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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Characteristics of Modes in Photonic Crystal Fibers Altfat Radi Jlod
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

In this article, both the vector effect index method (VEIM) and finite element method (FEM) are exploited to calculate the effective index of FSM for the solid-and porous core PCF. For the solid-core, the EIM applies one time to estimate the equivalent cladding index. Then, the conventional characteristics’ equation will apply to construct the 14neff"> . For porous-core PCF, the EIM applies two times one for the core and other for cladding. Next, also the conventional characteristic equation will apply to explain the 14neff">  at the porous-core PCF.Keywords: Finite element method, Porous core PCF, Vector effect method.
Molecular Investigation of Curli Fimbriae Genes in Enterobacter cloacae Isolated from Various Clinical Sources in Baghdad, Iraq Tiba Ayad Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Thirteen isolates were collected from various clinical sources during the periodfrom 22/10/2017 to 22/12/2017. All the isolates were diagnosed based on the microscopic and biochemical propertiesby Vitek-2 Compact system. All isolates formed biofilm 100%, with 30% of isolatesbiofilm produced strongly and 70% on medium. The results of the present study have shown the presence of Curli fimbriae genes in E. cloacae bacteria from cases of urinary tract infections, infected patient with blood bacteremia and inflammation of wounds. Curli fimbriae is considered to be an important factor in the virulence of E.cloacae bacteria, which plays an important role in adhering and combining cells on solid surfaces to form the biofilmand helps in the adhesion of bacterial cells. As well as their involvement in the invasion of the host cells, and their interaction with the host proteins and activate it for the host's immune system.
Monosodium Glutamate Effects on Inflammation Status in Male Rats: Molecular and Physiological Study Eman H. Al-Fadhili
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The current study included the effect of Monosodium Glutamate (MSG) on male rats by measuring the level of  Physiological parameter by determining the level of  total serum  protein, albumin and by measuring the level of  Molecular parameter  by determining the level of IL-6, NF-κb, IKK and TNF-a. The study was conducted at in the Department of Biology, College of Science, University of Wasit from November, 2017 until April, 2018. Study was used nigh teen adult wister rats male weighing 150-250 g and 10-14 weeks age were used and then randomly divided into three group six animal in each group. The first group was control; while the second group was orally dose the MSG 100g/kg dissolved in distilled water and third group take orally dose from MSG 200g/kg dissolved in distilled water via orogastric gavages  for 30 days. The results were as follows:  weight gain significant increase (p ≤ 0.05) of for group that treatment with 100 mg/kg and 200 mg/kg when compare with control group and no a significant (p ≤ 0.05) in concentration of total serum protein, albumin and globulin in male rat that treated with MSG 100 mg /kg . Whereas serum total protein, albumin and globulin  show a significant decreases in rats that treated with  200 mg /kg of MSG  compere with control group, increases of Nf- κB treated with MSG as 100 mg/kg and 200 mg /kg when compere with control group, increases of IL-6 treated with MSG as 100 mg/kg and 200 mg /kg when compere with control group, increases of TNF-a treated with MSG as 100 mg/kg and 200 mg/ kg when compere with control group and decreases of IKK treated with MSG as 100 mg/kg and 200 mg/kg when compere with control group. Conclusion: MSG as food additive can cause weight increase, soluble total protein decrease significant, MSG increases gene expressionKeywords: MSG, Gene expression, Obesity
Urease Activity Level in Crude Extract From Peels of Some Legumes and Cucurbits Zainab M. Dahham
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Ureases are an important group of enzymes with various applications in the analysis of food and water, chemicals, clinical, agricultural and pharmaceutical industry, besides having great interest for the treatment the industrial waste. The main objective of the present project is to extract urease enzyme from economical sources which can be utilized in biotechnology, medicine and industrial fields, as well as clean the environment from the plant wastes and recycle it. In this study urease was extracted from peels of some legumes and cucurbits: (bean, pea, water melon and melon), as well as bean seeds were also used as a known main source of urease for comparison. The enzyme was extracted from peels by electrical blender homogenization with phosphate buffer (0.2 M, pH 7), then protein concentration, urease activity, pH stability, thermal stability and storage stability were determined in crude extract. Urease activity and specific activity extracted from pea peels was the highest among the other extracted wastes, which showed stability at neutral pH 7 at room temperature, also it was very stable when incubated at (40-50 °C) for 20 min, and during storage at -18 °C at pH 7 for 3 months indicating that this enzyme was very stable. No significant differences were found between urease activity using pea peels with that measured by standard kit for the blood urea determination in serum of normal and patients. So, pea peels considered as an important economic source of urease enzyme.Keywords: Urease activity, Pea peels, PH stability, Thermal stability.
Regulatory Effect of Endothelial Dysfunction and Microcirculation Pathology in Pregnant Women Diagnosed with Diabetes Mellitus Tatiana Avramenko
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

The steady incidence of pregnant women diagnosed with diabetes mellitus in the world stimulates the development of research in this direction and deserve special attention. This article presents new methods in usage factors of endothelial dysfunction in development complications of pregnancy with diabetes mellitus. Aim of this research was to study role of endothelial factors in development of obstetrical and perinatal pathology in pregnant women diagnosed with diabetes mellitus. This paper presents the results of the study of 120 pregnant women diagnosed with diabetes mellitus. They were grouped according to the pregnancy complications (pre-eclampsia) and fetal disorders (moderate and severe asphyxia). The researchers defined blood content of prostaglandins Е2 and F2а, prostacyclin, thromboxane, endotheline-1, nitrogen oxide and L-arginine. It was established that the decreased concentration of prostaglandins, nitrogen oxide and L-arginine combined with considerable increase of the thromboxane and endothelin in the recent pregnancy period is an unfavorable prognostic factor for the subsequent pregnancy development course and pregnancy outcome. The decreased concentration of prostaglandins, NO and L-arginine combined with considerable increase of thromboxane and endothelin content in early pregnancy period is an unfavorable prognostic factor of the pregnancy development and outcome. The administration of therapy aimed at correction of the endothelial dysfunction is path genetically grounded, and its timely administration will provide for the decrease of incidence of pregnancy disorders and obstetrical pathologies in diabetic pregnant women.Keywords: Pregnancy, Diabetes Mellitus, Endothelial Dysfunction, Obstetrical Pathology, Microcirculation, Diabetic Fetopathy.
Antimicrobial Activity of Olive Leaf Extract and Dental Gel against Some Pathogenic Fungi and Bacteria Ghadeer H. Al-Jader
Journal of Global Pharma Technology .
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Abstract

The results of chemical  detesters for some active substances in Olive leaf extract  Revealed that contains Glycosides, Flavones, Saponine, Alkaloids and Turbines The statistical analysis of the results showed of the inhibitory effect of olive leaf extract on the growth of some pathogenic fungi, there are significant differences below the level of probability (P<0.05) between the inhibitory effectiveness of olive leaf extract of the studied  species, compared with the standard antifungal (Itraconazole) used as control in the present study, table  (2). The  alcoholic extract of the olive leaf plant gave higher inhibition  impact compared with the inhibitory effect of Itraconazole at the concentration 100% (Figure 1), the inhibitory effect of the extract at concentration of 100 % was (32, 35, 33, 36, 31, 35) mm to species (T. mentagrophytes, T. verrucosum, M. gypseum, M. audouinii, T. schoenleinii, M. canis) respectively, while was the inhibitory effect of Itraconazole  (30, 31, 30, 34, 30, 30) mm respectively.Keywords: Denta gel, Olive leaves extravt, Antimicrobial Activity, Pathogenic bacteria. 
Synthesis, Characterization and Biological Effect Study of Some New Azo and Azo–Chalcone Compounds Derived from 2, 6-Diaminopyridine Nihad I. Taha
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The objective of this work was to prepare azo and azo-chalcones derivatives out of 2, 6- diaminopyridine (2, 6-DAP) which has extensive use in the synthesis of pharmaceutical compounds. The azo-diamine (S1-S6) was prepared from the coupling reaction of diazonium salt prepared from various substituted aromatic amines with 2, 6-diaminopyridine. The product (S1) was reacted in basic condition with one equivalent of different substituted aromatic aldehydes in methanol to give ten new azo-chalcones (S2-S11) in good yields. The final products were identified by their physical properties besides their UV-visible, FTIR and 1H NMR spectra. Biological activity of the compounds (S1-S6) was investigated and compounds (S1 and S2) showed high activity against B. subtilis and E. coli.Keywords: Azo- Chalcone, 2, 6-Diaminopyridine, diazonium salt, Pyridine.
Comparative Characteristics of QT Interval Measurements on ECG Performed Manually and by Automated Method in Male Patients at Rest Vadim A. Dulskiy
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

In the medical practice of cardiologists, cases of incorrect measurement and interpretation of QT interval length are very frequent. The consequences make an incorrect diagnosis and inadequate treatment. The aim of this work is to investigate the efficiency of measuring the QT interval length on an ECG in manual mode and automated mode at rest among male patients. The sample included 3925 ECGs performed among males aged over 15 years old. Each measurement of QT, QTc intervals was performed both in manual and automatic modes. The numerical values matched only in 4.3% of cases. Automatic interval measurements exceeded the real values in 83.8% of cases. The prolongation of QTc intervals over 440 ms in the automatic mode was detected in 20.4% of cases. Over diagnosis was noted in 17.4% of cases. As a conclusion, manual adjustment is required in most cases measurements of prolonged QT, QTc intervals measured in automatic mode. Among the prevailing errors in automatic measurement, the most common were connected with T-waves (lack of diagnosis of T-wave displacement, its low amplitude and alternation). These erroneous measurements amounted to 53.3% of all measurements in automatic mode. The uncertain wave Q (R) accounted for 35.0% of all cases. In addition, 8.3% of cases were attributed to an undetected diagnosis of differences between manual and automatic methods. Keywords: T wave, Manual ECG diagnostics, Automatic ECG diagnostics, interval lengths QT, QTc.
Potency of Phitofert in Improvement of Reproductive Efficacy in Sulpiride-Treated Rats Nahla J. M. S. Al-Shahery
Journal of Global Pharma Technology .
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Abstract

The current study was designed to investigate the persisting of hyperprolactinaemic (Hprl) symptoms because the impact longstanding of sulpiride injection (the 2nd model of Hprl), to prove these symptoms when they compared with these in 1st model of Hprl. Also we investigated whether Hprl had ablility to induce altering in the activity of ovarian hydroxy steroid dehydrogenase (HSD) enzymes and oxidative status in the ovarian tissue. The goal of this study was to evaluate the potentiality of phitofert product in adjustment of Hprl status for each 2nd model of Hprl. Therefore, female rats were divided as follows: G1: female rats were injected with normal saline (0.9% NaCl) for 28 successive days (control1). G2: female rats were injected with 40 mg/kg b.w. of sulpiride for 28 successive days (as a first model). G3: female rats were injected with normal saline (0.9% NaCl) for 28 successive days, and they were orally administrated with d.w. for another 28 successive days (control2). G4: female rats were injected with 40 mg/kg b.w. of sulpiride for 28 successive days, and they were orally administrated for another 28 successive days with d.w. (as a second model). G5: female rats were injected with 40 mg/kg b.w. of sulpiride for 28 successive days, and they were orally administrated with 7 mg/kg b.w. of phitofert for another 28 successive days. The hyperprolactinaemia signs primarily a significant (P≤ 0.05) elevation in the serum prolactin (Prl) and progesterone (P) levels were found, while the serum FHS, LH and estrgen levels were found to be significantly (P≤ 0.05, P≤ 0.001) decreased in G2 and G4 than controls (G1and G3). The hyperprolactinaemic rats (G2 and G4) also, showed a significant (P≤ 0.05) decreased in the activity of an ovarian 20α-HSD enzyme, compared to G1 and G3. The oxidative stress (OS) as evidenced by significantly (P≤ 0.05) increased in the activity of lipid peroxidation (MDA) and decreased in the ovarian activity of GSH and CAT levels were found in these groups.  Also the estrus cycles and ovulation process were ceased in hyperprolactinemic groups (G2 and G4). Whereas the results of G5 showed that, the phitofert had a positive role in the reverse of all above assessed parameters in sulpiride-induced hyperprolactinemia groups. The phitofert treatment resulted regular estrus cycle and the restoration of ovulation, ditto the ovulated oocytes were able to fertilize in vitro. These fertilized oocytes of G5 were succeeded in the development in vitro to blastocyst stages. So the transferred blastocysts into recipient females were able to implantation compared to those in control (G3). Thus, our findings proved the ability of phitofert product in therapy of HPRL.
Influence of Role Model for Professional Development in Medical Education Mainul Haque
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Influence of Role Model for Professional Development in Medical Education

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