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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Evaluation of Antioxidant Levels in Blood Sera of Iraqi Patients with T2DM Kadhim K. Ghudhib
Journal of Global Pharma Technology .
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Abstract

Back ground: oxidative stress is one of the problems that can encounter of diabetic patients. Reactive oxygen species formed as a result of oxidative stress. Antioxidants system serves to protection of cells from damage that may be occurred due the action of these species. In this work, we attempt to investigate the biochemical parameters including enzymatic and non- enzymatic antioxidants in patients with type 2 diabetic mellitus. Subjects and Methods: Blood samples were collected from 58 subjects include 29 males and 29 females, in age range of 40-72 years. They were classified into two groups, the first group represents patients group that include 30 patients. Second group consist of 28 healthy persons as a control group. BMI was calculated,   fasting blood glucose, uric acid, urea and creatinine levels were measured by enzymatic methods. Glutathione peroxidase (GP x) and glutathione reductase (GR) levels were measured by enzyme linked immunosorbent assay (ELISA) method. Trace elements levels (zinc, magnesium and selenium) were estimated by flame atomic absorption spectrophotometer. Results: Results showed a significant increase in levels of FBG, UA, creatinine and significant decrease in levels of GP x, GR, Zn, MN, and Se in patents group related to the control group. There is no significant difference in level of urea between patients and control groups.  Conclusion: Free radical generation increase in diabetic case, that lead to decrease in antioxidants levels of GPx1, GSR, Zinc, Selenium  and Manganese. The levels of GPx1, GSR, Se, Zn, and Mn are the better indicators to evaluate the oxidative stress, and can be used as markers for early detection of diabetes.Keywords: T2DM, glutathione peroxidase, glutathione reductase, zinc, manganese, selenium.
Examining the effect of Consumption Time of Different Levels of Restaurant Waste Rice on Blood Factors and Liver Enzymes in Lori Fattened Lambs Mehdi Aali Joodaki
Journal of Global Pharma Technology Volume 08 Issue 11
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Abstract

To examine the effect of replacing time of different levels of restaurant rice waste with barely on blood parameters and liver enzymes in Lori fattened lambs was used forty heads of male lamb of strain of Lori with an average weight of 25 kg, randomly divided into 5 groups. Energy and protein diets were identical and determined based on 80% concentrate and 20% forage. Restaurant rice waste at a ratio of zero, 25 percent, 50 percent, 75 percent and 100 percent was replaced by barley in diets of lambs. Feed and water were Fed freely to livestock. Lambs adaptation period to the experimental diets for 15 days and fattening period for 75 days was considered. On the days 30, 60 and 90 of test were performed sampling through the jugular vein in the neck of lambs, and hematological parameters including glucose, cholesterol, triglyceride, HDL, LDL, VLDL and liver enzymes including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were measured. The results showed that the concentration of triglyceride and VLDL in blood serum and liver enzymes of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were significantly affected by different treatments (p<0.05). But treatments had no significant impact on the concentration of HDL, LDL, glucose and cholesterol in blood serum and liver enzyme of alkaline phosphatase in fattened lambs (p>0.05). Sampling time had no significant effect on the concentration of triglyceride and VLDL in blood serum and liver enzyme of alkaline phosphatase in fattened lambs (p>0.05), but made significant changes in the concentration of HDL, LDL, glucose and cholesterol in blood serum and liver enzymes of alanine aminotransferase and aspartate aminotransferase in fattened lambs (p<0.05). Generally, the results showed that can use restaurant waste rice in diet of fattened lambs, without having harmful effects.Keywords: Rice waste, Hematological/blood parameters, Liver enzymes, Fattened lambs.
Synthesis, Stabilization, Characterization, and Study of Biomedical Alterations Induced By Nanoparticles Zainb Mohammed Jassim
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Wet chemical harmonics provide the ability to mimic the control of a number of nanoparticle characteristics, including size, shape, and distribution in both water and organic solvents, and the chemistry of custom-made surfaces due to unique applications. There is a rapid need for large volumes around the fixing of connectors or surfactants at some stage of the synthesis in proportion to the properties of nanoparticles. The liquid / anti-liquid solvent pair (usually Ethanol / Toluene and Ethanol / Hexane because of the gold nanoparticles, GNP) remains old in line with both partially modified and purified nanoparticles. We reserve the dispersion of neutrons at a small angle (SANS) according to the verification of the ligand form however response of modified alkanethiol gold order of silver nanoparticles under various condition to combat solvent (CO2 ethanol). Legend lengths and solvent ligand for kanithol riches, however, silver NPs have been determined to decrease along with high anti-solvent concentrations that immediately affect the dispersion of the solution. This research led to an increased appreciation for liquid precipitation procedures due to metallic nanoparticles, yet provides vital consequences for modeling the strength of future interaction.Keywords: Wet synthesis, Biomedical application, Bone Regeneration, UV-ViS.
Executive Dysfunction in Frontotemporal Epilepsy Due to Traumatic Brain Injury Dewa Putu Gde Purwa Samatra
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Traumatic brain injury has been recognized as a cause of epilepsy. Epilepsy could impair cognitive function and the cognitive profiles are as heterogenous as the epileptic syndromes themselves. In most idiopathic epilepsies, cognition is only mildly deteriorated or even normal, whereas symptomatic epilepsy disorders are accompanied by focal deficits according to the specific functions of the respective areas. Poor cognitive outcome is generally associated with an early onset and a long duration of the seizure and with poor seizure control. We report a 31-year-old man, with a specific generalized tonic clonic seizure during sleep since one year ago. MRI shows cystic encephalomalacia in left frontal lobe due to head trauma 3 years ago. This patient had executive function disorder which was caused by uncontrolled frontotemporal epilepsy due to traumatic brain injury. We propose AED and cognitive stimulation to be performed routinely to prevent further cognitive deterioration.Keywords: Executive function, Frontotemporal epilepsy, Traumatic brain injury.
Analysis, Status Verification and Transmission of HIV/AIDS of Children of Karaganda Area (Epidemiology, Clinical Presentation, Diagnostics and Rehabilitation) Kizatova Saule
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

We analyzed Status Verification and Transmission of HIV / AIDS by children with AIDS from 2010-2015. In Karaganda region for the entire period, based on data from the Regional Center for Prevention and Struggle for Survival from AIDS, registered cases of HIV-infected mothers who gave birth to a total of 395 children with HIV was documented despite activities directed to reach a successful prevention of HIV transmission from the mother to child. The diagnosis of HIV-infection's in children is 30 (9.3%), 61babies, transmitted from women with HIV infection.Keywords: HIV-infection, Vertical transmission, Children, Epidemiology, Clinical presentation, Diagnostics and rehabilitation.
Effect of Flax Seeds (Linum usitatissimum L.) Extract in Male Reproductive System of Albino Rat Treated with Cyproterone Acetate Maysaa Adil Hadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The purpose of this report to assess the possible protective effects of 20%methanolic extract of flax seeds on cyproterone acetate mediated reproductive dysfunction of adult albino rats. Albino rats (35) place din a random manner into 7 groups, 5 rats in each. The normal control rat was the first group, while the second control group was given corn oil. Third group received cyproterone acetate (CPA) (10 mg/kg) as (positive control). Fourth and fifth groups were treated with 250&500mg/kg of flaxseeds extract respectively. The other protected sixth and seventh groups received CPA (10mg/kg) with flaxseeds extract 250 and 500 mg/kg respectively. All groups treated for 50 days orally by gavages tube. In CPA group, the outcome displayed significant reduction (P≤0.05) in the body weight, sperm parameters and FSH level, a significant raise (P≤0.05) in sperms abnormality and level of testosterone, and non-significant decline (P˃0.05) in reproductive organs and the accessory glands/ body weight ratios and LH level as compared to oil control. Treatment with flaxseeds 250&500 mg/kg caused decrease in the body weight but it considered as significant raise(P≤0.05)in comparison with CPA group, while group treated with flaxseeds extract 250 mg/kg make on-significant changes (P˃0.05) in each of reproductive organs and accessory gland/body weight ratios, LH level record non-significant decrease (P˃0.05) and significant decrease(P≤0.05) in testosterone level as compared to control D.W and CPA group whereas treatment with flaxseeds extract 500 mg/kg recorded significant increase in testes and epididymis/body weight ratio as compared to D.W, corn oil controls, and CPA groups. Furthermore, oral administration of the flaxseeds extract with CPA at two doses 250 & 500 mg/kg with CPA could reduce the negative effect of CPA in the body weight but it could not enhance the most of the sperm parameters and histological changes of both testes and epididymis caused by CPA. In conclusion, CPA (10mg/kg)induce degenerative changes in the reproductive organs of male rats and the 20%methanolic extract of flaxseeds were exhibit similar effect of CPA but at less extent in the male reproductive system.Keywords: Flax seeds (linum usitatissimum L.), Cyproterone Acetate, Reproductive Male system, Albino Rat.
Synthesis, Characterization and Study of Liquid Crystalline Behavior of New Compounds Containing Thiazolidin-4-one, 1, 2, 3-Triazole and Benzimidazol Rings Tareq K. Ibraheem
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

All new compounds synthesized by many reactions starting from a product the compounds [I]a,b from reaction of 3-phenylenediamine  or 4-phenylenediamine  with chloroacetyl chloride, then the compounds [I]a,b reacted with potassium thiocyanate to yield compounds [II]a,b. While  the compounds[III]a,b yield from  reacted the compounds [I]a,b with sodium azide then the compounds [III]a,b reacted 1,3-dipolar cycloaddition reaction  with   acrylic acid to give compounds [IV]a,b and the later compounds reacted with phenylene diamine to product benzimidazole  compounds [V]a,b . In addition to synthesized acid chloride compounds [VI]a,b  by reacted the compounds  [IV]a,b with   thionyl chloride .Finally reacted the compounds [VI]a,b with  different aromatic amines to give amide compounds[VII-X]a,b . The synthesized derivatives characterized viamp. , FTIR, 1HNMR in addition to mass spectroscopy .The liquid crystals properties were studied by using polarized optical microscope (POM) and differential scanning calorimetry(DSC).Keywords: liquid crystal; benzimidazol; thiazolidin-4-one.
Hematologic and Clinical Features of Thalassemia Patients with Early or Late Onset Transfusion in East Java, Indonesia Retno Dwi Wulandari
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Thalassemia is a genetic disorder of hemoglobin production which causes chronic anemia. Complete blood count showed lower HbA, MCV, MCH, increase RDW-CV and increase HbA2 (>3,5%) and HbF (>1,5%). Thalassemia major patients need regular and lifelong blood transfusion which started early in life. Thalassemia intermedia, usually with milder symptoms, require blood transfusion at later age, with lower transfusion rate. This study aims to compare hematologic, HbA2 and HbF profiles as well as height, weight, Body Mass Index and spleen size in thalassemia patients grouped based on transfusion start whether in early or later age (before or after 10 yo). Results showed that the hematologic, HbA2 and HbF profiles were not significantly different in both groups. The clinical profiles i.e. Height and weight were below 3rd percentile in both groups; low BMI and more patients underwent splenectomy in group of those with early onset blood transfusion.Keywords: Thalassemia, Transfusion, Hematologic, Height, Weight, BMI.
Evaluation of Blood Sugar Levels in Diabetes Mellitus Patients with Gangrene Complications in Hospital at Palu City Ingrid Faustine
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

From year to year, the amounts of gangrene patients continue to gradually increase. This is due to lack of consistent routines in checking blood sugar levels which result in blood sugar levels being uncontrolled. In gangrene patients who do not receive treatments, this will lead to amputation and can reduce the patient's quality of living. This study aims to determine the blood sugar levels in patients with diabetes mellitus with gangrene complications in hospitals in Palu City. The method used in the study is cross-sectional with prospective data collection, in which for examination of GDP is implemented using the auto check tool. The results of this study utilized the wilcoxon test to see a decrease in blood glucose levels before and after receiving antidiabetic and insulin therapy. The total research samples consisted of 30 patients within 1 month monitoring duration. From the results of research conducted for 3 months, it showed a significant decrease in fasting patients' blood glucose levels, with an average value before and after using antidiabetic therapy indicated as 285.87 mg / dl and 173.07 mg / dl. It is then concluded that there is a decrease in blood sugar levels in patients who suffer from diabetes mellitus with gangrene complications due to the use of antidiabetic therapy, namely insulin.Keywords: Blood Sugar Levels; Diabetes Mellitus; Gangrene; Insulin.
Study the Pharmacological Effect of Letrozole and Gonadotropine on the Level of Serum Glycoprotein’s (HRG, Inhibin B, and AMH) in Infertile Women and their Effect on Stimulating Ovulation Narjis Hadi Al-Saadi
Journal of Global Pharma Technology .
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Abstract

Objective: To study the effect of medication (letrozole, and gonadotropine) on ovulation induction and its relation with glycoproteins. Methods: Thirty-three infertile women were enrolled from outpatient women’s clinic and twenty-two healthy fertile women were enrolled as a control group. Their ages ranges from (15 to 44) years old. Histidine Rich Glycoprotein (HRG), Inhibin B and Anti Müllerian hormone (AMH) concentrations were measured in sera using (ELISA) technique. Results: Follow-up examinations four months after receiving treatments revealed a significant raise in serum HRG concentration (p=0.01) and a considerable decrease in serum AMH concentration (p=0.04) among infertile women. Pelvic ultrasonography, showed a significant (p = 0.000) increase in the size and the number of oocytes in both left and right ovaries infertile women.  Conclusion: Letrozole and gonadotropin treatments are effective in changing the levels of HRG and AMH in infertile women. Keywords: Women infertility, HRG, Inhibin B, AMH, letrozole, gonadotropin.

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