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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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E-Prescription in Nigeria: A Survey Adebayo Omotosho; Justice Emuoyibofarhe; Peace Ayegba; Christoph Meinel
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Electronic prescribing or Electronic prescription (EP) is the computer-based electronic generation and transmission of a prescription.  EP systems help to increase accuracy and safety of patient prescription and reduce costs through improved legibility and electronic delivery. The motivation for EP is greater safety of drug use and to counter the current unacceptable levels of adverse drug events. This study evaluated the feasibility of hospitals in Nigeria to adopt an EP system. A survey was conducted in four hospitals in Nigeria to determine the economic, technical and organisational feasibility of adopting e-prescribing. Respondents included 42 medical practitioners - doctors, pharmacists, pharmacy technicians and assistants - working at the hospitals at the time of the survey. Respondents felt that implementation of an EP system is economically feasible (p=0.031) and organisationally feasible (p=0.032) but were ambivalent as to whether it is technically feasible (p=0.446). However, inadequate funding by the government does not provide for the health sector to acquire the necessary resources and training skills.
Investigation on the Effect of Origin of Carbon Steel Reinforcing Bar on the Corrosion Behavior in Artificial Concrete Solution Abdulkareem M.A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The corrosion of steel reinforcing bar in concrete is very important point in fractures and damage of concrete building structures, many factors play important role in this problem. This research focuses on the effect of the origin of the carbon steel reinforcing bar on the corrosion parameters in simulate concrete solution (artificial), consisted of (Ca (OH) 2 (2gm), KOH (22.44mg), Noah (8mg). Two familiar types in the Iraqi local markets were followed, namely; locally produced sample and Ukrainian imported samples. Tafel plots and cyclic polarization procedures were conducted to estimate the corrosion parameters and pitting susceptibly of the two types using three electrodes potentiostat.The effect of temperature and some thermodynamic functions were measured in the range 20 to 50ᴼC. The microstructure and morphology was imaged using optical and atomic force microscope (AFM) respectively.Keywords: Steel reinforcing, Concrete solution, Artificial, Tafel.
Physico-Chemical Attributes of Soursop Fruits during Storage under Treatment of 1-Methylcyclopropene (1-MCP) Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Owing to high moisture content, soursop (Annona muricata) fruit has a short shelf-life by turning soft and bruised easily after harvesting. It quickly becomes unacceptable for fresh consumption. This valuable fruit should be preserved for a long shelf life. However, the lack of improved postharvest technology limits it on domestic and foreign markets. This research evaluated the effectiveness of 1-methylcyclopropene in different concentration (0, 50, 100, 150, 200 ppm) to shelf-life of soursop fruits during 12 days at ambient temperature storage. The use of this ethylene inhibitor at 150 ppm improved the shelf-life and quality of soursop fruit, including lower weight loss, maintain firmness, retent ascorbic acid and soluble solid during preservation Keywords: Soursop, 1-methylcyclopropene, Preservation, Firmness, Weight loss, Soluble solid, Ascorbic acid, Post-harvest.
Cardioprotective Activity of Polyphenolic Extract of Tubers of Cyperus Rotundus and Taurine against Isoproterenol - induced Myocardial Infraction in Rats: Troponin-I and Histological Findings Alyaa Majid
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The polyphenolic extract of tuberus of cyperus rotundus and taurine was studied for the cardio protective activity using isoproterenol induced myocardial infraction in female rats. Materials and Methods: Sixty of female rats (Rattus norvegicus) were used in the present study. Animals were divided into 10 groups ( 6 for each group). MI was induced in rats with ISO (85 mg/kg) twice at an interval of 24 hrs. ISO produced significant alterations in the troponin-I and necrosis in the heart. The effect of polyphenolic extract of tuberus of cyperus rotundus oral treatment for 21 days at two doses (15 mg and 30 mg/kg, body weight) and taurine at two doses (100 mg and 200 mg/kg, body weight) was evaluated against ISO- induced cardiac necrosis. Results: Significant myocardial necrosis and increase in serum levels of troponin-I were observed in ISO- treated animals as compared with the normal control animals. Polyphenolic extract of tubers of cyperus rotundus and taurine showed a significant cardio protective activity by lowering the levels of serum troponin-I and less myocardial necrosis. Conclusion: These findings the synergistic cardio protective effects of polyphenolic extract of tubers of cyperus rotundus and taurine during ISO-induced myocardial infraction in rats.Keywords: Isoproterenol, Cardiac troponin I, Myocardial necrosis, Histology, Cyperus rotundus, Taurine.
The Adsorptive Acid Orange 7 using Kenya tea Pulps Ash from Aqueous Environments Hamed Biglari
Journal of Global Pharma Technology Volume 09 Issue 04
Publisher : Journal of Global Pharma Technology

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Abstract

The control of environmental pollutions specially water resource pollutions is one of the main challenges throughout the world. The discharge of industrial wastewater such as textile industries containing toxic dyes like acid orange 7 has added to this concern. In this research, the adsorption of acid orange 7 anionic dye on the raw fine-grained tea waste modified with an acid and calcined has been investigated through the adsorption method. To achieve this purpose, the adsorbents of fine-grained CTC tea waste were studied in three forms of raw, treated with concentrated phosphoric acid, and calcined at 350, 450, and 500 °C for the adsorption of acid orange 7 with 50-500 mg/L concentrations from the aqueous conditions at pH 2-10 and t 0-120 min using 1-10 g/L adsorbents. The results showed that the best removal yield is about 98% at pH 2 and time 120 using 50 mg/L of dye and 10 g/L of adsorbent, and the modifications have a negligible effect on the improvement of the raw fine-grained tea waste adsorption. The most adsorption capacity (41.66 mg of orange 7 dye) was obtained using 1 g of the adsorbent. Also, the results illustrated that the adsorption pattern is in agreement with the Langmuir and Freundlich isotherm models. The adsorption pattern in the Freundlich model (R2 97%) is slightly more than Langmuir model (R2 85%). According to the granulated structure of tea waste (fine-grained tea) in three forms of raw, acidic and calcined, Kenya is an appropriate and low-cost adsorbent in the adsorption of orange 7 dye from the aqueous media.Keywords: Water pollution, Adsorption, Kenya tea waste, Acid orange 7dye
Study of Some Hormonal and Genetic Variants in Women with Polycystic Ovaries Syndrome in Baghdad City/Iraq Noor Thamer Hamood Al-Dolaimy
Journal of Global Pharma Technology .
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Abstract

The study was carried out to determine the impact of the levels of sexual hormones represented by (LH, FSH, Prolactin and Testosterone) and also to assess the damage in the genetic material of DNA (comet assay) through the standards which are represented by (Tail length, DNA in tail, and Tail moment). Hormonal levels were examined on the second day of the menstrual period for 50 women infected with polycystic ovary syndrome (patients) and 20 women without polycystic ovary syndrome (control). In addition to that, the hereditary caudate test was tested for 34 patients with polycystic ovary syndrome compared to 50 women in the control group. The results showed a significant increase in the level of Testosterone and a significant decrease in the level of Prolactin hormone levels of LH and FSH hormones were within normal values as well as the genetic instability of DNA is more common in women with polycystic ovary syndrome PCOS compared with control group women.Keywords: Sexual hormones, PCO and comet assay.
A Modified Version of Generalized Standard Addition Method as Quantitative Determination of Lysineacetyl salicylate-Glycine Complex Shams A. Nadhum
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The quantitative determination of lysine (Lys) and glycine ( Gly) in their complexes salts with aspirin was achieved using a modified version of the Generalized standard addition method ( GSAM)   that  aimed at the validation and standardization of analytical procedures with direct solid sample contain two types of amino acids without previous isolation. It was intended to separate aspirin quantitatively from them before determination by titration. It was intended to use spectrophotometry or titrimetric for determination of lysine and glycine. According to this method, two linear equations were solved to obtain the amounts of (Lys) and (Gly) by using two different wavelengths using  ninhydrin  as a color developing reagent in the spectrophotometric procedure, as it is the most selective among other coloring agent for spectrophotometric determination for amino acids. The high accuracy and precision of the results indicate that this method is simple, fast, precise and suitable to be used as a quality control procedure for analysis of commercial product (aspegic).Keywords: Aspirin, glacial acetic acid, glycine (as aspirin amino acid salt), Hydrochloric acid, lysine (as aspirin amino acid salt), ninhydrin,  perchloric acid, UV spectrophotometer.
Immunohistochemical Detection of Cryptosporidium-Induced Intestinal Tissue Alterations in Dexamethasone Treated & Un-Treated Mice Hagar F. Abdelmksoud
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Cryptosporidium parvum (C. parvum) is coccidian protozoan that causes cryptosporidiosis, a parasitic disease of the mammalian intestinal tract.  C. parvum is considered one of the most important waterborne pathogen among the most relevant parasitic enteric agents in man and animals. It is resistant to all practical levels of chlorination and it is an obligate intracellular pathogen. It has been the cause of multiple diarrhea outbreaks in developed and developing countries. The present work was carried out to evaluate the pathological, immuno-histochemical and molecular changes in the ileocecal region induced by chronic irritation with different inoculum sizes of cryptosporidium (50,500 oocysts) in immunocompetent and immunosuppressed mice. The mice were euthanized at different dates starting from 14, 21, 36, 45, 57 till day 64 to study these transformations. Histopathological examination of the ileocecal region revealed neoplastic changes in the form of dysplasia, polypoid structures, architectural distortion, glandular crowding, marked cellular atypia, exophytic adenomatous polypi, intramuscular adenocarcinoma and marked nuclear anaplasia. Immunohistochemical results showed positive K-ras expression. The present study proved that Cryptosporidium species is one of the infectious agents that may induce intestinal neoplasia, which is highly affected by repeated exposure and elevated parasite loads.Keywords: Cryptosporidium Mice, Intestinal tissue alterations, Histopathology, Immunohistochemistry.
Temperature Discrepancy and its Relation to the Most Important Physiological (Hormonal) Variants According to Teaching Climate in Handball Lesson Nazar Hussein al-Naffakh
Journal of Global Pharma Technology .
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Abstract

The study includes several aspects focused on the importance of identifying hormones levels in the blood of (female) students according to the climate of teaching at different temperatures and recognizing the dysfunction of students. The method was through dividing the samples into three groups each group contains six students and the blood sample is withdrawn before, during, and after the lesson, each group within a certain climatic period, divided into a moderate period, a cold period, and a hot period, where the specialist took blood samples from students at different temperatures in the environment of teaching handball. The first period of the climate is the moderate period where the specialist took blood samples and examined them in vitro. The results were recorded. In the second period, the cold weather, blood samples were also taken from the students. They were examined and the results were obtained. Finally, the hot period, the specialist also drew blood from the students, examined them and obtained the results. After finalizing the field work, the results of the three groups were collected and statistically compared.Keyword: Temperature Discrepancy, Physiological, Teaching Climate and Handball Lesson.
Effect of Anti-Hypertension Counseling Training on Increased Pharmacist Knowledge in Public Health Centers in Pandeglang Regency Yusransyah .
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Pharmaceutical Care by Pharmacist at Public Health Centers in Pandeglang is not considerably optimal. This can be seen from the increasing of the using anti-hypertensive drugs from year to year at Public Health Center, as the biggest cause of death in Pandeglang Regency categorized to non-communicable diseases. This requires pharmacists to optimize their roles further by increasing their knowledge and capability through training. This study aimed to assess knowledge level and ability of Pharmacists in Public Health Centers in Pandeglang Regency and to find out whether a significant influence could be emerged before and after training. This research was a pre-experimental study with the design of one group given pretest and posttest. Training was held twice. The first training was held in Pandeglang Regency and about Communication Skill and the second one was held in Bandung City and about Anti-Hypertensive Therapy. The results of this study indicated that in the first training the number of respondents who was not good or respondents classified as poor knowledge was 42.86% before training, the number declined after training to 7.14% and the increasing on the number of respondents classified as good enough or fair respondents, from 57.14% before training to 92.86% after training. The average score was 66.57 after training higher than the score before training was 55.36. Moreover, the second training indicated that the number of respondents who classified as poor knowledge before training was 85.71%, the number of declined after training to 14.29% and the increasing on the number of respondents classified as knowledgeable or good respondents, from 0% before training to 14.29% after training. The average score after training was 68.9 higher than the score before training was 42.5. In conclusion, both the first training and the second training can increase Pharmacist knowledge and ability to give Pharmaceutical Care about anti-hypertension.Keywords: Anti-hypertension, Counseling Training, Knowledge Level, Pharmacists.

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