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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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A Brief Review Self Nanoemulsifying Mouth Dissolving Film: Formulation and Applications in Herbal Medicine Lusi Nurdianti
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

The use of herbal medicines is increasing, because of the belief that natural medicines have fewer side effects than synthetic drugs. But many herbal products show low therapeutic action due to problems with solubility and improper molecular size which have an impact on low bioavailability despite having good potential. The development of self nanoemulsion (spontaneous nanoemulsion) in fast-dissolving intraoral film preparations is one alternative formulation that can be used, to improve the limitations of bioavailability and increase patient acceptance and compliance because the application of developments is effortless, given through the oral cavity, so that direct absorption occurs in the cavity mouth and enter the systemic circulation without experiencing the effects of the first cross metabolism. This study aims to explain the concepts and techniques of self nanoemulsion formulation in intraoral (mouth dissolving film) preparations to increase the bioavailability of natural active compounds in extracts with low solubility in water and their characterization and evaluation.Keyworlds: Self nanoemulsifying, Mouth dissolving fim, Herbal medicine, Bioavailability.
Synthesis and Characterization of New Schiff Bases Derivative from 2, 5ـ Dimarcaptothiadiazole Israa Taha Ibraheem
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This research includes synthesis of new heterocyclic containing Schiff bases derivatives of 2, 5ـdimarcapto thiadiazole. The preparation process started by the reaction of  2,5ـdimercaptoـ1,3,4ـthiadiazole (1) with ethyl chloroacetate to give diethyl 2,2`-(1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl)diacetate (2). Compound (1) reacted with hydrazine hydrate to give 2, 5ـbis (mercaptoـacetichydrazide) 1, 3, 4ـthiadiazole (3). The reacted with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new Schiff bases derivatives (4-13).Keywords: 2, 5ـ dimercaptoـ1, 3, 4ـthiadiazole, Schiff bases.
The Potential Healing Properties of Systemic Probiotic-Prebiotic Supplement on Angular Cheilitis Malath Nabil Jafar
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Angular Cheilitis frequently caused by anemia and malnutrition such as iron, B12, folate and zinc deffiency, but can also be caused by fungi. Probiotics are live organisms thought to benefit human health. Aim of the study: to test the efficacy of probiotics in the healing process of angular Cheilitis in elderly individuals. Materials & Methods: The sample included 58 individuals (both genders) with clinically apparent angular Cheilitis. The duration of the disease was between 8-10 days. The age ranged between (55-65) years. Probiotic-prebiotic food supplement selected to be used is (max biotic XL) sachets. Results: the majority of recovery cases recorded during the 2nd week in both genders, females showed better response as compared to males. The recovery potential declines with age. Conclusion: The main conclusions that have obtained in this research that the treatment is effective 89.5% for both genders. And it is more effective for females than males, the healing time for most patients is two weeks, and the treatment is more effective on age 60 for both genders. Keywords: Probiotics, Prebiotics, Cheillitis, Supplement, Healing.
Evaluation Some Immunological Markers in Patients Infected with Hydatid Cysts Saleem Khteer Al-Hadraawy
Journal of Global Pharma Technology .
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Abstract

A hydatid cyst is the important disease reported parasite worldwide. The aim of this study was to investigate the PGE2, GM-CSF, TGF- β1 and IL-13 concentration in patients infected with hydatid cyst. We registered 60 patients with Hydatidosis which separated as30 male and 30 female and the control groups consisted of healthy subjects 30 separated as 15 male and 15 female. The results demonstrated that there was a significant increase (P < 0.05) in the PGE2, GM-CSF, TGF- β1 and IL-13 levels, Hydatidosis patients as compared to the healthy group.Key words: Hydatid cyst disease, IL-13, TGF- β1and GM-CSF.
CLINICAL AND DERMOSCOPIC FEATURES OF SKIN CANCER AT SANGLAH GENERAL HOSPITAL, DENPASAR: A CASE SERIES STUDY Made Wardhana; Nila Puspasari; Prima Sanjiwani; Darmaputra Darmaputra
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Background: Dermoscopy or epiluminescence microscopy (ELM) is a non-invasive clinical examination technique of pigmented skin lesions and early stage skin cancers.Methods: This was a retrospective study of patients with skin cancer at dermatology outpatient clinic of Sanglah Hospital from January 2013 to December 2014. These patients were firstly assessed with unaided eye before underwent a dermoscopic examination. All diagnoses were confirmed with a histopathology examination.Results: There were 22 patients with skin cancer who enrolled in this study. The study participants were redominantly women (59.1%), age over 50 years (72.7%), working outdoor (90.9%), with the predominantly predominant site being on the face (96%). There were 7 patients (31.8%)  with malignant melanoma and the predominant dermoscopic features were: atypical pigment network (71.4%), blue whitish veil (57.1%) and irregular streaks (57.1%). There were 10 patients (45.5%) with basal cell carcinoma, with the predominant dermoscopic feature being the arborizing vessel (60%) and ulceration (70%). There were 5 squamous cell carcinoma patients (22.7%) and the predominant dermoscopic features observed were keratin (80%) and hairpin vessels (100%). The histopathological examination results were in accordance with the description of dermoscopy featuresConclusions: Dermoscopy is a non-invasive tool for diagnosis of early skin cancer prior to performing a biopsy for histopathologic examination.
Serum Zinc Level Correlation with urinary Arginase in Patients with Bladder Cancer in Babylon Governorate Ahmed F.F. Al-Baaj
Journal of Global Pharma Technology .
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Abstract

The present study aims to determine the level of serum zinc and its correlation with urinary arginase level in patients with bladder cancer compared to healthy control group. The type of present study is a case-control study. Forty-five patients with bladder cancer and forty-five healthy persons as a control in Babylon province /Iraq participated in this study. Results of the present study were shown significant decreases in serum zinc and significant increases in the urinary arginase levels in patients with bladder cancer when compared with control group, especially in muscle-invasive bladder cancer. Also, there was significance negative correlations of serum zinc level and urinary arginase level, In conclusions, present study propose that patients with bladder cancer in Babylon province have low zinc level comparing to normal subjects and this level decrease extremely as the cancer progress to higher stage. As regard zinc have antioxidant and immune boosting properties, zinc is a cofactors for a wide range of enzymes, zinc deficiency leads to decrease superoxide dismutase activity and that may be an important cause for initiating oxidative stress and worsen the prognosis of bladder cancer. The present study also proposesthat Increased level of urinary arginase in bladder cancer patients is related to increased production of polyamine and this will promote cancer growth and development to a higher stage. Keywords: Bladder cancer, Zinc, Urinary arginase.
Analytical Study for the Ability of Some Polymers to Gain Transitional Elements Ionsions in Different Temperature, PH Acidity Functional and Time Situations Abdulrahman R. Mahmood
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The compound [K1] was synthesized from the reaction of dichloromethane with linear alkyl benzene (Lab9) using ethanol as a solvent, and from(chloro methyl)-4-nonylbenzene) [K1] it was possible to synthesize the compound Z(4-(nonan-3-yl)phenyl) methane amine) [K2] containing the amine group by synthesized from [K2] reaction with appropriate phenolic aldehydes and using Ethanol as a solvent in the preparation of vinyl chloride4-(((4-nonylbenzyl)imino)methyl)phenol-4-(((4-nonylbenzyl)imino methyl)benzene-1,3diol) [K3-K4] bases has been used. Preparation of a number of Phenolic polymers4-(2-hydroxy-3.5-dimethylbenzyl)-2-methyl-6-(((4-4-(2hyroxy-3, 5-dimethylbenzyl)-2-methyl-6(((4 nonylbenzyl) imino) methyl) benzene-phenolnonylbenzyl) imino) methylbenzene-1,3iol [K5-K6] has been used from the reaction of K3-K4 with phenol formaldehyde. The analytical capacity of chelating resins prepared using the meal supply method for some of the transition element ions (Co+2, Fe+3, Cu+2) can be studied. The loading range for resins can be determined and the effect of the treatment time and pH is determined, with the temperature and concentration of the ions under study and the amount of resin this study shows that the loading capacity of resins increases as the processing time and pH increases. The compounds synthesized above in this study were identified by infrared spectroscopy (IR), H-NMR (1), and mass thermodynamic analysis (TG, DTG).Keyword: Phenolic Schiff base derivative, Polymer, Chloromethane, Aldehydes Phenolic. 
A Comparative Study of Tuberculosis Diseases in Diyala Province in 2010 and 2015 Raghad Ibrahim
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Tuberculosis (TB) is one of the concern worldwide public health threats. A retrospective study conducted during the period (2016/11/14) until (2017/4/7) to comparative the incidence of tuberculosis disease in Diyala province between 2010 and 2015 years, the study-included number of patients with the chest and respiratory infections visited the central treatments of tuberculosis infections in Diyala. The patients included males and females with   ages from (20-90) years, they had been done X-ray chest and laboratory tests, including: examination of the septum with Ziehl–Neelsen testand (E.S.R).Examination had been identified a positive cases of tuberculosis among them, the number of patients infection with TB in (2010) were (147) cases from (1429) and (405) cases from (5772) patients   in (2015). The study showed that tuberculosis infections were  decline in 2015 to 7%  compares with  2010 to10.3%  .The results showed that (44.89%) of male and 55.1% in female  with TB infections in 2010. Also 47.90% of males  and 52.09% of females infected with TB in 2015 , the high rate of infection among age group  (31-50) in 2010, and (51-70 years) in 2015  , while the age group (71-90years) are showed the lowest ratio  were infected with TB infections for both 2010 and 2015. The results  appeared urban area  were high   incidence of infection in  both 2010 and 2015 in contrast  with rural area  , was  85(52.82% ) in urban  and 62(42.17%) in rural area in 2010 ,   with 207 (51.1%) in urban area and 198 ( 48.9%) in rural areas in 2015.Keywords: TB, Seroprevelance, Diyala province, Iraq.
Detection of Colorectal Cancer Specific APC Deletion in Peripheral Blood Culture in Iraqi Population by FISH Technique Haidar J. Muhammed
Journal of Global Pharma Technology .
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Abstract

Colorectal cancers (CRC) are classified as tumor phenotypes based on molecular profiles in which the most common defect is inactivation of adenomatous polyposis coli (APC) gene. This study included (20) patients male and female suffered from tumor of CRC range aged less than 20 and farther 60 years compared with (5) healthy individuals as a control. Samples collected from colonoscopy unit from Baghdad Teaching hospital and National Center Hospital for early detection of cancer related to Ministry of Iraqi Health. Deletion of APC gene was further verified on chromosomal level on metaphase spreads by peripheral blood lymphocytes (PBLs) culture so as value screening by using fluorescence in situ hybridization (FISH) technique. The results described the identification of classical familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP) and  sporadic colorectal cancer as in58.3%, 25%,and 16.7 % respectively which were showed significant differences (P≤0.01) compared with healthy control, so as a deletion of arm specific 5q of APC gene which showed significant differences (P≤0.01). In conclusion of this study explained the APC gene alteration localized on 5q arm have an essential role in prognosis and prognostic of colorectal cancer.Keywords: APC gene, 5q arm chromosome, AFAP and FAP gene incolorectal cancer. 
Characteristics of Erectile Dysfunction Patients in the Andrology Unit of Dr. Soetomo Hospital, Surabaya, Indonesia Akmal Ramadhan
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Erectile dysfunction (ED) is a  common problem in the medical field. In contrast to worldwide data, the prevalence of ED and its risk facftors in Indonesia is still unknown. The objective of this study was to determined the characteristics of male erectile dysfunction patients in the andrology unit of Dr. Soetomo hospital, Surabaya, Indonesia. A descriptive cross-sectional design was implemented in this study. There were 83 male patients at URJ Andrology RSUD dr. Soetomo Surabaya. The highest prevalence of erectile dysfunction patients in the age group was age 41-50 years old (22.9%). The degree of IIEF-5 was the most in severe degree  (39.8%), while the EHS score was the most in score 2 (38.6%). The highest internal risk factors were vasculogenic (90.4%), the external risk factors was the lifesyle factor (56.6%). In Surabaya, Indonesia, the incidence of erectile dysfunction has increased in the 40 year age group with severe degree, which mostly caused by vascular disorder combined with lifestyle factors. Multidisciplinary treatment and healthy life are needed for erectile dysfunction management to improve the quality of life.Keywords: Erectile dysfunction, Patient characteristic, Surabaya, Indonesia.

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