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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
Synthesis, Analytical, Thermodynamic Studies and Uptake Behavior of: Copper and Cadmium by New Schiff-base Chelating Resins W.S. Hanoosh
Journal of Global Pharma Technology .
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Abstract

The present work carried out a study on new Schiff-bases ligand derived from (P-phenyl amine and O-amino phenol) with 3-hydroxy benzaldehyde, which has been successfully prepared in warm alcoholic medium. These ligands were characterized by FTIR spectroscopy, CHN analysis & Uv-Visible spectra. From the UV –Vis spectra show that both heavy metal [Cu2+, Cd2+] form complexes with both schiff-bases in the ratio (1:2) [M: L]. Thermodynamic parameters were evaluated at different temperature using vant-hoff equation. Finally polyurethane foam from these ligand were prepared through the reaction with diisocyanate compound (MDI) and thermal study of these prepared polymers were evaluated by using thermogravemetric analysis (TGA)Keywords: Schiff-base, Polyurethane foam, TGA analysis.
The Effect of Training on Spirituality Therapy on Reduction of Marital Along with Drug Control in Fidelity Crisis Betrayed in Isfahan City, Iran Mohsen Saeid Manesh
Journal of Global Pharma Technology Volume 08 Issue 02
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Increasing family betrayal and the conflict is a serious threat to the society and community, because upbringing a healthy generation for today and tomorrow, who can take the responsibility of society for today and future can't be reached in a peaceful and safe environment.  Hence, the need for improvement in marital interaction and diverse program has raised more than before. This study aimed the need for a training method based on spirituality therapy on reduction of marital infidelity crisis of betrayed spouses. So 60 people were chosen by simple random sampling, and were placed into two groups named test (n=30) and control (n=30). Each participant answered to three Enrich test, after Mississippi event, and questionnaire of spiritual effect on the Avants behavior, which the test group during 8 sessions of one hour and half by a group training received treatment based on spirituality. For analyzing the results, descriptive and inferential statistical techniques for data analysis, and use of the Kolmogrove-Smirnov test to verify the normal distribution of data as a prerequisite analysis of covariance were used. Statistical results of the study show that group training based on spirituality therapy on reduction of marital in fidelity crisis betrayed on P>0.05 level is meaningless, and affect only some factors including: stress, depression, spirituality, personality, financial management, religious orientation, and these changes are preserved over one month investigation
Effect of Frying And Storage on the Quality and Shelf Life of Fried Sweet Potato (Ipomoea Batatas) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology .
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Abstract

Sweet potato is the seventh most important crop in terms of global production. Sweet potatoes are rich in antioxidants, such as phytophenolics and carotenoids which also provide distinct flesh colours. The high perishability of sweet potato roots during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. Consumers are increasingly health conscious and trends are moving toward foods with low oil content. This research has been focused on different parameters of drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and carotenoid; extending product shelf life during packaging and preservation. Results revealed that frying 2.0 cm of sweet potato chip in soybean oil heating at 150oC in 2 minutes was appropriated. Fried sweet potato chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried sweet potato products. Frying of sweet potato bars is carried out to convert the roots to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Sweet potato chip, Frying, Shelf life, Carotenoid, Flavonoid, Vaccum.
Preparation, Characterization, and Biological Evaluation of New Schiff Base Ligand and their Complexes with iron(II), cobalt(II), nickel(II) and Copper(II) Ions Mohammed Hamid Said
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In the present work a new schiff  base ligand was prepared by reaction of 6-amino penicillinic acid with 5-chlorosalicyldehde. The new ligand was characterized by using various techniques UV/ Visible, FT IR , Mass spectral ,1H NMR, and 13C NMR , It was also preparing four new complexes by interaction of ligand with transition metals ions ( Fe2+, Co2+, Ni2+, Cu2+ ) and characterized by UV/ Visible, FT IR, Magnetic moment and  molar conductance. Ligand shows tridentate   behavior demonstrated by the presence of three effective groups and complexes have taken octahedral form. The biological effectiveness was measured  for ligand and coordination complexes  against two types of bacteria ( Staphyllococcus aureus and Pseudomonas aeruginosa ) showed good effectiveness.Keyword: β-Lactam, Schiff base, 6.Amino Penicillinic, and tridentate ligand.
Effectiveness of Rota Vaccine among Children in Babylon Province, Iraq Mudher Hassen Noor
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Acute diarrhea is passing of watery stool > 10 ml / kg / 24 h. which stay less than two weeks. Diarrhea account for 9% of death in children and about 0.71 million deaths / year in the world .Gastroenteritis, also called as infectious diarrhea, It means infection of gastrointestinal tract by certain organism, it could be either viral, bacterial or parasitic. And the virus is considered the most common. Rota virus is common in children while Norvo virus more common in adult. Rota virus is RNA virus belongs to the Reoviridea family. Most of children up to the age of 5 years are infected with this virus at least one time .The immunity will develop after the infection or vaccination with Rota virus. The aim of the study is to evaluate the effectiveness of Rota vaccine in modification of severity and prevalence of rotavirus infection among children in Babylon province A total of (1041) stool samples were collected from child with age from six months to five years old suffering from acute diarrhea who are admitted to the emergency room or to the wards of Babylon teaching Hospital for maternity and children. And all these stool samples were submitted for detection of rotavirus by a strips containing specific rotavirus Ab. The prevalence of positive rotavirus infection was (231) from (1041) with (22.22%) of all children with acute gastroenteritis from the age (6 months-5 years). We conclude that, Rotavirus infection was decrease significantly in our province after routine introduction of rotavirus vaccination
Inverse Correlation between Combination of Antiretroviral Therapy with the level of Serum Interleukin-6, Ferritin, and Hepcidin in HIV Patients with Anemia Chronic Disease I Ketut Agus Somia; Ketut Tuti Parwati Merati; I Made Bakta; Ida Bagus Putra Manuaba; Wayan Putu Sutirta Yasa; I Dewa Made Sukrama; Ketut Suryana; Rudi Wisaksana
Journal of Global Pharma Technology .
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Background: The purpose of this study was to determine whether the cARV therapy correlates with the serum level of IL-6, ferritin, and hepcidin in HIV infected patients with ACD.Methods: A cross-sectional study conducted in HIV patients with ACD, aged 15-65 years with exclusion criteria such as chronic renal disease, chronic liver disease, treated for anemia in the last 3 months, taking iron supplements in the last 3 months, history of blood transfusion in the last 1 year, suffering from acute infection, tuberculosis infection, malignancy, hepatitis C virus infection, acute hypersensitivity reaction and pregnancy. Blood specimen examined by high sensitivity human IL-6 In vitro ELISA, DRG Hepcidin- 25 ELISA, serum ferritin by agglutination method and CD4 cell count by flow cytometry. Results: A total of 86 HIV patients with ACD consist of 42 subjects with experienced cARV and 44 subjects with naive cARV. There are several differences between cARV naïve and experienced cARV including: Hb (g/dl) [ 10.8 ( 9.88 – 11.75) Vs. 11.60 (11.00 – 12.34) p: 0.058 ], serum iron (mg/dl) [ 50.00 (31 – 66.8) Vs. 71.40 (56.00 – 108.00) p: 0.121 ), serum ferritin (ug/dl) [ 630 ( 194 – 1101) Vs. 195.40 (128.25 – 589.47) p: 0.008 ], IL-6 (pg/mL) [7.20 (3.88 – 10.76) Vs. 4.03 (1.69 – 8.49) p: 0.009), serum hepcidin (ng/mL) [45.54 (16.74 – 95.31) Vs. 23.35 (6.58 – 49.99) p: 0.007] , CD4 cell count (cell/uL) [31.5 (14.25 – 90.75) Vs. 307 (168.5 – 458.75) p : < 0.001)] There is a significant inverse correlation between the cARV therapy with level of serum IL-6 ( r: - 0. 285, p: 0.008), ferritin (r: - 0.321, p: 0.007) and hepcidin (r: - 0.293, p: 0.006). While there was a significant positive correlation between the cARV therapy with CD4 cell count (r: 0.676, p: 0.001). There was no correlation between the cARV therapy with serum iron levels ( r: 0.176, p: 0.121).Conclusion: There is an inverse correlation between the cARV therapy with serum level of IL-6, ferritin, and hepcidin in HIV patients with ACD.  Keywords: cARV, ACD, IL-6, Ferritin, Hepcidin.
Efficacy and Safety of Anti-Tumor Necrosis Factor-Α Biosimilars in Rheumatological Practice and Their Registration, Patenting Elena Litvinova
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The aim of the work is to analyze and systematize data regarding the efficacy and safety of anti-tumor necrosis factor-α biosimilars, as well as their registration and patenting. Studies were conducted using a databases on the Internet: Ukrainian patent office, the European patent office, the US patent office, the Food and drug administration, European Medicines Agency, State enterprise “The State Expert Center” of Ukraine. The breakthrough in the treatment of rheumatoid arthritis is the discovery and administration of anti-TNF-α agents, such as infliximab, adalimumab, etanercept, certolizumab pegol, golimumab. Numerous randomized clinical trials and meta-analysis data indicate high efficacy and acceptable safety of anti-TNF-α biosimilars for the treatment of rheumatoid arthritis. The development and registration of anti-TNF-α biosimilars reduces the costs of health care and patients for biological therapy, increases patient access to treatment with the latest drugs, and contributes to the further development of biotechnology. Thus, effective anti-tumor necrosis factor-α biosimilars may be more accessible to the general population with rheumatoid arthritis. Despite certain hazards and risks associated with possible violations in the implementation of biological products in real practice, the industry of highly effective biosimilars brings progress both for the development of science and for practical healthcare.Keywords: infliximab, adalimumab, etanercept, certolizumab pegol, golimumab, biosimilar, efficacy, patent.
Molecular Diagnosis of the Toll-like Receptor 4 Genes and its Relationship with the Levels of some Immunoglobulin’s and Cytokines among Infected Women with Trichomoniasis Zahraa Zuhair Mohammed Al- Mamoori
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Trichomoniasis, simply, is a sexually transmitted disease typically asymptomatic in men and resulting in vaginitis with a copious, frothy discharge and itching in women, caused by Trichomonasvaginalis. The study was conducted in Babylon Province during the period from October 2017 to June 2018 in AL-Hilla Teaching Hospital and AL-Zahra Hospital, to diagnosis Trichomonasvaginalis and toll like receptor 4usingpolymerase chain reaction. The relationship of TLR4 receptor with levels of some immunoglobulin and cytokines was investigated by immunological method. A total of (125) blood and fluid vagina samples were taken from women aged between (15-45) Years. The results showed that the total infection percent of T. vaginalis at a rate of (13.6 %) in PCR technique. And the total of TLR4 at a rate of  (86.66%). The results revealed that a significant elevation (P<0.01) in serum concentration of pro inflammatory cytokines interleukin (4), and immunoglobulin E and A in T. vaginalis infection patients in compared to healthy control group. The result showed the association between IgE, IL4 and TLR4 receptor of patients.Keywords:  Genes; Immunoglobulin’s; Cytokines; Infected women.
The Effect of Bay Leaves (Syzygium Polyanthum) Administration Towards the Final Weight and Carcass Percentage of Laserpuncture-Induced Male Hybrid Ducks Lucia Tri Suwant
Journal of Global Pharma Technology Volume 11 Issue 04.
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The carcass weight of laserpuncture-induced male hybrid ducks is not maximum yet. Nevertheless, it can be resolved by using bay leaves (Syzygium polyanthum) as a supplementary feeding to support the optimal work of laserpuncture technology. This research aims to evaluate the impact of bay leaves (Syzygium polyanthum) towards final weight and carcass percentage of laserpuncture-induced male hybrid ducks. This research applied Completely Randomized Design (CRD) with three treatments. Each treatment consisted of six replications, and each replicate consisted of six male hybrid ducks with homogenous age and weight. The three treatments were P0 (Control), P1 (Laserpuncture), and P2 (Laserpuncture and bay leaves). The data were analyzed by using Analysis of Variance (ANOVA) and continued by Least Significant Difference (LSD). The results suggested that the bay leave administration on laserpuncture-induced male hybrid ducks (P2) provided a significant effect (P<0.05) in comparison with (P0) & (P1) on the final weight. However, an insignificant effect (P>0.05) was identified on the carcass percentage of male hybrid ducks. The bay leaves administration on laserpuncture-induced male hybrid ducks can intensify the final weight gained, but it does not affect the carcass percentage.Keywords: Hybrid Duck, Laserpuncture, Bay Leaves (Syzygium Polyanthum).
Gypsiferous Soil Analysis of Samara-Tikrit Area-Iraq Weam H. Kadum
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The soil properties are an important parameter for architectural and structural design of structures. Samara-Tikrit area in Iraq is a tourist destination, so in the last decade a number of multistory buildings, roads, etc. have been constructed. This study investigates the properties of the soil to give a base data, which can be used for the future construction design. This work aims investigating the gypsiferous soils texture, mineralogy and to interpret their geotechnical characteristics in Samara-Tikrit area, Iraq. A total of thirteen (13) soil samples were taken of gypsiferous soils distributed on three (3) sites. The results of grain-size analysis show that mixture of sand with variable percentages of clay and the silt fractions. The soil profile in site 1 reflect that the upper (0.9) m. is of sandy clayey silt, whereas the lower (2) m. is of silty sandy clay. The deep soil is of silty and clayey sand that reach 4.5 in depth. Concerning the soil profiles in site 2 and 3 representing silty sandy clayin general and silt beds occur at site 3. The soils within the three sites are fine-grained, yellowish light brown, moderately to highly gypsum, ranging from friable to very hard gypsiferous soil. The results of thin section are indicating that gypsum ranges from 12.3-35.4 %; clay comprise 12.0-26.2 %, while calcite and dolomite are from 9.6- 23.2 %. Quartz and Chert grains are ranging from 11.3- 26.0 %. Feldspar is ranging between 9.3- 19.0 %, while rock fragments is ranging from 7.2-15.7%, with heavy minerals ranging from 0.8 -1.9%.  The X-ray diffraction analysis reflects that non-clay type minerals are quartz, calcite, dolomite, gypsum and feldspar; while the clay minerals are chlorite, smectite, kaolinite, illite and palygorskite. The geotechnical properties results reflect that six samples (1a, 1c, 1d,2c, 2d, 3b) are classified as gypsiferous soil with  less  than 25% gypsum content and with less values of initial void ratio, coefficient of curvature, uniformity coefficient, collapse potential %, compression strength, cohesion, and plasticity index %  while the other seven samples (1b,1e,2a,2b,2e,3a,3c ) are classified as highly gypsiferous soil with more than 25% gypsum content and with relatively higher values of initial void ratio, coefficient of curvature, uniformity coefficient, collapse potential %, compression strength, cohesion and plasticity  index%  .Keywords: Gypsiferous soil, Texture, Mineralogy, Samara-Tikrit area, Iraq.

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