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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Green Synthesis of Reduced Graphene Oxide Using L-Cysteine as Reductant Hassan A. Alshamsi
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

Graphene-derived materials have been studied in many applications due to its excellent electrical, mechanical, and thermal properties .There remains a real need for the easy, eco-friendly and scalable preparation method of graphene due to various potential applications. Chemical reduction is the most versatile method for the large scale production of graphene. Here we report the operating conditions for a one-step, economical and green synthesis method for the reduction of graphene oxide using a bio molecule L-cysteine under mild reaction conditions. Characterizations of the resulting product have been done by thermo-gravimetric analysis, X-ray diffraction, FTIR, UV-visible spectroscopy, EDX spectrum and the morphology of the synthesized reduced graphene oxide (rGO) was examined by AFM, SEM and TEM.
Synthesis & Characterization of Chitosan Schiff Base Hydrogel for Controlled Drug Release Maha A. Younus
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Chitosan-schiff base with three different ratios of para-Dimethyl aminobenzaldehyde& chitosan Schiff base hydrogels have been prepared for controlled drug release study. The synthesized chitosan Schiff base and chitosan Schiff base hydrogel were characterized by FT-IR, UV-Visible, SEM, analysis. Swelling properties of the hydrogel were investigated at three different media pH (2, 7, 10). The swelling degree varied with the pH, amount of crosslinking agent glutaraldehyde and with the amount of para-Dimethylaminobenzaldehyde for the hydrogels. All hydrogels were used for controlled drug release system. Aspirin was used as model drug, in three different buffer solution (2, 7, 10) as release media. The rate of release of drugs in the pH2 is more than that of pH7 and pH10 in the polymer hydrogels.Keywords: Chitosan, Chitosan Schiff base, Hydrogel, Controlled drug release.
Patients’ Characteristics and Initial Therapy at Diabetic Center of Sanglah General Hospital in 2018 Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Diabetes mellitus (DM) is a chronic disease that requires medical treatment and education to prevent acute or chronic complications. Until today, there have been no published records in the incidence of DM in Bali. The goal of this study was to observe the characteristics of patients who visited Diabetic Center of Sanglah General Hospital in 2018. Methods: This was a cross-sectional, retrospective study. The subjects of this study were all patients newly-diagnosed with DM, aged 18 or older, who came to the Diabetic Center of Sanglah General Hospital. The sampling method was all-inclusive sampling. We recorded the age, sex, body height, body weight, body mass index (IMT), baseline fasting blood sugar, and baseline HbA1C. The data were analyzed descriptively.  Results: In 2018, 1,145 patients visited the Diabetic Center of Sanglah General Hospital. The majority of the subjects were men (66.11%), with the most frequent age-group was the 50-69 years age group (69.08%). As many as 117 patients received OADs as initial therapy, while 840 received insulin, and the remaining 665 received a combination of both OAD and insulin.  Conclusions: There were 1,145 patients visited the Diabetic Center of Sanglah Hospital in 2018, with the highest age-group was the 50-69 years age group. Only a small number of them received OADs as initial therapy, and most of received the combination of insulin and OADs.Keywords: Diabetes mellitus, Age, Sex, Bali, Indonesia.
Comparison of Proventriculus and Ventriculus Histology in Gallus Gallous Domestic us According to Food Composition Fatemeh Soltani S arvestani
Journal of Global Pharma Technology .
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Abstract

The most important part of alimentary tract in digestion is proventriculus and ventriculus in poultry. Histology of these organs increasingly is affected by food composition. This study was carried out to investigate Histology of proventriculus and ventriculus with two different food compositions. One group was fed with natural food such as chopped vegetables and fruit and the other group fed with artificial food diet was provided from commercial company, for 8 weeks. Sections of proventriculus and ventriculus was provided and stained with hematoxilin and eosin routine method, histometric studies showed, there was significant increase in thickness of mucosa layer and number of adenomers in sub mucosa layer in proventriculus in group with natural food composition in compare to the other group. Moreover Thickness of mucosa layer and number of secretional crypts in sub mucosa layer and diameter of muscular layers in ventriculus showed remarkable increase in compare to the group with artificial food composition.Keywords: histology, Poultry, Diet
Methodology for Development of Pediatric Medicines for Complex Treatment of Diseases of Immune-Dependent Nature Olga Rukhmakova; Tatyana Yarnykh; Olexander Tykhonov; Galina Melnyk
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The objective of the work – is to substantiate methodology for development of pediatric medicines for complex treatment of diseases of immune-dependent nature.Materials and Methods: at the first stage of research, their objective was set, its significance for science and practical pharmacy was shown. At the information search stage, the need for new children’s medicines was identified. The second stage of research involves determining the main directions of achieving the objective. The third stage is the choice and justification of means aimed at achieving the objective, namely, the objects and methods of research. The fourth stage is devoted to the complex of experimental studies on the development of pediatric medicines for complex treatment of diseases of immune-dependent nature. At the final stage of research technical conditions, relevant sections of registration dossier and projects of quality control methods for proposed medicines were developed.Results: based on the created general methodological concept of the development of pediatric medicines for complex treatment of diseases of immune-dependent nature, we have compiled a plan of experimental research, which is given in the article.Conclusion: methodology for development of pediatric medicines for complex treatment of diseases of immune-dependent nature has been substantiated.
Electronic Properties of Adsorption of CO, CO2, OH, and B2 on Nitrogen Doped Graphene Nanosheets as a Gas Sensor Application for Harmful Gases Rajaa K. Mohammad
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

In the present work, the sensitivity of hybrid nitrogen-graphene nanosheet (Ndoped graphene) toward a series of small gas molecules (CO, CO2, OH, and B2) has been calculated based on the first-principles calculations. The properties that have been investigated are the density of state, IR spectra, and the electronic and structural properties. Interestingly, we observed that the adsorptions of (CO, CO2, OH, and B2) on the N-doped graphene are small physisorption with adsorption energy (Ead) between 0.75 to 1.15 eV, whereas the adsorption of CO on N doped graphene is high chemisorptions. The adsorption of CO and CO2 on the electronic properties lead to a decreasing in the highest occupied molecular orbital (EHOMO) and lowest unoccupied molecular orbital (ELUMO) and Fermi energy (Ef), and increasing in the energy band gap (Eg). Our findings indicate the possibility of using this nanosheet as a gas sensor for harmful gases (CO, CO2).Keywords: Electronic properties, Nitrogen- graphene nanosheet, Gas sensor, Harmful gases.
Changes of Phytochemical, Antioxidant Characteristics of Sunflower Seed Roasting Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Sunflower seeds have various target specific biological activities. There has been an increase of awareness and interest in this valuable medicinal plant in recent times. Roasting is the key process in the production of value-added nuts having better taste, aroma, and a crunchy texture and exhibit enhanced crispiness. However changes of phytochemical, antioxidant characteristics of sunflower seeds during roasting have not been well understood. This research evaluated the roasing method affecting the phytochemical and antioxidant characteristics of sunflower seeds. The total polyphenol, flavonoid contents, the antioxidant activity characteristics in sunflower seeds were examined thoroughly. It may be desirable to use roasting at 200oC in 15 minutes to minimize the loss of total polyphenol, total flavonoid contents; maintain the most antioxidant activity. Keywords: Sunflower seed, Roasting, Total polyphenol, Total flavonoid, Antioxidant.
16Sr RNA Gene and reca Gene as Taxonomic Tool for Detection of Burkholderia Cepacia Isolated from Patients from Baghdad / Iraq Zahraa Kareem Raheem
Journal of Global Pharma Technology .
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Abstract

Twenty two isolates of Burkholderia cepatia (B. cepacia) were isolated from clinical sources and  diagnostic using VITEK 2 system and GNB ID cards. Two molecular diagnostic methods have been used to confirm the identification., the first method is the polymerase chain reaction (PCR) by 16S rRNA gene (1400bp) amplification followed by sequencing the product by send it directly for DNA Sanger Sequencing to Macrogen Company / Soul, Korea, data were analyzed and edit using Geneious Program and the edited sequence were compare with data base using BLAST (Basic Local Alignment Search Tool) to find the closed relation with submitted sequences, the second method is Real-Time Polymerase Chain Reaction by recA gene (385 bp fragment) amplification. The VITEK 2 System identify all the B.cepacia isolates with confidence values (97-99) %, 16S rRNA gene amplification and sequencing results confirm the identification with percentages of identification ranging from (96-99) %, after sequencing analysis, one of the B.cepacia isolate had been submitted in Gen Bank ((National Centre Biotechnology Information NCBI) under the accession number (MF678807). These results highlight the advantage of using these PCR assay to detect B. cepacia from different clinical sources that confirm the identification of isolates which may be misidentified when biochemically tested.Keywords: Burkholderia cepacia, Molecular identification, PCR, 16S rRNA gene sequencing, Real-Time PCR, recA gene.
Bio-Adsorption of Aniline from Aqueous Solutions using Activated Raw Sludge Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Aniline is a simple aromatic ring compound with wide application in several industries. Since it is soluble and highly toxic, aniline is threatening to human and environment and can disturb aqueous species life. Aniline also has mutagenic and carcinogenic properties. The aim of the present study was to eliminate aniline from aqueous solutions by the use of activated raw sludge. In this experimental study, the efficiency of activated raw sludge in eliminating aniline along with the impact of other influential variables such as pH (3, 5, 7, 9, 11), contact time (0-120 minutes), adsorbent dose (0.2, 0.4, 0.6, 0.8, 1.5 mg/L) and aniline initial concentration (10-250 mg) was investigated. Adsorption isotherm was assessed using Freundlich and Langmuir isotherms. The results indicated that the maximum efficiency of activated raw sludge in eliminating aniline was 80% which was achieved at the optimum condition of pH 11, contact time of 30 minutes, 0.2 mg/L adsorbent dose and aniline initial concentration of 200 mg/L. In addition, isotherm data showed the most fitness into Langmuir adsorption model (R2 0.990). Therefore, activated raw sludge possesses a high capacity to eliminate aniline from aqueous solutions and chemical industry wastewater.Keywords: Aniline, adsorption, sludge, adsorption, isotherms, Langmuir 
Effectiveness of an Educational Program on Nurses' Knowledge and Practices about Prevent Complication for Patients Undergoing Thyroidectomy at Al-Hussein Teaching Hospital in Al-Nasiriyah City Ali T. Hameed
Journal of Global Pharma Technology .
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Abstract

Thyroid surgery as any surgical procedure involves risks, which can cause life-threatening complications during the post-operative stage which includes (postoperative hemorrhage, respiratory obstruction, Infection, hypothyroidism, hypoparathyroidism, thyroid storm, and laryngeal nerve damage). So, educational programs concerning to prevent this complications is necessary to nurses to have practical skills and scientific knowledge to identify and detect early signs and symptoms of potential complications and take appropriate action, so early detection and fast response are vital to limiting damage and maintaining patient safety. For the purpose of evaluating effectiveness of an educational program on nurses' knowledge and practices about prevent complication for patients undergoing thyroidectomy in ICU and surgical wards at Al-Hussein teaching hospital in Al-Nasiriyah city; the researcher has constructed a questionnaire format in order to reach the objectives of the study. The questionnaire is consisting of (3) parts which are: Part I: demographic characteristics of the nurses such as (age, gender, and years of experience, educational level, and training courses). Part II: knowledge of nurses about prevent complication for patients undergoing thyroidectomy, it consists of (40) multiple choice questions in three Axes. Part III: The practices checklist for nurses (Observation checklist), is composed of (54) items divided into three part. Reliability of instrument was determined through the use intra examiner (test & retest), and inter examiners which is assessed by calculating alpha Cronbach, and the instrument validity was determined through a panel of (15) experts. The analysis of data was performed through the application of descriptive statistic (frequency, percentage, Mean of score (MS), Differences between pre-post Grand Mean of Score, Standard Deviation (SD), and (RS %) Relative Sufficiency) and Inferential statistical (Chi-Square test, Contingency Coefficients (C.C.) test, t-test, and (ANOVA) Analysis of Covariance). The results of the study showed that the effectiveness of an educational program on nurses' knowledge and practices about prevent complication for patients undergoing thyroidectomy in ICU and surgical wards are a positive. It also shows that there are highly significant differences in the study group between pre and post-tests in overall main domains related to nurses' knowledge and practice. The study concluded that the nurses working at ICU and surgical wards they really felt the gap in their knowledge and practices about prevent complication for patients undergoing thyroidectomy and they were aware of their lack of knowledge and their practices. So, this leads to conclusion that certainly in-service education should be provided for nursing staff to equip them to meet the new demands of nursing care based on latest technological advancement and knowledge explosion in the nursing. The study recommended that providing an educational programs should be ongoing for nurses to enhance their knowledge and skills about prevent complication for patients undergoing thyroidectomy. Also, Modern instructive facilities for nursing team at surgical wards should be provided to enhance nurse's knowledge and practices.Keywords: Effectiveness, Education Program, Nurses ꞌKnowledge &Practices, Prevent Complication, Thyroidectomy.

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