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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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Decrease of Sub-synchronous Oscillations Based on the Reduced-Order Observer Mahdi Mozaffari Legha
Journal of Global Pharma Technology Volume 08 Issue 06
Publisher : Journal of Global Pharma Technology

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Abstract

In this paper, a novel approach is proposed by using optimal state feedback, based on the reduced – order observer structure. The Linear Observer Method was adopted in this paper to study the SSR damping characteristics with TCSC. The study system was modified from the IEEE Second benchmark model by changing a part of the fixed series capacitor to TCSC. It is tried to stable torsional modes of turbine – generator units and improve their damping by using optimal linear control, with an practical viewpoint. The proposed method is applied to the IEEE Second Benchmark system for SSR studies and the results are verified based on comparison with those obtained from digital computer simulation by MATLAB.Keywords: optimal state feedback, TCSC, SSR, MATLAB software.
Isradipine Loaded Solid Lipid Microparticles for improved Oral Drug Delivery: preparation, solid state characterization and pharmacokinetic evaluation PALANISAMY VISHNU
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
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Abstract

Purpose: The objective of the study was to develop and evaluate the isradipine (ID) loaded solid lipid microparticles (SLMs) for enhanced oral delivery. ID is a dihydropyridine calcium channel blocker, having low oral bio-availability (15-24%) due to poor aqueous solubility and also hepatic first-pass metabolism.Methods: ID-SLMs were developed by hot homogenization coupled with ultrasonication method followed by lyophilized. The prepared SLMs were optimized. Solid state characterization and surface morphology of SLMs were analyzed using FTIR, DSC, XRD and SEM, respectively. The physical stability of optimized formulation was studied at refrigerated and room temperature for 6 months. Further, single dose oral bioavailability study was conducted in male Wistar rats compared to suspension at a dose of 5 mg/kg body weight.Results: ID-SLMs prepared with Dynasan-114 (ID8) having particle size, PDI, ZP and entrapment efficiency (EE) of 618.2±4.01 nm, 0.408±0.020, -25.9 mV and 94.85±3.61%, respectively and was physically stable for 6 months. Formulation ID8 SLM showed faster release, has less particle size and more zeta potential. FTIR and DSC, XRD studies revealed that no interaction between the drug and lipids, and conversion of drug to amorphous form. SEM studies showed nearly spherical shaped particles. From in vivo studies, indicated that 2.69-folds enhancement in the bioavailability of SLM compared with control.Conclusion: Thus, the results conclusively demonstrated the role of SLMs for significant enhancement in vivo effect of ID. 
New Diquinazoline Derivatives: Synthesis and Evaluation of Anti-Bacterial Activity Ameer A. Hussein
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Oxazine and quinazoline has a very important in organic chemistry especially in hetero cyclic fields. this research consist the preparation of 4H,4'H-2,2'-bibenzo[d][1,3]oxazine-4,4'-dione compound (1) from di acid chloride with 2-aminobenzoic acid in pyridine as solvent to give compound (2) 3,3'-diamino-2,2'-biquinazoline-4,4'(3H,3'H)-dione .compound 2 include free amino group .this compound was reacted with maleic and phthalic anhydride for synthesized of cyclic imide compounds (3,4).another reaction for compound 2 with some substituted aromatic aldehyde for prepared of some novel Schiff bases (5-9) contains quinazoline ring. compound 1 was treated with sulfathiazole and sulfadiazine for synthesized of sulfa compounds contains sulfone amide groups (10,11).compounds (12,14) were prepared from the reaction of  4H,4'H-2,2'-bibenzo[d][1,3]oxazine-4,4'-dione with some primary amine p-aminoacetophenone ,p-amino acetanilide to product of (12,13) but compound 14 was prepared from reaction of of compound 1 with 3-amino-2-phenylquinazolin-4(3H)-one to give compound 14 consist four rings of quinazoline. all synthesized compounds were measured for antibacterial activity and the structures of quinaolines were confirmed by thin layer chromatography, melting points ,Fourier transform infrared, H-NMR, elemental analyzer.Keywords: Dioxazine, Diquinazoline, dicyclicimide,antibaterials.
Development of Early Detection Instruments for Development in Children with Special Needs Nurwening Tyas Wisnu; Tutiek Herlina; Tinuk Esti Handayani
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Golden age is a very important period to pay attention to the development of children, especially if there is a suspicion that the growth and development is different from children of his age. Objective: To develop early detection instruments for growth and development in children with special needs. Method: The research design was Research and Development carried out in 2 stages. The first stage was identifying the DDTK instrument from the SDIDTK and Denver II manuals and then conducting FGDs with 70 participants. The second stage is test results development of 30 parents and their children with special needs to get recommendations on the results of instrument development. Methods to identify children with special needs by means of observation, interviews, documentation, orders and a combination of 3 methods. Data analysis using descriptive analysis, validity test and using product moment and reliability using Alfa Chronicle. There are eight questionnaires to detect blind, deaf, mentally retarded, disabled, disabled, autistic, ADHD and special intelligent. The development of this instrument has the addition of aspects of behavior and physical appearance that exist in children. The development of instruments for early detection of development of children with special needs consists of 8 questionnaires. The results of the instrument trial showed good results and the opinion of special school teachers and ABK therapists was very positive with the development of this instrument so it is recommended to be disseminated to posyandu cadres, the community and health workers. Keywords: instrument, early detection of growth and development, children with special needs
Obstacles of Educational Supervision in the Province of Kerbala as Seen by Educational Supervisors Diaa Saleh Mahdi Al-Attar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The main objective of this research is to identify the most common obstacles facing educational supervision in Karbala Governorate. The research community has identified a number of educational supervisors in Karbala Education Directorate. A sample of (90) supervisors and supervisors were selected. To complete the research, a questionnaire was prepared (45) items distributed on five axes, and indicated the search results to the physical and administrative obstacles that limit the effectiveness of supervisory practices and a high degree, and that teachers look passively supervisors greatly affect so that should be changed because the supervisors' colleagues to achieve the goals of practical education.Keywords: Obstacles and educational supervision.
LEPROSY DETECTION USING IMAGE PROCESSING AND DEEP LEARNING Suresh Kumar; HARSHIT Jain; SRIVINAYAK CHAITANYA ESHWA
Journal of Global Pharma Technology Volume 09 Issue 09
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Abstract

Leprosy, generally called as Hansen's ailment, is an enervating and ceaseless bacterial malady. As indicated by World Health Organization's report, there were 189,000 uninterrupted occurrences of Leprosy in 2012 with 230,000 new conclusions. Though it is reparable at later stages, an early conclusion expects nerve deliberation and the inadequacies it causes. The makers thusly put forward a Convolutional Neural Network based building for Leprosy damage affirmation. To set up the framework, researchers and scientist use DermnetNz datasets close by web scratched pictures to finish a best accuracy of 91.6% on a dataset split into 60% of get ready pictures, 20% of pictures are used for cross endorsement and 20% for testing of the results.
Synthesis and Thermal Characterization of new interpenetrating polymer network (IPN) Silicone- Epoxy Resins Ali M. Abdulla
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Polymers are widely used in industry and in our daily life because of their diverse functionality, light weight, low cost and excellent chemical stability. However, on some applications such as heat exchangers and electronic packaging, the low thermal conductivity of polymers is one of the major technological barriers.   Interpenetrating polymer network (IPN) is a novel type of polymer hybrids, which possess physicochemical properties suitable for high performance coating. Heat resistance IPN have been prepared from immiscible resins , epoxy and silicones using a cross-linking agent and a catalyst. The products were analyzed by, FTIR, TGA, DSC, UV-Vis and SEM studies .It was different from those of the individual resins. Silicone micro domains could be seen uniformly distributed in epoxy   regions.                                         Keywords: Silicone-Epoxy Resins,  Interpenetrating polymer network (IPN), Polymer.
Molecular Detection of Bio Film Gene in Pseudomonas Aeruginosa Isolates from Tonsillitis Enas Jalil Al-Mayali
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

This study aimed to investigate Pseudomonas aeruginosa that cause surface and core tonsils from patients suffering from acute or chronic tonsillitis. A total of 130 samples represented by 100 sample from surface tonsillitis and 30 sample from core tonsillitis after tonsillectomy were referred to Al-sader medical city and Al-Hakim general hospital in Al-Najaf province (Ear, Nose and Throat unit), within period from September 2016 to February 2017.These patients ranged from 2-60 years .A (70) of them were males .A( 60 )were females.The result indicated , 25 from all surface tonsillitis were  pseudomonas aeruginosa ,but not present this bacteria in core tonsillitis .Genetic ,study some genes encoding to virulence factors and responsible for pathogenesis to Pseudomonas aeruginosa by using PCR and electrophoresis. The results indicated ,all P. aeruginosa isolate contain AlgD , RpoS gene that responsible for polysaccharide (alginate) and alpha factor in RNA polysaccharide and responsible for encoding many virulence factor respectively and present high percentage from PsIA ,PelA gene from P. aeruginosa isolate that encoding to biofilm formation .
Effect of Edible Film Glazing to Physico-Chemical, Microbial and Sensory Attributes of Frozen Pangasius Fillet N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Pangasius is a type of catfish that is endemic to the waters of Mekong basin in south-east Asia, belongs to the family Pangasiidae. It is generally processed to frozen fillets for domestic consumption and also exported to Europe and USA. Freezing and cold storage is an efficient method which preserves taste and nutritional value. Glazing is a process used to reduce undesirable drying or dehydration of fish during frozen or cold storage. Objective of the current research studied the feasibility of edible coating in maintaing and preserving the chemical, microbial and sensory attributes of frozen Pangasius fillet. The frozen Pangagius fillets were glazed by different formulas (N0: control or glazing with clean water; N1: 3% w/w chitosan and glycerol; N2: 3% w/w whey protein concentrate and glycerol; N3: 3% w/w alginate an glycerol; N4: 3% w/w carrageenan). The chemical quality was based on the analyzed results of ammonia (µNH3/g) and pH; biogenic amines such as putrescine (mg/kg), cadaverine (mg/kg), histamine (mg/kg), spermine (mg/kg), spermidine (mg/kg); lipid oxidation or malondialdehyde value (mg/kg); microorganism such as Total plate count (cfu/g), Enterobacteriaceae (cfu/g), Coliform (cfu/g), E. coli (cfu/g), Staphylococus (cfu/g), Listeria (cfu/g), Salmonella (cfu/g), Vibrio (cfu/g); sensory score. All treated frozen Pangagius fillets were tested after 12 months of storage. Results revealed that the incorporation of 3% w/w chitosan and glycerol in ice‐glazing could inhibit microbial spoilage and lipid oxidation and therefore maintain the freshness of Pangasius fillet during frozen storage. Under the optimal conditions, the shelf‐life of Pangasius fillet could be extended up to 12 months at −18 °C. The study indicated that the combination treatment with edible coating could be commercially utilized to maintain the freshness and prolong the shelf‐life of frozen Pangasius fillet.Keywords: Frozen, Pangasius fillet, Glazing, chitosan, Glycerol, Whey protein concentrate, Alginate, carrageenan.
Icon as a Method of Choice for Injectable Treatment of Initial Caries in Patients with Fibrodysplasia Ossificans Progressive: a Clinical Case Svetlana Danshina
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The method considered in this clinical case makes it possible to treat the initial stages of the carious process in patients who are contraindicated by local injection anesthesia. The purpose of this study is to identify opportunities for treating the early stages of the carious process using ICON technology, without the use of injection methods of anesthesia, in patients who were diagnosed with Fibrodysplasia ossificans progressive (FOP). Conclusions: Patients were treated with infiltration of polymer material, without the use of injection methods of anesthesia. The result of this clinical case showed the effectiveness of this technique for patients diagnosed with FOP.Keywords: Fibrodysplasia ossificans progressiva (FOP), Painless, Icon, Carious process, Genetic diseases.

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