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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Correlation of on Admission Levels of Serum Uric Acid with Acute Myocardial Infarction: Case: Control Study Hayder Abdul-Amir Maki Al-Hindi
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Background: There are insufficient researchers studied serum uric acid (SUA) concentrations in patients with acute myocardial infarction (AMI or MI) at time of admission. We undertook the contemporary work to evaluate the value of SUA levels in admitted AMI subjects. Materials and methods:  The study subjects consist of 260 people divided in two groups, 100 age and sex matched healthy controls with 160 patients with AMI (28-80 years) diagnosed by clinical, laboratory findings, and echocardiography. Study populations were stratified according to their levels of SUA at their first 6-12 hours of admission, into three tertiles: first (<5 mg/dl), second (5-6 mg/dl) and the third (>6.3 mg/dl). The concentrations of the three serum UA tertiles were studied for their association with AMI patients. Research biochemical evaluations were directed using conventional techniques. An accepted level of significance was P < 0.05.  Results: For all study subjects, the mean age was 50.5±13.5 years. The ratio of men to women was 3.5:1 and there were no statistically substantial variations amongst the groups as regards the age and gender. The higher tertiles where positively correlated with increasing ages of individuals. The most common risk factors for all subjects of the study were hypertension (56%), then smoking (55%), then diabetes mellitus (26%). The mean serum concentrations of UA were higher significantly in those with AMI (5.96 ±1.8) than in control group (4.39 ± 1.3 mg/dl; P=0.05). Those with AMI has higher odds ratio (6.3, 95% CI: 2.26-17.6) than control group for the presence of highest Vis lowest SUA tertiles. Once several confounders (age, sex, diabetes mellitus, and hypertension) are being adjusted, the hazard ratios for developing AMI continue to be significant in the second and third tertiles of SUA. Conclusion: The outcomes of the study displayed that higher SUA concentrations are correlated with the incidence of AMI in admitted patients. High SUA levels independently can be considered as unconventional risk factor for the incidence of AMI.  Key words: Acute myocardial infarction, Uric acid and hyperuricemia.
The Effectiveness of Using Pre-Screening Questionnaires to Improve Mother's Knowledge and Skills in Implementing Early Detection of Early Childhood Development Ningsih Jaya; Ambo Dalle; Bahtiar Bahtiar
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Early childhood development can be detected through developmental pre-screening, with the aim of detecting early developmental disorders. The research objective was to analyze the effectiveness of the use of pre-screening questionnaires to improve the knowledge and skills of mothers in detecting early childhood development. The design of this study was a pre test - post test, involving 60 mothers of children under five. Observations were made before and after the intervention. Data were analyzed using the Wilcoxon test. The results showed that there was an increase in maternal knowledge and skills after being given the intervention. Thus, it can be concluded that the use of developmental pre-screening questionnaires is effective in increasing the knowledge and skills of mothers under five in early detection of child development. Keywords: Child Development, Child Development Pre-Screening Questionnaire, Knowledge, Skills
Investigation of SOD2 Gene Polymorphism in the Patients with Type Two Diabetes Disease in Babylon Province Zahraa Kamil Kadhim Lawi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Diabetes is a defect with body of human that causes blood glucose (sugar) levels to increase higher than normal. This is also named hyperglycemia. The free radical theory of many illness that reactive oxygen species (ROS) participate a key function in accumulation of cellular damage, The results of PCR-SSCP for SOD2  gene illustrated that two different haplotypes according to the numbers of bands in the SOD2gene including 5 and 6 bands. While, these haplotype was detected between two groups; in diabetes patient groups and control, the results indicate that was association between 3 and 4 bands in patients as compared with a control group. the patients groups, had greater levels of SOD in contrast with control groups result at significant differences (P≤ 0.05). Conclusion PCR-SSCP Is a good screening method to detection SOD2 snps gene in patient with diabetes type 2 diseaseKeywords: Antioxidant, SOD2, Diabetes, Oxidative, SSCP, PCR.
The Survey of the Relationship between the Social Support and the Mental Health among the City of Tabriz Citizens in 2014 Mohsen Hojat
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Objective the citizens are the focal point of the emotions and excitement, center if the joy and health, the pounding heart and the capitals of a nation and this is why the states pay a great deal of their attention to the citizens’ psychological health in the cultural and social planning and policy-making. The present study aims at the determination of the relationship between the social support and the citizens’ psychological health in the city of Tabriz in 2013. Methods The current study is an analytical-descriptive research. The study sample volume has been selected from an above-15-year old 398 individuals (200 women and 198 men) population based on a multistage clustering method in the city of Tabriz. The information collecting tools were the social support questionnaire and general psychological health questionnaire (GHQ-28). To analyze the data, there was made use of SPSS program ver.16 and the statistical tests such as linear regression tests and independent t-test. Findings According to the findings obtained through the data analyses performed in the current study it was found out that there is a significant relationship between social support and psychological health (P<0.001). The women social support is directly associated with their mental health (P=0.02). Also, there is an inverse relationship between social support with the women’s anxiety-sleep disorders symptoms (P=0.02) and the women’s intensive depression symptoms (p=0.04). Conclusion Social support is in a direct and significant relationship with the women and men’s mental health. Changing the policy making goals with the objective of enhancing the quality and the quantity of the supportive networks, particularly for the susceptible women, can cause the social supports protective effects to be corroborated.Keywords: Mental health, Social support, Gender.
Amikacin Induced Ototoxicity in an 8 Year Old Patient with UTI: A Case Report Lisa Mathew Adackapara; Keerthana Chandrasekar
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Ototoxicity is an adverse drug reaction of Amikacin and involves mainly bilateral high-frequency sensorineural hearing loss and tinnitus. This case report is essential to identify, resolve and create awareness of the predisposing factors which can lead to ototoxicity. It elaborates the rare adverse effect caused due to Amikacin induced ototoxicity and the treatment strategies adopted at a secondary care hospital in an 8 year old male child. Treatment for Urinary Tract Infection (UTI) included Amikacin for 1 day following which the next day he developed blocked ears and diminished hearing as an adverse reaction to the aminoglycoside antibiotic. Management emphasis is on prevention, as most hearing loss is irreversible. After 3 days of treatment, the patient’s condition improved and was discharged with advice to continue liquid paraffin 3drops-0-3drops in both ears for 3 days. Appropriate measures must be put into place to manage aminoglycoside-induced cochleotoxicity effectively, in order to maximize the affected individual’s quality of life.
A Comparative Study of Oxidation in the Preparation of Lacton and Bislacton Compounds and Biological Activity Study of Product Compounds Marwan Mohammed Farhan
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

The Oxidation of five Compound Pyrylium salts with Potassium Permanganate were carried out at different temperature (room temperature, 0c0, 50c0). The reaction proved to be Complex, giving rise to multiple products. However, several major products were isolated at different temperature and identified, unsaturated, five-member ring Lacton, Bislacton and other by-products like Benzoic acid and it is derivatives and diagnosing them Spectroscopically (I.R., 1H-N.M.R.) in addition to the quantitative analysis to its elements. Biological activity of the three types from product compounds was detected on nine pathogenic bacterial species E. coli, Shi. sonni, Ps. areguginos, K. pneumoniae St. pyogenes, St.  Pneumoniae, S. aeureus, Sal. Typhi, and P. morganella. It was found that the product compounds had a good effect to inhibit growth of some pathogenic bacterial species. The best effective concentration of the products compounds against the bacterial growth of most species was 8000 g /mL Also; the results showed that the best compound of three types in an inhibition process was Bislacton, whose prepared concentrations had large impact.
Synthesis, Characterization and Evaluation the Biological activity for New Mesogenic 1, 3-oxazepine-4, 7-dione Derived from Trimesic Acid Nasreen R. Jber
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

In this work new liquid crystalline oxazepine compounds derived from trimestic acid were prepared. In the first step, 1, 3, 5-tris-[3-thiol-4-amino-1, 2, 4 triazole-5-yl] benzene [E] was synthesized through the preparation of 1, 3, 5-benzenetricarboxylic acid hydrazide [C]. The second step was the condensation reaction between different aldehydes: 4-hexyloxybenzaldehyde, 4-heptyloxybenzaldehyde and 4-octyloxybenzldehyde to yield new Schiff bases compounds [F1-F3] respectively. In the final step, oxazepine compounds [G1-G3] were prepared from reaction imines compounds [F1-F3] with succinic anhydride in dry benzene. All these derivatives were characterized via FTIR spectroscopy, elemental analysis and 1H-NMR spectroscopy. Polarizing optical microscope and DSC were used to assessment the mesomorphic properties of the synthesized compounds. The synthesized compounds [G1-G3] were examined for antibacterial activity against Staphylococcus aureous, Staphylococcus saprophyticus (Gram-positive) and Kelebsiella pneumonia, Escherichia Coli (Gram-negative).Keywords: 1, 3-oxazepine-4, 7-dione, 3-mercapto-4-amino- 1, 2, 4- triazole, Liquid cystal, Antibacterial activity.
Evaluating Bactericidal Effect of the Antibiotics on the European Foulbrood Disease in Honeybees Varis Tuktarov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The paper discusses the results of testing the bactericidal and bacteriostatic effect of various concentrations of pefloxacin and enrofloxacin on European foulbrood pathogens in contrast to oxytetracycline. The work presents the therapeutic efficacy of pefloxacin in treating bee colonies affected by European foulbrood disease. The study tested different methods of introducing medicine in the field experiment. European foulbrood disease revealed at the studied apiaries is caused by Melisococcus plutonium, Bacillus alvei, and Enterococcus faecalis; Brevibacillus laterosporus. In Nurimanovsky and Baimaksky districts (Republic of Bashkortostan, Russia), Melisococcus plutonium, which is the primary causative agent of EFB, has not been detected. The minimum bactericidal concentration of pefloxacin is 0.001% for Enterococcus faecalis, while the minimum level for Brevibacillus laterosporus and Bacillus alvei is 0.01%. Oxytetracycline exceeds the index 10fold, and it is 0.01 % for Enterococcus faecalis and 0.1 % for Brevibacillus laterosporus and Bacillus alvei. The minimum bactericidal concentration of pefloxacin is 0.01% for Melisococcus plutonium, which is 100 times lower than the minimum concentration of oxytetracycline (1.0%). High therapeutic efficacy is achieved (93.8...95.9%) in treating bee colonies affected by European foulbrood disease with pefloxacin by adding the antibiotic to the feed syrup (1:1) at a dose of 0.01%. The value is significantly higher than the effect of oxytetracycline applied at a dose of 0.05% (87.4...88.2%).Keywords: Apis mellifera mellifera L, European foulbrood disease, Bactericidal activity, Fluoroquinolones, pefloxacin.
Effect of Bacterocin Produced by Enterococcus Faecium on Bacteria that Cause Diarrhea in Young Horses and a Goat Jinan Mohamed Husan Faeroozali
Journal of Global Pharma Technology Volume 09 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

400 samples (200 samples from feases healthy young goats and infected with diarrhea and 200 samples from feases healthy and infected horses) were collected from the veterinary hospital and veterinary health centers in Najaf city for the period from January to April 2016. All isolates were subjected to cultural, microscopic and biochemical tests using Vitek2 for identification up to the species. The results showed that (43) isolates belong to Enterococcus faecium of which (30) isolates from diarrhea cases and (13) isolates from of healthy young, (32) isolates of which (22) isolates belonged to E.coli and (10) isolates belonged to Salmonella spp. All isolates were subjected to cultural, microscopic and biochemical tests by using strip (API-20E). The sensitivity of these isolates (32) was tested for antibiotics. Results revealed that isolates showed multi resistance to antibiotics. All isolates of E.coli and Salmonella spp. resistant to some antibiotics for Gram- negative Bacteria and belonging to the group Enterobacteriaceae. And detection of the ability of E. faecium local isolates to produce Bacteriocin by testing the inhibitory activity on agar and broth in two media MRS, BHI and two methods against bacteria cause diarrhea.  And the isolates  showed clear effect on the gram -negative bacteria causing diarrhea in young goats and young horses , by inhibitor zone between (13-20) mm and was MRS liquid and solid the best media from the brain heart infusion.Keywords: Enterococcus faecium bacteria, Bactriocin, inoculation steps GPID Card, sensitivity bactria for antibiotics, biochemical test, Detection methods for bactriocin
The Effect of Repetition Training in Develop the Physical Fitness and Improve the Sense-Kinetic Perception for the players of Volleyball Labeeb Zouyan Moseekh
Journal of Global Pharma Technology .
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Abstract

This study aims at finding out the impact of a Repetition training on developing the kinetic sensory perception of Al-Anbar University players for the academic year 2017-2018, where, (14) player of Volleyball team in college of physical education and sports science_ have been subjected to this  training program. The researchers utilize the empirical method depending on the prior and post measurement for one group in order to determine the range of the physical fitness program effectiveness on developing some of the kinetic sensory perception variables. The results show that the conducted program actively affected on the sense of the muscular grip, of time, and of distance which contributes at improving the student's physical fitness level, as well as, at developing the kinetic sensory perception variables. Moreover, the results also show the decreasing of assessment fault of these variables of the sample. The researchers recommend the necessity of emphasizing the importance of physical fitness before the starting the motor skills and using the proposed program for developing the kinetic sensory perception variables.Keywords: Repetition Training, Physical Fitness and Sense-Kinetic Perception.

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