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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Modest Simultaneous Determination of Acetylsalicylic Acid and Salicylic Acid in Plasma by High Performance Liquid Chromatography UV Detection Yahdiana Harahap
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Acetylsalicylic acid (ASA) is one of the drugs used in antiplatelet therapy. ASA is rapidly hydrolyzed to salicylic acid (SA) and has low levels in plasma. Analysis of ASA and SA in plasma has been done using LC-MS/MS, UHPLC, and HPLC with hydrolysis and fluorescence detector. Compared to those methods, HPLC equipped with UV detector is less expensive. The method using HPLC with UV detector also has been done but not sensitive enough according to the LLOQ. Therefore a sensitive and selective analysis method needs to be developed. This study aims to develop an analytical method of ASA and SA in human plasma using HPLC with UV detector.Method: The method used in this study is Reversed Phase - High Performance Liquid Chromatography using C18 column (Waters, Reliant™ 5 μm; 250 x 4.6 mm) with UV-Vis detector and was detected at wavelength of 230 nm. This method was developed using furosemide as internal standard (IS). Human plasma containing ASA and SA was extracted after protein precipitaion method using 15% perchloric acid with a liquid-liquid extraction method using ethyl acetate.Result: The method obtained was linear (r ≥ 0.99) at concentration range of 0.05 – 1.5 μg/mL for ASA and concentration range of 0.2 – 5.0 μg/mL for SA. The validation result of ASA and SA analytical method fulfilled the validation requirement of EMEA Bioanalytical Guideline in the year 2011. Therefore the method provides modest, sensitive, and selective measurements of ASA and SA concentrations.
MTHFR gene rs1801133 +677C>T Exon4 Polymorphism in Susceptibility with Rheumatoid Arthritis in Najaf Population Rashad Kadhim Mahmood Al-Akhras
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The prevalence of Rheumatoid Arthritis (RA)   has been raised in Iraq. The medical costs of such increased prevalence are high. Global studies have revealed polymorphisms of MTHFR (Methylenetetrahydrofolate Reductase) gene to be associated with Rheumatoid Arthritis (RA). This polymorphism can cause changes in various metabolic variables. Methods: The current study consists of 100 RA patients and 100 healthy control individuals. Variable parameters data included Anti-Cyclic cytrulinated peptide expression (ACCP), Rheumatoid factor (RF), C - reactive protein (CRP) in serum and Erythrocytes sedimentation rate (ESR) levels. Genotyping of MTHFR gene polymorphism is carried out by RFLP-PCR. Various statistical analyses were applied to analyze the data. Results: The estimation of immunological and biochemical data pointed out significant differences in Gender, RF, ACCP, CRP, ESR and age in RA when compared with those of the control group. The genotyping results were found to be consistent with Hardy-Weinberg equilibrium. The analysis of the genotype distribution under various inheritance models highlighted significant differences in SNP of MTHFR gene polymorphism among RA patients when compared with the control group under the dominant homozygote, heterozygote and recessive homozygote. The genotype and allele frequencies of the MTHFR SNP rs1801133; highlighted significant rises of the risk of RA CT (P =0.0335), (OR=1.9409), (95%CI 1.0532-3.5766) when compared with control subjects. We found that the CT genotype is associ­ated with the risk of RA comparing with CC and TT genotypes. Clinical characteristics were observed to change significantly with respect to the genotype distribution (risk factors) of the investigated SNP. Conclusion: MTHFR gene polymorphism (rs1801133) is implicated in the pathogenesis of Rheumatoid arthritis in Najaf population.Keywords: Rheumatoid arthritis, MTHFR, Rs1801133, RFLP-PCR, ACCP, CRP, RF.
Synthesis and Characterization of Some New Derivatives of 8-Chlorothiophyllìne by Microwave-Assist Suzuki-Miyaura Coupling Reaction Salwa R. Abdul-Ameer
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Some new derivatives of 8-Chlorothiophyllìne (8-CTh) synthesized by Suzuki reactions when react 8-CTh with hydrazine to give 8-hydrazinyl thiophyllìne. This compound reacts with 4-bromo benzaldehyde to give imine compound. The microwave-promoted Suzuki-Miyaura coupling of the latter compound with different aryl boronìc acids gave (3-9) compounds with good to excellent yields. This reaction was checked by thin‐layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, and FT‐IR, 1H, 13C-NMR and 2D-NMR spectroscopy. The antibacterial action of these derivatives was also determined.Keywords: 8-Chlorothiophyllìne, Suzuki reaction, Microwave, Antibacterial, Antifungal.
Investigation of Oxidative Stress in Patient with Varicella Zoster Virus (VZV) Infection Nisreen Kaddim Radi
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

Varicella zoster virus (VZV) is a member of the eight known herpes virus that infect humans. VZV infection is specific to humans. It causes chickenpox (varicella), the most common disease affecting children, adolescents, young adults and herpes-scale (shingles) in the elderly; shingles are rare in children. In direct immune flourescens assay for determination of antibodies IgG/IgM against varicella Zoster virus in the samples collected from patient serum show 98%positive result. The patients groups, had greater levels of SOD in contrast with control groups result at significant differences (P≤ 0.05) .Conclusion these results suggest that severity infection within vortesella zoster virus causes high level of sod.Keywords: Antitoxidant, Immuno flourescens, Zoster, varicella, Oxidative.
Electrochemical Preparation and Characterization of Zinc Oxide Nanoparticles as a Model for Drug Delivery in Pharmaceutical Compounds Aqeel Mahdi Alduhaidahawi
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Zinc oxide nanoparticles (ZnO NPs) were prepared by electrochemical method in solution contains NaNO3 as electrolyte and Polyvinylpyrrolidone (PVP) as stabilizer. The prepared ZnO NPs were characterized by EDX, SEM, TEM, and AFM studies .EDX-Spectrum of ZnO nanoparticles exhibited signals of zinc and oxygen only, and that means the sample of ZnO NPs having high purity. SEM micrographs givesa homogeneous particles distribution and having sheets like structure. From TEM study the size of ZnO NPs was found to be about 60 nm and the shape of nanoparticles was a bipyramid like shape. The average size of synthesized ZnO NPs from AFM study was found to be 60.99 nm; this result was agreement with result that obtained from TEM.Keywords: Electrochemical Preparation, Zinc Oxide Nanoparticles, AFM; SEM; TEM.
Role of Leptin in Iraqi Male Infertility Batool A. Al-Haidary
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Many etiological factors participate in initiation and development of males’ infertility. Leptin is an adipokine that play a crucial role in obesity and many other biological effects. One of these its effects are on Hypothalamus and Pituitary glands to which males’ infertility may be attributed.  Aims of Study: This study was designed to investigate the role of Leptin and its’ receptor in development of infertility among Iraqi males Materials & Methods: Seventy sub-fertile males were included in this investigation to estimate Leptin and its receptor levels in seminal plasma by ELISA techniques. All patients had been diagnosed as a sub-fertile male under the supervision of consultant physician.  Seminal fluid analysis was performed for each patient. Body mass index for each patient was calculated besides sera LH, FSH and testosterone hormones determinations and the results of the above tests were compared with those for 30 normal fertile men who matched the patients in their ages. All data has been analyzed statistically. Results: The results revealed highly significant decline in the mean of leptin levels (27.283±3.034ng/ ml) among patients in comparison with healthy fertile control group (47.975±7.152 ng/ ml) (P=0.002). Moreover, LH hormone showed an increment in its mean level (34.699±1.594) in highly significant manner in comparison with control group (14.859±1.947) (P= 0.001). This study referred to highly significant correlation between leptin receptor and BMI (P=0.0001), in addition to significant correlation with testosterone (P=0.046). Meanwhile significant correlation was observed between leptin and FSH (P=0.027). Conclusion: In view of the above results it can be concluded that there is an association between Leptin and FSH which in turn significantly correlated with sperms’ count and theirs ’motility.Keywords: Leptin, Obesity, Sex hormones, LH, FSH, Testosterone, Seminal fluid analysis.
Effects of Emodin on CCl4 Induced Liver Fibrosis in Mice Model Mohannad Falah Hassan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Many compounds demonstrated an anti-fibrotic activity, but none have been used in the clinics. The current study aims to assess the in-vivo emodin anti-fibrotic activity in liver fibrosis. Thirty-two mice were divided into four groups; the first group is composed of eight healthy mice to be a negative control group, while the remaining twenty-four mice had received intraperitoneal carbon tetrachloride 1ml/kg twice weekly for six weeks. Then, eight of these mice were sacrificed to be a positive control group, while the remaining sixteen mice were divided into two groups; one received six intraperitoneal doses every other day of emodin 40 mg/kg and the other received silymarin 20 mg/kg. Mice livers have taken and examined histopathologically to confirm the diagnosis of liver fibrosis and to assess the antifibrotic effects of emodin, then immunohistochemical evaluation was done for collagen III and Interleukin-4 secretion. Statistics used are ANOVA test followed by Tukey’s post HOC analysis. Emodin reduces fibrosis significantly in histopathologic sections, collagen content and Interleukin-4 content (in which p˂0.0001 was significant). There is no significant difference between emodin and silymarin in lowering fibrosis grade (p=0.1411), collagen III level (p=0.958729), and interleukin-4 level (p=0.144028). Emodin anti-fibrotic effects is related to lowering nuclear factor-ĸB leading to IL-4 lowering, decrease of epithelial mesenchymal transition by increasing E-cadherin, suppression of TGF-ß1 Smad signaling, Up-regulation of metastasis‑ associated gene 3, inhibits the Toll-like receptor-4 (TLR-4) pathway, and blocking the migration and proliferation of HSCs induced by platelet derived growth factor. Emodins have anti-fibrotic activity comparable to that of silymarin and can alleviate liver cirrhosis.Keywords: Liver fibrosis, Collagen III, Emodin, Interleukin-4, Silymarin.
Nurses Awareness Regarding Detection of Tuberculosis Cases in Babylon Hospitals Hayder Mohammed
Journal of Global Pharma Technology .
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Abstract

Tuberculosis consider one problem that threaten a public health in world and specially in developing countries, the detection of TB cases is very important in eliminate the prevalence rate of this disease among society and also lead to success the treatment regime of TB. The  nursing staff has crucial role in given the appropriate care for patients and also direct contact with patients in various sites of health facilities, therefore the improve the nurses awareness regarding detection of TB cases is important to control and decrease the risk of spread this disease. Quantitative research, descriptive design cross sectional study consisting of 80 nurses working in different site at Al-Hilla General Teaching Hospital. The result show the number of male (52.5%) higher than the number of female (47.5%), more nurses with secondary certificate as educational level (44.0%), the assessment of response rate of study sample for knowledge and awareness related TB is moderate level (40.0%) as higher percentage while the attitude and practice related TB is equal assessment between low and moderate level (47.5%).  Keywords: Nurses, Awareness, Detection of Tuberculosis, Babylon Hospitals.
Streptococcus Pneumonia Phytotherapy Mehrdad Karimi
Journal of Global Pharma Technology Volume 08 Issue 11
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Abstract

Streptococcus pneumoniae belongs to gram-positive coccus family of Streptococcaceae from Streptococcus viridans group. Streptococcus pneumoniae is a bacterium that causes infections such as sinusitis, ear infection and earache, septicemia, pneumonia, and meningitis. Plants are rich sources of bioactive compounds, hence are effective in a wide variety of diseases. Paying special attention toward more medicinal herbs is due to the promising effects of plants in prevention and/or treatment of diseases. The present review is in fact a report of the most effective medicinal plants on Streptococcus pneumonia. In this research, search was carried out by using the key words such as bacteria, Streptococcus pneumoniae and medicinal plants. Databases of Web of Science, PubMed, Scopus, Google Scholar, and Science direct were used to search, and related articles were used to review. Based on the results of the review on the texts, 13 medicinal herbs are the most important herbs with antibacterial properties against Streptococcus pneumonia.Keywords: Streptococcus pneumoniae, Herb, Antibacterial.
Tuberculosis Correlation with Age and Gender in Kirkuk City-Iraq Ibrahim Mohammed Saeed Hussein
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The study performed from 1st of January 2017 to 1st of April 2018. It was included (1042) patients data were collected from patients attending the Consultant Clinic for Chest and Respiratory Diseases in Kirkuk City. Results of the diagnostic procedure performed by direct microscopically technique using Ziehl-Neelsen (ZN) stain method for detecting Mycobacterium tuberculosis. The data showed that 523 of them were male and 519 of them were female patients. The examination results registered 83(7.96%) positive cases, 37(3.55%) of them were male whereas 46(4.41%) were female patients. According to the age group the results indicated that the age ranges of (15-24 years) showed the highest percentage of tuberculosis infection 18(21.68%) of the total positive cases, 7(8.43%) occurred in males and 11(13.25%) occurred in females. It was concluded that the highest proportion of positive TB cases were among the age group of (15-24 years) in both males and females..Keywords: Active PTB, Tuberculosis, Age & sex.

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