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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Complications of TVT Treatment of Stress Urinary Incontinence in Women Georgi Hubchev
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The accent of the publication is the complications after the application of various TVT slings to correct stress urinary incontinence in women. The aim is to determine the type of complications and their frequency according to the method of TVT surgery. For the period 2005-2019, 436 women underwent TVT surgery, and 80 (18.3%) developed complications. In 334 women by the method of TVT-O-postoperative complications had 47 women (14.1%), in 78 operated by TVT-R, with postoperative complications were 23 patients (29.5%), and in 24 patients with TVT-Ophira-5 (20.8%) had postoperative complications. A retrospective method was used to determine the percentage of different complications depending on the type of TVT sling applied. The study concluded that intraoperative complications in 5 women (1.15%) obtained with the TVT-R method alone, and postoperative complications were observed in 75 of women (17.2%), using all three methods. Keywords: Stress urinary incontinence (SUI); TVT sling operations; Intraoperative complications; postoperative complications; Recurrence.
Seroprevalence and Determinants of Helicobacter Pylori among Primary Health Care Centers Attendants in AL-Nassiryia City at 2017 Mohammed K. Yousif
Journal of Global Pharma Technology .
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Abstract

Background: H. pylori are a gram-negative, spiral shaped; flagellated bacteria adapted to colonized the gastric mucosal layer. It is affects nearly one half of the world population, mainly in the developing countries. Increasing prevalence in developing countries is due to socio-economic status such as poor hygiene, overcrowding household and deficient sanitation. Methods: A cross-sectional study was conducted in Al-Nasiryia city in to twenty primary health care centers among general population for all age groups and both sex. The sample size was 386 individual from 4-75 years old age. In questionnaire we used collect socio-demographic data of studied population. The laboratory test used blood sample to estimate the H. pylori antibody, that by using special kit. Data were analyzed by (SPSS) version 24 to estimated frequency, percentage, Chi-square test, Fisher exact test, and logistic regression , in all cases p-value <0.05 was considered as statistical significant. Results: the overall prevalence of H. pylori infection among studied population of PHC attendants was 49.48%. In this study there was statistical association between H. pylori and some risk factors such as age, sex, marital status, smoking habit, occupation and cardiovascular disease were (0.0001) respectively.  Multivariate analysis to showing the effect and association of variable on positivity of H. pylori antibody result in sex, occupation , CVD, smoking habit, difficulty swallowing to solid food, were p-value less than 0,05 and exponential B were 0.343, 0.381, 0.368, 0.401, 0.215, 1.772 respectively. Conclusion: The study shows about half of studied population was infected with H. pylori. the highest prevalence of H. pylori antibody was among age >65 years old, male gender, divorced, illiterate level of education, of retired occupation, of urban residence, family size more than 7, of outer RO water supplement, having CVS disease, and very sever obese .  Keywords: H. pylori, Sero-prevalence, H. pylori antibody test. Thi-Qar.       
Performance Metrics Evaluation of Cache Coherence Protocols in Multiprocessors Environment Babak Aghaei
Journal of Global Pharma Technology Volume 08 Issue 03
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Abstract

The shared memory multiprocessors suffer with significant problem of accessing shared resources in a shared memory it will result in longer latencies. Consequently, the performance of the system will get affected. With the object of solving the problem of increased access latency due to large number of processors with shared memory, Cache is being used. Every processor has its own private cache, now they can update or access the data comfortably but again it leads to another serious issue i.e. cache coherency. The magnitude of the potential performance difference between the various cache coherency approaches indicates that the choice of coherence solution is very important in the design of an efficient shared-bus multiprocessor, since it may limit the number of processors in the system. In this paper we evaluate a typical multiprocessor system in terms of power and latency with different cache coherence protocols where GEM5 simulator is used. The traffic is generated with five injection rates (0.1, 0.2, 0.3, 0.4 and 0.5). Power and latency analyzing figures are made up and appeared in experimental result. The result shows MOESI_CMP_token has maximum latency and power consumption.Keywords: Multiprocessor, Cache coherency Protocols, Power, Latency.  
The Role of Autologous Adipose Derived Neural Progenitor Cells with Cognitive and Motoric Function in Cerebral Palsy Purwati .
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Introduction: Cerebral palsy (CP) is primarily a disorder of movement and posture due to neurological damage before, during, or within five years of birth that prevents the brain from developing properly. Supportive treatments, medications, and surgery may conduct, but no optimal results have been obtained. The main goal of this study was to investigate the effectiveness of the intraventricular implantation of adipose derived neural progenitor stem cells in post-cerebral palsy patients. Methods: 14 patients were included in this study. Small adipose tissue was isolated by small lipopectomy under local anesthesia, cultured and derived become neural progenitor cells. Intraventricular implantations were performed in the operating room. Patients were evaluated based on the Gross Motor Function Classification System (GMFCS) according to their motor skills before and after treatment in 12 months. The assessment includes cognitive functions, motoric functions and spasticity changes. Descriptive statistics are provided. Results and Discussion: Ten of twelve CP patients (83.33%) had a significant improvement after treatment. The improvement ranged from 1 to 3 levels on the GMFCS score, and improvement was most pronounced in motor skills and cognitive skills. There were no serious adverse events reported, limited to mild headaches, fever or vomiting, and all side effects resolved within few days. Conclusion: Because of the small sample size and non-randomized trial performed, we could not reach a definitive conclusion regarding the potential of intraventricular implantation. However, this small study shows that repeated intraventricular implantation of autologous adipose stem cells is advantageous.Keywords: Cerebral palsy, GMFCS, stem cell, Adipose tissue, Neural progenitor cells, Intraventricular implantation.
Cloud Point Extraction for the Separation, Preconcentration and Spectrophotometric Determination of Trace Copper (II) In Herbal Plants Samples Using New Synthesized Reagent Azhar A. Ghali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A new Cloud point extraction method was showed determination and preconcentration of copper in plant and herbs. The final products of analysis are complex of Cu (II) with new reagent is 6-(4-bromophenylazo) m-anisidine [6-(4BrPAA)]  in Triton X-114. Centrifuge is used after that, then the surfactant-rich phase is diluted by ethanol (1.5) mL after separation. Then measurement of the copper was done by spectrophotometry at 512 nm. The complexing agent concentration, pH, Triton X-114, centrifuge rate, time and temperature are important analytical parameters. The used analytical methods in the study are included limits of detection, molar absorptivity, linear range, quantification and sandell sensitivity, factors of improvement and preconcentration. Linear range was (0.007-1.50) μg mL-1 of Cu (II). The quantification limits and detection were (0.0199 and 0.0059) μg mL-1 of Cu (II), consequently. The cations and anions influence was examined; it is represent the method which used for evaluation the copper amount in the herbal plants samples.Keywords: Copper (II); 6-(4-bromo phenylazo) m-anisidine [6-(4BrPAA)]; Triton X-114; spectrophotometry; Cloud-point extraction.
The Comparative Effect of Liquid and Tablet Preparation of Purple Sweet Potato (Ipomoea batatas L) Extract to Lipid Profile, MDA, and SOD Level in Male Wistar Rats After Given High-Cholesterol Diet I Wayan Putu Sutirta Yasa; I Made Jawi; Putu Astawa
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background: Recent developments in tablet preparation of extract have brought advantages to keep active ingredients from plants in stable forms physically and chemically. This study aims to compare the liquid and tablet preparation of purple sweet potato (Ipomoea batatas L.) extract to lipid profile, MDA, and SOD level in rats after given high-cholesterol diet. Methods: A randomized pre- and post-test control group experimental study was conducted during 4 weeks among 21 male Wistar rats. They were divided into 3 groups in this study namely: control (only high-cholesterol diet), Treatment 1 (T1) group (high-cholesterol diet and 200mg/day tablet of purple sweet potato extract), and Treatment 2 (T2) group (high-cholesterol diet and liquid form of purple sweet potato tubers extract about 2 mL/day). Lipid profile, MDA, and SOD level examination were performed twice from retro orbital sinus blood drawn and analyzed using ANOVA in SPSS version 17.Results: Mean value of lipid profile was significantly lower in T2 group (Cholesterol 84.48 ± 3.38; LDL 23.05 ± 2.32; HDL 63.39 ± 1.56; and triglycerides 96.03 ± 3.82; P < 0.05) after study period. The mean value of MDA was also significantly lower in T2 group (1.25 ± 0.09; P < 0.05) and SOD level was significantly higher in T2 group (73.72 ± 4.14; P < 0.05) in the end of study. Conclusion: Liquid preparation of purple sweet potato extract showed a better efficacy in reducing lipid profile and MDA level, as well as enhancing SOD level in rats given high-cholesterol diet.Keywords: Lipid Profile, Liquid, MDA and SOD Level, Purple Sweet Potato, Tablet.
Spectrophotometric Determination of Copper (II) by using Amoxicillin Drug as Reagent Abbas Noor Alshirifi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Trace amount of Copper was determined by spectrophotometric technique by using   amoxicillin-Sodium drug as new reagent.  Amoxicillin-Sodium reacted in highly basic solution at pH 11 with Copper (II) to give a violet colored product which has a maximum absorbance at wavelength 540 nm. The reaction was immediate and its observance remained stable above 1 an hour.   The molar absorptivity   was found to be 0.3 × 104  L mol-1 cm-1, Shandell's sensitivity was 2.08 ×10-1μg cm-2 . And the linearity of the calibration curve, which obeyed to beer's low limits was obtained for 5-32 µg mL-1of Cu (II). The stoichiometric composition of the colored   product   was 1: 1 [Copper: Amoxicillin-Sodium] by using Job’s method, mole ratio method and molar conductivity.The Limit of Detection (LOD) and limit of quantifications (LOQ) were calculated by using suitable equations, which were found to be 0.29 μg/mL-1 and 0.97µg/mL-1 respectively.Interferences    due to Fe (III), Co (II), Ni (II), Zn (II), Ag (I) were investigated. The method is high selectivity and used for determination of copper in samples.Keywords: Copper(II) ,Amoxicillin drug , Reagent. 
Impact of Hypertension and Hyperlipidemia Screening with Intervention During the Utilization of Antihypertensive and Antihyperlipidemic Drugs Madheswaran M; Parimalakrishnan S; Manivannan R
Journal of Global Pharma Technology Volume 12 Issue 03 (2020) March 2020
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Abstract

The aim of the present study is to estimate the impact of intervention provided on screening programme to the participants and physicians and also proposed to study the factors influencing the physicians during prescribing antihypertensive and/ or antilipidemic agents. The study design was a cohort intervention study done at community pharmacies at Tamil Nadu, India. This was carried out for two years and data were collected from the patient record and interview. A screening prgoramme was arranged to measure blood pressure and total cholesterol levels. The primary outcome of measures was the percentage of patients prescribed antihypertensive and/ or antihyperlipidemic agents for 6 months before and after the intervention. Data were collected from 946 (75.68%) of patients visited the identified community pharmacies. 90.6%  and 9.4%of patients were allotted to the control and intervention groups to initiate antihypertensive and/ or antihyperlipidemic agents. After the intervention, the prevalence of antihypertensive agents prescribed was observed high among the intervention group when compared with the control group as the prevalence of antihyperlipidemic prescription. The similar results for the incidence were also observed for the antihypertensive agents and antihyperlipidemic agent prescription, during the study period after the intervention. This present study showed that the intervention was effective for improving the prescription containing antihypertensive and antihyperlipidemic agents as a primary outcome among patients with high blood pressure and lipid levels.
Comparative Study between some Species of Cassia and Senna from Fabaceae Family Using Leaf Epidermal Characters Zainab A. Al-Lamy
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The important taxonomic significance was obtained from this study helped to comparative species under the two genera Cassia and Senna grown in Iraq. The aim was to confirm some useful diagnostic features that may be used in comparison between the two genera. Our results detect important features that are helpful in the identification of each species. These include presence of stomata only in the lower surface of the leaves in the species of Cassia and in the species S. singueana in addition presence the Paracytic type pattern in it and differed from the rest species of Senna, so in the results of the current study was treated with this species as one of the types of Cassia depending on the old classification, so the species of two genus appeared differ in the shape of anticlinal walls of the ordinary epidermal cells, also found that the genus S. artemisioides was unique in the presence Actinocytic stomata pattern on the upper and lower surfaces, this feature considered an important to distinguishing it from the rest of the species, in addition this pattern absence in the species of Cassia and which helps to differentiate between the two genus under studies. The hairs in both genus species which Unicellular uniseriate type and from many sections of plants species collected from Iraq we not found multicellular hairs in the species under study.Keywords: Cassia, Senna, Epidermal features, Stomata pattern, Hairs.
Study of the Relationship between Some Genetic Markers and Some Productive Traits of Arabi Sheep in the Steppe of Muthanna Hadi Awad Hassooni Al-Brkat
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The study carried out in the first research station to the College of Agriculture-Al-Muthanna University, 12 km south west of Muthanna district and laboratories specializing in molecular genetics for the period from 15/11/2017 until 30/4/2018 in order to determine the relationship between genetic markers BM1258 and INRA023 with genotypes (90/125,120/135,95/140 and 100/90) and (190/220.180/200 and 185/170) bp Respectively and the production of milk and Its components the following are the most important results obtained: The presence outweigh the significant (P≤0.05) for marker BM1258 in ewes carrying genetic site 90/125 bp in the total production of milk and the length of the milking season the ewes bearing on others local 120/135 , 95/140 and,100/90 bp .while outperformed significantly (P≤0.05) ewes 120/135 bp genetic location in the proportion of fat significantly milk ewes bearing two hereditary 90/125 and 95/140 bp, which varied among them. The presence outweigh the significant (P≤0.05) for marker INRA023 in ewes bearing site genetic 185/170 in the total production of milk and the length of milking the ewes carrying two 190/220 and 180/200 season, while the superiority of ewes same location genotype 180/200 in the percentage of milk fat. Affected the results and there is a significant difference (P≤0.05) for Marker INRA023 in ewes same location genotype 180/200 bp in the proportion fat solids and protein content.Keywords: Sheep, Genetic markers, BM1258, INRA023.

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