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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Relationship between the HPV Cervical Infection and Intraepithelial Colorectal Lesions in Women Olga S. Alyautdina
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

A histological structure of anal epithelium shows obvious parallels with the structure of cervical epithelium including the presence of a transformed zone at the border between two types of epithelial cells.  In this connection, a process of anal benign tumor pathogenesis is similar to cervical cancer. In the present work, with the use of liquid cytology, a comparison of colorectal HPV infection in women patients with cervix dysplasia and control group of patients with no cervix pathology has been performed. The cytological investigation was performed with the use of a method of liquid cytology BD ShurePath based on a system of automatized scanning of preparations BD Focal Point. Identification of high oncogenic risk HPV was made with the use of a hybrid capture method (HPV digene-test hybrid capture II). Using cytological investigation of colon scrapings, we revealed intraepithelial damages of colon epithelium most probably associated with HPV infection in 24% of patients from the high risk group. In the same time, there were no similar changes in the control group of patients. Our results show that HPV-associated cervix pathology is a risk factor for colon intraepithelial HPV-associated damages development.  These patients are in the high risk group for colorectal cancer development and they must experience a regular corresponding medical examination. Keywords: HPV infection, Cervical cancer, Colorectal cancer, Liquid cytology.
The Relationship Between the Intestinal Parasitic Infections with Leptin Concentration and Some Biochemical Parameters in Babylon Province/Iraq Nebras A.J. Hussien
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The current study aimed to determination of the relationship between intestinal parasitic infections with leptin, reactive oxygen species (ROS) and total antioxidants in patients in Babylon province, Iraq from the December 2015 to April 2016. The total exanimated person who visited the hospitals (male and female) are 863 person, 85 (9.8%) persons were infected with intestinal parasites (Entamoeba histolytic and Giardia lamblia) included 56 females and 29 males. The  patients were divided by age into three groups included 52 ( 1-10 ) years ( 35 females and 17 males ), 19 ( 11-20 ) years ( 13 female 6 males ) and 14 ( 20> ) years ( 8 females and 6 males ). The healthy group included 40 persons which divided to the same groups of patient  20 ( 1-10 ) years ( 10 females and 10 male ), 10 ( 11-20 ) years ( 5 females and 5 males ) and 10 ( 20> ) years (5 females and 5 males ).The results showed significant increase (p<0.05)  in  serum ROS level in patients infected with parasite infections compare to healthy group, and significant elevated (p<0.05) in leptin level in female patients compared to male patients. When compare between age groups, the results obtained significant decrease (p<0.05) in leptin level in patients aged (1-10 &11-20) years and elevated in age group (>20) years compare to healthy group in the same age, also significant elevated in ROS level in patients aged (1-10 & >20) years compare to healthy groups. The results of parasite type showed significant increased (p<0.05) in ROS level in patients infected with E. histolytic compared to patients infected with G. lamblia. The result showed the infected with parasite effected both leptin and ROS levels, but the total antioxidant did not affect parasitic infections.
Molecular Identification of Bacterial Infections in Children with Intermittent Peritoneal Dialysis Rafeef Yousif Rasheed
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Background: Bacteria is a major cause of peritonitis infections and it is very important to have a reliable test to detect these bacteria in peritoneal fluid by molecular methods. Aims of the study: Detection of the most common bacteria in peritoneal fluid from pediatric patients with acute and chronic renal failure who undergo peritoneal dialysis, through molecular diagnostic methods. Methods: One hundred clinical peritoneal fluid isolates were submitted to molecular methods (Polymerase chain reaction (PCR) and DNA sequencing) for detection. Results: By molecular methods according to PCR technique, the following bacteria were identified: S. aureus which was seen in 17 (17.0%) of samples, S. epidermids which was identified10 (10.0%) and Pseudomonas spp. which was identified 10 (10.0%) and according to DNA sequencing technique, the following bacteria were identified: S. aureus10(10.0%) of samples, S. epidermids 16 (16.0%), E.coli 6 (6.0%),Bacillus spp. 8 (8.0%). Streptoccous and Microccous1 (1.0 %) for each one. Conclusion: The most common bacterial were the best. pathogene responsible for peritonitis were S. aureus, Psudomonasspp., S.  epidermids, and E. coli.Keywords: Peritonitis, Molecular detection of bacterial peritonitis, Peritoneal dialysis infections.
Physical Factors in the Treatment of Chronic Venous Insufficiency of the Lower Extremities Aleksandr Derinov
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Trophic ulcers are one of the most severe complications of chronic venous diseases, leading to functional insufficiency of the lower extremities and a sharp decline in the life quality. Complex of preoperative preparation and combination with various methods of surgical correction are essential in this case. Higher results can be obtained with combined application of several techniques. Topical application of combined low-intensity laser radiation and micro dispersed drug irrigation is a pathogenetically substantiated non-invasive method of conservative treatment and preoperative preparation of trophic ulcers in patients of the C6 class.Keywords: Bactericidal therapy, Pain syndrome, Varicose veins, Trophic ulcers.
Effect of Cinnamon (Cinnamomum burmannii) Bark Oil on Testicular Histopathology in Streptozotocin Induced Diabetic Wistar Male Rats Mustofa Helmi Effendi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The purpose of this study was to determine the effect of cinnamon bark oil (CBO) on testicular histopathology. The variables taken were the diameter of the seminiferous tubules and the number of leydig cells in the testes of white male rats (Rattus norvegicus) which had been induced by streptozotocin. Twenty white male rats adult Wistar strains aged 2-3 months with an average weight of 150-250 grams were used in this study. The rats were divided into five experimental groups (4 rats each group) treated with a combination of streptozotocin and cinnamon bark oil (CBO) which were designed as follows: K(-), K(+), P1, P2, and P3. P is white rat injected with streptozotocin with a single dose of 45 mg / kg body weight intraperitonially, followed by therapy. K(-) without streptozotocin and only given drug solvent, K(+) given drug solvent, P1 treated with CBO 100 mg / kgBB orally, P2 treated with CBO 200 mg / kgBB orally, P3 treated orally with CBO 400 mg / kg orally for 14 days. White rat animals were then mutilated and testicular organs were taken for histopathological preparations using HE staining, then the diameter of the seminiferous tubules and the number of Leydig cells were calculated. Data were analyzed with One Way ANOVA and followed by Duncan's test. The results showed that streptozotocin had the potential to reduce the size of the seminiferous tubule diameter and the number of Leydig cells, while CBO at a dose of 400 mg / kgBW could increase the size of the seminiferous tubule diameter and the number of Leydig cells. It can be concluded that CBO can be used to reduce testicular dysfunction induced in diabetic rats.Key words: Cinnamon bark oil, Seminiferous tubule diameter, Leydig cells, Streptozotocin, Male rat.
Histological Effect of Androgenic Anabolic Steroide Dianabol in Heart and Some Blood Parameters of Male Albino Rats Ahmed Obaid Hossain
Journal of Global Pharma Technology .
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Abstract

Anabolic androgenic steroids (AAS) standup between the drugs most broadly ill-treated with the goalmouth of improving athletic ability, appearance or muscle mass. Androgenic anabolic steroid (AAS) the most widespread types of steroids in general and particularly between young people as it works to increase the body’s metabolism, The current study was performed to examine effect of androgenic anabolic steroid dianabol in heart and some blood parameters for male Albino rat . In this research the rats were divide in to three groups, ( 4 replicates for each) . The first group control was orally received normal saline for such period . while the second group (t2) and third (t3) treated groups orally received dianabol suspension at concentrations 30 and 50 mg/kg/day for 8 weeks respectively. The results in heart tissue (both groups) show mild hemorrhage and no singes of necrosis in the tissues. The results showed that significant increase`(P<0.05) in RBC count , platelets total , Hb , p.c.v and ratio of lymphocytes in treatmssents groups compared with control , while the WBCs count show significant decrease (p<0.05) in percentages of granulocytes and monocytes, furthermore
Organized by Re-Engineering Approach and its Relationship with Organizational Innovation at the Melli Bank of Zabol Mohammad Ghasemi
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

The current era's organizations confront with numerous issues and challenges such as quick, instantaneous and unpredictable changes, special orders and different tastes of customers. Therefore organizations have taken different forms and will embark on the changes to survive and preserve their positions. Examining the literature of reengineering and organizational innovation, explanation of the relation between organizing and reengineering of organizational innovation approach as the main target and in addition auxiliary targets such as explanation of the relation between the fivefold dimensions of reengineering of organizational innovation improvement and explanation of the relation of each of these dimensions with the threefold dimensions of organizational innovation are examined in this study. The method of the research is descriptive and of correlation type. The statistical society of the research is all the staff of Melli bank of Zabol. In order to determine the sample volume, Morgan table was used. Collected data are analyzed using the standard questionnaires of reengineering and organizational innovation, statistical test and SPSS software. Validity of the questionnaires was confirmed by professors and experts and their reliability was confirmed through Cronbach's alpha. The results obtained from the tests and research tool indicate a meaningful relation between the two variables. The main hypothesis stating that implementation of reengineering approach and organizational innovation improvement have a meaningful relation with each other was confirmed with a correlation coefficient of 0.961 and an error of less than 0.05 together with auxiliary hypotheses. Keywords: Reengineering, Organizational Innovation, Melli Bank, Redesign Of Business Processes, BPR.
Effectiveness of Edible Coating to Preservation of Passion Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Passion fruit (Passiflora edulis) is considered an exotic species with attractive flavor and aroma. This is a rich source of bioactive compounds, as polyphenols. The interest in P. edulis has been increased because of its antioxidant compounds. Passion fruit is generally considered to have a short storage life, because it is a very delicate, perishable fruit. The main problem of postharvest losses associated with passion fruits is rapid loss of firmness. The objective of the present study was to identify the effect of different carrageenan concentrations (1.0%, 1.5%, 2.0%, 2.5%, 3.0%) and storage temperature (8 oC, 12 oC, 16 oC, 20 oC) to the weight loss, firmness, total soluble sugar and ascorbic acid in passion fruit (Passiflora edulis) fruits during preservation. Moreover, shelf life (0 day, 7 days, 14 days, 21 days and 28 days) of passion fruit (Passiflora edulis) fruit in storage also clarified. Results demonstrated that carrageenan 2.5% and storage temperature 8 oC could maintain passion fruit (Passiflora edulis) fruit quality for 28 days without any deterioration. This is an opportunity to develop value‐added products reducing the postharvest losses, improving nutritional value and generating additional revenue for passion fruit growers.Keywords: Passion fruit, Carrageen an, coating, Firmness, Shelf life, Preservation.
Determine The PH Domaine of PLC-gamma in the Egg of Starfish during Fertilization Rana Hussein Naser
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The PLC gamma function in fertilization has been indispensable over the years of researches. The fertilization and the insight communications with the human beings, plants and animals started from the beginning of human life. In this study, the PH-domain of PLCγ will be fused with GFP and this PH-GFP fusion protein will be used for localization studies in the starfish Patiria miniate.Keywords: Domaine; PLC-gamma; egg; Fertilization
Safety, Health and Feasibility Local Wisdom and Regulation of Marine Products: Convergence and Case Study of Mare Island, Tidore Islands Husen Alting; Suwarti Suwarti; Irfan Ahmad
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Purpose: to finds a convergence between the local regulation and wisdom in Mare regarding the sustainability of resources and marine products and its safety, feasibility and health standards. Methods: this study is a descriptive qualitative study which describes regulations on the safety, feasibility and health standards of processing seafood and local wisdom regarding the preservation of marine resources. Result: Local wisdom in Mare has not been able to achieve regulations related to safety, feasibility and health standards of seafood but the local wisdom was able to maintain the sustainability of marine resources. Both of these things can be converged with technology so that the sustainability of marine resources can be achieved while realizing the safety, feasibility and health standards of marine produce. Conclusion: local wisdom is not a static thing so that between local wisdom and the preservation of marine resources and safety regulations, feasibility and health standards of seafood can be converged upon them.

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