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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Chromosomal Abnormalities as a Cause of Recurrent Abortions in Iraq Samia Khalil Mahmmod
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

To evaluate the incidence of chromosomal abnormalities in Iraqi couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis. The present study examined 70 couples with at least two pregnancy losses were referred to the Iraqi Center for Cancer and Medical Genetics Research. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Among the 70 couples tested, Chromosomal abnormalities were detected in 16 (11.42%) of 70 couples, seven males (4.99%) and nine females (6.42%). Fifteen of chromosomal abnormalities were structural and one of them was numerical. These abnormalities included four balanced reciprocal translocations, one Robertsonian translocation, one case of trisomy X-chromosome and the other cases have a different chromosomal aberration inversion, deletion and derivative. Our results showed that 11.42% of couples with recurrent abortion had chromosomal abnormalities, with no other abnormalities. Couples who experience ≥2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.Keywords: Recurrent abortion, Chromosomal abnormality, Balanced carrier.
Synthesis, Characterization and Anti-Inflammatory Activity Assessment of New Ibuprofen Analogues Containing Imidazole-4-One Derivatives Monther Faisel Mahdi
Journal of Global Pharma Technology .
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Abstract

Ibuprofen suffers from general side effects of NSAIDs, owing to the presence of free carboxylic group. The study was aimed to retard the adverse effects of gastrointestinal origin. New series of imidazol-4-one derivatives of ibuprofen were synthesized 6a-e. The structures of synthesized compounds have been established on the basis of their spectral FT-IR and 1HNMR data. In vivo acute anti-inflammatory effects of the synthesized compounds were evaluated in rats using egg-white induced edema model of inflammation. The tested compounds and the reference drug produced significant reduction of paw edema with respect to the effect of propylene glycol 50% v/v (control group). ). The effect of Ibuprofen and all tested com pounds started at time (120 min.) except (6c) and (6e) started at (60 min.) which indicate fast onset of action. The effect of tested compounds and Ibuprofen continued until the end of experiment. Compounds (6a), (6b) and (6d) produced significantly lower inhibitory effect than Ibuprofen at time (120-240 min.).Although, compound (6c) exhibit significantly higher inhibitory effect than ibuprofen at time (60-240 min.),but compounds (6a, 6b & 6c) show lower effect at time (120-240 min).Keywords: Anti-inflammatory activity, Imidazol-4-one, Rat paw edema, Ibuprofen analogues.
Anticancer Properties of Amniotic Membrane Epithelial Cells Hakimeh Zali
Journal of Global Pharma Technology .
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Abstract

Cancer is one of the important causes of mortality worldwildly. Abundance ofunsuccessful therapeutic methods, their side effects and the high cost of treatments, have led scientific societies to search novel targeting treatments. Anticancer properties of amniotic epithelial cells were emphasis previously, so in this study will review the anticancer factors secreted from this cell. These releasing factors including TNF-α, TNF-β, TGF-β, GM-CSF, NTF3, CCL18, BDNF, GCP-2, IL 2, 4, 6, and 8 induced apoptosis process in a variety of cancer cells. In sum up, this kind of stem cell with anticancer molecule are appropriated to use directly in cell therapy of cancer or indirectly use condition medium.
The Effect of the Dye Concentration on the Nonlinear Properties of the Laser Dye DQOCI Doped with PMMA Films by Using Z-Scan Technique Amal F. Jaffar
Journal of Global Pharma Technology .
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Abstract

In this study the effect of the laser dye DQOCI concentration doped films on the nonlinear properties was studded by using z-scan technique which showed an interesting nonlinear optical characteristic. The dye DQOCI was dissolved in ethanol with different concentration and doped with the polymer PMMA by a spin coating method. Z-scan experiment was performed using Nd: YAG pulsed laser at532 nm, in two parts. The first part was done using a closed-aperture placed in front of the detector to measure the nonlinear refractive index. In the second part; the aperture in front the detector was removed (open aperture) to measure the nonlinear absorption coefficient. The experimental results for closed aperture show that the dye doped films exhibits negative refractive index (self-defocusing) for all concentrations. The results show also that the nonlinear refractive index and the third order nonlinear susceptibility increased with the increasing concentration. The observed nonlinearity curves of the doped films by using open aperture z-scan exhibited third order nonlinearity as it fit to saturation absorption. Most of the molecules occupy the excited state, and the ground state is bleached, the system becomes increasingly transparent to the incident laser puls at 532 nm resulting in a saturation of absorption .The third order absorption coefficientβ and the imaginary part of susceptibility I’m χ(3). Values were increased as the concentration of the dye was increased .This is due to increasing of the number of dye molecules which thermally excited resulting in an enhanced effect. DQOCI doped films with different concentrations have a good optical limiting response. The limiting threshold and the limiting output power were reduced as the concentration was increased which make these films a good candidate for optical limiting applications.
Impact of Sub-Minimal Inhibitory Concentrations of Ciprofloxacin, Amikacin and Gentamicin on the Production of Staphylococcus aureus β- Toxin ʺThe Biofilm Ligaseʺ Thikra Adnan Jawad Banimuslem
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Beta toxin (β- toxin) plays an important role in Staphylococcus aureus infections by two mechanisms: sphingomyelinase cytotoxic activity and biofilm ligase activity. The biofilm ligase activity is considered as a promising property for biofilm matrix establishment. The present study investigated the influence of sub minimal inhibitory concentrations (sub-MICs) of ciprofloxacin, amikacin and gentamicin on the capacity of S. aureus (wound isolates) to produce β-toxin and form biofilm. After determination of the MIC for each antibiotic, bacteria were grown in sub-MICs of these antibiotics then the ability of beta hemolysin production and biofilm formation were evaluated. The results indicated that 1/8 MICs of all antibiotics have induced  β- toxin  and biofilms whereas  the 1/2 MICs were inhibitory and a high correlation between the  β- toxin  production and biofilm formation has been observed in all isolates under the influence of antibiotics, when the  β- toxin decrease, the biofilm also decrease.Keywords: S aureus, β- toxin, biofilm, sub-MIC, ciprofloxacin, amikacin, gentamicin.
Cesarean Hysterectomy in Cases of Placenta Adhesiva Involving Urinary Bladder: Serial Cases Report Anak Agung Ngurah Jaya Kusuma
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: Placenta adhesiva is an obstetrics complication with potentially high maternal and neonatal morbidity and mortality. Its incidence is increasing, but the management remains controversial. Antenatal diagnosis and method of delivery are the main issues. Many clinicians now prefer a conservative approach. While cesarean hysterectomy remains the method of choice in most cases, it still exposes women to torrential bleeding risk, with reported mean blood loss of 3.000-10.000 ml. We present four cases of placenta adhesiva with suspected urinary bladder involvement during antenatal care, which is managed with cesarean hysterectomy. Case Presentation: A 34 years old multigravida (G3P2A0) at 32-33 weeks gestational age (GA) and a-39 year’s old multigravida (G4P3A0) came to the clinic complaining of painless vaginal bleeding. In another case, a 38 years old multigravida was also referred from a regional hospital diagnosed with G5P2A3 32-33 weeks GA + antepartum bleeding (total placenta praevia) suspected placenta adhesiva. And the last case was A 24 years old multigravida, with known low-lying placenta for 20 weeks of GA. Greyscale Ultrasonography (US) showed placental implantation at anterior uterine corpus covering entire internal uterine ostium (IUO), seen multiple lacunas crossing the vesicouterine serous border and placental protrusion into the urinary bladder. The cesarean hysterectomy was performed in all cases by placental identification, preoperative bleeding control, and careful tissue resection, as proposed in the triple-P procedure. The cases show a promising outcome following CS hysterectomy in cases of placenta adhesiva involving urinary bladder. Conclusion: We recommend a comprehensive team approach for decision making and management of patients suspected of placenta adhesiva with careful preparation to avoid complications. Keywords: Placenta Adhesiva, Caesarean Hysterectomy, Urinary Bladder.
Preparing, Identifying, and Electrochemical Studying of Cobalt Complexes with Aspartate and Benzoate Ligands and Comparing Their Consumption Rates in Food Industry Ali Bakhshi
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

Aspartame is a synthetic sweetener and sodium benzoate is the second most consumable preservative substance, used widely nowadays in processing and packaging foods. Excessive consumption of these additives is harmful for health, and uncontrolled consumption of these additives is associated with side effects. In this research, the interaction between cobalt metal and aspartate and benzoate ligands was examined to evaluate their reactivity and the obtained product was identified by FT-IR and UV-VIS methods and examined electrochemically by cyclic voltammeters. The FT-IR spectrum of the resulting complex showed the frequencies of 2956, 3133 and 3321 for groups C = O and C = N, and the transfer electron spectrum related to ligand at 700,1738 and 3207 nm range, and the d-d metal transfers in the 380 and 630 nm range.Keywords: Aspartame, Sodium Benzoate, Electrochemical, Cobalt (II) Nitrate
Using of Chlorella Vulgaris for Livestock Wastewater Treatment and the Expression of NR Gene Nasrin Moshtaghi
Journal of Global Pharma Technology .
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Abstract

Algal treatment was performed for 30 days in three autoclaved livestock wastewaters. Nitrate concentrations in the three batch cultures and autoclaved livestock wastewaters were determined by spectrophotometer method. It was found that the capacity of Chlorella vulgaris removal was reached at rates of 89.22% nitrate in cattle livestock wastewater, 89.34% in sheep livestock wastewater and 89.41% in poultry livestock wastewater. Also, we studied the growth characteristics of C. vulgaris under three wastewater treatments within thirty days. The results showed that in the lag phase, the microalgae was treated in the wastewater with 501.33, 406.66, 381 mg. l-1 nitrate with a biomass productivity of   0.1, 0.09, 0.03g/l perday. On the other hand, we studied the removal of nitrite from wastewater by C. vulgaris. The results showed that the capacity of Chlorella vulgaris for nitrite removal reaches 87.50%, 43%, 65.15%, respectively. Moreover, the expression of nitrate reductase (NR)was analysed over six days in BG11 medium and livestock wastewater treatment. The highest fold of transcription was observed 96 hours after treatment in both of wastewater and culture medium. The transcript of gene at 96 hours in cattle wastewater was higher than BG11 culture medium. These result showed high potentials of Chlorella vulgaris to gene expression related to uptake of toxic nutrient and suitable candidate for gene isolation.Keyword: Algae, Livestock waste water, Nitrate reductase, Transcript.
Calculation of Stabilization Energy of Tetrahedrane with its Nitrogen Substituted Derivatives by DFT Method and Driving an Empirical Relation Connect it with Charge Functions of the Molecule Fatimah Ayad Abdul Jabbar
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In this work the strain energy of tetrahedrane and its nitrogen substituted molecules were calculated by isodesmic reaction method according to DFT quantum chemical fashion, the used basis set was 6-31G/B3-LYP, in addition all structures were optimized by RM1 semi-empirical method. From the obtained data we estimate an empirical equation connect between strain energy of the molecule with charge functions represented by dipole moment of the molecule plus accumulated charge density involved within the tetrahedron frame plus the number of nitrogen atoms. The results indicate the charge spreading factors by polarization and 14n→σ*">  processes are the most important factors in decreasing the strain energy.Keywords: Tetrahedrane, Azaetrahedranes, Isodesmic reaction, Strain energy.      
Physiological Study about the Hematological Effects of Rosuvastatin and Lovastatin as Compared with Sophoretin in Rats (Rattus Norvegicus) Madlen Qassm Abbas
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

To compare the possible hematological effects of the statins lovastatin and rosuvastatin with the flavon sophoretin, the present study was accomplished on rats. Thirty male rats allocated as five groups were used. The groups were: control, cholesterol, rosuvastatin, lovastatin and sophoretin groups. The animals of the control group were maintained on standard diet, while other groups were maintained on cholesterol diet 15mg/kg of diet and dosed orally and daily as follow: rosuvastatin 20 mg/kg body weight, lovastatin 4 mg, and sophoretin20 mg respectively. The study comprised some hematological parameters including red cells count, hemoglobin concentration, leukocytes count, hematocrit, differential leukocyte count, platelets count, red cells indices, and platelets indices. The results showed that cholesterol caused a significant increase in red cells count (RBC), hemoglobin (HGB), and hematocrit (HCT) with a significant decrease in total white cells count (WBC) and platelets count (PLT). Rosuvastatin caused a significant decrease in HGB, HCT and WBC while lovastatin caused a significant decrease in WBC, and PLT. For sophoretin, all the parameters were without significant differences as compared with control group at (P≤0.05). Considering other blood indices, they are more detailed in the results.Keywords: Sophoretin, Quercetin, Rosuvastatin, Lovastatin, Rats.

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