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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Functionalized Graphene Oxide (FGO) on the Electrical and Dielectrical Properties of PVA Films Sundus H. Merza
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

In the present work, nanocomposite of poly (vinyl alcohol) (PVA) incorporated with functionalized graphene oxide (FGO) were fabricated using casting method. PVA was dispersed by varying content of FGO (0.3, 0.5, 0.8, 1 wt %). The PVA- FGO nanocomposite was characterized by FT‐IR, FE-SEM and XRD. Frequency dependence of real permittivity (ε’), imaginary (ε’’) and a.c conductivity of PVA/FGO and PVA/GO nanocomposite were studied in the frequency range 100 Hz- 1 MHz.  The experimental results showed that the values of real (ε’) and imaginary permittivity (ε’’) increased dramatically by increasing the FGO content in PVA matrix. PVA/ FGO (1 wt %) nanocomposite revealed higher electrical conductivity of 6.4×10-4 Sm-1 compared to 1.4×10-8 Sm-1 for PVA/GOKeywords: Dielectric spectroscopy, Functionalized Graphene oxide, Nanocomposite, PVA, Maxwell-Wagner-Sillars polarization.
Effect of Climate Change on Occurrence of the Vectors Borne and Infectious Disease A Jabbar A
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Climate geographical maps are one over the essential roles within the manifestation regarding climate phenomena in conformity with understanding and analyze climate or health. This lookup centered concerning to signify the fitness synthesis then if global local weather exchange started according to stay explored, results on vector-borne ailments bear been a focal point because of the personal sensitivities on arthropod vector biology then vector-borne pathogen transmission after climate. Early studies raised the hypothesis regarding great effects on local weather exchange on vector-borne ailment chances but had been countered by way of arranging over research and opinions. This contends has centered about major mosquito-borne ailments up to expectation are transmitted beyond some human in imitation of some other with the aid of the vector or slave no longer involve animal hosts and the lawsuit was once these days committed because a more nuanced assessment of the effects of climate exchange about the length on different sorts over vector-borne disease. This community would have the capability to join epidemic talent yet infectious disease surveillance along meteorological, entomological, lotus quality, remote sensing, yet ignoble data, because of multivariate analyses or predictions. Insights from it analyses could then information adaptation strategies yet guard population health beyond ensuing threats associated after climate change.
Synthesis and Biological Activities of Some New Derivatives Based on 2-amino-5-mercapto-1, 3, 4-Thiadiazole Containing Imide, β-Lactam Rings Iftikhar Ahmed Hussein
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

New series of 2-amino-5-mercapto-1,3,4-thiadiazole derivatives compounds are synthesized [S1-S4], then converted to Schiff′s base [S5-S10] which is reacted with chloro acetyl chloride due to the existence of  ????-Lactam compound[S11-S16]. The prepared derivatives are identified by infrared spectra studies, 1HNMR, and physical properties. The antibacterial strains have been investigated: an activity has been shown against Gram (+ve) bacterial (stapylococus and Gram (- ve) bacteria (Esherichiacoli).Key words: 1, 3, 4-Thiadiazole, Schiff bases, Heterocyclic rings, Biological activity.
Response of the Green Alga Chlorococcum humicola Developed in Chu-13 Culture Medium to Different Concentrations of CO2 Ibrahim M.A Alsal
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Microalgae response is one of the criteria that is adopted in estimating the efficacy of any species or genus in tolerance or the fixation and withdrawal of the influential concentrations of CO2 either in its natural or supplied or combined forms with other gases. For the purpose of the application, the current study was chosen Chlorococcum humicola alga belonging to the green algae to follow the effect of different concentrations of CO2 supplier were (25, 50, 75, 100%) volume/volume, of culture volume in curves, growth rates, times of multiplication, biomass and some fatty acids. The experiment and development of alga in the Chu-13 culture medium was carried out under controlled environmental conditions of temperature and density of light and pH, as they were in the order of (25 ±2, 3000 lux, 7.6) and with a lighting system of 16:8 hour light to darkness. The alga cells was incurred into mentioned concentrations for one time by injection of the algal culture by CO2 using a device (gas-flow-meter) for three repeaters of each concentration. The results were recorded at time of Zero and daily for 18 days. The results showed that the growth curve based on the absorbency values at the wavelength 650 nm recorded from the fourth day a higher value than the standard sample of all the concentrations. The highest values of 0.71 with the concentration (50%).As for the time of multiplication, the study found that a slight differences between the standard sample and all concentrations and recorded the highest value (1.84) in the control sample for the 18th day. The dry biomass at harvest in the end of the experiment, the values were recorded (370, 360, 410, 340) mg dry weight/L at the concentrations (25, 50, 75, 100%) volume/volume respectively, while the control recorded 310 mg/dry weight/ L. The HPLC technique that has been applied to diagnose some fatty acids has also indicated the presence of acids: (Arachidic C20:4, LinoleicC18: 2(Omega6), Oleic C18:1(Omega 9), Plamitolic C16:1, Palmetic C16:0, Myristic C14:0). The highest value (403.93) % was recorded for the palmetic acid with a 100% concentration of CO2 supplier and a lower value of (82.38) % for arachidic acid with a 25% concentration of CO2 compared with the standard sample.  The conclusion of the study that the treatment with CO2 although it has not given growth rates and times is remarkably multiplied but on the other side it gave an increase in the biomass ranged of (19.35, 16.13, 32.25, 9.67%) for CO2 concentrations (25, 50, 75, 100%) volume/volume respectively. As well as identified fatty acids stimulated the increase of total percentage after harvest on day 18th of the treatment with values:  (32.443, 47.820, 53.443, 121.211, 144.409, 262.636) for each (Palmetic, Pamiotolic, Myristic  Oleic, Linoleic, Arachidic) respectively.Keywords: Microalgae, CO2, Biofixation, Capturing of CO2, Chlorococcum humicola alga.
Evaluation Cytotoxic and Anti-Cancer Effects of Salvia Officinal’s Leave Sex Tracts against Some of Cancer Cell Lines Amal Rasheed Farhan
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The free radical scavenging actions were studied using DPP Has stable free radical compound in this paper. Consequences revealed that the increasing in extract concentration the more scavenging free radicals percent. The ranged concentrations (26.2 to 1000µg/ml) that were used, nevertheless the Ascorbic acid extract of S. officinal’s significantly displayed the highest antioxidant activity (86% at 1000µg/ml) among Methanol, Ethyl acetate and hexane extracts which were 84.5.1% , 56% and 54% respectively at 1000µg/ml. This work also aimed to study the cytotoxic and anticancer effects of Salvia officinal’s Leaves extract on some cell lines, The most significant reduction in viable count cell was 400 µ/ml which related to ascorbic acid extracts  appeared to cause the induction of cell lose  spatially in the cell lines A549, HepG2, MCF-7 respectively.Keywords: Salvia officinal’s, Cancer cell lines, DPPH, Cytotoxicity.
Correlation of LIF and Glycodeline an in Prediction of Embryo Implantation of Infertile Women with and without PCOS Zena F. Hussien
Journal of Global Pharma Technology .
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Abstract

Implantation of the blastocysts into the maternal uterus is a crucial step in mammalian reproduction, which is controlled by a number of complex molecules like hormones, cytokines, and growth factors and their cross talk. A network of these molecules plays a crucial role in preparing receptive endometrial and blastocysts. This study aimed to found out the role of Glycodeline A,LIF gene expression, concentration,  in the endometrial that may interfere with implantation process of polycystic ovary syndrome (PCOS) and non-PCOS women, A convenient blood sample of 80 infertile women undergoing in vitro fertilization (IVF) program were intentionally divided according to the cause of infertility into 40 healthy women their husbands complaining from male infertility factors, and 40 infertile women with polycystic ovary syndrome. Glycodeline A, LIF were measured on ovulatory and  luteal phase of cycle (CD14-CD16,17) at the day of ovarian pickup and embryo transfer by using quantitive polymerase  chain reaction (qPCR ) and Elisa technique , Results of the present study   showed that The gene expression of PAEP ,LIF in addition to levels of  serum(Glycodeline A, LIF)  were  more valuable in  predicting  the  pregnancy out come in infertile PCOS women than in  non-PCOS women  This result  can be utilized to be used as predictors  of  implantation window for successful implantation and pregnancy.Keywords: Implantation, Glycodeline A, PCOS, IVF program, LIF.
Determain Kind and Concentration of Allium sativum L.Plant Ingredients and its Effect on Isolated Bacteria Causing Urinary Tract Infections Ayyub J. Abdl-Rahmaan Al-Baytay
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Atotal of  (190)  samples urinary were collected patients with Urinary Tract Infections(UTIs) from the period 2017/11/18 to 2018/2/17 ,for determain kind and concentration of Allium sativum L.ingredients and its effect on growth of the Gram-negative bacteria isolated from urinary tract infections in Al-Alam city/Tikrit Governoratr/Iraq,The study was carried out in the laboratories of Al-Alam Hospital and the laboratories of the College of Education for Women , Department of life Science,chemical analysis by HPLC apparatua showed the plant contain severel active ingrdients: S-ally cysteine,Y-glutomycysteine, Vinyl-{4H}1,2dithlin(agoene),di-allyldisulfide and Diallytrisulfide with concentrate,5.72% 9.75%, 53.09%,9.72%,12..85% and 10.60% respectively,also appeared many bacteria genus on In the samples taken from patients patients: E.coli, Klebsiella, Pseudomonus,Proteus,Serratia and Chromobacterium with isolates concentration reached for each genus reached, 44.2%, 23.5%, 17.6%, 5.5%, 5.8% and 2.9% respectively,and the current study for aquoues and alcoholic for  extracts appeared a clear contrast on inhibition of studied bacteria kinds, as it was alcoholic extract of Allium sativum more inhibiton than aquoues extract on the concentration 100% throught observation inhibition diameter on the concentration 25,50 and 100%.Keywords: Allium sativum+plant extract+bacteria.
A survey of quality of life among elderly population in Yogyakarta: A questionnaire-based study Dani Hanif Koncoro; Susi Ari Kristina
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Indonesia, as one of the world's developing countries, faced a demographic transition. Indonesian people's life expectancy has risen over time. It imposed the escalating elderly population in Indonesia. Quality of Life ( QoL) was an important assessment to be measured in the elderly as many comorbidities involved. This research aimed at determining QoL among the elderly population and QoL-related factors. A questionnaire-based survey was conducted among 210 elderly participants attending Yogyakarta's Elderly Community Services (Poslansia). QoL was evaluated using WHOQOL-BREF. Socio-demographic variables were analyzed using a questionnaire. Data was analyzed using SPSS version 22. QoL score differences among elderly characteristics were analyzed using Mann Whitney test. QoL score among respondents showed dimensions of social relationships had the lowest score among domains (QoL score 46.78 ± 10.72). Participants with spouses had better QoL scores than widowed participants (p 0.032). Participants who had better QoL scores than smoker participants (p
Nosocomial Infection in Al-Hilla City Hospital Amean A. Yasir
Journal of Global Pharma Technology .
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Abstract

Some of the problems are reviewed. Methods suggested for dealing with them are probably not the ideals that should ultimately be attained but minimum standards to serve as immediate objectives for the search about Nosocomial infection. They concern indications for and methods of isolation control of infection from staff, environmental contamination, and a few technical procedures. A new type of dressing towel for wounds is described.Keywords: Nosocomial Infection, Control of infection, Healthcare-associated infection, Mechanism of infection control.
Antileishmanial Activity of 2-Phenoxy Nicotinic Acid Hydrazide Sulfonamide against Leishmania (L) Major [MRHO/IR/75/ER] Promastigotes: An In-Vitro Study Parisa Kianfar
Journal of Global Pharma Technology Volume 08 Issue 07
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Abstract

Introduction: cutaneous leishmaniasis is parasitic disease in Iran and a major health problem in the country. The aim of this study was to compare the efficacy-achieved derivatives of 2-phenoxy nicotinic acid hydrazide sulfonamide and glucantime is in the treatment of leishmaniasis. Material and method: In this experimental- laboratory study Leishmania major promastigotes, a standard strain MRHO / IR / 75 / ER were cultured in NNN medium. Then in tubes containing medium, 105 Leishmania (equivalently100 ml) and 0.5 ml of dilution of 2-phenoxy nicotinic acid hydrazide sulfonamide and glucantime at a concentration of 2/0, 1, 5, 25 and 125 µg/ml separately added. Cell proliferation assay done by using BrdU (XTT) kit. Result: The results of variance analysis showed that 2-phenoxy nicotinic acid hydrazide sulfonamide derivatives and Glucantime have inhibitory effect on the parasite Leishmania. all concentrations tested 2.0, 1, 5, 25 and 125 µg/ml decreased the number of Leishmania parasites that their effects compared to control group was statistically significant (P = 0.000). Conclusion: 2-phenoxy nicotinic acid hydrazide sulfonamide derivatives able to inhibit the in vitro proliferation of Leishmania major and compared to Glucantime had better inhibitory effect on major promastigotes growth of Iranian rural leishmaniasis. Keywords: 2-phenoxy nicotinic acid hydrazide sulfonamide, Leishmania major, Glucantime, promastigotes.

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