study was to determine the pulmonary Cryptococcosis in a specimen of immune compromised patients by utilizing traditional and molecular strategies.  Methods: This study included a total of two hundred (n=200) clinical samples from 100 immuno compromised patients and control group included 100 samples from immune competent individuals were enrolled in this study during the period from the January2015 to February 2016. Result: Among those 100 immune compromised patients 43 (43%) were males and 57 (57%) were  females , their mean ages was 54.56 ±16.46 years which ranged from 16 to 90 years, compared with 100 samples from apparently healthy individuals used as a control group. Out of 20 patients were PCR positive for pulmonary Cryptococcus’s 12(60%) were females and 8 (40%) were males. Five (5%) samples out of 100 immuno compromised patients were nigrosine stain positive; Three out of 100 samples were culture positive for C. neoformans. Conclusion: diagnosis and treatment of pulmonary cryptococcosis are as yet difficult. In any case, with early diagnosis and appropriate management, most non-AIDS patients with pulmonary cryptococcosis have a good prognosisKeywords: Pulmonary cryptococcosis, Cryptococcus neoformans, Bronichoalveolar lavage (BAL), Pleural effusion (PE), Nigrosin stain. 

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