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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Ability of Manufacturing of Bioformulations using Trichoderma spp for Biological Control of Some Plant Pathogenic Fungi Ahmed Mshari
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

The aims of this study were to Ability of manufacturing of bioformulation using Trichoderma spp, Seven isolation of Trichoderma spp are evaluated as antagonist of five soil-borne fungal diseases, in dual culture, antagonistic activity of T. harzianum (Th3) was showed highest percentage inhibition compare with the other Trichoderma species, which caused 100, 79.16, 69.23, 63.88 and 58.33 % inhibition mycelial growth of Fusarium solani , Fusarium oxysporum f. sp. lycopersici, Fusarium oxysporum f. sp. melonis, Macrophomina phaseolina and Rhizoctonia solani  respectively. Among five groats grains used as substrate for Th3,  Corn substance  has  recorded  the maximum colony forming unit (CFU) produce  27 x 108 g or ml  followed  by  Millet, Barley, Wheat and Rice which record 20,66, 16, 10,33 and 8,66 respectively. Prepared nine different Trichoderma formulations and tested for their shelf life up to 150 day the result showed formulation which has higher shelf life and stress protection was ThT and ThS which record 20.33x108 and 19.66 x108 CFU/ ml respectively and followed by ThG, STCG, CTCG and LTCG which record 11.33 x108, 4.33 x108, 3.33 x108 and 3 x108 CFU/ ml while minimum CFU was  by  ST ,LT, and CT to 1.33 x108 CFU/ ml, 1 x108 CFU/ ml, and 0.66 x108 CFU/ ml respectively.Keywords: Bioformulation, Soil-borne fungal diseases, Antagonistic, Substance, Shelf life.
Food Poisoning and Its Prevention on the Example of Listeria Monocytogenes Ekaterina Savelyeva
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Listeriosis is one of the most serious and severe foodborne diseases characterized by a high mortality rate of 20% to 44%. The purpose of the research is to study the age-related features of the clinical symptoms of listeriosis in adults, as well as the influence of comorbid conditions on its course. The study included 73 patients with listeriosis (43 (58.9%) men and 30 (41.1%) women; average age (48.83 ± 6.29) years). They were divided into 2 groups: group 1 (n = 29) - patients aged 18-49 years, group 2 (n = 44) - patients aged over 50 years. Septicemia is most common clinical syndrome in patients with listeriosis, presented in 46 (63%) patients. It’s followed by damages of the central nervous system, namely meningitis and meningoencephalitis in 26 (35.6%) patients; gastroenteritis in 10 (13.7%) patients; and skin lesions in 3 (4.1%) patients. Septicemia was a typical clinical syndrome for patients over 50 years old - in 33 (75%) patients compering to 13 (44.8%) in the younger age group (OR = 3.69, 95% CI [1.36-10.04]). The damages of the central nervous system, namely meningitis and meningoencephalitis were typical for younger age group - 16 (55.2%) patients while 10 (22.7%) cases among the older age group (OR = 4.18, 95% CI [1, 51-11.56]). The mortality rate was 27.4% (of which 80% of deaths occurred in the older age group). Listeriosis is characterized by a severe course and a high mortality rate from septicemia and CNS damages. It is the cause of concomitant pathology development in immunocompromised individuals. Keywords: Adult listeriosis, Age-related features of listeriosis, mortality in listeriosis, Comorbid conditions and listeriosis, Prevention of listeriosis.
Application of Central Composite Design Method to Oxidative Coupling Spectrophotometric Determination of Metoclopramide Hydrochloride in Pure form and Pharmaceutical Preparations Mohanad HN Halboos
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

A rapid, simple, and sensitive spectrophotometric method was developed for the quantitative determination of metoclopramide hydrochloride (MCP.HCl) in its pure form and in pharmaceutical formulations. The recommended method is based on the coupling between MCP.HCl (after oxidized with a NaIO4) and ellagic acid (EA) to form a colored product which shows a maximum absorption at 422 nm. In addition to univariate one factor a time optimization, chemometric central composite design (CCD) and response surface method were applied to design the experiments for three factors viz volume of oxidant, the temperature of oxidant, and temperature of coupling and to find out their optimum conditions. Under the best achieved experimental conditions, the analytical characteristics of the method were obtained. The linearity range of (MCP.HCl) is (0.1-15) μg.mL-1 at with molar absorptivity (40248.48) L.mol-1.cm-1, Sandell's sensitivity (0.00880) μg.cm-2, LOD (0.00835) μg.mL-1 and LOQ (0.02783) μg.mL-1. The results showed there are no significant interferences of additives (Exclusions) on the determination of the drug. The method proposed in this study was compared with the reference method classified in the British Pharmacopoeia and calculated F-test (0.1394) for 6 degrees of freedom and t-test (0.4517) for 12 degrees of freedom, the proposed method was found to be similar to the reference method in accuracy. The proposed method has been successfully applied for the determination of (MCP.HCl) in pure and pharmaceutical preparations (tablets, oral drops, syrups and injections).Keywords: Chemometric, Metoclopramide hydrochloride, Ellagic acid and oxidizing coupling.
Antimicrobial Effect of Bacillus Spp. on MRSA Samarah Jafar Alwash; Zahraa A. Jabur; Maha Mohammad; Saad Sabah Fakhry; Farqad Farhan Abdulhammed
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

There are many antimicrobial peptides produced by Bacillus species, which have a bacteriostatic and/or bactericidal activity. The aim of this study is to investigate the antimicrobial activity of Bacillus spp. against methicillin-resistant Staphylococcus aureus (MRSA) by analyzing 59 Bacillus spp. isolated from rice and spices using the agar well diffusion method in terms of their general inhibition effects on some MRSA isolates. Nine isolates were found to be effective against MRSA and their effects were compared with some antibiotics. The study showed that many Bacillus spp. has antimicrobial effect against MRSA3 which is resistant to all antibiotics except vancomycin. It has been found that Bacillus lentus is more effective against MRSA when compared with some antibiotics. Further studies may be required to assess the use of Bacillus lentus as therapeutic and bio preservative in food processing industry.Keywords: MRSA, Bacillus lentus, Antimicrobial peptides, Antibiotic, API-CHB-50.
Survey Study about the Association between (Epstein Barr Virus) (EBV) Infection and Breast Cancer Attending Al-Sadder Teaching Hospital in Al-Najaf Al-Ashraf during Years 2017 Ali Abdul Razak Al-Saegh
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This study was conducted in from January to December 2017, located was doing in Al-Sadder Teaching Hospital in Al-Najaf Al-Ashraf, to detect the relationship between the breast cancer and the EBV which causes cancer, total female attending to the Teaching Hospital is 16 cases the average age was between 31-64 years. Clinical symptom and X-ray was examined at first, Biopsy was doing and sent to the Department of Analysis technique Al-kafeel University for Histopathological and immunohistochemical examination. The aim of this study was to determine where there are associated between EBV and female breast cancer, be that breast malignancy risks in patients testing positive for EBV in Al-Najaf governor for the first time.
Epidemiology of Staphylococcus Aureus Clinical Isolates Causing Skin and Soft Tissue Infections Among Patients in the Community Settings At Primary Healthcare Centres in Sidoarjo Region-East Java, Indonesia Sugiharto .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objectives To determine percentage of case finding of Staphylococcus aureus, methicillin resistant Staphylococcus aureus (MRSA) and panton–valentine leukocidin (PVL)-positive Staphylococcus aureus (S. aureus) isolated from skin and soft tissue infections in the community settings at Primary Healthcare Centres in Sidoarjo region, Indonesia and the relationship of risk factors of Staphylococcal skin and soft tissue infections. Methods S. aureus isolates from clinical cultures of patients in 2 Primary Healthcare Centres were included. Wound cultures were performed to identify the MRSA phenotypically using VITEK® 2 system. The mecA gene and genes encoding PVL were detected using Polymerase Chain Reaction (PCR). Clinical data including gender, age, hospitalization history in primary health care center and hospital, comorbidity (diabetes mellitus) history and antibiotic history, were collected from questionnaires and medical record. Statistical analysis was done by Chi-square-Fisher’s exact test. Results In total, 45 patients involved in this study. The 20 patients consisted Staphylococcal strain, and 25 patients did not. Of the 20 Staphylococcal strains, 3 samples were Staphylococcus coagulase negative, 1 sample was Staphylococcus gallinarum and another sample was Staphylococcus haemolyticus. There were 15 patients (33.3%) were infected by S. aureus. Of these, 13 isolates were MRSA-positive (28,9%) and 1 isolate was PVL-positive (2,2%). Analysis showed no relationship between the risk factors and finding of S. aureus, neither MRSA and PVL in all patients (p > 0.05).Conclusions S. aureus is common in the community. The MRSA is clinical importance in Indonesia, not only in hospitals, but also in the community settings. High case of MRSA was found in this study. However, the case of PVL-positive S. aureus was low. It is very important to promote case finding by detecting MRSA in the community settings. A national surveillance system should be set-up for further monitoring this.Keywords Methicillin-resistant S. aureus, Panton–valentine leukocidin, Staphylococcus aureus, community setting, Prevalence.
Comparative Laboratory Study: Phytoremediation Ability for Lead, Cadmium, and Copper Using Three Aquatic Plants from the Tigris River in Baghdad City/Iraq ZR Taha
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The present study was investigate carried out to investigate the possible use of three aquatic plants Hydrilla SP, Vallisneria sp. and Polygonum sp A group of the Tigris River within the Baghdad area to remediate polluted water with lead, cadmium, and copper. after exposure to the concentration (10, 20, 30) ppm of Pb, Cd and, Cu Both individually and for 10 days laboratory, the percentage accumulation of these elements within the plant tissue has been measured as the results showed high efficiency of the Polygonum sp. in Pb accumulation of 55.3, 58, 171.5% in the three respectively and copper accumulation by (52, 65.8, 60.2) % for the concentration (10, 20, 30) Compared to other plants, while the Hydrilla SP exceeds.  In the cadmium accumulation of the three concentration (28, 31.1, 40.2)% respectively compared to other plants, as the results prove to be a factor, Pb Cd and cu in the samples of the water from the Tigris River during 2017 within the study area have exceeded the limits allowed by the World Health Organization,  Therefore, Hydrilla sp, Vallisneria sp, and Polygonum sp, which are naturally spread in the Tigris River, Which can be used in the Phytoremediation of the river's polluted water by heavy elements.Keywords: Polygonum, Vallisneria, Hydrilla, Phytoremediation.
Correlations of Serum Vitamin D and Thyroid Hormones with Other Biochemical Parameters in Iraqi Pregnant Women with Preeclampsia Disease Namir I.A. Haddad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Objectives: Preeclampsia is disorder of hypertension in the second half of pregnancy. This study aimed to find correlation of preeclampsia with Vitamin D, thyroid hormones and other parameters in Iraqi pregnant women. Methods: Case study of fifty-eight pregnant with preeclampsia (twenty-nine pregnant women with mild preeclampsia, and twenty-nine pregnant with sever preeclampsia) and twenty-nine healthy pregnant in third trimester was included this study. Serum of Vitamin D, TSH, T3, T4 and other biochemical parameters were measured. Results: The results showed significant decrease (P<0.001) in serum T3 and T4 in mild and sever preeclampsia groups compared to healthy group (1.31±0.31ng/ml and 1.32±0.15ng/ml vs.1.53±0.26ng/ml) and (7.65±0.73µg/dl and 7.40±0.85µg/dl vs. 8.953±0.66µg/dl) respectively. Serum TSH showed significant increase (P<0.001) in mild and sever preeclampsia groups in comparison to healthy group (2.76±0.76µIU/ml and 3.81±0.94µIU/ml vs. 2.43±0.64µIU/ml) respectively. Also, significant decrease in serum vitamin D in mild and sever preeclampsia groups in comparison to healthy group (9.152±1.03ng/ml and 8.564±1.67ng/ml vs. 21.992±5.59ng/ml) respectively. Conclusion: Our results found positive correlation between T3 level with age (P=0.033), gravidity (P=0.024) and history of abortion (P=0.002). Positive correlation T4 level with BMI (P=0.021), gravidity (P=0.040), parity (P=0.039), while a negative correlation with family history (P=0.003) was found. Level Vit.D had positive correlation with gravidity (P = 0.044) and parity (P=0.019), although no correlation found between thyroid hormones and Vit.D during the 3rd trimester. Also, levels TSH, T3, T4 and Vitamin D can be used to predict the severity of PE.Keywords: Vitamin D, TSH, T3, T4, Preeclampsia, Mild PE, Sever PE.
Variation of Nicotine Metabolism in Adult Men in the Jakarta Clinical Laboratory R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: Nicotine, a mayor addictive constituent of tobacco plays a critical role in smoking addiction.  Nicotine is primarily metabolized to cotinine. The objective of the research was to determine the variation of Nicotine metabolism in adult men in the Jakarta Clinical Laboratory. Methods: The research was done to 27 men aged 19-45 years old, which consisted of 6 smokers and 21 nonsmokers. Nicotine and cotinine of the plasma concentration 2 hours after chewing one piece of nicotine gum were determined by Liquid Chromatography-Mass Spectrometry (LC-MS) method. Results: The cotinine/nicotine ratio of the plasma concentration was calculated as an index of nicotine metabolism. Scatter plot cotinine/nicotine ratio of showed distribution heterogeneous (not homogeneous).Conclusion: It could be concluded that variation nicotine metabolism could be categorized to light nicotine metabolism (<0, 22), medium (0, 22 - 4, 19), and heavy (> 4, 19).Keyword: Nicotine metabolism, Cotinine/nicotine ratio.
Comparing Autoimmune Hypothyroidism Patients with Normal Subjects in Terms of Serum Vitamin D Alireza Mehdizadeh
Journal of Global Pharma Technology .
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Abstract

Introduction Autoimmune diseases of the thyroid known as Graves and Hashimoto are the most common autoimmune diseases that vitamin D levels of these patients is different from that of healthy individuals. In this study, we examine vitamin D level in patients with Hashimoto's thyroiditis and compare them with the healthy group. Method This research is a case-control study. In this study, 65 patients with Hashimoto thyroiditis and 60 healthy people were randomly selected. Hashimoto thyroiditis patients diagnosed recently and not treated with any hormone were referred to laboratory to examine the 25-hydroxy-vitamin D and the results were analyzed using SPSS16.Results The results of this study showed that there is no significant difference between two groups of study and control in terms of variables such as age, height, weight, 25-hydroxy D3, BMI and TSH, and gender.Discussion and conclusion there is no correlation between 25-hydroxy D3 and TSH and Anti TPO, and most of other studies confirm this result.Keywords: Autoimmune, Vitamin D, Patients.

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