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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Formulation and In-Vitro Evaluation of Dabigatran Etexilate Loaded Nanostructured Lipid Carriers Haithem Najmuldeen Abed
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The nanostructured lipid carriers (NLCs) is an interesting delivery system that can protect the encapsulated drugs and improve their dissolution, permeability and over all bioavailability. The aim of the present study was to prepare dabigatran etexilate (DAE)-encapsulated NLCs (DAE-NLCs) using glyceryl monostearate (GMS) and oleic acid (OA) as solid and liquid lipid matrix respectively, together with different surfactant types and ratios; DAE-NLCs were prepared using the hot emulsification-ultrasonication technique and the prepared formulations were characterized in terms of their particle size distribution, encapsulation efficiency (EE%), zeta potential, surface morphology and physical state characteristics. The prepared lipid nanoparticles shows a spherical shape with a particle size (62.4±5.75nm), poly dispersity index (PDI) of (0.286±0.001), zeta potential (-33.81±0.001 mV) the EE% was (92.42±2.31) and the drug loading capacity (LC %) was found to be (7.69±0.17). the in-vitro drug release study shows a bi-phasic drug release pattern with initial burst followed by a prolonged drug releasing phase with a 92% of the loaded drug was released in 24hr the release kinetics was fitted to Korsmyere-Peppas model with anomalous release mechanism. The solid state characterization depict an amorphous state of entrapped drug within the lipid matrix of the optimized DAE-NLCs. Short term stability study shows no significant change in nanoparticle characterization at refrigerator compared to room temperature. DAE-NLCs could be a potential delivery device for improved drug loading with controlled release properties that will improves oral bioavailability of the drug.Keywords: Dabigatran Etexilate, Hot emulsification/ultrasonication, Nanostructured lipid carriers, Cremophor-EL.
Synthesis and Characterization of Some Metals Complexes with New Heterocyclic Azo Dye Ligand 2-[2ــ-(Benzimidazolyl) azo]-5-DimethylaminoBenzoic Acid Faiq F. Karam
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

A new chelating imidazolylazo groups were synthesis. New ligand of azo dye 2-[2ــ- (benzimidazolyl) azo]-5 -dimethyl amino benzoicacid (BIABA) have been synthesized by diazotization in alkaline alcoholic solution. Complexes of this ligand were prepared with a series of metallic ions Cu (II), Co (III), Ni (II). These complexes were examined using UV-Vis spectroscopy, the surface nature, morphology and elemental composition of individual novel (BIABA) ligand particles were characterized using Field Emission Scanning Electron Microscope (FE-SEM) coupled with an Energy Dispersive X-ray system (EDX). The structures of the synthesized dyes were determined by analysis of their Mass spectrum, Fourier-transform infrared (FTIR), 1H NMR. The physical properties of ligand have been studied via check its melting point.Keywords: Azo dye; Benzimidazol; Benzoic acid; 1H NMR; FESEM; X-ray system.
Synthesis of a New Three-Dimensional Network Co-polymer and Studying the Ability of Drug Delivery System Zahraa Mushtaq Abd Al-Aama
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

In this work, a new co- polymer was synthesized from the reaction of pentarythritol with fumaric acid to form the linear co- polymer. Three different moles of acrylic acid monomer (0.5, 1.0 and 1.5 mole), were added to obtain three new co- polymers. Swelling of the polymer samples were measured in the buffer solution in the basic and acidic medium. The albumin protein was loaded onto the co- polymer samples and then the release of the albumin protein was measured in the acid and basic medium. The results obtained showed that the protein loading and release process in the basic medium were higher than in the acidic medium, indicating that the combined co-polymer is selective in the medium.Keywords: Hydro gel; Polymer; Condensation polymerization; Three-dimensional network; Selectivity; Swelling; Buffer solution;  Drag delivery system.
Isolation of active compounds from aerial parts of Albizia Procera S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

The purpose of the study is to isolate active compounds from herbal plants that have various effects on living systems. The plants are indispensable sources for both preventive and curative medicinal preparations of various traditional medicine systems practiced worldwide. Albizia species is used to treat anxiety, cancer, depression, insomnia, sore throat and to reduce swelling associated with trauma. Isolation of active constituents and pharmacological screening can assist us to find new therapeutically active drugs. The compound (1) 2,2- dimethylvinyl methyl ketone and  compound (2) 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexene (C30H50) are isolated from hexane and ethyl acetate fraction of albizia procera belonging to the family mimosoideae. The above isolated Compound (1) is an intermediate to synthesis a number of different types of organic compounds and Compound (2) showed potential hepatoprotective effect against drug induced hepatotoxicity. The structure of compound have been established [1] by IR, 1H NMR, 13C NMR and MASS spectrophotometry.
Phenotypic and Genotypic Characterization of Some Virulence Factors among Proteus mirabilis Isolated from Clinical Samples in Al-Najaf Al-Ashraf/ Iraq Ahlam Kadhum Al-Yasseen
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present study aimed to investigate the phenotypic and genotypic pattern of some virulence factors in Proteus mirabilis isolates from clinical samples. A total of 110 urine samples were collected from patients with urinary tract infection from both sexes and 100 vaginal swabs were collected of women with vaginal infections during the period from October 2017 to January 2018. The results of primary isolation and identification of bacterial isolates depending on microscopic, culturing on CHROM agar and biochemical test showed that 36.3% of isolates were belong to Proteus while the results of PCR techniques that used to confirmed identification using 16SrRNA revealed that 27.2% of isolates were belong to Proteus mirabilis. Variable results in the ability of bacterial isolates to produce protease and hemolysin have been obtained in which 30% and 100% of bacterial isolates gave positive results respectively. Also the results of PCR technique showed that all isolates (100%) were possess zap A, rsb A and mrp A encoding for the production of protease, protein that regulates  bacterial swarming behavior and mannose resistant pilli (MR /P) respectively by the appearance of amplicons with molecular weight  552, 485 and 366 bp.Keywords:  Genotypic; Proteus mirabilis; Phenotypic; and Clinical Samples.
Breast cancer awareness and breast screening practice among women in Yogyakarta Susi Ari Kristina; Nada Nisrina Salsabila
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Low public knowledge and understanding, contributing to late diagnosis, has identified cancer morbidity and mortality from breast cancer. This study was designed to describe breast cancer knowledge and awareness and evaluate breast screening practice among Yogyakarta women. Methods: A cross-sectional study of 350 low socioeconomic women in rural and urban Yogyakarta areas was conducted using a validated self-designed structured questionnaire. Analyzing data using descriptive statistics. Results: A vast majority of respondents knew that breast cancer is a severe disease (85.14%) and can be detected as early as possible (60.00%). Genetic and family cancer history was the best accepted risk factor for breast cancer (61.43%), followed by oral contraception (44.57%), radiation (31.43%), smoking (28.86%) and alcohol intake (21.71%). Over half of respondents (65.14%) correctly identified niple and color discharge as one of the symptoms of breast cancer, followed by breast lump (60.00%), breast swelling (56.29%) and breast fluid (44.57%). While 56.57 percent of respondents had heard of breast self-examination ( BSE) and mammography, only 26.86 percent of respondents had regularly performed BSE, and only 28.00 percent of respondents reported daily mammography. A large proportion of respondents (72.86%) never diagnosed breast cancer. Conclusion: In Yogyakarta, the study reported inadequate breast cancer awareness and poor breast screening practice among women with low socioeconomic status aged 20-50 years. Health care professionals are fairly required to educate women about breast cancer and promote early detection and breast cancer screening programs to prevent and reduce breast cancer incidence and mortality.
Synthesis , Characterization , Antimicrobial of Studies New 2,2'-[(1Z,2Z)-ethane-1,2 diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and their transition metal complexes Ibrahim . A Flifel
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

A new ligand 2,2'-[(1Z,2Z)-ethane-1,2-diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and its Cr(III) , Co(lll) and Ni(ll) complexes were synthesized . The new ligand and its complexes have been characterization on the basis their spectra of 1HNMR, mass, Fourier transform infrared (FTIR) , as well as magnetic susceptibility, elemental analysis[C,H,N] and conductance measurements  . The program of Hyperchem 7.51 has been used up for theoretical accounts using PM3 method [1] to study the electrostatic potential that provided good information about the complexity site. Of the results obtained we can suggested octahedral geometrics for Cr (III) and Co (III) complexes, while tetrahedral geometry for Ni (II) complex .A ligand and its complexes were screened for their antibacterial activity against two kinds of strains Escherichia coli (gram negative bacterial strains) and staphylococcus aureus (gram positive bacteria strains), This research showed excellent results in comparison with Ciprofloxacin as standard drug. Keywords: ligand, complexes, Characterization, Hyperchem, electrostatic potential, antibacterial.     
Structural Equation Modeling (SEM) of Performance Evaluation Indexes of Judo & Kurash Federation of the Islamic Republic of Iran Azam Abdollahi
Journal of Global Pharma Technology Volume 08 Issue 01
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Abstract

This study sought to model the structural equation of performance evaluation of Judo and Kurash Federation of the Islamic Republic of Iran using the BSC approach.This was a descriptive and field-based research. The statistical population consisted of the members, managers, referees, veterans, and experts of the Judo and Kurash Federation of the Islamic Republic of Iran. Purposive sampling technique was used to select the study sample.To collect data, a researcher-made questionnaire was used. The content validity of the questionnaire wasapproved by experts. The reliability was calculated as 0.96 running Cronbach's alpha coefficient. In order to analysethe data and model the structural equation, PLS software was applied. Performance evaluation model of Judo and Kurash Federation of the Islamic Republic of Iran had four factors, 10 dimensions and40indicators, in a way, learning and development factor had 3dimensions and17indicators, internal processes had 3dimensions and 11 indicators, financial factor had 1 dimension and4indicators and customer and sport results had 3dimensions and7indicators. Internal operating processes, customer and sporting results, learning and development and finance were the most important factors, respectively.According to the results, to evaluate their performance, Judo and Kurash Federation of the Islamic Republic of Iran should consider four perspectives of BSC because these dimensions have cause and effect relationship with each other. Also, the federation should consider the dimensions and examined indexes of the current study if it seeks to plan and manage performance evaluation in order to provide the required backgrounds for development.Keywords: Performance Evaluation, Judo and Kurash Federation, balanced scorecard.
Isolation and Dignosis of Penicillium Expansum from the Cosmetics Which Ability to Produce Patulin and using Zinc Oxide Nanoparticles as Antifungal Compound R. A. Sahib
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

 In this study Penicillium expansum was isolated from the cosmetic samples, 50 cosmetic samples which were used such as (eye shadow, face cream, face mask, lipstick and  hand cream). The sabouraud dextrose agar was used to test  the presence of  P. expansum.  Thin layer chromatography (TLC) was appeared yellow spots of patulin toxin with rate of flow (RF) is 76% under UV light exposure.The UV-visible spectroscopy result proved the wavelength of patulin is located with 270 nm and 1.8 absorbance.High performance liquid chromatography (HPLC) results show that retention time of major peak of standard patulin and a filter extract of P. expansum are  located at (15 and  15.1) min, respectively,  which are located  in the same area. Zinc oxide  nanoparticles using as a fungicide to control development growth of P. expansum which proved high efficiency to decrease growth of P. expansum by percentage of (33,50,77) % respectively in the concentration (2,4,6) mmol/L, while 8 mmol/L of ZnO caused complete inhibition growth of P. expansum as compared with the control group which untreated with ZnO NPs. Scanning electron microscopy (SEM) images show that ZnO NPs caused decreased with disrupted of conidia and decreased number of  mycelium.Keywords: Penicillium expansum, Cosmetics, UV-vis, HPLC, SEM, Zinc oxide nanoparticles.
Technical Parameters Influencing to Cayratia trifolia Fox Grape Wine Making N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Cayratia trifolia is a weak herbaceous climber. Its fruit is fleshy, juicy, dark purple or black. Cayratia trifolia Linn. Is a medicinally important plants and used in the treatment of various diseases. In order to utilize this valuable fruit, objective of this study focused on major technical parameters such as sugar supplementation and yeast ratio in the primary fermentation; different clarifying agents such as gelatin, kaolin, egg white, bentonite  in the secondary fermentation. Results showed that sugar concentration and yeast ratio in the initial must were very important to the ethanol, titratable acidity and aroma in wine. Gelatin was suitable in fining step to control haze turbidity in wine. From this study, consumers had more chance to enjoy a healthy food drink orginated from natural source. Keywords: Cayratia trifolia, Wine, Yeast, Sugar, Gelatin, Ethanol, Acidity, Turbidity.

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