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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Predict the Level of Physical Performance in Terms of Some Functional Indicators for Basketball Players Waleed Adnan Khafeef
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

The science of sports training is a science that has been interested in the field of physical education in addition to other sciences in terms of field applications, which seeks to improve the levels of sports in various skills and activities, as access to high levels of sports and win will not be an easy process because the level of sports in Most of the activities have reached high levels in terms of technology and tactics. Among these games are the basketball game, which has witnessed a remarkable development in most countries of the world. In recent years, there has been an increasing interest in researching and exploring new methods of training players. As well as relying on the scientific basis of the determinants of the selection process of players who have the preparations and capabilities to enable them to play the game of basketball and predict their levels in the future. The researchers used the descriptive method in the method of associative and predictive relationships to suit the nature of the problem on the players of the basketball club Solidarity for the season (2018) of the (15) players. After testing the research sample and emptying the data in tables, the statistical process was carried out to reach the results through which the most important conclusions were reachedThe explosive power of the arms has a direct effect on the functional variables because the presence of explosive power is the result and indicator of the presence of adaptation in the functional variables that helped the player to produce high explosive power.Transient velocity is important in the success of movements and skills to a large degree where the transition speed is also the product of adapting functional variables at performanceKeywords: Prediction, Physical Performance, Functional Indicators and Basketball.
Fixed Orthodontic Appliance Associated With Change in Bacterial Diversity During First Stage of Active Orthodonotic Treatment Ahmed S. Al-Janabi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: some researchers have noted that fixed orthodontic appliance (FOA) have stirring on oral hygiene that lead to high cariogenic challenge. Moreover, based on the difficulty of maintaining oral hygiene, it can also affect germs under the gums by orthodontic devices, These variables would probably lead to the colonization of pathogenic bacteria, which are responsible for inflammation of the gingival, destruction of the periodontal support and changes in the enamel surface. Objective:  Isolation and identification of bacteria among orthodonotic patients at progressive time during first stage of active orthodonotic treatment and molecular identification of highly cariogenic bacteria Streptococcus mutans as well as an in vitro evaluation of antibiotic sensitivity/resistance for bacterial isolates.  Material and Methods: Sixty-five patients treated with fixed orthodontic appliance (FOA) their age between 12-25 years. Imprint swab samples were collected between brackets on the tooth surface monthly at zero day, 1st, 2nd and 3rd to be cultured aerobically and anaerobically. Bacterial isolated were identified in all age groups at progressive time. Molecular detection of S.mutans was performed using species specific primer Sm 479. The antibiotics sensitivity were done by use Kirby- Bauer disc diffusion method for bacterial isolates, the antibiotic selected was most common antibiotic used during orthodontic infection ( amoxicillin, amoxi-clav, cefotaxim, erythromycin and ciprofloxacin). Results:  A total 186 bacterial isolates were obtained from 65 sample of tooth swabs in zero day (immediately after orthodontic device appliance) and 183 bacterial isolates were obtain at first month after wearing orthodontic device, while 195 bacterial isolates were obtained at second month after wearing the device, in the last visit (3rd month after put orthodontic device) 202 bacterial isolates were obtained, and all samples give positive bacterial culture as shows in table (2). Also the result shows that Staphylococcus spp. was the most bacterial isolates appear in patients with fixed orthodontic appliance (FOA). The study indicated neglected statistically significant difference over progressive time except alpha and beta streptococci and P.aurginosa according to Chi-square test. The bacterial isolated during this study include Staphylococcus (S. epidermidis and S.aurus), Lactobacillus spp., Streptococcus (alpha, beta, and gamma), E.coli, Klibsilla spp., Enterobacter spp., and P.aurginosa. Species specific primer Sm 479F/R using polymerase chain reaction (PCR) indicated that S.mutans was detected and increased from 60% at zero day to 80% at 3rd month. The antibiotic sensitivity test recorded that ciprofloxacin and amoxi-clav shows high effective against bacterial isolates. Conclusion: The studies conclude that oral cavity colonized by large number of microorganisms that contribute in infection during orthodontic treatment. Staphylococcus (aurus and epidermidis) was the most common bacteria isolated from patients during initial stage of orthodontic treatment which appear in (81.5%) of the total isolates followed by Lactobacillus spp. and then streptococcus spp. which appear non-statistically significant difference (p ≥0.05) among progress with treatment. The most common gram negative bacteria in zero day is E.coli (20%), Klibsilla (18%), Enterobacter spp.(20.8) while pseudomonas aeriginosa (10.6) and also shows non-statistically difference except P.aurginosa, The flora exists in harmony with the host but this relation may be broken due to orthodontic device. The molecular detection of S.mutans by species specific primer shows increase in percentage from 60% in zero days to 80% in third month. All gram positive showed high level of susceptibility   to amoxi-clav followed by ciprofloxacin and cefotaxime while gram negative show high sensitive to erythromycin followed by ciprofloxacin and cefotaxime.Keywords: Fixed orthodontic appliance, Bacterial diversity, Antobiotic sensitivity, S. mutans.
Marital Satisfaction, Anxiety, and Health-Related Quality of Life in Myocardial Infarction Patients Devi Wulandari
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Anxiety is predictor of cardiac incidents and mortality, its relationship with Health-Related Quality of Life (HRQL) remains unclear, especially in married couples, yet a marital relationship as part of the immediate environment that can be a source of support or stress. The objective of this study is to shed light on the relationship between anxiety and HRQL by adding marital satisfaction as an independent predictor and moderator. A cross-sectional study was conducted on 214 myocardial infarction patients. The patients completed three questionnaires (McNew Health-Related Quality of Life, Couple Satisfaction Index, Cardiac Anxiety Questionnaire), analysed using a four-step moderated hierarchical multiple regression. In conclusion, anxiety and marital satisfaction significantly predict patients’ HRQL. There were no significant interaction effects between anxiety and marital satisfaction in predicting HRQL. These findings could spur further research in addressing the limitations of this study and similar studies, which in turn may direct future policies in healthcare.
Herbal cure for the leukemia- A challenging progression Kirthika Dhanraj; Anitha Joseph; Renuka Saravanan; Sivakumar Ramalingam
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Traditional medicine system is still used by approximately 65-80% of the world’s population in developing countries because of its fewer side effects. Most of the molecules derived from plants are effective against different cancer with different targets. The review mainly deals different plants such as Alisma orientale, Annona glabra L, Tinospora cordifolia, Euphorbia formosana Hayata which are used in the treatment of leukemia. It throws light on the therapeutic efficacy of different plant molecules such as berberine, flavanoids, caffeic acid and kolavirion with the mode of action in different cells, which have already been used for the treatment of leukemia. This review will promote research towards the development of plant based drugs which could be used for the treatment for the cancer.Key words: Leukemia, Medicinal plants, Phytoconstituents and HL-60. 
In Vitro Study of He, Ne Laser as an Agent for Melanin Formation to Vitiligo Treatment Saja I. Dawood
Journal of Global Pharma Technology .
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Abstract

The standard curve for optimum concentration of different lymphocyte samples, were carried by ELISA using the procedure mention in the ELISA kit , using He-Ne laser for irradiated samples for different time, this study found there is a good correlation between the concentration of tyrosinase and optical density R2 =0.9615, by measuring the optical density of lymphocyte samples shows that for healthy person the concentration of tyrosinase  more than patients but,  the response for producing tyrosinase for patient is more than that  for healthy person after using laser for different dose. This result indicates that laser radiation dose to enhance tyrosinase in lymphocyte to produce pigment cells. Keywords: Tyrosinase; Lymphocyte; Melanin; Vitiligo; He-Ne laser.
Ameliorative Role of Vitamin C against Toxicity by Food Additive in the Male Rats Afyaa Sabah Nasir
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Food additives are widely used in the food for example MSG present in variety types of food so the current study is proposed to evaluate the protective role of vitamin C in the male white rats for 30 days. The results showed the significant increase (p<0.05) in the levels of liver functions tests and lipid profile as well as significant decrease (p<0.05) in the biochemical parameters include total protein and albumin. Also, the histological examination for liver tissues demonstrate the histopathological change include degeneration, bleeding and necrosis. So that, the results appear MSG is highly toxic and treatment with vitamin C can to decrease the toxic effect for MSG in the biochemical parameters and histological changes in the liver tissues.Keywords: MSG, Liver functions, Vitamin C and rats.
Shariah Models-Based on Ethics Innovation In Nursing Documentation Halimatussakdiah Halimatussakdiah; Hidayat Arifin; Wiwin Haryati; Alhuda Alhuda; Nur Asiah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Nurses who work full time require religious support in patient care and professional documentation tools. The purpose of this research was to test a model development of patients’ satisfaction through nurse performance with an empirical study on innovation in nursing services and shariah ethics. Methods: A quantitative design was used with a cross-sectional approach. The samples were 420 postoperative patients. Respondents were obtained through multistage sampling. The independent variables were innovation service with Electronic Nursing Documentation and shariah-based ethics. Nurse performance was the mediating variable and the dependent variable was patient satisfaction. Data collection was performed using a questionnaire and data analysis with SEM version 22. Results: The results of this study indicated there was use of standard operating procedures in patient care about shariah-based ethics, which can improve the quality of nursing services where nurses can document the patient's nursing process comprehensively using Electronic Nursing Documentation (END). All the variables tested in the model development, namely service innovation, shariah ethics, and nurse performance, affects patient satisfaction. SEM test results obtained GFI (Goodness of Fit Index) values which should be within the expected cut-off value range (p Value ≤ 0.05). Conclusion: The use of SOPs on shariah ethics with END is interrelated between service innovation, shariah ethics and nurse performance and affects patient satisfaction. It is expected that nurses will be able to provide shariah ethics-based services and documentation to improve patient satisfaction.
Genotypes and Haplotypes of TIM-3 Gene and Risk of Tuberculosis Jwan Ahmed Al Hamawandi
Journal of Global Pharma Technology .
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Abstract

Tuberculosis is a cosmopolitan infectious disease caused by Mycobacterium tuberculosis. The disease outcome depends largely on the activity of T-lymphocytes. Certain variants in TIM-3 gene may influence the activity of these cells against the causative agent. To assess the influence of three single nucleotide polymorphisms in the TIM-3 gene on the susceptibility to pulmonary tuberculosis this case/control study included 68 patients with pulmonary tuberculosis and 40 apparently healthy controls. DNA was extracted from blood samples obtained from each participant. The flanking regions in TIM-3 gene promoter for -1541 C/T, -1516 G/T and -574 A/C were amplified which PCR using specific primers. Allele-specific PCR or restriction fragment length polymorphism used for Genotyping.Keywords: Pulmonary tuberculosis, TIM-3 gene, single nucleotide polymorphism.
Efficacy of Extraction and Microencapsulation of Betacyanin extracted and Freeze-Dried from Red Dragon Fruit (Hylocereus polyrhizus) Peel N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Microencapsulation is utilized to prevent chemically sensitive bioactive components from degradation due to harsh environmental conditions and is also applicable to handle the emission of the encapsulate. One of the key factors to be considered in the microencapsulation process is the coating material.  Dragon fruit peel derived from processing companies contains an abundant of betacyanin, a valuable pigment. In our research, different parameters of solvent extraction (kind of solvent, pH, ratio of solvent: material); microencapsulation (kind and concentration of coating agent, synergistic effect of combined coating agents) were thoroughly investigated. Our results showed that betacyanin can achieve the highest yield by extraction with water at pH 5.0 with dissolving ratio 5.5: 1.0 (water: material) within 8 hours at ambient temperature. The filtrates were then mixed with 20% maltodextrin+10% β-cyclodextrin as microencapsulating agent during the freeze-drying to get dried powder (6.5% moisture content). By this approach, the highest betacyanin could be maintained at utmost level.Keywords: Dragon fruit peel, Betacyanin, Extraction, Microencapsulation, Maltodextrin, β-cyclodextrin.
Long Term Consequences of Infliximab among a Sample of Spondyloarthropathic Patients Attending Baghdad Teaching Hospital Atta Ah mousa Al-Sarray
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Objective: To determine LFT, lipid profile and the increase in weight after one year of infliximab treatment among a sample of spondyloarthopathic patients attending ‘Baghdad teaching hospital’   Patients &Methods: prospective study was carried out for a period of one years  In Baghdad teaching hospital(biological unit) on 1st of January  2016 and ending on December 2017 .A total of 120 cases Anky losing  and psoriatic arthritis on biological agent(infliximab) had two reading of liver function test  , lipid profile  and body mass index first reading at( zero week)  and second reading at (one-year) after biological agents . Results: The mean age of study sample 36±10.3,mean age of onset 29±11.5and duration 11±8.5Significance abnormality of liver function test (ALT,AST and AP) at two reading (baseline and after one year of biological agent( p=0.0001).Regarding total Cholesterol , Triglycerides ,High Density Lipoprotein & Low density  Lipoprotein (TC,TG, HDL-c and LDL-c) Significance differences(p<0.0001) were seen  after biological  therapy in study sample. Significance differences were seen regarding body mass index and weight gain after one year of follow up of patients. Conclusion: Significance rise of LFT, abnormal lipid profile and weight increment in the study sample after one year of follow up after infliximab therapy in patients with spondyloarthopathy. Recommendation: Our findings suggest the need for more prospective studies regarding the relative contribution of infliximab treatment for abnormal Liver function test, Lipid profile and weight gain Keywords: Patients, Infliximab, Anti-TNF agents.

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