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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Driver Perception toward Road Traffic Accidents in Babylon City Amean A. Yasir
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

Babylon has one of the highest road traffic accident (RTA) related fatality rates in Iraq. Yet, still little is known about the factors contributing to the high number of RTAs .For the first objective, identification of the main human factors that contribute to the occurrence of RTAs in Babylon, the study on human factors conducted by Gründl (2005) was replicated. The results revealed three human factors that significantly increase the risk of causing an RTA in Babylon. These factors are according to the strength of their impact: namely the human (inappropriate speed, fatigue and having a conversation with the passenger), the vehicle and the road environment. Objective this study aimed to identify the main human factors that contribute to the occurrence of RTAs in Babylon and to investigate the human road interaction as a contributing factor to the occurrence of RTAs in Babylon.Keywords: RTAs, Human, Inappropriate speed, Fatigue, Having a conversation with the passenger, the vehicle and the road environment.
Distribution of Both Fungi and Bacteria Detected from the Nasal and Oral Cavity (Statistical Survey in Kirkuk) Sanaa H. Mohammad
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The study was carried out at the period from 1st march 2018 to 31st june 2018 in order to determine the relationship of the allergic fungi with the worker in services and restaurant also university student and study the occurrence of fungi and bacteria detected from nasal  and oral cavity among University  Students , Restaurant workers and  services workers with mean age (47.40±22.14) subjects from different areas of Kirkuk City(107) isolates of bacteria and fungi isolated from the nasal cavity in the same time( 45) isolates of bacteria and fungi isolated from the oral cavity the isolates represented by :  A.  niger,  A.  flavus,  A. fumigatus,  A.  nidulans,  A. terreus, A.  japonicas, A.  japonicas, Alternaria spp, C. albicans, C. parapsilosis,  Penicillium spp, Rhizopus spp,  S.pyogen, S.aureus .The statistical analysis, existence of significant differences at the level of probability (P< 0.05) between the type of isolates the high frequency isolation represented by, A.niger, and S.aureus in the oral and nasal cavity which appeared with high occurrence  .  The subjects in this study were divided into five age groups.  On the other hand the statistical analysis of the existence significant differences (P< 0.05) between the fungal and bacterial isolation infection and age for all age groups, it had been found that the age group 26-35 years was the most influential of these infections, compared with the other age groups.Keywords: Fungi, Bacteria, Nasal and oral cavity
Estimation of Alpha-L-Fucose and Vitamin D3 Levels in Beta Thalassemia Patients in Al-Najaf Province Mohammed Abdulrazzaq Assi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present study deals with the prominent inherited disease that is thalassemia. Β-thalassemia is an extreme hereditary blood disorder resulted after a change in the gene encoding for the hemoglobin β chains. Hemoglobin is made up of a genetic defect in the synthesis of a globin chain, or more, which results in a reduced rate of these chains. The creation of atypical hemoglobin molecules is a result of the reduction in the synthesis of one chain of the globin, and thus, leads to the most specific symptom of the thalassemia; anemia. This study was conducted with 40 subjects, whose age ranges from 4-20 years, divided among (males 30 and females10), who has visited the Thalassemia Center at Al-Zahraa Teaching Hospital in Najaf province, Iraq, for managing the disease, and 40 voluntary healthy as a control group. The study has been done between September and February 2019. This study was performed to evaluate the levels of serum of Vitamin D3 and L-Fucose in major and intermediate beta-thalassemia patients. It also estimates protein-bound fucose (PBF), hemoglobin (Hb), hematocrit (HCT), liver function tests, calcium, TIBC and Ferritin. The results showed a significant increase in the levels of alpha -L- fucose and protein-bound fucose in thalassemia patients as compared with control. The results showed a very important reduction (P<0.001) in Vitamin D3,Hb, HCT, TIBC and calcium in thalassemia patients in both males and females in comparison with the healthy control, except ferritin, AST,and ALT which is increased significantly(p<0.001) in those patients in comparison with control. Keywords: Thalassemia, Vitamin D, L-Fucose.
Association of Heat Shock Proteins (HSP70), Reactive Oxygen Species and Inflammatory Mediators in Male Infertility Nuha Yaarub Al-Harbi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Heat shock protein 70 (HSP70) is considered as a gene which affects semen quality traits. The present study attempted to investigate the relationship between the HSP70 expression level and physiological status in Normozoospermia and an Asthenozoospermi. The current study was planned to investigate the relationship between the HSP70 gene polymorphism and infertility in infertile males with normal sperm parameters. A complete of sixty patients and thirty control subjects were collected between February to May 2019. The genotyping of the HSPA1L gene was performed using polymerase chain reaction (PCR) in addition to restriction fragment length polymorphism (RFLP). We tend to determine vital variations within the genotype frequencies of HSPA1L asthenozoospermia patients and controls. Our results showed highly significant differences between asthenozoospermia patients and control groups in levels TNF, IL-6, and ROS, (p
Thickness Effect on Some Physical Properties of the Ag Thin Films Prepared by Thermal Evaporation Technique Mohammed Ahmed Mohammed
Journal of Global Pharma Technology .
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Abstract

Silver (Ag) "thin films were successfully deposited by thermal evaporation using Edward’s Auto 306 Magnetron Sputtering System"(homemade). Theirstructural, optical and electrical properties were investigatedby using XRD, AFM, SEM, UV-Vis, electrical conductivity and the Hall effect, respectively. The average grain size increased from 20.03nm to 51.86 nm with increasing thin film thickness. The deposited Ag thin films had an absorbance ranging between 0.21-0.1, the values of energy gap were obtained in the range of 3.2-2.0 eV.Keywords Thermal evaporation, Thickness of thin film, Ag films, Hall effect, X-ray diffraction.
Effects of Transcranial Direct Current Stimulation along with Drug Control on Working Memory, Automatized Rapid Naming and Aphasia Quotient in Patients with Stroke Seyed Mojtaba Sohrevardi
Journal of Global Pharma Technology Volume 08 Issue 02
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Abstract

Aphasia after stroke in the left hemisphere is acommonsymptom. This people are often incomplete recovery intensive speech therapy experience. Direct electrical stimulation of the brain, which is a technique to stimulate the brain in neurological and psychiatric patients used. The aim of this study was to investigate the effects of stimulation on recovery of naming ability, working memory, and the non-fluent aphasia patients with aphasia and its effects were lasting. In this interventional study was conducted in 20 patients (12men and 6women, meanage 55/ 93years) with non-fluent aphasia after stroke were selected. Ratings of Aphasia quotient, working memory and naming ability to call them four times before and after treatment, after shamand twomonths after treatmentwas compared. 10 sessions of sham electrical stimulation (20min) and anodic and cathodic stimulation of10 sessions per patient (2mA- 20minutes) in the dorsal lateral perifrontal cortex received. Data analyzed was performed using cross over material with repeated measurements and friedman nonparametric test. The data showed that the ability of naming, working memory and aphasia quotient. In non-fluentaphasia aphasia patients after treatment and Two months after treatment compared with sham has grown significantly (p <.05).The results of this study seem to transcranial direct current stimulation can Sustained improvementin naming function, working memory and language abilities in patients with non-fluent aphasia is and can be used in the rehabilitation of these patients.
Various Factors Affected the Production of Pickled Chinese Jiaotou (Allium Chinense) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Chinese jiaotou is fresh during the harvesting season but perishable under the prevailing conditions of temperature and humidity as well as lack of adequate storage facilities. An alternative approach of preserving surplus Chinese jiaotou could be fermented to pickle products. Preservation of the Chinese jiaotou by lactic fermentation can eliminate the undesired taste and improve flavor of the vegetable. Therefore we explored a lactic fermentation from Chinese jiaotou by focusing on the effect of different parameters such as salt soaking concentration, sun drying time and CaCl2 soaking as pre-treatment; sugar concentration and fermentation time to physicochemical, microbial and sensory characteristics of pickled Chinese jiaotou. Experimental results revealed that 15% salt is soaking, sun drying in 6 hours, 0.4% CaCl2 soaking as pre-treatment for raw Chinese jiaotou; then 6% sugar in 21 days of fermentation was appropropriated to get a pleasant pickled Chinese jiaotou quality. Chinese jiaotou pickles are considered as one of the health supplements.Keywords: Chinese jiaotou, Pickle, Lactic fermentation, Soaking, Drying, Sugar, Salt.
Synthesis, Characterization and Antibacterial Activities of Some Heterocyclic Compounds from valproic Acid Drug Ahmed Yousif Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

With a view to reducing the acidic effect of valproic acid, its carboxylic group has been recoated to produce 5-membered and 6-membered heterocyclic rings. Heterocyclic derivative as -Thiadiazole, Imidazole, -Oxazine, Quinazoline, Pyrazole and Oxadiazole. Derivatives of valproic acid were prepared by cyclization under different reaction states to produce a good yield. The microbial inhibitory effect of these compounds was assessed in vitro against Gram-positive and Gram-negative bacteria as well as tested against two strains of bacteria (Escherichia coli and Staphylococcus aureus compared with starting material. Compounds (4, 5, 8) showed the highest antibacterial as well as antifungal activities. All compounds have been characterized by IR, 1H NMR and C.H.N analysis.Keywords: Valproic acid, Thiadiazole, Imidazole,-oxazine, Quinazoline, Pyrazole, Oxadiazole, biologically active compounds.
Pharmacognostical Study and Isolation of Terpene of Iraqi Quisqualis Indica L. Thamer Mouhi Jasiem
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Quisqualis indica L. has been used in traditional medicine for treatment many diseases .Q.  indica containing many of secondary metabolite products like tannins, flavonoids, steroids, carbohydrates, protein, amino acids, saponins and phenolic compounds .The leaves of plant Q.  indica L. were collected from AL-Musaeeb city , for  phytochemical screening we used ethanolic extract of plant leaves with  standard methods of phytochemical tests .In microscopically study of Q.  indica leaves both fresh and dried as finely powdered . Determination of the components of leaves was observed under microscope. The microscopical examination results were referred to anomocytic type of stomata at upper and lower surface of leaves. Unicellular UN branched covering of trichomes with fibers, Calcium oxalate with starch grain and stone cells were presented. The GC-MS analyses of hexane extract of leaves were carried out identification of Methyl palmitate 10.4%, Methyl linolate 8.6%, Trans – squalene 5.1%, Tetratetracontane 7.1% and Heptacosane-1-chloro 7.9%. Phytochemically, Iraqi plant contains tannins, flavonoids, terpene, coumarin and saponins, while alkaloid, steroids may be absent or present as a minor constituent. Which indicates that the Iraqi plant have some medicinal properties.Keywords: Quisqualis indica, Phytochemical study, GC/MS analysis, Pharmacognostical study.
Inflammatory Response of Annona Muricata Linn Leaves Extract in Colorectal Cancer Patients Ingrid Suryanti Surono
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Annona muricata L (AML) is a member of Annonaceae with antioxidant, anti-inflammatory and anticancer properties.  A randomized double blind placebo controlled pre post-trial on twenty colorectal cancer patients who had undergone primary tumor resection were conducted in two groups, each group was supplemented with A. muricata leaves extract, and maltose as placebo. Inflammatory responses were assessed using ELISA method. There is no significant difference between pre and post on cytokine and cyclooxygenase serum level, also between two groups. A strong significant correlation between serum level of TNF-α and IL-10 cytokine (coefficient correlation = 0.64, p = 0.01) and significant correlation between IFN-g and IL-10 (coefficient correlation = 0.47, p = 0.05) was found after 8 weeks AML supplementation, as shown by increasing of IL-10 production, in response to  TNF-α and IFN-γ in an inflammatory condition. This study  is  registered  in Clinical Trials.gov ID:  NCT02439580Keywords: Annona muricata L, inflammatory response, colorectal cancer, cytokine, cyclooxygenase, TNF-α, Interleukin-10, Acetogenin. 

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