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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Early Detection of Prostate Cancer by Tumour Marker PSA, CEA and CA19.9 Sahira H. Kareem
Journal of Global Pharma Technology .
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Abstract

Prostate cancer is the most common cancer and the second leading cause of cancer deaths in men. , tumor markers are substances that can be found in the body when cancer is present, Prostate-specific antigen (PSA) is well known as a specific tumor marker for prostate cancer Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) elevating adenocarcinomas originating in the prostate gland. In the present study have been investigated the levels of cancer antigen and some of trace element in fifty men, aged were 50 – 75 year they divided into two groups included prostate patients and control groups. This study showed significant increasing (P<0.05) in the level of PSA, CEA and CA19.9 concentration in forty cases of prostate patients and significant increasing (P<0.05) in CEA and CA19.9 concentration with a note that the concentration of PSA was low in ten cases of prostate cancer patients and significant difference in serum trace element concentration.Keywords: Prostate Cancer, PSA, CEA, CA19.9 and Trace Element.
DYNAMICS OF IMMUNOLOGIC INDICES IN DISEASES OF BACTERIAL ETIOLOGY AND THE CORRECTION OF IMMUNE STATUS OF CALVES I.A. Kondakova
Journal of Global Pharma Technology Volume 08 Issue 11
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Abstract

Compensation of defects of intestinal tract colonization resistance during correction of immune status of calves with the help of phytogenic medicinal preparations was characterized by an increase in the total amount of T-lymphocytes, T-helpers, relative content of B-lymphocytes and level of IgG, IgM, IgА with a simultaneous growth of phagocytic index and phagocytic activity of neutrophils. Keywords: Diseases of bacterial etiology, Young stock of farm animals, Immune correction, pine buds, Propolis.
The Effect of Different Surface Treatments of Cad/Cam Sub-Structures on Microleacage of Veneering Composite Resins Mustafa A. Zeinalabdeen
Journal of Global Pharma Technology .
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Abstract

Purpose: The aim of the study is to evaluate the effect of different surface treatments on the microleacage of hybrid composite resin to Lava Ultimate and Vita Enamic hybrid resin-nanoceramic CAD/CAM blocks. Materials and Methods: In this in-vitro study for each CAD/CAM block (4) samples were prepared and divided according to surface treatment to (4) groups as follows: control, 50 μm (Al2O3) airborne-particle, fem to second laser & combination of 50 μm (Al2O3) airborne-particle and femtosecond laser. One additional sample for each CAD/CAM block was prepared for each surface treatment group for SEM analysis. Filtek Z250 hybrid composite was adhered onto each sub group after application of universal single bond adhesive. Microleacage test for each sample was evaluated after (1000) thermal aging cycle. Dye penetration technique using a solution of 0.05% basic fluxin solution to evaluate microleacage between composite resin and CAD/CAM block.  Results: Examination revealed that there is no microleacage occurred in any of tested groups (0). Conclusions: As a result of this study using these methods of surface treatments is expected to increase clinical success of the restorations.Key words: Micro-tensile bond strength, Surface treatment, Fem to second laser, CAD/CAM.
Modified ZnO for Efficient Photo-Catalysis by Silver/Graphite oxide Nanoparticles Firas H. Abdulrazzak
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

ZnO was modified with ternary composites Ag:ZnO/GOto enhance the interaction/reaction activities by simple evaporation/ photo-deposition of Graphite oxide and Silver respectively. The ternary composites were characterized by analysis the structure or morphology with X-ray diffraction, UV-visible diffraction to find band gap and surface area SBET. The process include change in sequence of preparations which tested by removing Eosin yellow by adsorption and photocatalytic degradation. The results shows that ZnO after modifications was more active then pristine phase and Ag :(ZnO/GO) was more activities then (Ag:ZnO)/GO in photo-reaction but less abilities in adsorption.Keywords:  Eosin Yellow, Ternary composites, Ag: ZnO/GO, Degradation.
Cytomorphological Monitoring of the Rate of Healing of Aft and Traumatic Injuries of the Oral Mucosa Anton Timoshin
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The oral mucosa is an indicator that shows the state and functioning of internal organs and systems of the entire body. Inflammatory diseases of the oral mucosa are a pathology that affects patients of various ages. And it causes some discomfort to the patient and disrupts the usual rhythm of life. With a long course of this pathology, there is a violation of the endocrine glands, the immune system, and against the background of a painful symptom, psycho emotional tension may occur. The inflammatory process on the oral mucosa can be caused by factors such as bacterial, viral, fungal, and others. Regardless of the etiological factor, the inflammatory process itself does not pose a threat to the patient's life, even in spite of the etiological factor, although it complicates it. However, in the absence of treatment and prolonged course, it can lead to malignancy of the process. This is facilitated by the constant impact on the pathological focus of mechanical, chemical and thermal stimuli when eating. Also, if the patient has chronic somatic diseases that occur against the background of a decrease in immunological protection, the threat increases. Keywords: Oral mucosa, Inflammation, Pathology, Farmadont III.
OCT Angiography in the Diagnosis of Small Choroidal Tumors Elena Myakoshina
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Introduction small choroidal melanoma is a malignant tumor with early metastasis. It is similar to delimited hemangioma, choroidal nevus and choroidal metastatic carcinoma. The main sign of tumors is their own vessels diagnosed with various methods. However, optical coherence tomography angiography (OCT-A) was not used before. Purpose of this research is to study and compare the OCT-A criteria in the cases of small melanoma, delimited hemangioma, choroidal nevus and choroidal metastatic carcinoma cases. Methods in small melanoma, delimited hemangioma, choroidal nevus and choroidal metastatic carcinoma cases, there was performed a prospective and non-randomized OCT-A with a NIDEK RS-3000 Advance Optical Coherent Tomography (Japan). Results this method was used to examine 120 patients with small choroidal melanoma (41), delimited choroidal hemangioma (32), choroidal nevus (37) and choroidal metastatic carcinoma (10). Tumors thickness: degree – 2.2 ± 0.3 mm, diameter – 8.1 ± 0.6 mm. In the case of small melanoma, vascular network is loop-shaped with elements interweaving under the retinal vessels. In the case of delimited hemangioma, we have pictured a rich tree-like vasculature organized as a large trunk with branches (20) and diffuse scattered one organized as many small convoluted vascular branches (12). In the case of choroidal nevus, we have detected a capillary-free zone with dilated choriocapillarises around the periphery. In the case of choroidal metastatic carcinoma, vascular system was organized as a web of small vessels. Conclusion OCT-A allows diagnosing the features of angioarchitectonics in small melanoma, delimited hemangioma, choroidal nevus and choroidal metastatic carcinoma cases to provide further adequate eye-preserving treatment.Keywords: Small Choroidal Melanoma, Choroidal Delimited Hemangioma, Choroidal Nevus, Choroidal Metastatic Carcinoma, Optical Coherence Tomography Angiography (Oct-A). 
Water Purification of Sea of Oman and Persian Gulf with Humic Acid and Measurement of Copper Ion (II) by Differential Pulse Voltammetry Abouzar Tahkor
Journal of Global Pharma Technology .
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Abstract

The present research intended to remove heavy metals from the water samples of the sea of Oman and the Persian Gulf using Humic acid. The antimicrobial experiments showed that Humic acid can also remove Escherichia Coli (E. Coli) Coliform, a water pollutant, from surface water. After the removal of heavy metals ions, only copper ion (II) was measured by differential pulse voltammetry technique. Several parameters such as optimal conditions for measurement by differential pulse voltammetry, time, and pre-concentration of pH were considered in water purification and measurement of copper ion (II).The calibration curve changed linearly before passing through humic acid column 160-1 (µM), after passing through humic acid column 400-1 (µM) and after being washed with Hydrochloric acid 400-1 (µM) using standard addition technique in order to measure the concentration of copper ion in the sea of Oman. Accordingly, the concentration of copper ion (II) was obtained as 13 ppb before passing through humic acid column, 8.1 ppb after passing through humic acid column and 2.4 ppb after being washed with Hydrochloric acid column. Furthermore, the calibration curve changed linearly before passing through humic acid column 400-8 (µM), after passing through humic acid column 400-1 (µM) and after washing humic acid column with Hydrochloric acid 400-1 (µM)in order to measure the concentration of copper ion in the water of the Persian Gulf. Accordingly, the concentration of copper ion (II) was obtained as 28.72 ppb before passing through humic acid column, 14.69 ppb after passing through humic acid column, and the absorbed ion was 10.95 ppb after being washed with Hydrochloric acid column. Using standard addition technique, the limit of detection (LOD) of measured coper was calculated as1.69×10-6 (µM) in the imposed potential of the sea of Oman and -0.25×10-6 (µM) in the water of Persian Gulf.Keywords: Differential pulse voltammetry technique; Water purification of sea of Oman and Persian Gulf; Humic Acid; Copper Ion (II).  
Effect of Cayratia trifolia Ethanol Extract on Bcl-2 expression and Apoptotic Cells in Dmba-induced Breast Cancer of Sprague Dawley Rats I Ketut Sudiana
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The study aimed to clarify the effect of the administration of ethanol extract of Cayratia trifolia plants to breast cancer. This study was an experimental study using female animal model of Sprague Dawley rats, consisting of three groups, K0, the normal experimental animals, K1, the experimental animals with breast cancer receiving CMC 0.5%, and KP, experimental animals with breast cancer receiving ethanol extract of Cayratia trifolia in a dose of 300 mg/kgBW at 0.5% CMC.  The material to induce breast carcinoma formation was DMBA of 20 mg/kg in corn oil. The extraction of Cayratia trifolia plants used ethanol. The variables were the number of cells expressing Bcl-2 observed with immunohistochemical methods, and the number of cells undergoing apoptosis, which was observed using tunnel assay method. Statistical analysis was performed using ANOVA test. The number of cells expressing Bcl-2 and those undergoing apoptosis in breast cancer tissue between groups of animals receiving and not receiving ethanol extract of Cayratia trifolia showed significant difference (P<0.05). Oral administration of Cayratia trifolia ethanol extract has an effect on the decrease in the number of cells expressing Bcl2 and an increase in the number of cancer cells undergoing apoptosis.Keywords: Breast carcinoma; Proto-oncogene; Tumor suppressor gene; Cayratia trifolia.
Isolation and Identification of Fungal Propagation in Iraqi Meat and Detection of Aflatoxin B1 Using ELISA Technique Rawaa Emad Jaloud
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The study was conducted at the College of Education for Pure Sciences (Ibn Al-Haitham /University of Baghdad. The aim of this study was to isolate and diagnose fungi from meat samples and detection of aflatoxin B1. The samples included different types of sheep meat that collected from the local slaughter areas and government approved in Baghdad (Al-Karkh and Al-Rusafa); this study included the collection of 50 samples from fresh sheep meat (25 liver and 25 triceps muscles), 13 of minced meat and 12 of basterma samples. Two methods of isolation were used which are direct and indirect to detect Fungi in the samples; the results have been found the presence of various genus of fungi including Aspergillus spp., Penicillin spp.,Rhizopusspp.,Mucorspp.,Cladosporiumspp.,Fusariumspp.,Moniliaspp., Botrytis spp., Trichothecium spp., Ulocladium spp. And Yeast spp. According to the type of isolation method, Aspergillus spp. is the most common genus that isolated from the samples using direct method, while yeast was the most predominant in the samples using indirect method in all samples except in the muscles where Aspergillus spp. Were the predominant fungi in both isolation methods? Results of the detection of aflatoxin B1 showed that 71 of the samples were contaminated with toxin; the samples included minced meat, basterma, liver and muscles with different concentrations of aflatoxin ranging from 42-467 ppb, 25-442 ppb, 44-492 ppb and 242-459 ppb for respectively.
Extraction of Genomic DNA from Formalin Fixed - Paraffin Embedded Tissue for Forensic DNA Analysis: Influence of Proteinase K Maysaa Adil Hadi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A huge part of tissues preserved throughout the world used in diagnostic aim is formalin-fixed and paraffin embedded tissue (FFPET) which are a highly worthy supply for retrospective (genetic) application contain screening of mutations in cancer-critical genes in addition to detection of pathogens. The purpose of present study was to estimate the best method in the extraction of DNA from FFPET for utilizing in the forensic analysis by comparing three various extraction methods with and without proteinase K digestion and estimated the influence of these procedures of extraction in DNA quality, quantity and polymerase chain reaction (PCR) amplicon. In this study, the comparison was between three DNA extraction methods from five identically processed FFPET. The extraction methods, including DNA extraction kit, phenol: chloroform: isoamyl alcohol with and without proteinase K methods. Amplifiable DNA fragment size was assessed by amplification of exon 7 of CYP1A1 gene and the size of the fragment was (312 bp). Extractions by different methods used in this study were found suitable for amplification of fragment (312 bp) from all tissues used. The best amplification was after extraction without proteinase K and DNA extraction kit. In conclusion, amplification by PCR shows extremely affected by the method of extraction utilized. Pre-treatment of proteinase K was not a prerequisite for extractions of DNA from FFPET and the suitable extraction method was phenol: chloroform: isoamyl alcohol method without proteinase K as it was less time, less cost, yielding a good DNA quantity and quality.Keywords: Formalin Fixed-Paraffin Embedded Tissue, Forensic Analysis, Proteinase K.

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