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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Spectral and Antibacterial Activity of Mixed Ligand from Lanthanium (III) Complexes of Schiff Base Ligand with Some Amino Acids Shatha M. H. Obaid
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

In this work, lanthanium (III) complexes were synthesized using by Schiff base ligand (L) derived from benzaldehyde and o-aminoaniline with five amino acids (AA) from glycine (Gly), L-alanine (Ala), L-valine (Val), L-asparagine (Asp) and DL- phenylalanine (Phe). The Schiff base ligand has been characterized by elemental analysis, (MASS, FTIR, 1HNMR, 13CNMR, UV-VIS) electronic spectra. The structures of the new complexes have been described of analysis of elements, molar conductivity, (UV-Vis electronic, FT-IR, mass) spectra also magnetic moment. The molar conductivity values of the complexes indicat this every of complexes are electrolytes and other analytical studies reveal octahedral geometry for La (III) ion. The Schiff base ligand, five amino acids, La(III) salt and mixed ligand complexes were tested against four pathogenic bacteria such as G+- bacterial and such as G-- bacterial. These bacteria were found that compounds show, it has no effect on five amino acids and Schiff base ligand, while it has been shown to have a clear effect on lanthanum complexes.Keywords: Schiff base ligand, Amino acids, Mix ligand complexes, Spectral studies and antibacterial studies.
Clinico-Epidemiological Study of Thalassemia in Wasit Governorate Atta AH Mousa Al-Sarray
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Globally, thalassemia is the most common genetic hemoglobin disorder. In the developing world, the majority of patients die before the age of 20 years. Objective: To determine the prevalence of thalassemia and different Clinico-epidemiological factors associated with thalassemic patients in Wassit governorate Subjects and Methods: A cross sectional study conducted at thalassemia center in Al-Kut hospital for Gynecology obstetrics and pediatric in Wasit governorate, included 425 patients, the data collection continued for the period of five months stating on 1st of March 2019 to 30th of July 2019. Results: The prevalence of thalassemia was 34.45% of the total patient attending Al-Kut Hospital for Gynecology Obstetrics and pediatrics during the period of the study with a mean ±SD age of patients 14.71±8.5years. Most cases from beta thalassemia, and major genotype regarding the genotype of thalassemia and clinical characteristics highly significant association were found between genotype and age of onset, age at first transfusion, frequency of blood transfusion, and regular blood transfusion. Regarding the complications of thalassemia higher percentage of study sample were iron overload, splenomegaly , protrusion of facial bones and teeth, (89.9%, 83.1%, 55.5%) respectively, while the lower percentage were visual impairments, hepatitis B, AIDS (5.6 %, 0.9%, 0.2%)   respectively. Conclusion: The prevalence of thalassemia was 34.45% of the total patient attending Al-Kut Hospital for Gynecology Obstetrics and pediatrics during the period of the study Most cases from beta thalassemia, and major genotype significant association were found between genotype and age of  onset, age at first transfusion, frequency of blood transfusion, and regular blood transfusion  Recommendations: We recommend a comprehensive medical examination on the identification of pre-marital hemoglobin electrophoresis to enhance genetic counseling and to help reduce the transmission of these genetic diseases among generations, and use of the system-centered risk stratification model in order to individualize patient treatment for each.Keywords: Thalassemia, Hemoglobinopathies, Iraq, Prevalence, Wasit.
The Prevalence of the Gram Positive and Gram Negative Bacteria in Open Fractures and their Resistance Profiles to Antimicrobial Agents Aamal Ghazi Mahdi Al-Saadi
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

Objectives:  We aimed to evaluate the bacteriology of open fractures and to determine the susceptibility patterns of the identified bacterial species to some antimicrobial agents. Methods:  150 superficial swabs were collected from open fracture wounds of patients visited private fractures clinics in Al- Diwaniya city/ Iraq in a period from January to December 2016. Bacterial species recovered from the collected samples were identified by cultural, morphological and biochemical characteristics, then confirmed using Vitek2 compact system. Susceptibility to antimicrobial agents was determined using disc diffusion method. Results: A total of 119 bacterial isolates were obtained from culture positive fracture wounds. The most frequent identified bacterial species was Staphylococcus aureus (23.52%)  followed  by Acinetobacter spp ( 19.32%) ,then E.coli (14.28%), Pseudomonas spp (11.76%), Enterobacter spp ( 9.24%), Klebsiellaspp (6.72%), Coagulase Negative Staphylococci (5.04%), Citrobacterspp (4.20%), Proteus spp (2.52%), Diphtheroids (0.84),Streptococcus pyogenes (0.84%), Viridans streptococci(0.84%),  Micrococcus spp (0.84%).Most of isolates ( 64.70%) were obtained from upper extremities compared with the lower extremities (35.29%). The average resistance rate of  Staphylococcus aureus in the current study was (38.31%), the Coagulase Negative Staphylococci( 26.7%), Diphtheroids (70%), Streptococcus pyogenes (40%), Viridans streptococci( 20%), and Micrococcus spp(10%)., Acinetobacter spp (58.36%), E.coli (43.58%), Pseudomonas spp(62.19%), Enterobacter spp (48.21%), Klebsiella spp (40%), Citrobacter spp (32.5%), Proteus spp (35%).  Inhibitory effects of citric acid and vinegar on all isolated bacterial species growth were recorded. Conclusion: S. aureus and Acinetobacter spp were the predominant bacterial species isolated from open fractures patients with extensive antibiotic resistance patterns for most of isolated bacterial species underscoring the need to monitor the antibacterial resistance pattern routinely in order to select the right prophylaxis and treatment to open fracture wounds infections. The use of citric acid and vinegar is recommended to effectively eliminate multiple antibiotic resistant bacteria in open fractures.Keywords: Open fractures, Gram positive bacteria, Gram negative bacteria, Antimicrobial agents.
Effect of Faba Bean (Vicia Faba) in Growth Performance, Feed Utilization, Muscle Hardness and Crispness of Red Tilapia (Oreochromis Sp) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Among phytochemicals, phenolic compounds are gaining an increasing interest for their health promoting properties. Faba bean has a large variability of the levels of total polyphenols in seeds. Red tilapia (Oreochromis spp.) is an abundant freshwater fish with a white flesh meat. Customers prefer to fish fillet with more hardness and chewiness. Objective of this research focused on the effect of faba bean (Vicia faba) replacement in growth performance, feed utilization, muscle hardness and crispness of red tilapia (Oreochromis sp.) during rearing. The finding revealed that 30% faba bean in fish meal could improve the hardness and chewiness of red tilapia muscle while compromising to growth rate and feed utilization. This investigation was potentially applied not only for red tilapia but also for other aquaculture species so that the added value of fish cultivation could be enhanced.Keywords: Faba, Red tilapia, Hardness, Chewiness, Growth rate, Feed utilization.
Purification and Characterization of Alliinase from Iraqi Garlic (Allium sativum) Iman Hadi Al-Taai
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The study including purification and characterization of alliinase (EC: 4.4.1.4, Cys sulfoxide lyase, alliin lyase) from Iraqi garlic. Enzyme extraction with sodium phosphate buffer, pH 6.5, the extract was precipitated by addition of an ammonium sulfate with saturation (30-70)%. Gel filtration chromatography was done to purification enzyme by ÄKTA Pure 25 apparatus using superdex 200 column, three peaks were obtained with a good enzyme activity and an enzyme purity were identified by the absence of denaturation substances for protein SDS. Characteristics of pure enzyme showed that optimum pH for an activity was 6 and optimum pH for the stability was between 6-8, while optimum temperature for an activity and the stability were 35°C, 30-45°C respectively. Effect of ions Na, K, Mg+2, Fe+2, Zn+2, and Mn+2 was found stimulate enzymatic reaction while Ca+2, Ni+2, Cu+2 and Hg+2  inhibit the enzymatic reaction. Standard alliin used to determine a value of Km and Vmax and found to be 0.35M and 121.5 µmol/ml/min. respectively. The molecular weight of pure enzyme by electrophoresis technique with the presence of SDS was equal to 49 KDa.Keywords: Alliinase, Alliin lyase, Iraqi garlic, Purification, ÄKTA Pure 25.
Mastication Profile and Alternative Healthy Mastication Model using Coconut Frond Shaving in Karo Women Ulina Karo-Karo
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction: The use of tobacco in mastication activity has been widely known throughout the world. In China, the prevalence of mastication activity using betel leaves during student age is around 3.9%. Karo women in Deli Serdang are one of the population in Indonesia whose known have mastication habit since a long time ago. This study aimed to know the profile of the mastication model in Karo women as a primary aim and introduce coconut frond shavings mastication as the healthy mastication model. Method: This research was a combination of qualitative-quantitative diffusion of innovations research, with four stages, those are: diagnosis of action, plan of action, implementation of actions, and evaluation of an action. Results: Systolic blood pressure, diastole blood pressure, and blood sugar levels among coconut fronds chewers were less than tobacco chewers. This data also showed statistically different among two variables (p
Quality Assurance of Essential Primary Health Care Services at Primary Health Care Centers in AL-Najaf AL-Ashraf Governorate Haider K. Al Jebore
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Objective(s): To determine the quality assurance for essential primary health care services in AL-Najaf AL-Ashraf Governorate, identify the relationships between the quality assurance for essential primary health care services and characteristics of the organizational system, client satisfaction, and provided service. Methodology: A descriptive study is conducted throughout the period of September 1st 2016 to August 3rd 2017. A simple random sample of (504) subjects is selected through the use of probability sampling approach. The sample is divided into three groups which include (18) directors of primary health care centers, (18) primary health care services providers, and (468) consumers.  A simple random sample of (504) subjects is selected through the use of probability sampling approach. The sample is divided into three groups which include (18) directors of primary health care centers, (18) primary health care services providers, and (468) consumers.  Data is collected through the utilization of constricted questionnaires and the interview technique as means of data collection and keeping records of all available contacts that facilitate the access to the study sample. Interviews are conducted with directors of primary health-care centers, consumers, and workforce. Each interview takes approximately (5-10) minutes. The data collection was carried out from March 25   to June 6 2017. Content validity of the instrument is determined through a panel of (15) experts, and reliability through a pilot study. The data are analyzed through the application of descriptive and inferential statistical analysis procedures. Conclusions: The findings of the present study indicate that the mean catchments population for PHC centers is high; shortages of the medical, medical assistants, and administration workforce. The nursing, medical assistants, and administration staff are poorly distributed, maternal and child health services including family planning and health education services are in critical level, consumers showed inadequate overall satisfaction with primary health care services. Recommendations: The study recommends that to increase the total number of PHC centers according to the numbers of consumers within area; collaboration and coordination should be initiated between Ministry of Health, Ministry of Higher Education and Educational agencies to establish planning system to provide  PHC facilities with workforce needed according to the numbers of consumers within the area, taken into accounts national standards; provision of scientific booklet on standards operating procedures (SOPs) and guided by clear job description in all fields of primary health care service provision.Keywords: Quality Assurance, Primary Health Care Services, Primary Health Care Centers.
Detection of Molds Which Present in Domestic's Refrigerators in Baghdad City Ahmed Sahi Dwaish
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Twenty  species were isolated from 50 samples of domestic's refrigerators in Baghdad city , during September 2016 which were  Aspergillus niger, Aspergillus. flavus,  , Aspergillus. fumigatus, Aspergillus duricaulis , Aspergillus novofumigatus,  Aspergillus heteromorphus Aspergillus aculeatus , Aspergillus nidulans , Curvularia lunata ,Penicillium sp., Fusarium oxysporum,  , Alternaria alternate, Cladosporium sp.  Trichoderma sp., Mucor,  Rhizopus sp., Rhodotorula  mucilaginosa,  , Stachybotrys and yeast. Among the isolated species Aspergillus niger, was the most abundant (14.92%) followed by Aspergillus flavus (10.14%), while less abundant (0.95 & 0.63 %)  Cladosporium sp.  &., Mucor  respectively.
Synthesis and Characterization of New4, 5-dihydrooxazole and 1H-imidazole-5(4H)-one Derivative and Study its Effects on some Antibacterial Fadhel Omran Essa
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

New1H-imidazole-5(4H)-one derivatives have been prepared to start from the reaction of 2-phenyl-4H-1, 3-benzoxazine-4-one with tyrosine. The reaction of compound 1 with thionyl chloride produced 3-(4-hydroxyphenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanoyl chloride2. Condensation of compound 2 with glycine afforded 2-(3-(4-hydroxyphenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanamido)acetic acid3.The reaction of compound 3with acetic acid, acetic anhydride, and benzaldehyde derivatives yielded 3-(1-(4-benzylidene-4,5-dihydrooxazol-2-yl)-2-(4-hydroxyphenyl)ethyl)-2-phenyl-quinazolin-4(3H)-one derivatives 4a-e.Treatment of compound 4a-d with hydrazine hydrategave3-(1-(1-amino-4-benzylidene-4,5-dihydro-1H-imidazol-2-yl)-2-(4-hydroxyphenyl)-ethyl)-2-phenylquinazolin-4 (3H)- one derivatives 5a-d. The reaction of compound 5a-d with benzaldehyde derivatives resulted in the formation of 3-(1-(-4-benzylidene-1-(benzylidene amino)-4, 5-dihydro-1H-imidazol-2-yl)-2-(4 hydroxyphenyl) ethyl)-2-phenyl-quinazolin-4(3H)-one6a-6b.The structure of novel synthesized compounds were assured from IR, 1HNMR, and13CNMR spectra.Keywords: Phenylquinazolines, Imidazole, Benzylideneamino, Dihydrooxazole.
Correlation among Transforming Growth Factor , Tumour Necrosis Factor- , Prostate Specific Antigen, and Testosterone with Prostate Stromal to Epithelial Ratio in Benign Prostate Hyperplasia Gede Wirya Kusuma Duarsa
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Introduction: Benign Prostatic Hyperplasia (BPH) occurs due to an imbalance between cell proliferation and the apoptotic process. Many factors influence the growth of the prostate. This study aims to determine which factors among TGF-b, TNF-a,, PSA, testosterone, correlate the most the stromal-to-epithelial ratio of the prostate. Methods: The study was conducted in 83 BPH subjects in several hospitals in Denpasar. From all subjects, blood was taken for PSA and testosterone examination. TGF-b and TNF-a were examined from the histopathological examination of prostate tissue specimens. Data were collected, then statistical analysis was done with SPSS 22.0. Results: From all parameters, only PSA was significantly negatively related to stromal-to-epithelial ratio, although the strength was negatively weak (r -0.28). Multivariate analysis showed that the combination of PSA and TGF- levels had an effect of 10.8% on the epithelial-stromal ratio. Conclusion: PSA showed a significant association with the ratio of prostate epithelial stroma and had an effect value of 10.8% when combined with TGF-bKeywords: Prostate enlargement, Epithelial-stromal ratio, TNF-α, TGF-β, PSA, Testosterone.

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