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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Modification and Anticancer Activity Study of Polyvinyl Alcohol Containing 1, 3, 4-thiadiazole Ruwaidah S. Saeed
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

Beginning from 2-amino-5-mercapto-1, 3, 4-thiadiazole a variety of new cyclic imides linked to 1, 3, 4-thiadiazole moiety. A  series of novel cyclic imides containing1,3,4- thiadiazole ring [1-6]through reaction of various cyclic anhydrides with 2-amino-5-mercapto-1,3,4-thiadiazole .Compounds [1-6]were reacted with anhydrous sodium carbonate  of distilled water as a solvent, then of chloroacetic acid was added to produce compounds [7-12].The compounds [7-12]reaction with SOCl2 in the presence of Benzene to producing the compounds [13-18].Chemical modification of Poly(vinyl alcohol) were obtained by reaction of PVA with compounds [13-18]using the Dimethyl formamide to produce compounds [19-24]. The structure of the synthesized compounds was identified by their analytical and spectral data such as, FTIR spectra, 1H-NMR. UV-Vis Spectroscopy, Thermal analysis [Differential Scanning Calorimetry (DSC), Thermo gravimetric analysis (TGA)], Scanning electron microscopy (SEM), Elemental analysis (CHNS) and Antibacterial activity screened via two types of bacteria. Anticancer activity also examined for all modified polyvinyl alcohol.Keywords: 1, 3, 4-thiadiazole, Polyvinyl alcohol, Antibacterial, Anticancer activities.
Prevalence of Medication Errors in a Tertiary Care Teaching Hospital Manoj Kumar Sethi
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: The purpose of current research is to identify the incidence of all possible prescription errors and to categorise them in a tertiary teaching care hospital of south India. Methodology: This is a prospective observational study conducted for nine months of various departments of (SVS) Medical College and Hospital, Mahabub nagar, Telangana. Suitable data collection forms were designed to meet up the criteria. Patients those agreed to give informed consent were included and those not willing to give consent and of (ICU) were excluded from this study. Patients were monitored on a regular basis from the time of admission to the date of discharge for any type of prescription error and recorded accordingly. Results: Throughout the study duration total 2000 prescriptions were analysed and observed that 400 prescriptions contains some kind of medication errors. More incidences of errors observed in surgery department (34 percent) and least was found in gynaecology department (3.75%). Major types of errors were omission error. Parenteral formulations constitute maximum no. of errors than oral and other external routes.  Conclusion: Most of the errors were omission of dose followed by illegibility, omission of prescriber signature, error in units, omission of route of administration (ROA), over writing, omission of frequency, under prescribing, omission of medication, omission of superscription, irrational prescribing, over prescribing, abbreviations, error in writing ROA, error in dose. Thus the present study threw some light on the need of proper education and training of all health care professional to minimize medication errors by which proper therapeutic goal can be achieved.Keywords: Prescription errors, Omission error, Commission errors, Medication errors.
Coating of Plastic Materials with Metals Under Low Pressure Ban Khalid Mohammed
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

There the outcomes concerning the investigations regarding floor energy then chasm durability on abrasive then other enormously strong substances the usage of the approach regarding micro stress so much affords high dosage about localization on the software over an external force action, are presented. The fundamental regularities over elastic-plastic deformation or brittle defeat of the procedure on micro indentation have been determined because of every the investigated materials. Based of the studies we additionally identified the power or energy conditions about elastic-plastic deformation and slight dud of the manner on micro indentation of fairly solid or brittle materials. It was once found, to that amount within the 1st flooring on the corrosion manner the precise work of break and the power depth element are immediately proportional after the bulk on the stress concentrator, i.e. the imprint diagonal. Therefore the power depth component so is widely used of mechanics or micromechanics concerning materials can keep legitimate solely when that is described among terms over sustainable increase concerning cracks of the 2nd board regarding unsound cleft of the investigated material. According in imitation of take a look at consequences we present the important traits regarding power then crack toughness on a quantity concerning abrasive substances ancient in enterprise or lookup organizations.Keywords: Method of micro pressure; Brittle fracture; Micro volumes; Origin; Critical stress; The relative elastic deformation.
Theater Performing Art: a Strategy to Improve Self-efficacy and Social Support in Patient with Type 2 diabetes Mellitus (T2DM) Mahendro Prasetyo Kusumo
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: The lacks of self-efficacy and social support are two neglected issues in patients with type 2 diabetes mellitus (T2DM). One of the popular methods to enhance those factors is theater performance art education (TPA), but its evidence in T2DM is lacking. Therefore, this study was aimed to measure the effectiveness of TPA toward social support and self-efficacy in T2DM. Methods: This study used quantitative methods with a quasi-experimental non-equivalent pre post-test control group design. The two variables measured were self-efficacy and social support. The subjects of this study were Prolanist member of patients with T2DM in the four primary health care centers in Sleman Yogyakarta Indonesia. Pre-test and post-test measurement were taken and compared to determine the efficacy of the TPA. Results: 102 subjects were used in this study (32 in control and 70 in intervention group) with women and 45-60 years old age group comprised the majority of the subject population. Mann-Whitney test showed that the self-efficacy score increased more pronouncedly in intervention group compared to control group (Δ mean intervention: 3.34±4.74; Δ mean control: -0.75±3.98; p: 0.000). Same result was also observed in social-support variable (Δ mean intervention: 1.63±1.84; Δ Mean control: 0.38±1.84; p: 0.002). Multiple logistic regression revealed that TPA only significantly affected self-sufficiency (Adjusted OR: 0.173; p: 0.001; 95%CI: 0.062 - 0.479) while barely influenced social support. Conclusion: The implementation of theater performing art-based community empowerment as part of social education helps in improving self-efficacy in patients with T2DM. Keywords: T2DM, Theater performing art, Self-efficacy, Social support.
The Patient Care and Complications of Hemodialysis Procedure for Renal Failure Patients: A Descriptive Study at al Nasiriya city, South of Iraq Firas Fadhil Alyassin
Journal of Global Pharma Technology .
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Abstract

Objective: the aim of this study is to describe the side effects and complications of renal failure and hemodialysis procedure. It also evaluates the general clinical care and nursing interventions for hemodialysis patients treated at the artificial kidney unit in Al Hussein-teaching hospital. Subjects and methods: this study is performed in Al-Hussein teaching hospital in Al-Nasiriya city, south of Iraq from October 1st, 2015 to May, 2016. Eighty patients [(54) males and (26) females], age (10 – 85 years) and were enrolled in this study. All of the patients were diagnosed with renal failure by specialist doctors and currently on hemodialysis renal replacement therapy. The data collected from patients through a questionnaire list designed and developed for this study. The list concerned with the adverse effects, complications, mortality and morbidity related data in addition to the patients' general information. The collected results were analyzed in order to construct tables, figures and other necessary research requirements. Results and conclusions: in this study, most of the hemodialysis cases are caused by hypertension (37.5%). The most common complications in hemodialysis patients were edema (78.75%), anemia (63.75%), and arterial hypertension (60%). The most common side effects associated with hemodialysis procedure were nausea and vomiting (47.5%) , dyspnea (21.25%)  and headache (25%).  The major treatments and diets of patients in this study were erythropoietin injection (66.25%), protein restriction (86.25%) and restriction fluid (77.5%). The clinical care and nursing interventions for hemodialysis patient enrolled in this study were relatively good according to the results (82%).Keywords:Hemo dialysis, Renal failure, Nasiriya city, Iraq
Potential Regulatory Functions of Propolis to Ameliorate Hematopoietic Disorder in Diabetic Mouse Model Muhaimin Rifa’i
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Diabetes mellitus (DM) in autoimmune case, related to cytotoxic T cells activation as a response to autoantigen. In the recent studies, propolis is known as a potential immunomodulator. The aim of this study is to determine the effect of propolis as a regulator to ameliorate diabetic mouse model. In vivo experiment was done using streptozotocin-induced diabetic mice. There are five experiment groups; that are DM group (diabetic mice model without treatment); propolis ethanolic extract treatment group doses of 50, 100, and 200 mg/kg BW; and normal mice group. Effect of propolis was observed 14 days post treatment by flow cytometric analysis. The number of CD8+CD62L-, CD4+CD25+CD62L+(Treg), B220+,  and NK+ cells was assessed from splenic cells. The result showed that administration of propolis for 14 days could reduce the number of cytotoxic T lymphocytes (CTL) memory significantly (p ≤ 0, 05). Especially the doses of 100 and 200 mg/kg BW could suppress the activation of CTL quite similar to those normal groups. Propolis with the dose of 200 mg/kg BW increase the number of  Treg, B220, and NK cells. The increase of Treg may reduce the activation of CTL and prevent tissue damage by autoreactive cells, and finally hematopoietic imbalance can be overcome. Keywords: B220, diabetes mellitus, immunomodulatory, NK, propolis.
Oxidative Stress Statue in Follicular Fluid of Infertile Women Treated with IVF/ICSI-ET Rusul Hashem
Journal of Global Pharma Technology .
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Abstract

Introduction Oxidative stress (OS) in follicular fluid (FF) may affect in vitro fertilization (IVF) outcomes in infertile women undergoing IVF/ICSI-ET. Aim of study to assess the effects of total peroxide (TPX) concentration, total antioxidant capacity (TAC), oxidative stress index (OSI), malondialdehyde concentration (MDA), glutathione-s-transferase (GST) activity, and superoxide dismutase activity (SOD) on IVF and pregnancy outcomes in PCOS, male cause infertility, and unexplained infertile (UI) patients undergoing IVF cycles. Subjects, material, and methods A prospective case control study was performed among (40) control group (male cause), (40) polycystic ovary syndrome (PCOS) group, and (45) unexplained infertility (UI) group, all of which undergoing IVF/ICSI-ET. FF samples were collected at the day of oocytes aspiration. TPX, TAC, MDA levels, GST, and SOD activities were measured in FF. oxidative stress index were calculated.  Results When control, PCOS and UI groups were compared in term of IVF outcomes, there were no significant differences in M II oocyte, G1 embryo, maturity rate, cleavage rate, fertilization rate, and chemical pregnancy state among the three studied groups (P˃0.05). In addition, comparison of OS parameters among the studied groups showed no significant differences in TAC, MDA, GST activity, GST specific activity, and SOD activity (P˃0.05); however, significant differences in TPX, OSI percentage, and SOD specific activity (P˂0.05) were found. Association analysis between OS parameters and IVF outcomes showed a significant positive correlation between GST activity (and GST specific activity) with G1 embryo, GST activity with pregnancy, as well as, SOD activity and maturity rate in control group (P˂0.05). In addition, GST activity and GST specific activity showed significant positive correlation with both cleavage rate and fertilization rate, GST activity with pregnancy, as well as, TPX with cleavage rate and fertilization rate in PCOS group (P˂0.05). OS parameters in UI group did not show any significant correlation with IVF outcomes (P˃0.05).  When control, PCOS and UI groups were subdivided according to pregnancy outcome, mean TPX and TAC concentrations were higher in pregnant group compared to non-pregnant group; while mean MDA and OSI were lower in pregnant group compared to non-pregnant group in the three studied groups. Antioxidant enzyme activities in pregnant group were higher compared to non-pregnant group in the three studied groups. Conclusion The results of this study demonstrated that the oxidant-antioxidant balance in the oocyte surroundings must be obtained to improve IVF and pregnancy outcomes in patients treated by IVF/ICSI-ET.Keywords: Oxidative stress, Follicular fluid, Polycystic ovary syndrome, Antioxidant, Intra-cytoplasmic sperm injection.
Efficacy of Curcumin-Chitosan-Based in Glazing of Cooked Shrimp and in Coating of Dry-salted Shrimp to Extend Product Shelf-life during Preservation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Chitosan has a wide range of potential applications in food science. It’s one of the best edible and biologically safe preservative coatings for different types of foods owing to its biochemical and biodegradable property, non toxicity, film-forming, antimicrobial action. Curcumin is one of the few promising natural products with a variety of therapeutic effects. Our present research demonstrated a new edible coating formula by combining chitosan 1.5% with different curcumin concentration (0.01%, 0.02%, 0.03%, 0. 04 %). This research was conducted from 2018 to 2019 in the scientific laboratory of Mekong  University. Results revealed that the chitosan-based coating layers (1.5 %) emdeded with curcumin (0.03%) could maintain the shrimp quality in glazing of cooked frozen shrimp as well as coating of dry-salted shrimp during storage. Curcumin played an important role as antioxidant in making chitosan-based film. Nontoxic, non-pollution biodegradability, surface barrier, biocompatibility, and edibility are some benefits of edible curcumin-chitosan-based coatings over plastic bags. It has been shown that it’s significantly improved the quality and increased the shelf-life of shrimp product. The improvement in the product quality is achieved through inactivation of microbial growth, reduction of lipid oxidation and enhancement of sensory characteristic.Keywords: Shrimp, Curcumin, Chitosan, Coating, Shelf-life, Lipid Oxidation, Microbial growth, Sensory characteristic.
Development of Covid-19 Disaster Risk Instruments for Children Hery Sumasto
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Background. Children need to get protection during the Covid-19 pandemic, in accordance with Presidential Regulation 12/2020 on The Determination of Non-Natural Disasters. The purpose of the research is to develop non-natural disaster risk instruments for children. Research methods. This type of research is Research and Development. Instrument development is carried out in 5 (five) stages, namely: 1) evaluation of instruments; 2) development; 3) experiment; 4) socialization; 5) recommendations. FGD population of 40 respondents is target-1 as many as 20 people, target-2 as much as 20. Experts in this research are methodology experts and child disaster experts. Research Result: Phase I disaster risk, namely threat, vulnerability and capacity, obtained 7 standard components of disaster instruments for children: 1) economic status; 2) knowledge; 3) attitude; 4) infrastructure; 5) institutional organization; 6) threat level; 7) disaster risk reduction behavior. Validity and reliability tests show that of the 32 valid items, 25 items are all reliable because the Cronbach alpha value is above 0.7. Not valid for 7 items. Phase 2: instrument testing was conducted on 267 respondents. Test with google form. The test results of instruments for children potentially exposed to Covid-19 amounted to 69% who were not exposed to 31%. Of those 69%, strong exposure is 2%, high exposure is 15% and medium exposure is 83%. Conclusion: There are 32 question points on non-natural disaster risk instruments, developed from 7 disaster risk variables for children. The instrument has good functionality in terms of efficiency, functionality and usability. Output: 1) disaster risk instruments for children; 2) intellectual property rights; 3) international journal publications 4) monograph books. Keywords: Instruments, Non-Natural Disaster Risk, Children
Green Synthesis Silver Nanparticles Using and Rographis Paniculata (nees) and its Antimicrobial Activity against Human Pathogens K Vijayakumar; G Thiruneelakandan
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

In the present examination, an undertaking was made to nanoparticle by using a remedially fundamental plant Andrographis panticulata. The applications plant materials which would help in the neutralizing activity of human pathogens. Silver nitrate (AgNO3) was used to coordinate the silver nanoparticle by using leaves focus of A. paniculata was used as a diminishing and offsetting administrator. The organized silver nanoparticles from 1mM AgNo3 game plan through the leaves expel were depicted using UV-VIS spectrophotometry, Scanning Electron Microscope (SEM) and Fourier Transform Infra-Red (FTIR). The nanoparticles should remarkable antimicrobial activity against multi-sedate safe human pathogenic sorts of the two tiny living beings and Fungi (Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Streptococcus fecalis, Aspergillus conicus, Aspergillus flavus, Aspergillus niger, Aspergillus terreus and Rhizopus. sp). The result reveals that the most outrageous antimicrobial activity was seen against the test life frame when stood out from the control.Keywords: Silver nanoparticles, Andrographis paniculata, SEM, UV-VIS spectroscopy, FT-IR, Antimicrobial activity.

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