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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Effect of Calcium Oxide Nanoparticles on Liver Enzymes in White Rats Shurooq Wesam Al-Shaibani
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Calcium is the five elements that found on the crust of the earth. It`s the essential mineral for all organisms because the important role in the functions of the life cells , and its essential mineral for binding the bone and teeth by producing calcium phosphate. The decreasing of calcium element in the body leads to weakness, dental caries, and muscle cramps. Present study was designed to evaluate the effect of calcium oxide- nanoparticles on the serum levels for liver enzymes of white rats. Two group of White rats ( 3 rats each group) received calcium oxide- nanoparticles which were orally administered with 50 and 100 (mg/kg) from of body weight of calcium oxide- nanoparticles suspension daily for 10 day. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured at start and at the end of the study.  Changes of the specific parameters indicated that liver were significantly affected in both experimental groups , the changes between the levels of total alanine aminotransferase , aspartate aminotransferase and alkaline phosphatase indicate that calcium oxide- nanoparticles induces liver damage and may be lead to hepatic toxicity in the experimental rats.Key words: CaO-Nanoparticles, (ALT, AST and ALP), White rats.
Study the Effect of Ribavirin Drug on the histological structure of the testes in Albino mice (Mus musculus) Thekra Atta Ibrahim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The results have gotten from this study was showed that all animals of two experiment groups that inoculated with Ribavirin drug appeared change in the thickness of seminiferous tubule wall of the testes and contraction in them where its appearance became irregularly and crooked as well as observed emergence of Vaculation. Also some sections of the sperm tubules Seminiferous tubule revealed increased in the widening of the distance between the germ cells and ecdysis of the epithelial tissue and aggregation in the cavity of some Seminiferous tubule also the occurrence of degeneration and raised the distance between neighboring Sertoli cells.Keywords: Testes, Sertoli cells, Ribavirin, Seminiferous tubules, Leydig cells, Mus musculus.
Pregnancy Course and Outcome in Relation to Maternal Age Suzan Yaseen Mahmood Alzubaidy
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Background: Pregnancy is considered as a special period during which woman needs special care and management of certain signs and symptoms. Advanced maternal age is defined as more than 35 years during pregnancy, while teen pregnancy is pregnancy during 15 – 18 years old. It is well established that advanced maternal age or teenage Pregnancy is associated with adverse effects that may affect the mother or the neonate like gestational hypertension or diabetes or preterm labor and others. Objective: The aim of this study is to observe the effect of maternal age during conception on the course and outcome of pregnancy Methods: The sample included 300 mothers chosen conveniently from four different PHCC in Baghdad during the period 1/2/2015 to 31/5/2015. The mothers were divided according to age groups. Data were collected by direct interview and answering the questionnaire, which provided demographic and health information about the mother and pregnancy. Results: Most mothers in the study were in the 18 – 35 years age group (61.7%). For the mothers aged less than 18 years, 64% of them had one child during the study period, 9%had abortions, 73%had term labor, 13%had preterm labor and 5%had post term labor. On the other hand, most women more than 35 years old had more than four children (64%), with abortion rates 15%, term labor 69%, preterm labor 10% and post term labor 5%. The study revealed that the rate of complications during pregnancy was 36% in the age group fewer than 18 years, 55% in the 18 – 35 years age group and 56% in the age group older than 35 years. Conclusion:  the number and rank of pregnancy are related to maternal age. 2. Term labor is the most frequent outcome of pregnancy in all age groups, with higher rates of preterm labor in young mothers and abortions in old mothers. 3. C.S is the most frequent mode of delivery in all age groups with higher rates in old aged mothers than young and preferable groups. Improved education level resulted in reduced complications during pregnancy in all age groups. Based on the findings we recommend regular visits by the mother to PHCC to reduce occurrence of complications during pregnancy, and advising families to delay the first pregnancy in teenage girls when early marriage happens.Keywords: Pregnancy course, Maternal age, Pregnancy complications. 
Psychological Tension in Some Individual Games for Students of the Third Stage in the Faculty of Physical Education and Sports Science - University of Al-Qadisiyah Mohamed Abdulrahman Mohamed
Journal of Global Pharma Technology .
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Abstract

Today, the progress in physical education and mathematical science is clear and tangible in all sports activities, leading to higher achievement through the training process, and the introduction of all sciences to raise the level of skill performance. These sciences have a direct impact on the students' results; play an important role in achieving the desired objectives. They affect the level of students and may contribute to the implementation of technical and planning duties. Psychological stress is one of the most important psychological factors, which can be observed through the behavior of the individual in his responses to the new sports situations, in order to discourage the skillful performance of the lesson. Fencing, wrestling and gymnastics are one of the most popular games. These students from the possibilities of the skillful performance of what has been taught and these games differ from other sports in the size of sports skills, which is increasing with increasing importance, especially in the academic stages. The importance of research is to study the psychological tension among the students of the third stage in the Faculty of Physical Education and Sports Sciences who practice (dueling, wrestling and gymnastics) and compare them according to the game to know any game with a high degree of psychological tension. Through the poll of experts and specialists and the fact that researchers teaching at the college noticed, it appeared that the psychological preparation processes did not take the integrated dimension of the teachers and staff memory in the field of training, since these operations did not take sufficient quota as well as physical and skill preparation for the purpose of psychological tension control student who It reflected on the student's performance level. And to know the level of our students in the performance of the basic skills in (fencing, wrestling and gymnastics).Teachers do not treat the psychological side well during the training and the exam. It is necessary to study the side of psychological stress in the students in the third school stage to know the best material in this aspect. And compared the psychological stress of the three games in the third phase. The sample included (80) students from the Faculty of Physical Education and Sports Sciences / University of Al-Qadisiyah, which included three subjects, distributed (20) students for fencing material (20) ), A student from the Gymnasium for the academic year (2017 - 2018). The researchers used the statistical file (SPSS), which does not find the statistical analysis of the research. The researchers concluded that the students of wrestling and gymnastics subjects have the lowest proportion of students of fencing with psychological stress and recommended that students take into account the psychological stress of students in the performance of practical examinations.Keywords: Psychological tension, Individual games, Physical Education and Sports Science.
Synthesis, Thermal and Electrochemical Properties of Four New Bis Oxadiazole Copolymers Based on Azo Monomer Juman A. Naser
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Four new copolymers were synthesized from reaction of bis acid monomer 3-((4-carboxyphenyl)diazenyl)-5-chloro-2-hydroxybenzoic acid with five diacidhydrazide in presence of poly phosphoric acid. The resulted monomers and copolymers have been characterized by FT-IR, 1H-NMR, 13C-NMR spectroscopy as well as EIMs technique. The number averages of molecular weights of the copolymers are between 4822 and 9144, and their polydispersity indexes are between 1.02 and 2.15. All the copolymers show good thermal stability with the temperatures higher than 305.86 °C when losing 10% weight under nitrogen. The cyclic voltammetry (CV) measurement and the electrochemical band gaps (Eg) of these copolymers are found below 2.00 ev.Keywords: Oxadiazole, Copolymer, Azo, Monomer, Thermal Properties, Electrical Properties.
A Capillary Electrophoretic Method for the Analysis of Bupivacaine and Its Metabolites Roza Askarova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The article studies a capillary electrophoretic (CE) method for the analysis of urinary extracts of the local anesthetic, bupivacaine, and its three main metabolites, desbutylbupi vacaine, 3’-hydroxybupivacaine, and 4’-hydroxybupivacaine, in rat urine. After collection of blank urine, the rats were given a 20 mg/kg intramuscular injection of bupivacaine, and urine was collected for 12 h after dosing. CE analyses were performed using the CAPEL®-205 capillary electrophoresis systems. The data was collected using the Elforan® specialized software. The use of methanol to reduce peak tailing was investigated at different concentrations, but 20% and 30% v/v were proved to be the most optimal at the preparatory stage of the experiment. The resolution of 3’-hydroxybupivacaine and 4’-hydroxybupivacaine was 1.09, 0.98, 0.89 and 0.89 at 15, 40, 70 and 110 s, respectively. The initial resolution (Rs) of desbutylbupi vacaine was achieved with all studied injection periods as Rs = 1.09, 0.97, 0.96 and 0.96 at 15, 40, 70 and 110 s, respectively. Separation efficiencies for 3’- and 4’-hydroxybupivacaine were312×103, 257×103, 196×103 и 169×103μlat injection times of15, 40, 70 and 110 s, respectively. The results showed that the mass of bupivacaine, desbutylbupi vacaine, and 3’- and 4’-hydroxybupivacaine significantly recovered in the rat urine after the dose was administered. The recoveries as a percent of the dose were 0.04, 0.80, 0.15 and 0.05% for desbutylbupi vacaine, bupivacaine, 3’-hydroxybupivacaine, and 4’-hydroxybupivacaine, respectively. Separation of bupivacaine and its metabolites was achieved in 15 min. A particular advantage of this approach over published HPLC methods is that separation of the two hydroxy positional isomers of bupivacaine is possible. A number of unknown peaks were also observed in the electropherograms from the rats dosed with bupivacaine. These did not correspond to any peaks appearing in the blank urine samples. Characterization of these unknown peaks may prove useful for the further understanding of bupivacaine metabolism. Keywords: Bupivacaine, Capillary electrophoresis, Desbutylbupivacaine, Hydroxybupivacaine, metabolites.
Comparative Study for Measurement the Diameter of Red and White Muscle Fibers in two Iraqi Fish Species Barbus Grypus (Heckel, 1843) and Barbus Sharpeyi (Gunter, 1874) Mohammed W. H. AL-Muhanna
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The present study conducted to study the measurement of red and white muscle fibers in two Iraqi fish species (Barbus grypus and Barbus sharpeyi) belonging to the cyprinidae family specimens of fish collected from AL-Hindyiah river at Kerbala province using gill net and cast net. The results declare clear differences in the mean values for the different studying length groups of both species under investigation. The mean diameters of red muscle fibers were less than that of white muscle fibers diameter at different regions of the the body and studying length groups.  The results revealed that the diameter of red muscle fibers ranged from (40.68 - 73.32 microns) in comparison with (69.58 – 102.41 microns) for white muscle fibers for both species. On the other hands the results revealed that diameter of both red and white muscle fibers decrease toward the posterior region of the body, which is perhaps related to the mechanism of movement or swimming of the fish.Keywords: Barbus grypus, Barbus sharpeyi, Red muscle fibers, White muscle fibers.
Intelligent Prediction of Suitable Physical Characteristics Toward Archery Performance Using Multivariate Techniques Mainul Haque
Journal of Global Pharma Technology Volume 9 Issue 07
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Abstract

The present study aims to explore different physical characteristics towards a successful performance of archery and to predict the most vital attributes that contribute to the achievement of high archery scores. 32 archers drawn from different archery programmes participated in the study. Standard physical characteristics tests were conducted, and archers’ shooting scores of one end were recorded. Multivariate techniques of principal component analysis (PCA), hierarchical agglomerative cluster analysis (HACA) and discriminant analysis (DA) were used to achieve the aims of the study. The PCA after varimax rotation indicates two variables containing 12 and 2 varifacators (VF). The First VF revealing high positive loadings from weight (0.94), calf circumference (cc) (0.89), abdomen cc (0.97), hip cc (0.97), thigh cc (0.95), triceps thickness (0.76), biceps thickness (0.75), subscapular thickness (0.83), suprailiac thickness (0.85), abdominal thickness (0.85), front thigh thickness (0.76) and medial calf thickness (0.80) revealing that endomorphic body positively affect the performance of the sport. The second VF discloses high negative loadings from height (-0.88) and arm length (-0.90) describing that body height, and arm length negatively affects the performance of the sport. HACA classified the archers into three classes based on the PCA outputs namely; High-performance class, Medium-performance class and Low-performance class. Standard, backward and forward stepwise DA discriminate the classes from the 14 predicted variables with accuracies of 74.19%, 96.77% and 93.55% respectively. The findings from the current study can be helpful in mapping out potential athletes in archery based on their physical characteristics.Keywords: Intelligent prediction, Archery, Physical characteristics, Multivariate techniques.
Study of Some Immunological and Biochemical Parameters Related with Vitiligo Patients Alaa Jawad Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The current study aimed to determine the relationship between certain immunological and biochemical parameters with Vitiligo patients.  The results revealed that a significant decrease (P<0.05) in the concentration of  CD8 (ng/ml) and a significant decrease (P<0.01)  in concentration of hormone T4 (ng/dl) in patients compared to healthy group , whereas there was non- significant differences in the levels of  CXCL-10(pg/ml) and TSH(µIU/ml), but there were a significant difference (P<0.01) in  the concentrations of  T3 (ng/ml) and reactive oxygen species(ROS) (ng/ml). According to the gender the males of patients has shown a significant decrease (P <0.05) in the concentration of CD8 in comparison with males control group and a significant decrease (P <0.01) in the concentrations of T4 and TSH hormones, while the data noticed a significant increase (P <0.05) in the concentration of (CXCL-10) as well as a significant increase (P<0.01) in the concentrations of ROS and T3. The comparison between females of patients with control showed a significant decrease in the concentrations of CD8, CXCL-10, T4, and TSH, but there was a significant increase in concentrations of ROS and T3.Keywords: Vitiligo, Immunological parameters, Hormones.
Correlation between Central Vena Pressure Measurement with Collapsibility Index of Internal Jugular Veins in Critically ill Patients Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Central venous pressure (CVP) is popular for assessing fluid estimation, especially critically ill patients. Another method in assessing the CVP today is by using ultrasonic cardiac output monitors (USCOM) using transaortic or transpulmonary Doppler’s ultrasound. The objective of this study was to determine the correlation between CVP and IJV collapsibility index to monitor the adequacy of the intravascular volume status in critically ill patients in ICU. Patients and Method: This analytic, cross-sectional study involved 70 patients of 19 to 64 years. The internal jugular vein (IJV) collapsibility index was examined with ultrasound cardiac output monitoring (USCOM) to assess the patient's intravascular volume status, then the data was compared to CVP. The Spearman rank correlation was used to test the hypothesis. Results: The subjects consisted of 38 males and 32 females, with an age range of 19-64 years. The Spearman’s rank correlation test showed a statistically negative correlation between the CVP value and the internal jugular venous pressure index collapsibility value (R=-0.844, p <0.001). Conclusion: There is a strong negative correlation between IJV collapsibility index and CVP in patients treated in the ICU.Keywords: Hemodynamics, Volume status, CVP, USCOM, Collapsibility index.

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