cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 231   232   233   234   235 
Synthesis and Identification of Some New Derivatives of Benzoxazole Bearing Pyrazole and 1, 2, 4-Triazine Rings Ahmed S. Hamed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this work, new derivatives of benzoxazole bearing two types of heterocyclic rings; pyrazole and 1,2,4-triazine have been described. This work involved preparation hydrazide derivative 5 as a key material in the synthetic route, which was obtained over five sequence steps. Reaction of 2-aminophenol with CS2 under basic conditions afforded 2-mercaptobenzoxazole 1 in 61% yield.  Michael addition of 1 to ethyl acrylate provided the desired ester 2 in a good yield (74%). Thereafter, hydrolysis of the ester group at 2 using basic conditions yielded the corresponding acid 3. The acid 3 was then converted to acid chloride 4, followed by nucleophilic addition of hydrazine hydrate was performed in a one-pot reaction and provided the desired hydrazide 5 in a 71% yield. Pyrazole derivatives 6-11 were then obtained via reaction of 5 with 1, 3-dicarbonyl compounds. Whereas, treatment of 5 with 1, 2-dicarbonyl compounds and NH4OAc in the presence of K2CO3 as a base gave the desired 1, 2, 4-triazine derivatives 12-17.        Keywords: Benzoxazole, Anticancer, 1, 2, 4-Triazine ring, Heterocyclic.
Assessment of Patients with Coronary Artery Diseases Need to Discharge Plan regarding to Living and Home Arrangement at Babylon Teaching Hospitals Kareem Waheed Mohamed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Coronary artery disease is one of the most serious diseases affecting human health, leading to more disability, economic cost and death (Hussein. 2014). Implementing the discharge plan from the health personals in the hospital correctly is to reduce the patient's long stay in the hospital also to improve the coordination of services after the discharge to home and reduce the frequency of admission to the hospital (Shepperd, ET .al. 2013). Objective: To assess the needs of patients with coronary artery disease for discharge plan related to living arrangement and home activities. Method and Results: Descriptive- cross sectional design selected to carry out this study, two Babylon Teaching Hospitals used to collect the study from the period between 1 Sep. 2016 to 1 Sep. 2017.Non- probability purposive sample of (100) patients who admitted to the Coronary Care units or medical ward were selected to participated in the study. Special questionnaire prepared after comprehensive literature review, face-to-face interview used as a method to collect the data. The statistical results shows that the majority (65%) of the study sample were male, (64%)were 60 or above 60 years old, (41%) were illiterate, most of the sample (34%) were retired, related to the living arrangement and home activities they recorded poor responses regarding most items. Conclusion: Significant need poor related to home and living arrangement discharge plan for patients with coronary artery disease. Which need health team intervention? Poor responses recorded by the patients with coronary artery disease, significant need to structured discharge plan related to living arrangement and home activities clearly appears. Significant need, poor responses recorded by the patient with coronary artery disease related living and home arrangement. Recommendation: Special discharge plan may take place to cover the patients need and increase their knowledge related to the home activities and living arrangement, which enhance life style and reduce expected complication.Keywords: Discharge plan, Coronary artery disease, Living and home arrangement.
Regression on cause-specific hazard in Competing Risks for Survival analysis sujatha vishnumoorthy
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In the study of  survival analysis, Kaplan–Meier (KM) estimates of survival curves and Cox proportional hazard models were widely used to describe survival trends and identify significant prognostic factors. All these statistical analyses deal with only one type of event like death, independently of its cause. Most part of the analysis are all  based on the hazards. In a competing risks setting, There are two types of hazard namely, the cause-specific hazard and the sub distribution hazard. The cause-specific hazard is the instantaneous risk of progression to a specific type of event, conditionally on being at risk for experiencing that event, generally hazards are not the probabilities, they are the rates., and used to quantify the probability of the crude risk or cause-specific cumulative incidence to progress to a specific cause by time t, When estimating the cause-specific hazard, the individuals experienced a competing event leaving behind the risk set. The cause-specific regression model was applied on to the real data sets and  try to shed light on causal mechanisms and prediction at the population level.
Synthesis and Characterization of Silica-Thioamide Hybrid Compounds Derived from Rice Husk Ash with Expected Biological and Catalytic Activity Hayder Hamied Mihsen
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The thiosemicarbazide (TSC) and thionicotinamide (TNA) were immobilized onto silica extracted from RH (rice husk) using 3-chloropropyltriethoxysilane (CPTES) forming solid organic-inorganic hybrid compounds labeled as RHACTSC and RHACTNA, respectively. The   BET data of the new compounds reported that the surface area for RHACTSC and RHACTNA to be 240 m2g-1 and 153 m2g-1 with an average pore diameter of 4.63 nm and 5.25 nm, respectively. The analysis of CHNS and FT-IR spectra revealed that the thiosemicarbazide and thionicotinamide have successfully incorporated on RHACI. The amorphous nature of RHACTSC and RHATN was investigated using X-ray diffraction technique, while the scanning electron microscope (SEM) technique showed that the surface was smooth with white rocky shape particles. Thermogravimetric analysis (TGA) of RHACTSC and RHACTNA indicate that the disappearance of  physical adsorb water between 25- 217 °C, while at 588°C the residual parts of materials were decomposed.Keywords   Rice husk ash; thiosemicarbazide ; thionicotinamide; organic-inorganic hybrid ; surface area.
Ability of Staphylococcus spp. Isolated from Meningitis Patients to Adhesion Luma Abdulhady Zwain
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A total 248 clinical samples of cerebrospinal fluid (CSF) were collected from meningitis patients, for the period of July to October 2018 from the Child Protection Teaching Hospital in the Medical City Compound in Baghdad. All isolates were identification depending on macroscopic, microscopic, biochemical tests and definite with Vitek-2 compact system. The results showed a growth in 42 samples.  Sixteen isolates of Staphylococcus spp. were obtained from samples .The number of the percentage of isolates according to species as follow: 7/16) 44%) of S. epidermidis, 3/16 (19%) of S. hominis, 3/16)19%) of S. haemolyticus, 2/16 (12%) of S. aureus, 1/16 (6%) of S.warneri. The ability of isolates on adhesion were studied and the results showed the use polystyrene plates, that the number of adherent cells of S. epidermidis was 230 cells / field, S. hominis was 62 cells / fields, whereas S. aureus was 3 cells / field, while in S. haemolyticus >300 cells / field, finally the number of cells in each field of S.warneri reached 40 cells / field.  In use epithelial cells (Vero cell line), the results of our current study we observed that, the number of all Staphylococcus spp. in zero dilution were >300 cfu. and  S. epidermidis, S .hominis, S. aureus, S. haemolyticus , S. warneri were (85,120,>300 , ,>300  ,>300 )cfu respectively   at 1:10 dilution, while  at the dilution 1:100 the number were(9,30, >300, >300 ,292)cfu respectively.Keywords: Staphylococcus spp., Meningitis, Adhesion.
Preformulation Parameters Characterization towards Design, Development and Formulation of Etodolac Loaded Nanoparticles Saminathan C
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The purpose of the present study was to systematically investigate some of the important physicochemical properties of Etodolac loaded nanoparticles. Etodolac is a non-steroidal anti-inflammatory drug, is used to manage rheumatoid arthritis associated symptoms. Almost all drugs are marketed as tablets, capsules or both. Prior to the development of these major dosage forms, it is essential that pertain fundamental physical and chemical properties of the drug molecule and other divided properties of the drug powder are determined. This information decides many of the subsequent events and approaches in formation development. A modified release nanoparticle of Etodolac was prepared by solvent evaporation method using EUTRAGIT RS 100 as coating material. Hence along with selection of excipients, the preformulation study of drug Etodolac is completed for successful formulation of modified release nanoparticles. Preformulation studies included solubility, pKa, dissolution, melting point, assay development, stability in Solution, stability in solid state; microscopy, bulk density, flow properties, excipients compatibility, entrapment efficiency and release profile of nanoparticles were investigated. The experimental values and results of this study will be presented. Keywords: Nanoparticles, Entrapment efficiency, Etodolac, EUTRAGIT RS 100, Preformulation.
A Brief Review of Probiotic: Action Mechanism, Benefits, and Clinical Application on Human Health Dewa Ayu Agus Sri Laksemi; I Ketut Tunas; Ni Luh Putu Eka Diarthini
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Probiotics are live microorganisms that are commonly used as food supplementation to provide a positive impact on human health. There was an increasing number of studies concerned with the benefit of probiotics due to the enhance community awareness of health. The primarily role of probiotics are known strengthening the epithelial barrier, increasing attachment to the intestinal mucosa, inhibiting the attachment of pathogenic bacteria, competitive exclusion of pathogenic microorganisms, producing anti-microbial substances and thereby modulating host immunity by initiating specific genes activation in the host intestinal tract system. The benefits of probiotics are not only limited to the gastrointestinal system but the mechanism of action includes other organs such as respiratory, urogenital, endocrine, and immune system. Hence, this review study will focus mainly on three aspects such as benefits, action mechanism, and its clinical application of probiotics on human health.Keywords: Action mechanism, Benefits, Clinical application, Probiotics.
Sustainable Exploitation from Aquifer of Shahrekord Plain Using the Various Scenarios Rahim Alimohammadi Nafchi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Human's insufficient information of its role that naturally played for the water cycle in nature (hydrologic cycle) and the set of these treats and performances are as main factors to divulge source of economic, environmental and social challenges at the different communities. Lack of appropriate use and comprehensive management of water resources in the catchments were caused that was made imbalance at the water balance in catchments and aquifers. In this regard, for implementing the integrated water resources management in the Jahanb in catchment and to avoid the negative performance and balance of Shahrekord plain, to protect and continuing of aquifer life and sustainable exploitation from it, this project was implemented at the Jahanbin catchment for two years. To analyze the situation of water resources in the future by predicting five scenarios from the method of water balance equation and using software Modflow, behavior and reaction of Shahrekord plain aquifer were used. The results indicate that the water balance of aquifer is always negative. Negative performance and reaction of aquifers has caused to be having a subsidence from 1976-1977to2013-2014that is 14.9 m. According to the conditions of 2013-2014, the results show that a subsidence in groundwater level will be in the short term (5-year in 2018) and the medium term (12-year in 2025) 17.8 and 43.4 m, respectively and the most of area tube wells will be dryin long-term (20-year in 2033). It should be noted that if a specific program was not carried out to manage water resources, it caused that catchment subsidence and finished the stored water of aquifer off.To prevent events as the subsidence, drying up wells, and unemployment of people and prevent the migration of residents, it needs to adhere to optimize water use and integrated water resources management in catchment by executive ruling and precise and intelligent control of water extractions in the Jahanbin catchment.Keywords: Jahanbin catchment and Shahrekord plain, Various scenarios, Sustainable and integrated water resources management, Water balance. 
Real Time PCR and Urine Cytology for Detection of BK Human Polyoma virus in-patient with Hemorrhagic Cystitis in Iraq Faiz Kamel Al-Salami
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hemorrhagic cystitis (HC) is considering one of the important complications in lower UT. Hemorrhage, hematuria, and dysuria are most common symptoms. In hemorrhagic cystitis, short-term hematuria can also be seen in bladder infections a result of viral infection. Viral cystitis represents another form of non-bacterial urinary tract infection touching adult and children. Human polyoma virus BK types I and V, Adenovirus types 21 and 11 and CMV viruses also can be cause of hemorrhagic cystitis. For direct detection BK polyoma virus from the aim of the present study work was to find out the relation of polyoma virus BKVS with acute syndrome consists of hematuria. This study was performed on two hundred and thirty bloody urine and blood specimens were collected from patients group comprised 170 male and 60 female age group 6 -65 years  Patient samples (Urine and blood) were collected for detection of Human polyoma virus (BKVS) by using urine cytology, Real time PCR and conventional PCR technique. All bloody urine cultured on ordinary media to differentiate between bacterial and viral infection.  The result of  present  study was found that 154 samples (67%) have positive bacterial culture which excluded and the other 76 samples(33%) give negative bacterial culture were included as suspected  a viral cause of hematuria. All negative culture cases was classified as 4(5.26%) patients with glomerulonephritis, 15 (19.73%) chronic renal failure, 14 (18.42%). urinary tract infection, 27(35.5%) kidney transplantation 16 (21.5%) cystitis. urine cytology for detected decony cell (DC) showed that 13(17.1%) samples were positive for BKVS and 87(82.9%) were negative. All urine patients 76 with 25 urines samples of control were analyzed by RT-PCR for detection BVS. It was found only 5(6.67%) as a positive result. In conclusion this study report the design, development and application of real time PCR and  urine cytology assay for rapid, specific and highly sensitive detection of   BK virus genotype I2b.Keywords: Real Time PCR, Urine cytology, BK virus& Haemorrhagic cystitis.
Effect of Blanching and Lactobacilus Acidophillus to Pickle Bitter Gourd (Momordica Charantia) Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bitter gourd is (Momordica charantia) widely cultivated as a vegetable and medicinal herb in Vietnam. Bitter gourd is a highly nutritive plant composed of different benificial compound including bioactive chemicals, vitamins, minerals, antioxidants. Bitter gourd has lot of health benefits with good nutritional value but it is not consumed extensively due to its bitterness, the processing methods improved nutrients. Lactic acid fermentation may be considered as a simple and valuable biotechnology for maintaining and/or improving the safety, nutritional, sensory and shelf life properties of bitter gourd. The objective of this study was to evaluate different aspects affecting to the fermentation of bitter gourd such as concentration of CaCl2, temperature and time for blanching; effect of ratio Lactobacilus acidophillus to the antioxidant, firmness and bitterness of pickle bitter gourd. Results showed that bitter gourd should be blanched in hot water 95oC in 10 seconds with the present of 2.0% CaCl2. Moreover, the fermentation process for pickle Bitter gourd (Momordica charantia) had the best antioxidant by Lactobacilus acidophillus at ratio 1.5 x 108 cells/ml. Blanching and fermentation had significantly affected to antioxidant capacity, bitterness and firmness of pickle bitter gourd (Momordica charantia).Keywords: Bitter gourd, Momordica charantia, Pickle, fermentation, Blanching, Lactobacilus acidophillus, Antioxidant.

Page 233 of 244 | Total Record : 2439

 231   232   233   234   235 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue