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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Right for a Healthy Environment in Indonesia: Comparison of Global Laws Sigit Sapto Nugroho; Sarjiyati Sarjiyati; Anik Tri Haryani; Yuni Purwati; Susiani Tri Wahyuningsh; khudzaifah dimyati; Heru Santoso Wahito Nugroho
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Objective: The research purpose is to explains according the constitution every citizen has the right to obtain the constitutional guarantee to live and access the healthy environment. Method: The research methods is normative juridical method is conducted by examining literature material. Citizens also have the right to live in a good and healthy living environment for their growth and development. This is regulated in Article 28 on the Declaration of the Human Rights, the Stockholm Declaration, and the constitutions of countries in the international world. Results: Result of the research is the rights for a good and healthy environment brings a burden of responsibility for the state to protect and to sustain the living environment’s supporting power for the sake of the future generations. Conclusion: The conclusion from this research is that the efforts to uphold these rights may be guaranteed by the constitution. Thus, every citizen may file a lawsuit to the court if the state does not fulfil this right
Vinblastine Based Iron Oxide Nano Drug Delivery System Mohammed S. K. Albermani
Journal of Global Pharma Technology .
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Abstract

Magnetic nanoparticles are a class of nanoparticles with significant properties which make them a highly promising to contribute in a drug design. The size depend property is the key issue that nondrug delivery system relaying on as well as the size of these submicron nanoparticles compared with the volume ratio. Many researchers in the being time focusing on the use of the innovated property of Magnetic nanoparticles applications in drug delivery systems due to their stability and biosafety compared with the others nanoparticles. Hence  Iron Oxide have been chosen for this study and formulated by co-precipitation method with the size ranging between 50-100 nm in diameter the size and the morphology of the iron oxide were conformed using SEM. Vinblastine sulfate which is well known as a powerful chemotherapy against cancer have been incorporated with the iron oxide NPs and tested on MCF-7 a breast cancer cell line at different intervals of time 24hrs, 48hrs and 72hrs, a bright field and fluorescent  image was taken to show the health growing of the cells. MTT survival assay have been conducted to measure the cytotoxity of the iron oxide-vinblastine and compare it with the pure vinblastine. The entire Vin- Fe3O4have shown more efficiency to inhibit the growth of MCF-7 cell line compared with the pure vinblastine. This formulation can be considered as a useful functional drug to cure cancer.
The Effect of Oral Vitamin D on Patients with Alopecia Areata Ethar Salah Nadhim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Patients who had alopecia areata (AA) presented with markedly lower levels of vitamin D3. Adding to that, vitamin D supplementation could have a protective role in human autoimmune illnesses such as AA, so the aim of the study was to identify the role of systemic vitamin D effect on patients with AA in comparison with the other medications, study the effect of combination of vitamin D and other medications on all symptoms of AA and study the C-reactive protein (CRP) and its relationship with AA. Conclusion: The patients with AA who were treated by combination treatment (steroids and vitamin D) had a better response than the patients who were treated by steroids only, and the response of the group of patients with AA who were treated by vitamin D only was not significant. There was non-significant association between CRP and AA.Keywords: Vitamin D, Alopecia areata, Vitamin D deficiency.
Changes in Some Biochemical Properties during Different Maturity Stages of Peels, Pulps and Fruits of Pomegranate (Punicegranatum) Marwa Ali
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Fully ripe, mid-ripe and unripe pomegranate fruits were gathered from the fields of Hilla city Iraq during the year 2016/2017 to estimate Na, K elements and some biochemical parameters such as coumarin gallic acid and tannin ,also the peels and pulps of pomegranate for three different countries (Yemen Iraq and Egypt) were separated to determine Na, K and some biochemical compounds which analyzed by (HPLC) owing to this study the mid-ripe fruit had the highest quantity of Na and K whereas fully –ripe fruit had the highest quantity in gallic , coumarin and tannic acid Yemeni an pulp had the highest quantity of Na where, as unripe Iraq pulps had the highest amount of K  while peels and pulps of Egyptian pomegranate had the lowest amount of K element . The results of active compounds indicated that Iraq unripe peel had the highest quantity of coumarin and tannic acid compared to the others, where as they had the lowest quantity of these acids in pulp part of pomegranateKeywords: Pomegranate, Comuranin, Active compounds, Ripe and unripe fruits.
Using the Water Quality Index as a Powerful Tool to Assess the Water Quality for Drinking Purposes in Al-Salam, Western Region of Baghdad City, Iraq Jalal N. Jeber
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Tap waters play an important role in fulfilling the people needs for drinking and domestic purposes. Contaminate the tap water with different pollutants has become an issue of great concern for 90% of people who are depended on the tap water as the main source of drinking. Pollutants can make their way easily into the delivering pipes which suffer from the leaking resulting in decreasing the quality of water. Objective: Therefore, assess the water quality for drinking purpose by calculating the water quality index is an important tool to ascertain whether the water is suitable for human consumption or not. Methods: In the present work, the water quality of the Al-Salam, western region of Baghdad city, Iraq was investigated for 7 months (Jan-July 2017). 63 tap water and 7 water station samples were collected and analyzed using standard methods. The index proposed measuring nine parameters which are: TDSs, pH, TH, DO, phosphates, nitrates, temp, BOD5, fecal coliform, turbidity and conductivity. The calculated values of parameters were normalized into the scale (0-100) and converted to the quality rating statements (Excellent, good, medium, bad and very bad). Results: The results show that WQI values of the tap water samples have ranged from 64- 83% while it ranged from 88-94 for the water station samples. Also, it can notice that none of the water samples is recorded WQI=100 during the entire period of the study. The proposed NFS index was able to determine the water quality and it presents an accurate, rapid and modern way to evaluate and monitor the water quality.Keywords: Water quality index, Drinking water, Pollution.
Evaluation of Disincentive Effects of 70% Isopropyl Alcohol and 10% Povidone-Iodine Safety Antimicrobial Agents of Skin Nada Khazal Kadhim Hindi
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Many disinfectants were used clinically in both single and mixture applications, however there had been few research on disincentive electricity according to sterilization series when the use of an aggregate of disinfectants. Aim; the purpose of present study was to evaluate the antimicrobial of two disinfectants each one alone and when the usage of a combination of them on skin isolates bacteria. Methods; One hindered and eight healthy volunteers were recruited. first groups were treated with a70% isopropyl alcohol on forearm, second groups were treated with 10% povidone-iodine on forearm and third groups were treated with  combination of 70% isopropyl alcohol and 10% PVP-I on forearm included disinfections on the both forearm with isopropyl alcohol first followed by 10% PVP-I. Skin cultures have been acquired the usage of cotton swabs three minutes after application of each disinfectant, and then had been inoculated on blood agar plates for bacterial lifestyle Result; There was no significant difference in the number of positive cultures between subject treated with single disinfect  (first groups, 150bacterial isolates for subject  treated with a 70% isopropyl alcohol; while in the second group 108bacterial isolates for subject  treated with10% povidone-iodine (P < 0.01)).Third groups was more effective than disinfection with a single agent  since there were only 48 bacterial isolates  suggesting that there is relationship between disincentive power of mixed two disinfectants that  used in present study. Conclusion: The combination of 70% isopropyl alcohol and 10% PVP-I was more effective than disinfection with a single disinfects of them with either 70% isopropyl alcohol or 10% PVP-I disinfect.Keyword: Antimicrobial agents, 70% Isopropyl alcohol and 10% povidone-iodine.
Evaluation of In-Vitro Anticancer Activity of Hibiscus Rosa Sinensis against HeLa cell Line P. Sampath Kumar
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

            The antifungal activity of Hibiscus rosa sinensis was evaluated against the following pathogenic fungi such as Candida albicans, Aspergillus niger, Trichoderma viride and  Rhizopus microsporus. The acetone extract of Hibiscus rosa sinensis flower showed little antifungal activity.  The acetone extract of Hibiscus rosa sinensis flower showed higher activity against HeLa cell line using MTT assay. The results obtained from the study revealed that Hibiscus rosa sinensis flower  Possess anticancer  activity against HeLa cell line using MTT assay.  
Technical Variables Affecting to Production of Pickle Ficus (Ficus Racemosa) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The plant Ficus racemosa occupies a vital place in the traditional system of medicines. It contains antioxidants which quenches free radical damage to cells and tissues. The short shelf life of ficus can be a major cause of postharvest losses especially during peak harvesting season. Fermentation is one of the most convenient technologies for the production of shelf stable food product. The objective of this study was to evaluate different variables influencing to the fermentation of ficus such as concentration of CaCl2, temperature and time for blanching; effect of ratio Lactobacilus acidophillus to the antioxidant of fermented ficus. Results showed that ficus should be blanched in hot water 95oC in 15 seconds with the present of 3.0% CaCl2. Moreover, the fermentation process for pickle ficus had the best antioxidant by addition of 15% sugar, Lactobacilus acidophillus at ratio 2.0 x 108 cells/ml. Blanching and fermentation had significantly affected to antioxidant capacity and firmness of pickle ficus. The pickle ficus had a high content of antioxidant as well as firmness. This plant holds a great prospective source for developing herbal products and thus a vital source of income for the pharmaceutical industry.Keywords: Ficus, pickle, fermentation, blanching, Lactobacilus acidophillus, antioxidant.
Evaluation of Narrow Band Ultraviolet B (NBUVB) Treatment in Patients with Lichen Planus Farah Saleh Abdul-Reda
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background: In lichen planus, cutaneous lesions usually resolve within 2 years; however, treatment may be justified to reduce time till resolution and relieve the symptom of itching. Treatment may include a variety of agents that have been described as 1st line, second line and third line therapies. Oral lesions may resolve spontaneously within 5 years; but most cases are chronic, therefore treatment must be justified when ulcerative lesions interfere with normal feeding, otherwise treatment should be avoided because the burden of side effects is much more than the obtained benefit.  Aim of the study: to evaluate the response of patients with lichen planus to narrow band ultraviolet B phototherapy. Patients and methods: The present cohort study included 40 patients with lichen planus with and age range of 11 to 55. The study was carried out at the dermatology unit, Al-Diwaniyah Teaching Hospital located at Al-Diwaniyah province, Mid-Euphrates region of Iraq. The duration of study extended from January 2018 till March 2019.All patients were treated twice weekly (two sessions per a week).The starting dose was 150-200 mj/cm2, then the dose was increased 10-20% per session. All patients were followed for a period of 6 up to 12 months in order to record the quality of response and relapse and number of relapses if ever happened. Results: Patients received treatment sessions that ranged from 25 up to 50. Patients with excellent response accounted for 20 (50 %), patients with good response accounted for 10 (25 %), patients with fair response accounted for 7 (17.5 %) and patients with poor response accounted for 3 (7.5 %). Response to treatment showed no correlation to any of demographic characteristics. After 6 months of follow up only 5 patients developed relapse and after one year the number rises to 7 patients. Conclusion: In view of the available data obtained from the current study and previous reports it is obvious that NBUVB treatment in patients with lichen planus is associated with an acceptable complete and partial response rate with good patient satisfaction.Keywords: Lichen planus, Narrow band ultraviolet B therapy.
The Study of Morbidity Structure in Children Using Automated Computer Technology Dmitriy Karlov
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The combination of new computer and electronic technologies with methodologies for analysing large databases is considered efficient for increasing the effectiveness of screening methods for detecting diseases. Aim of the research is to study the effectiveness of using an automated complex of dispensary examination (ACDE) for detecting pre-nosology conditions and pathologies of organs and systems in children compering to traditional medical examinations. 948 children aged 6 to 17 years were examined. There were 437 (46.1%) boys and 511 (53.9%) girls. The average age of children was (11.36 ± 1.25) years. First, all children underwent a traditional preventive medical examination, and then a programmed medical examination for all organs and systems using an automated complex of dispensary examinations. The following diseases predominated according to the structure of pathology among the children examined: the musculoskeletal system (in 74.3% of children), cardiac pathology (in 52.5% of children), dental diseases (in 51.4% of children), and diseases of the nervous system (in 48.6% of children) and ophthalmic pathology (in 46.5% of children). The detection frequency of pre-nosology conditions / pathology of organs and systems using the automated complex of dispensary examinations is significantly higher (p

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