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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis and Characterizations of Chitosan/EDTA/PVA Nanofiber for Antimicrobial Applications Ammar M. Hamza
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The aim behind this study was to fabricate thermally crosslinked Chitosan. (CS)/ Ethylenediaminetetraacetic acid (EDTA)/ Poly (vinyl alcohol) (PVA) and pure chitosan as nano fiber mats. The CS/EDTA/PVA nanofibers and/or pure chitosan were prepared using elctrospinning technique. The suitable cross linking ratio and cross linking times for CS/EDTA/PVA nanofiber were look into. The scanning electron microscopy and X-ray Diffraction was utilized to investigate influence of adding polymers to chitosan on the morphological and diameter of the nanofiber. The FTIR was carried out to evaluate the spectroscopic properties and functional groups which present in the compounds. The antimicrobioal test was examined by using Staphylococcus Aureus which is a spherical gram-positive bacterium and common test for antimicrobial applications. The result of antimicrobials test was made the CS/ESTA/PVA as nano fiber is viable materials for biomedical applications.Keywords: Antibacterial, Biopolymer, Nanostructure, Physical properties.
Assessment of the Effectiveness of Simulation and Recitation Training for Traffic Control Volunteers (Supeltas) on Cervical Spinal In-Line Position Stabilization with Helmet Removal Maneuvers Ferry Efendi
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Motor vehicle traffic accidents are a leading cause of death for an individual in Indonesia. This study aimed to evaluate the effectiveness of training using simulation and recitation models focusing on the achievement of the pre-hospital performance of traffic-control volunteers (Supeltas) in stabilizing cervical spinal in-line position in helmet removal maneuver. This study applied pre-test and post-test design with 248 respondents. Data were collected using questionnaires and evaluation papers to assess volunteers during practical tests. Data statistical analysis procedures included One-Way ANOVA, Wilcoxon-signed rank test, and N-gain score test. Differences were noted in the demographic data with significant findings and effects associated with age (p= 0.041) and education (p= 0.046) of Supeltas in stabilizing the cervical spine. The intervention group exposed to SMT training model showed a difference in the average scores of knowledge (mean 60.85 to 85.67; p= 0.010) and skills (mean 59.80 to 86.81; 0.002), which were greater than the scores of the group receiving RMT (mean 53.65 to 65.06; p = 0.028) and skills (mean 59.20 to 84.73; p= 0.043). The knowledge (N-gain score = 61.35%) and skills (N-gain score= 61.41%) of the group receiving a role-playing model (SMT) increased more effectively, compared to the increase experienced by the group receiving an assignment (RMT) (N-gain score knowledge= 23.57%; skills= 17.29%). This study suggests that the simulation model is more effective than the recitation model in improving the ability of Supeltas in stabilizing the cervical spinal in-line position for helmet removal in trauma situations. Keywords: Recitation, Simulation, Stabilization, Training.
Effects of ascorbic and cinnamic acids on the Albumin glycation level in breast cancer patients Israa Ghassan Zainal
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Abstract: Glycation is the non-enzymatic interaction of carbohydrates with proteins. It is considered as a factor that leads to Alzheimer's disease, diabetes, aging, neuropathy, cancer, and atherosclerosis. In vitro and in vivo glycation was studied with human and bovine serum albumin as a model of the protein. A concentration of 0.1M glucose was used as a glycation agent. The level of the Amadori product was determined by thiobarbituric acid calorimetric assay after hydrolysis. Advanced glycation end products (AGEPs) was measured by UV-Visible spectrophotometry. Different concentrations of ascorbic acid (vitamin C) and cinnamic acid were found to be potent inhibitors of both the subsequent end products and the glycation reaction. The result showed that the level of glycation in breast cancer patient is significantly high and ascorbic and cinnamic acids as inhibitors, decreased the glycation reaction of albumin.
A PARAMETRIC APPROACH ON ACCELERATED FAILURE TIME MODEL sujatha - vishnumoorthy; Dharanidharan vishnumoorthy
Journal of Global Pharma Technology .
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Abstract

Survival analysis techniques have become standard tools for statistician in controlled clinical trial. The application of survival models to clinical trial data is valid when the endpoint of interest is the “time to the occurrence of a particular event”. The Cox’s proportional hazard model and its extension are used comprehensively for the past two decades. The Accelerated failure time(AFT) model is also presented and competing to proportional hazards model in the analysis of clinical trial data where the effect of treatments are to accelerate the event of interest in a tuberculosis controlled clinical trial over a treatment period of six months. It is concluded that the proportional hazards models demonstrate significant lack of fit while the accelerated failure time model in this and an illustration about the added advantages of AFT model
Corrosion Inhibition of Copper by Olive Leaves Extract as Environmentally Friendly Inhibitors in Acidic Media Zainab W. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

An inhibition effect of olive leaves extract in corrosion of copper alloy in hydrochloric acid solution was studied by means of potentiodynamic polarization and scanning electron microscopy (SEM). The inhibition efficiency has as inhibitor concentration increased but decreased with increase in temperature. Fallouts have depicted that the inhibition takes place throughout adsorbing inhibitor molecules on the metal surface that agrees with Langmuir adsorption isotherm. Several thermodynamic parameters 14∆Gads." style="width: 41.25pt; height: 15pt;"> in addition to activation energy 14Ea" style="width: 22.5pt; height: 15pt;"> have been determined to explain the process of corrosion inhibition. The measurements of polarization indicated that olive leaves extract is of cathodic type. The surface characteristic of the inhibited and uninhibited metal tasters have examined by SEM.       Keywords: Corrosion inhibition, copper, olive leaves extract, Adsorption Mechanism thermodynamic parameters.
Investigation of Dried Herbal Tea Production from Breadfruit (Artocarpus Altilis) Pulp Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The fruits are great source of carbohydrate and it has low fat. Since the fruit can be steamed, fried, baked, roasted and fried, they can be eaten at all stages of growth. Drying was described as the reduction of material moisture to the required dryness values as a definite process and it is of major interest in food processing. To increase breadfruits popularity and expand their use in the food industry, it’s neccesary to explore the appropriate postharvest handling and storage. Therefore, objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to cinnamic acid (mg/100 gDW), antioxidant activity (mmol·Fe2+/kgDW), color (sensory score) of the dried breadfruit (Artocarpus altilis) tea. Results showed that breadfruit (Artocarpus altilis) should be blanched in hot water 95oC at 4 seconds in the present of CaCl2 2% and then beeing dried by heat pump dryer at 40oC until 6.5% moisture. The final herbal tea could be preserved under vacuum in PET/AL/PE bag at 4oC to maintain antioxidant activity for 12 months Keywords: Breadfruit, Artocarpus altilis, Herbal tea, Blanching, Drying, Antioxidant activity.
Effects of coal dust particulate matter exposure on H2O2, MDA, IL-13, TGF-β3 level and bronchioles sub-epithelial fibrosis in allergic asthma mice model Fujiati .
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C mice were divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice  (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value= 0.000). This was based on the scale of fibrosis (0=<5 μm, 1=5-10 μm; 2=11-15 μm; 3=>15 μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness. Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.Objective:Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C micewere divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value=0.000). This was based on the scale of fibrosis (0=<5μm, 1=5-10μm; 2=11-15μm; 3=>15μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness.Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.
Treatment for Patients with Primary Immunodeficiency Diseases Anastasia Gradskaya
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Primary immunodeficiency diseases occur with a frequency of 1: 10,000 pp. among population. The purpose of this study is to evaluate the most common forms of primary immunodeficiency among patients in Moscow based on the Russian registry for primary immunodeficiency, as well as to analyse the treatment tactics of three patients. The studies were conducted in 2016-2018 among 73 patients aged 5-12 from Russian Children's Clinical Hospital (RCCH), all diagnosed with primary immunodeficiency. The classification of patients was carried out according to the Russian registry by type of primary immunodeficiency. Lethal cases, gender and age distribution were considered. The treatment tactics of three patients were analysed. The number of boys exceeds the number of girls by 7.2 times (p ≤ 0.001) for defects in antibody production, by 6.0 times (p ≤ 0.001) for combined immunodeficiency, by 1.4 times (p ≤ 0.05) for phagocytic defects, and by 2.5 times (p ≤ 0.01) for other types of immunodeficiency. The patients with defects in antibody production predominated, namely by 1.5 times - patients with combined immunodeficiency (p ≤ 0.05), by 2.8 times - patients with phagocyte defects (p ≤ 0.01), by 4.7 times - patients with other types of immunodeficiency (p ≤ 0.001). 73 patient patients under the age of 12 years with primary immunodeficiency had their anamnesis analysed that helped to identify 4 main forms. Boys prevailed in gender composition (80.8%), and there were no significant differences between boys and girls in age. The lethality prevailed among patients with combined type immunodeficiency. Thus, there were 1.3 times less lethal cases among patients with phagocyte defects comparing to the combined type (p ≤ 0.05), but 2.4 times more compering to the other types of immunodeficiency (p ≤ 0.01).Keywords: Primary immunodeficiency diseases, Patient registry, Combined immunodeficiency, Defects in antibody production.
Preparation, Diagnosis and Evaluation of the Bioavailability of New Heterogeneous Ring Compounds of Albendazole Hala Shkyiar Lihimes
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The study includes the preparation of 12 new derivatives of heterogeneous cyclic derivatives of bendazole. The hydrazid (A1) derivatives of bendazole reaction with hydrazine in absolute ethanol were prepared, and from its reactor (A1) with 4-diethylamine benzaldehyde (A2). The ring closure was performed using succinic   anhydride to obtain the oxazepine ring (A3). Carboxylic acid derivative (A4) was prepared from hydrolysis of bendazole using concentrated hydrochloric acid, and its derived reactor (A4) with thainoid chloride obtained the acid chloride derivative (A5). After that the derivative (A6) was synthesized from its A5 derivative reacted amino acid glycine in NaOH (10%). ring closure was then performed using a number of different aromatic aldehyde   with acetic anhydride to obtain the oxazole ring (A7a, A7b). (A7a, A7b) were obtained and obtained derivatives (A8a, A8b), which were used in two different routes. First track obtained the pyrazole (A9a, A9b) by ring closure the reacted with hydrazine. The other path was to obtain hydrazide derivatives (A10a , A10b) by interacting with the aromatic aldehyde to obtain Schiff bases (A11a, A11b) and then conduct the ring closure of the derivatives above for derivatives (A12a, A12b). The compounds prepared by melting points, infrared spectra and H1NMR were diagnosed. Biochemical efficacy was also assessed.
Some of the Biomechanical Variables and Their Correlation in the Performance of the Cartwheel Skill on the Surface of Movements in the Gymnastics for Women Ruaa Ali Hussein
Journal of Global Pharma Technology .
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Abstract

The importance of research in the knowledge of the relationship between some of the biomechanical variables and the performance of human wheel skill on the ground movements of women in the players of the team of the Faculty of Education for Girls / University of Kufa, which can be invested correctly and in a scientific way to achieve good performance and through the researchers to the nature of the educational process of basic skills In the gymnasium and their teaching and training experience, the following question is answered in this study:What are the biomechanical variables that are related to the performance of cartwheel skill on the surface of movement for women in the gymnastics?The researcher used the descriptive approach in the method of correlative relations to suit the nature of the research problem. The descriptive approach is one of the best approaches to achieve the research objectives. The research society was (10) players of the team of the Faculty of Education for Girls in gymnastic / University of Kufa. The experiment was conducted first, Field research through video imaging and analysis of biomechanical variables and reaching the results identified by the power platform device, which dealt with statistics using the statistical file (SPSS), which enabled the researchers to reach conclusions:There is a significant correlation between positive biomechanical variables and the cartwheel. Biomechanical variables are important in the performance of the gymnastic skills, where the correct performance paths of the skill are shown. The recommendations are the need to focus on the biomechanical variables examined for possible development through exercises to help them achieve the best achievement. This is the desired goal.Keywords: Biomechanical variables, Cartwheel skill, Surface of movements and gymnastics.

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