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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Molecularly Imprinted Solid-phase Extraction for the Selective Determination of Ciprofloxacin Designer Drugs in Pharmaceutical Preparations Yehya Kamal Al-Bayati
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

We have developed a new method with high sensitivity, low cost and high stability. Using a functional monomer, this method is based on a molecular polymer (MIP).Which is 2 (Trifluoromethyl) acrylic acid (TFMA), 3 (Trimethoxysilyl) propylmethacrylate (TMSA),suitable cross  linker and ciprofloxacin (CPF) template for the production of monolithic solid  phase micro  extraction (SPME) fiber. Used_ UV. Vis_ as (detector).All these analytical methods used to extract, preconcentration and selective Ciprofloxacin determination (CPF). Competence, The stability and duration of the manufactured fiber plays a fundamental and indispensable role in SPME. The aim of this study is to examine the factors influencing the polymerization and extraction procedures, as well as to explain the selectivity of the manufactured fiber in the CPF solution. Also related and unrelated compound selectivity .Under optimum conditions. For five patients repeated experiments for three measurements the relative standard deviations) RSD percent are range of at (10ـ50)ppm of CPFH)Percentage (2.57ـ3.25). The relative recoveries obtained for CPF are within the range of (95.40 ـ 99.28) in spiked human urine samples.Keywords: Ciprofloxacin / Molecularly imprinted polymer solid-phase extraction / UV. Vis.
Health Coaching to Improve Mother’s Self Efficacy in the Implementation of Prevention Malnutrition in Children Yuni Sufyanti Arief
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction. One of the factors causing nutritional problems that can be modified and has an influence on the nutritional status of children under five is the pattern of parenting or child care by the mother, because the mother is a personal preference in fulfilling family nutrition. The family will play an important role in preventing nutritional deficiencies in each member of the family. The purpose of this study was to examine the effect of health coaching on maternal self-efficacy in preventing malnutrition. Method. Quasy-experimental design with pre-post control group was used as a method in this study. A total of 30 parents were used as respondents, divided into 15 for the treatment group and 15 for the control group. The sampling method used was purposive sampling based on inclusion criteria. Self-efficacy as the dependent variable and health coaching as the independent variable. The data were collected by means of a questionnaire and analyzed using the Wilcoxon rank sign test and the Mann Whitney U test with a significance level of ≤ 0.05. Results. The results showed the wilcoxon results for the treatment group p 0.008, the control group showed a p score of 1,000. Mann Whitney test showed a p score of 0.003. Conclusion. Health coaching is effective in increasing maternal self-efficacy in preventing malnutrition. The mechanism of change is by changing the Health inhibiting Thinking (HIT) in the mother to become Health enhancement Thinking (HET). The results of this study can be used as an alternative health promotion method.
Calcium Status with Some Inflammatory Markers in the Blood of Pregnant Women with Diabetic in Al-Samawa City/Iraq Habiba Khdair
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Background: Diabetes mellitus (DM) is a group of metabolic diseases regarded as by hyperglycemia resulting from defects in insulin action, insulin secretion or both. The chronic hyperglycemia of DM is related with dysfunction of Kidneys and long-term damage, heart, blood vessels, and nerves. Menstruation in Women with Diabetes: Menstrual abnormalities, especially irregular rotations, are common in diabetic women, particularly in those with obesity and poor diabetic control. Many women with DM type 1 diabetes have ovulatory rotations, with secondary or oligo amenorrhea although oligo menorrhea is more common among diabetic women than general population Materials &Methods:  colorimetric analysis for Glucose concentration; had been applied for Erythrocyte Sedimentation Rate (ESR), Alkaline Phosphatase (ALP), Ca+2, and serum C-reactive protein (CRP) test *. Results & Conclusions : In this study There is a significant increase in (ESR, glucose, ALP,  Ca+2  level in pregnant patients as comparison the control group (P < 0.0383- 0.0002),  but  no significant in ( CRP level) in  pregnant patients as comparison the control group ,  there is  no significant difference between (ESR, Glucose, ALP,CRP , Ca+2) level in  pregnant patients with duration of the disease between patients ( duration  <12 weak) & (( duration  12-24) weak )  .There is a significant difference between ( Ca+2 ,CRP level ) level in  pregnant patients  with duration of the disease between patients ( duration  <12 weak) &( duration  > 24 weak). There is no significant difference between (ESR ,Glucose , ALP ) level in  pregnant patients  with duration of the disease between patients ( duration  <12 weak) &( duration  > 24 weak) There is a significant difference between (Ca+2,Glucose  ,CRP  ) level in  pregnant patients  with duration of the disease between patients ( duration  12-24 weak) &( duration  > 24 weak) . There is no significant difference between (ESR, ALP) level in pregnant patients with duration of the disease between patients (duration 12- 24 weak) & (duration > 24 weak).Key words: Glucose, Alkaline phosphatase (ALP), and Calcium (Ca) ;titer ELISA method for C-reactive protein (CRP) and vertical 20cm Western tube for erythrocyte sedimentation rate ( ESR).
Vaginal Birth After Cesarean Characteristics with Maternal and Perinatal Out Come in Sanglah Hospital, Bali, 1st January 2015 to 31st December 2016 Period:A Descriptive Study I Ketut Surya Negara; Gede Agus Hendra Sujana
Journal of Global Pharma Technology Volume 09 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Cesarean section delivery is a common choice for some women because it is often considered faster and safer. Over the past few decades, the cesarean section continues to be performed more frequently. As a result, there is also an increase in the number of women with a history of cesarean section and become a problem for pregnancy and subsequent types of labor.  Method This is a retrospective descriptive study obtained using medical records in Sanglah Hospital Bali, 1st January 2015 to 31st December 2016 Period. Results Within 2 years since January 1, 2015 - December 31, 2016, the number of births in Single Deposer hospital as many as 2502 cases, consisting of 1753 (70.06%) vaginal delivery and 749 (29.94%) with cesarean section. Of all deliveries, the total number of deliveries with uterine scarring were 247 cases, consisting of 190 (76.92%) of direct cases of cesarean section, and 57 (23.08%) cases were decided by TOLAC. Of 57 TOLAC cases, 49 cases were successful VBAC (85.96%), while 8 cases were unsuccessful VBAC (14.04%).The incidence of VBAC was most frequently found in the age group of 20-35 years old (82.46%), body mass index (BMI) of ≤30 kg/m2 (91.23%), and gestational age of ≤40 weeks (84.2%). Based on the number of previous vaginal deliveries after cesarean, women with a history of vaginal delivery was most common with 29 cases. Based on previous cesarean section indications, fetal distress had the highest number of cases (35.09%). Women with cervix dilatation of ≥4 cm are more likely to have successful VBAC (85.96%). Almost all VBAC was spontaneous vaginal delivery (97.96%), except one. Almost all newborn have a birth weight of less than 4 kg (98.25%). Anemia and hysterectomy are among maternal morbidities found in our study. Based on perinatal morbidity, asphyxia, neonatal dengue, ARDS, and jaundice, were found in our study and only four newborns needed to be treated in the neonatal intensive care unit (NICU). Conclusion The success rate of VBAC in this study was high, the indications of previous cesarean section most due to fetal distress. Moderate asphyxia was the most common perinatal morbidity, followed by ARDS, severe asphyxia, neonatal dengue and jaundice. However, in most cases there is no perinatal morbidity. Keyword: Vbac, Tolac, Maternal Perinatal Outcome.
Testing the Efficiency of Zinc Oxide Nanoparticles, Honey, Honey Supported by Zinc Oxide Nanoparticles and Phylex in Degradation of Aflatoxin B1 in stored Sea Maize Seeds Dema A Yousif
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This study was conducted at the Mycotoxins Laboratory/ Department of Plant Protection /College of Agriculture/ University of Baghdad to test the efficacy of zinc oxide nanoparticles (ZnO (NP)), honey, honey supported by zinc oxide nanoparticles and Phylex in inhibition of Aspergillus flavus and degradation the toxin that produced by the fungus. The efficacy of ZnO(NP) was tested with concentration 2% and honey with concentration 20% and honey supported by ZnO(NP) with 20% concentration and the Phylex 0.2% under storage conditions. The results indicated that all treatment resulted a significant decline in the reduction rate and concentration of Aflatoxin B1 (AFB1) in stored Sea maize seeds with a significant difference from control treatment, which was 0.0 and 1.13 μg/kg by using high performance liquid chromatography (HPLC). As for choosing best concentration for each of the materials used to inhibit fungus growth, the results showed the used of ZnO(NP) and the Phylex have the highest reduction rate. This rate in Aflatoxin B1 was 93.80% with a concentration of 0.07 μ/kg and 91.15% with a concentration of 0.10 μg/kg respectively. The results of using honey showed the reduction rate of Aflatoxin B1 79.64% with a concentration of 0.23 μ/kg. Then was followed by the use of honey supported by ZnO(NP) with a reduction rate of Aflatoxin B1 82.30% and concentration 0.20 μg/kg. The results showed the efficacy of ZnO (NP), honey and honey supported by ZnO(NP) and Phylex in degradation A. flavus and prevent producing of Aflatoxin B1 in Sea  maize seeds in compression of control treatment that was 1.12 μg/kg using HPLC device. It was found when using ZnO(NP) reduction rate of Aflatoxin B1 was 96.42% with concentration of 0.04 μg/kg, while the rate of Aflatoxin B1 reduction was 72.32% at a concentration of 0.31 μg/kg when using honey. The results of the use of honey supported by ZnO(NP) indicated a rate of reduction Aflatoxin B1 was 83.92% B1 with a concentration of 0.18 μg/kg, the results of the use of the Phylex showed the reduction rate of Aflatoxin B1 was 94.64% with a concentration of 0.06 μg/kg.Keywords: Aflatoxin B1, ZnO(NP), Phylex, honey, Inhibition, Aspergillus flavus.
The Effect of Echinococcus granulosus on TP53 and CTNNB1genes Sequence Alteration among hepatocellular Carcinoma Patients Zaynab Kh. Rasheed
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Echinococcus granulosus is one of the small tap worms that causes Hydatid cyst.  This study was planned for detection of the incidence among cancer patients at Tumor unit in Baghdad medical city. Eleven samples of liver biopsy out of 40 specimens taken from patients with liver cancer in this study. All patients were suffering from Hydatid cyst infection Patients of migratory encampment in and around Baghdad city Kirkuk, Diyala, and Tikrit Hospitals, suffering from hydatidosis. The present study showed that the predominance of hydatidosis was in the patients whose ages ranged between (≤20-60) years. The sensitivity and specificity of ELISA with hydatid cyst IgG were 96%. While Casoin test (immediate hyper sensitivity skin test) was 100%.  The majority incidence was recorded between (50-60) years. The study showed that the predominance of hydatidosis was higher in females 28(70%), than males12 (30%). Analysis of the gene sequence showed that there were genetic mutations occurred in the hepatic cells, and several locations underwent change in genetic sequence including TCC to TCT in exon 147(5), GGT to AGT in exon 152(5), ACT to CCT in exon 160(5), TAT to TGT in exon 203(6),ATG to CTG in exon 235(7).Keywords: TP53 gene, Mutation, Tumor, Hydatid cyst, Gene sequencing.
Relationship between STK39 Genotype and Vitamin D3 in Hypertension Zahraa Sabbar Omran
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Vitamin D is a lip soluble molecule obtained through exposure to sunlight and intake of foods containing this nutrient naturally. A diet deficient in vitamin D3 in conjunction with inadequate sun exposure causes osteomalacia, the study was designed to relation between STK39 genotype and vitamin D3 in hypertensive, In study included 70 hypertensive patients with no signs and symptoms of renal impairment and another 30 control subjects .The links between genotype and vitamin D3 in hypertension were examined. The results showed that there were Vitamin D3 deficiency is present in 82.2% of the female hypertension group compared with 17.8% in control group, and There is a significant association between STK39 genotype and 25 (OH)D3 at (p=0.02) particularly in males .
The Protective Effect of Sesame Oil on the Male Reproductive System in Male Rabbits Exposed to the Experimental Hyperlipidemia Omar A. Kanosh
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The current study aimed to investigate the protective effect of sesame oil on the male reproductive system in male rabbits exposed with experimental hyperlipidemia. The study was conducted at the Animal House of the College of Education for Pure Sciences / University of Tikrit and included 15 rabbits of New Zealand rabbits and distributed to 3 groups and each group consisting of 5 animals. First group) Control group (: Treated with standard mixture of food and regular drinking water. Second group: were treated with standard mixture of food and added cholesterol (1% g / kg) .Third group: treated with a standard mixture of food and added cholesterol at a concentration of (1% g / kg) and sesame oil (1 ml / kg). The experiment lasted for 21 days. The results showed a significant decrease in concentrations of Cholesterol, HDL, LDL, VLDL and MDA in cholesterol and sesame oil groups and significant increase in GSH concentration compared with the cholesterol group. The results showed that hypercholesterolemia resulted in a significant decrease in the level of sperm and natural and live sperm and a significant increase in the level of deformed and dead sperm, while treatment with sesame seed oil showed a significant increase in the ratio of natural and live sperm and vitality and a significant decrease in the proportion of dead and deformed sperm. From that we conclude that sesame seed oil has excellent role on the prevention of the negative effects of hypercholesterolemia on the properties and vitality of the sperms.Keywords: Hypercholesterolemia, Sesame oil. Lipid profile, Glutathione, Malondialdehyde.
Cell-based Therapy: A Good Option for Retrieving Nephropathy Induced by Cyclosporine Hanaa H. Ahmed
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: The main goal is to address the role of mesenchymal stem cells derived from bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) in mitigation of cyclosporine A (CsA)-induced nephropathy in rats. Methods: Isolation and propagation of MSCs from both sources were performed and the cells were recognized by the microscopic appearance and estimation of specific surface antigens (CD90, CD105 and CD45) using flow cytometry. In this study 40 adult male rats were distributed into 4 groups; (1) control group, (2) CsA group, (3) BM-MSCs group and (4) AD-MSCs group. Two month after stem cell infusion, urea and creatinine serum levels were estimated. Also, serum levels of MCP-1, NF-κB, nephrin and NAG activity were evaluated. Also, histopathology of kidney sections was carried out. Results: Microscopic photo documentation and CD surface markers proved that the isolated cells have typical characteristics of MSCs. The outcomes of the in vivo study indicate the beneficial effect of BM-MSCs and AD-MSCs in kidney restoration as manifested by the significant blunting in serum urea, creatinine, MCP- 1, NF-κB levels and the significant inhibition of serum NAG paralleled by the significant increase of serum nephrin level and GFR. These findings were also appreciated by the histopathological observation of kidney tissue sections as the cell therapy elicited marked betterment in the structural organization of kidney tissue. Conclusion: This study provides great evidence favoring the significant role of MSCs, particularly isolated from AD, in retrieving experimental nephropathy induced by cyclosporine. The efficiency of MSCs could be ascribed to their immunomodulatory effect, anti-inflammatory and anti-apoptotic property.Keywords: Mesenchymal stem cells, Nephropathy, Inflammation, Apoptosis, Rats.
Comparison of the Casting Accuracy of Monopren in Two Different Implant Systems Elham Soltanpanah Dorbidi
Journal of Global Pharma Technology .
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Abstract

Statement of the problem the correct fit of implant-supported frameworks is obtained through taking a precise master cast which is quite similar to the patient’s intraoral orientation. The accuracy of implant casts depends on several factors including the impression technique and material, tray, implant angulations and depth, impression coping, the geometry of implant torque, and cast expansion. Purpose: this study aimed to evaluate the accuracy of open-tray and closed-tray impressions in two implant systems. Materials and method: two master casts of edentulous mandible were made of transparent acrylic resin. Bio horizon (n=30) and dio of implants (n=30) were inserted in either cast at 0 and 20° angles. Open- and closed-tray impressions were taken by using monopren material, and were poured with type iv stone cast. The related abutments were installed on the prepared casts. Digitizer in association with the 3d scanning system of atos software created point cloud of the casts and master casts. Finally, a comprehensive report of the deviations in x, y, and z axes were presented. Results: both the impression technique and implant system affected the impression accuracy significantly (p=0). but, the effect of implant angulations was statistically insignificant (p=0.793). Moreover, the interaction of implant system and impression technique was significant (p=0). However, no significant interaction was noted between the implant angulations and system or between the implant angulations and impression technique (p=0.944).conclusion: the impression technique and implant system play the key roles in the implants impression accuracy.Keywords: Impression accuracy; Impression technique; Implant system; Implant angulation; Impression material.

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