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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Association of -34 T > C CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia in Babylon Province, Iraq Abdulsamie H. Altaee
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Benign prostatic hyperplasia (BPH) is the most common benign tumor in men, and its incidence is age-related. This study aims to investigate the effect of -34 T > C CYP17 gene polymorphism on BPH susceptibility and clinical progress.Fifty males patients with BPH clinically diagnosis attended to Al-Hillah Teaching Hospital, as well as fifty males apparently healthy control in a case-control study were subjected to present study. The -34 T > C CYP17 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.Genetic analysis of -34 T > C CYP17 gene polymorphism shows a significantly higher difference when comparing patients with the control groups. The dominant and codominant models of -34 T > C CYP17 gene polymorphism were shown significant change when compared with healthy control The T/C-T/T is genotyping responsible and related to the risk of BPH.In conclusion, -34 T > C CYP17 gene polymorphism could have an important role in the development and pathogenesis of BPH.Kewords: Benign prostatic hyperplasia, CYP17 gene polymorphism, PCR-RFLP, Babylon, Iraq.
In Vitro Assessment of Total Phenolic, Total Flavonoid and Sunscreen Activities of Crude Ethanolic Extract of Belimbing wuluh (Averrhoa bilimbi) Fruits and Leaves Muhammad Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Averrhoa bilimbi, namely belimbing wuluh in Indonesia. It’s the fruits used to food in vegetable dishes. Belimbing wuluh’s leaves and fruits are traditional herb in Indonesian. This study aim to determined total phenolic content, total phenolic content and sunscreen activity from ethanolic extract of Belimbing Wuluh fruits and leaves. Total phenolic content of fruits ethanolic extract is 19.8022 ± 1.6696 mg GAE/g more than leaves ethanolic extract 6.5886±0.0590 mg GAE/g. Both have significant differences after tested t test (sig<0.05). Total flavonoid content of fruits ethanolic extract 24.7458±0.3291 mg RE/g more than leaves ethanolic extract 13.3126±0.5695 mg RE/g. Both have significant differences after tested t test (sig<0.05). Sun Protecting Factor of leaves ethanolic extract better than fruits ethanolic extract. Only one leaves ethanolic extract concentration of 300 ppm can be drawn in the total block valuation category with ultra protection. The conclusion is leaves ethanolic extract has good potential as an active sunscreen ingredient although it has a total phenolic content and a lower total of flavonoids than fruits ethanolic extract of belimbing wuluh. These data indicate that the sunscreen active ingredients found on the leaves of belimbing wuluh are suspected of phenolic compounds and other components that have a conjugated double bond that can absorb UV light in the 290-320 nm range.Keywords:  Averrhoa bilimbi, Total Phenolic Content, Total Flavonoid Content, Sunscreen Activity.
Path Analysis of the Influence of Nurses Role on Family Caregiver Diabetes Self-Management Capabilities with Empowerment as Intervening Variables in Indonesia Rondhianto Rondhianto
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction:  Nurses have a responsibility to empower the family that is a preventive promotion effort to improve the ability of the family caregiver to manage diabetes. The purpose of this study was to analyze the role of nurses on the ability of family caregivers through family caregiver empowerment. Methods: This study was an analytic observational study with a cross-sectional design. This study was conducted in the Jember Regency, East Java Province of Indonesia, with a sample size of 150 respondents using a multi-stage random sampling technique. The instrument were namely the Role of the Nurse Perception Questionnaire, Psychological Empowerment Scale, and Diabetes Management Self Efficacy Scale. The data analysis used descriptive analysis and inferential analysis with Structural Equation Modeling-Partial Least Square (SEM-PLS). Results: The results showed that nurse's role had a direct effect on family caregiver empowerment by 93.80% (t = 89.558; p = 0.000 <0.005), but did not have a direct effect on the diabetes self-management capabilities (t = 0.508; p = 0,600> 0,005). However, nurse's role has an indirect effect on the diabetes self-management capabilities through family caregiver empowerment of 64.50% (t = 4.036; p = 0,000 <0.005). This path analysis model is fit model and  has an accurate predictive relevance to the existing constructor has a relevant ability to predict (SRMR Value = 0.053 <0.8; Q2=0.331 >0). Conclusion: The nurse's role has a direct influence on family caregiver empowerment and has an indirect effect on the diabetes self-management capabilities through family caregiver empowerment. The efforts to empower family caregivers by nurses through enabling, reinforcing, and supporting as a preventive-promotion intervention need to be improved to enhance the ability of family caregivers in type 2 diabetes management.Keywords: Diabetes Self-Management Capabilities; Family Caregiver Empowerment; Nurse's Role; Type 2 diabetes.
Estimation Level of IL-12 in Blood of Patients with Tuberculosis Eklass N. Ali
Journal of Global Pharma Technology .
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Abstract

Background: Tuberculosis (TB) is caused by mycobacterium tuberculosis; which is considered as one of the most common infectious diseases and major cause of morbidity and mortality worldwide. Methodology: The study included 45 patients with TB (38 males and 7 females) with age range between (10-69) years, and 16 apparently healthy subjects (as control) (14males and 2 females) who have been collected from the Specialized Center for Chest and Respiratory Disease in Baghdad. Specimens from TB patients were divided into three subgroups: 21 specimens from new diagnosis, 13 specimens from old patients (under treatment) and 11 specimens from Multi Drug Resistance (MDR). This study included bacteriological tests such as smear microscopy by ziehl-Neelsen stain for sputum samples and immunological diagnosis by estimation the concentration of cytokine (IL-12) and control by Enzyme Linked Immune sorbent Assay ELISA technique has been applied for patients and healthy groups (control), all TB patients sample were positive by smear microscopy. Results: This study showed a significant increase in the serum level rate of IL-12 in the patients (82.1)pg/ml comparing with the control group (48.9) pg/ml whereas The serum level of IL-12 in new cases & MDR TB was elevated than in old cases (p<0.05) and the concentration  of IL-12 was significantly increased  among  young age (10-19) compared to other age group and was non-significant increased among females. The prevalence of fever, positive chest-X-ray finding, weight loss were    more among the newly diagnosed patients (p<0.05) while the prevalence of positive DM patients was more among old cases (p<0.05). This study verified the correlation between the serum levels of IL-12 with different clinical forms of tuberculosis. It was reduced in patients with positive DM (71.8) pg/ml in comparison with patients with Negative DM (95.89) pg / ml with statistically significant differences between two groups (p<0.05). Conclusion: the high  serum level of IL-12 in TB patients indicate an important role of these cytokine in the pathogenesis of tuberculosis, so they could be considered as good biomarker for diagnosis and considered as a target for future therapy. Keywords: TB, MDR, IL-12, chest-X-ray.
FUNCTIONALITY EVALUATION OF EXCIPIENTS MANUFACTURED BY DIFFERENT MANUFACTURERS BS Muddukrishna
Journal of Global Pharma Technology Volume 08 Issue 10: (2016) October 2016
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Abstract

Purpose: The main aim of this article is to develop an alternate source for excipients manufactured bydifferent manufacturers. Methods: Four different excipients were selected for this study and evaluated based on theirfunctional characteristics. Results: From the results obtained, the both vendors of the materials were showingequivalent each other when we compared with the monograph specifications, analytical results and functionalitycharacteristics. Conclusion: Functionality evaluation of excipients were determined based on the specificationcomparison, analytical results comparison and finally with functionality characteristics of excipients and their impacton formulation.
Synthesis and Characterization of Some New Benzothiazine, Dihydroquinazolinone and Oxazepine Derivatives from 1, 8-Naphthalic Anhydride and Evaluation of Their Antimicrobial Activity Mohammed G. A Al-Khuzaie
Journal of Global Pharma Technology .
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Abstract

New benzothiazine, hydroquinazolinone, and oxazepine derivatives had been synthesized from the reaction of 1, 8-naphthalic anhydride with p-phenylenediamine to give 1,8-naphthalimide derivative (1), which in turn react with a number of aromatic aldehydes to give Schiff  bases derivatives (2-7) that reacted with three different reagents (2-mercaptobenzoic acid, anthranilic acid and phthalic anhydride) respectively to form benzothiazine (8-13), dihydroquinazolinone (14-19) and oxazepine (20-25) derivatives, respectively. The structures of synthesized derivatives were characterized by [13C-NMR, 1H-NMR, and FTIR] and measuring of characteristic physical properties and specific reactions. Moreover, the biological effect of some of preparing compounds was tested on fungicidal and some of bacteria.Keywords: 1, 8-naphthalic anhydride, benzothiazine, hydroquinazolinone, oxazepine, anti-microbial activity.
Evaluation of Antioxidant (GSH, CAT, SOD) and MDA in Iraqi Women with Breast Cancer Mohammed Ayyed Najm
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Oxidative stress is considered to be involved in the pathophysiology of all cancers. The aim of this study is to examine oxidative stress and antioxidant status in patients with breast cancer by evaluation of the serum levels of lipid peroxidation products as malondialdehyde (MDA) and glutathione, catalase, Superoxide dismutase (GSH, SOD, CAT) of 30 new diagnoses with malignant breast cancer in and 30 healthy women were determined. Significant high levels of GSH, SOD, CAT were detected in control compared to patients with breast cancer (p<0.0001). Serum MDA levels of the patients were higher compared to the controls (p<0.0001). Keywords: Breast Cancer, Malondialdehyde, Catalase, Superoxide Dismutase, Glutathione.
Radiation and Hygiene Assessment of the Consequences of Nuclear Tests at the Semipalatinsk Test Site Nikolay Meshkov
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The analysis of the spatial and intra-profile distribution of cesium-137 (137Cs) reserves in the soils of the Altai Mountains, as well as the dynamics of the specific activity of this radionuclide in food products produced in the territory of the Republic of Altai and the Altai territory, in 1966-1985, was performed. Individual annual effective doses of internal radiation of the adult population of the Republic of Altai and the Altai territory due to the receipt of 137Cs with food were calculated and a forecast of long-term radiological consequences for the population of the Republic of Altai was made. Keywords: Radioactivity; Radio nuclides; Cesium-137; Semipalatinsk.
New Turbidity Method to Determine of Calcium Ion in Pharmaceutical Preparations Samples Shaymaa Ibrahim Saeed
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

A new turbidity method was used to determination of calcium ion in the pharmaceutical preparation samples. The proposed method was supported reagent and sodium dodecyl sulfate (SDS) as anionic surfactant. The main factors affecting was study such as  order addition effect,  pH  solution, concentration of reagent, concentration of surfactant, effect of equilibrium temperature and incubation time, effect of interferences. The calibration curve was linear in the range of 0.3-30.0 µg /ml with a correlation coefficient r2 = 0.9996 at pH 4.42. The relative standard deviation obtained 0.0656, and the limit of detection was 1.0 µg /ml. The method used in this research has been successfully utilized in the estimation of Ca (II) in pharmaceutical preparations samples.Keywords: Calcium ion, Turbidity, Cloud point extraction, Sodium dodecyl sulfate.
Nurses Knowledge toward Heparin Intake for Patient’s in Intensive Care Unit at AL- Imam AL-Hussain Medical City in Holy Kerbala Fatma Makee Mahmood
Journal of Global Pharma Technology .
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Abstract

Heparin is used to prevent or treat certain blood vessel, heart, and lung conditions. It is used in low doses to prevent the formation of blood clots in certain patients, especially those who must have certain types of surgery or who must remain in bed for a long time. Objective This Study aims to assess nurses’ knowledge toward Heparin Intake for Patient’s in Respiratory care and to find out the association of Respiratory care unit s nurses knowledge with some of socio demographical characteristic (level of education, and years of experience in Respiratory care unit (.Methodology A descriptive study was carried out at respiratory care unit of Baghdad teaching hospitals started from December 25th, 2015 through   through end of May, 2016. Non-probability (purposive sample) of (30) nurses, who were working in respiratory care unit, were selected from AL- Imam AL-Hussain Medical City. The data were collected through the use of constructed questionnaire, which consist of two parts (1) Demographic data form that consist 6-items and (2) Nurses’ knowledge form that consist of 27 items, by means of direct interview technique of the nurses. Reliability of the questionnaire was determined through a pilot study and the validity through a panel of (15) experts. Descriptive statistical analysis procedures (frequency, percentage, mean of score) and (person correlation coefficient, contingency coefficient) were used for the data analysis.  Were used for the data analysis. Results The findings of the study indicated that there was an adequate knowledge about heparin intake in respiratory care unit. A significant relationship was found between nurses’ knowledge and their level of education and years of experience in respiratory care unit .Recommendations The study recommended that the importance of employing Academic nurse in respiratory care unit, a booklet should be designated and distributed to all nurses who were working in respiratory care unit including the standard actions that should be applied and followed to care for patients in respiratory care unit, and an educational program should be designated to the nurses who were working in respiratory care unit including the standard actions that should be applied to care for patients in respiratory care unit Keywords: Anticoagulant, Heparin, Respiratory care unit Critical Care Nurses.

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