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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Isoniazid Induced Psychosis Sharad Chand
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
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Abstract

Isoniazid (INH) is one of the primary drugs used in the treatment of Mycobacterium tuberculosis infection. The common side effects of INH are peripheral neuropathy, hepatitis, rashes. Rarely psychosis, convulsions, and even death have been reported on regular doses of this drug. We present a case of Isoniazid induced psychosis occurring in a 36-year-old female patient was admitted to the general medicine unit for tuberculosis. The case was analyzed for suspected ADR and found to be probable ADR of isoniazid. The drug was discontinued, and antitubercular therapy was changed to modified approach,i.e. (R- Rifampicin 450mg, I- Ethambutol 800mg, S-Streptomycin 750mg and O- Ofloxacin 400mg) which shows clinical improvement in the patient.
Microencapsulation of Lactobacillus plantarum in Lactic Acid Fermentation of Winter Melon (Benincasa hispida) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Winter melon (Benincasa hispida) is a popular vegetable that were grown primarily for its use as a vegetable and usually recognized for its nutritional and medicinal properties. Consumers tend to prefer the food and beverages that are fresh, highly nutritional, health promoting and ready to consume. Objective of this study focused on different technical parameters such as the initial soluble solid content (6.0, 6.5, 7.0, 7.5, 8.0 oBrix), loading ratio of Lactobacillus plantarum encapsulated in calcium alginate bead (2.0, 4.0, 6.0, 8.0 10.0 g/100mL), fructo-oligosacharide (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) as prebiotic affecting to the lactic acid fermentation of winter melon juice. Results showed that the best quality of the fermented winter melon juice would be achieved by the initial soluble solid content of juice 7.5 oBrix, Lactobacillus plantarum bead loading 8.0 g/100mL, fructo-oligosacharide 2.0%. Through fermentation, winter melon juice was preserved and maintained, while improving the nutritive and sensory properties. Lactobacillus plantarum was stable under acidic condition by the microencapsulation. The probiotic winter melon juice is very beneficial for health as health it plays an important role in immune system improvement.Keywords: Benincasa hispida, Lactobacillus plantarum, Microencapsulation, Fermentation, Fructo-oligosacharide, Juice.
Estimation of Adenosine Deaminase in Adult Iraqi Patients with β-Thalassemia Hassanain K. Al-Bairmani
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Beta-thalassemia is a well-known hereditary hemoglobinopathy. Patients with major and intermedia thalassemia require periodic blood transfusions. The diagnosis of this disease involves the investigation of several biochemical and hematological markers. Adenosine deaminase (ADA) has received much attention due to its role in purine catabolism, and in this work the activity of ADA was estimated among two patient groups of thalassemia (major and intermedia) and control group. A significant increase was found in studied groups as compared with control group. The levels of Iron, ferritin, transferrin, ALT and AST were also estimated in the current study. It was found that the levels of these parameters were correlated with the activity of ADA.Keywords:  Beta-thalassemia; Adenosine deaminase; ALT; AST
Antibiotic Susceptibility Pattern of Some Clinical Gram Positive Isolates Ehsan F. Hussein
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

One hundred fifty samples have been collected through the period from July/2016 to December/2016. Were for isolation and identification of pathogenic gram positive bacteria. The samples were involved fifty samples from each skin, mouth and soil for isolate Staphylococcus aureus, Streptococcus pyogenes and Bacillus spp., respectively. Isolates were identified according to microscopic features and biochemical tests .Antibiotics susceptibility pattern were examined by disc diffusion method. The antibiotics explained different action modes and some of the have significant differences when comparisons together. The Trimethoprim antibiotic has high activity against Staph. aureus, and Strep. pyogenes while the Carbnicillin, Rifaxim in and Trimethoprim antibiotics have high activity against Bacillus spp.  These antibiotics were Amoxicillin, Ampicillin, Trimethoprim, Aztreonam, Phamethoxazole, Carbnicillin, Novobiocin, Erythromycin, Rifaximin, Penicillin-G, Oxolinic Acid, Bacitracin and Clindamycin. Trimethoprim antibiotic has high activity when comparison the activity of these antibiotics together.Keywords: Pathogenic bacteria, Trimethoprim, Antibiotics, Resistant.
Antibacterial Evaluation of Gradient Extracts of Stenochlaena palustris (Burm.f) Bedd. Towards Bacteria Involved in Skin Diseases Toji Thomas
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: The work attempted to analyse the antibacterial character of gradient distillate of Stenochlaena palustris, a healing fern used to treat burn. The plant was evaluated for its antibacterial capability towards bacteria occupied in skin infections. Methods: Whole plant of S. palustris was examined for its antibacterial potential and phytochemical constituents in different solvents extracts of incrementing polarity. The typical disc diffusion method was done to inspect antibacterial activity. Basic phytochemcal assessment was accomplished by various standard spraying reagents and used to detect the same. Minimum inhibitory concentration and minimum bactericidal concentration were established towards Pseudomonas aeruginosa. Results: The plant could basically demonstrate antibacterial activity in acetone extract. P. aeruginosa was the most sensitive organism observed out of the tested bacteria. Water extracts did not provide antibacterial activity to the analysed bacteria. Phenols, flavonoids, polyphenols and sterols were track down in various extracts. Flavonoids, phenols, polyphenols and sterols found in acetone extract of the plant could be responsible for its antibacterial activity. Acetone extract of the plant yielded minimum inhibitory concentration as 12.5 mg/ml and minimum bactericidal concentration as 25.0 mg/ml towards P. aeruginosa. Conclusion: S. palustris manifested antibacterial activity in acetone extract notably towards   P. aeruginosa, a bacterium frequently associated with nosocomial infection. Keywords: Stenochlaena palustris, Antibacterial activity, Pteridophytes, Disc diffusion, Phytochemicals.
Role of Vitamin B12, Folic Acid and Oxidative Damages, in Serum of Patients with Vitiligo Sherief Mahdy Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Vitiligo is a chronic common disease which may cause as a result of oxidative stress which is proposed to implicate in its etiopathogenesis. Vitiligo is an autoimmune disease affecting skin, hair and oral mucosa. This disease is characterized by a loss of melanin. Disturbance of thyroid hormones has been known as a key trigger of this pathology. Objective: The aim of this study is to determine the levels of vitamin B12, folic acid , oxidative stress (lipid peroxidation ;MDA),total antioxidant capacity (TAC), Paraoxanase (PON1)in serum of patients with  vitiligo  compared to matches control group. Materials and subjects:  The study included 42 patients from Egyptian population suffering from generalized vitiligo (29 male patients and 13 female patients; mean age 35.1 years; ranging from 28-45 years and 36 healthy volunteers as control group (22 male patients and 14 female patients; mean age 36.2 years; ranging from 25–47years). Vitiligo patients were recruited from Medical research center of excellence of National Research Centre, Egypt, during interval of 6 months (1 October, 2018 to 31 March , 2019). Vitiligo diagnosis is based on if areas of patient's skin, hair or eyes lose coloring and confirmation is done by using Wood’s lamp. Blood samples were obtained from the patients and controls. PON1, MDA, TAC vitamin B12 (vit.B12) and folic acid biomarkers were analyzed in serum samples of both control and vitiligo patients. Results :  The present results declared  significant elevation of  oxidative stress ; MDA  (+159.26), which is associated with significant decrease in PON(-34.10) ,TAC (-35.89),vitamin B12(-53.41)  and folic acid (-89.23) in vitiligo patients compared to  control group. Conclusion: Oxidative stress and antioxidant balance are strongly implicated in the vitiligo patients .Vitiligo disease should be examined for multifactorial such as homocysteine levels for a possible implication due to the  postulation  in the pathogenesis of vitiligo based on the previous  findings . Moreover, the therapeutic role of supplementation with Vitamin B12/folic acid in vitiligo needs to be studied further.Keywords: Autoimmune disease, Melanin loss, Oxidative stress, Vitiligo, Vit. B12, Folic acid, TAC,PON.
The Implementation of No-Smoking Area Policy to Improve Community Health and its Relationship to the Country’s Pharmaceutical Policy: A Study in Semarang City in Indonesia Kusworo .
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
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Abstract

Cigarettes smoking in Indonesia is rampant despite of its harmful effects on human health and the environment, which calls for government intervention. This study examines the implementation of the No-Smoking Area Policy in increasing the degree of public health in Semarang city by focusing on the inhibiting factors of the policy, and the efforts taken by government to overcome obstacles in its implementation. The study used qualitative research with action research method. Data collection techniques were semi-structured interviews, observations, and documentation study. The data analysis technique used was the triangulation method. Findings indicate that the No-Smoking Area policy has been implemented in Semarang city but it is still in the socialization stage. There are several obstacles in its implementation that still need proper handling by the Semarang City local government, especially its health office, notably the program’s implementation, compliance and responsiveness, and resources involved, including its relatedness to the pharmaceutical policy implementation. The efforts made by the city government to overcome the obstacles in the implementation of the policies include providing guidance to the entire staff of Semarang City Health Center, socialization of the policy to the community through community health units, making No-Smoking signs, stickers, leaflets, and banners, and performing activities during the celebration of the world’s no-tobacco day. Keywords: Tobacco, Smoking and No-Smoking Area, Policy Implementation, Pharmaceuticals and Narcotics, Public health.
Dyslipidemia among Apparently Healthy Adults in Baghdad, Iraq Shaymaa A Naji
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Introduction Circulating lipids and lipoproteins are long being recognized as risk factors for developing cardiovascular diseases (CVD). Objective To evaluate the prevalence and profiles of dyslipidemia in apparently healthy (AH) and asymptomatic subjects.  Method In this cross sectional study we had randomly selected 217 AH individuals of the both the genders that were of 18- 69 years of age and disease free. Individuals having history of any medications for diabetes, hypertension and CVD were excluded from the study. The remaining healthy individuals underwent detained physical examinations and tests of lipid profiles.  Results In the overall population, the prevalence of high density lipoproteins HDL (64.5%) and very low density lipoproteins VLDL (13.8%) were most common lipid abnormalities found.  Conclusion Thus it is concluded that the AH subjects is highly susceptible to develop dyslipidemia and HDL-C abnormalities and this information could be used to design the preventive polices for future CVD events and seriously may affect the choice of AH subjects as control group in clinical researches .Keywords: Apparently healthy subjects, Lipid profile, Dyslipidemia.
Separation with Determination Iron (III) and Paracetamol Drug via Onium System Safa S. Zayied
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Onium technique used as sensitive method for extraction and determination Fe(III) by using paracetamol drug so determination this drug by using Fe(III) within a study for determination the optimum conditions appear onium species formed wave length for maximum absorbance is equal to λ max =247nm,  so this formation for stable onium species need existence 1.5 M HCl in aqueous solution and 1x10-4M paracetamol, with 15 minutes shaking time, also and in order to enhancement the extraction efficiency need operation existence 50% methanol and 0.1 M NaCl in the aqueous phase thermodynamic study shows the operation was endothermic with data equal to Δ Hex = 0. 0397  KJmol-1 , Δ G ex = -54.44 kJmol-1, Δ Sex =174.06 J mol-1k-1 , the study involved also organic solvent effect , interference and spectrophotometric determination of Fe3+ and drug paracetamol.Key words: Onium System, Iron (III), Paracetamol, Determination.
46, XX Infertile Male: A Case Report and Review in Infertility Gito Restiansyah Wasian
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: 46, XX Testicular Disorder of Sex Development (46, XX Testicular DSD) is a genetic disorder that can cause male infertility. The clinical feature of this disorder varies, ranging from ambiguous genitalia to normal male genitalia characteristics. This disorder is rarely diagnosed early and is often only found during fertility tests. The objective of this work was to determine the characteristics and managements of patient with 46, XX testicular DSD. Methods: Case report and literature review. Results: A 30-year-old came with complaints of wanting to have children after a 7-year marriage. From physical examination, it was shown normal male external genitalia with small testicular volume. Sperm analysis showed azoospermia. From hormonal examination, hypogonadotropin hypogonadism is obtained. Cytogenetics gives an overview of 46, XX male with positive SRY gene. Conclusion: Patient characteristics vary depending on the mutation that occurs. Furthermore, 46, XX testicular DSD with can be found during holistic infertility examination, such as semen and hormonal analysis and karyotyping and SRY gene detection. A multidisciplinary approach should be performed too in the management, particularly for assisted reproductive technology with sperm donor or adoption.Keywords: 46, XX male, Testicular DSD, Male infertility, SRY gene.

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