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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Effect of Ethanolic Extract of Mangosteen Peel As Adjuvant Therapy to TNF-Α And IL-10 in Wistar Rats Infected with M.tuberculosis H37rv Indah Widyaningsih
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This study was an experimental study of wistar rats infected with M. tuberculosis H37 Rv and then given isoniazid  INH as an anti-tuberculosis drug and ethanolic extract of mangosteen peel as adjuvant therapy. Method: Rats infected with M tuberculosis H37rv 106 Mc Farland, as 100µl intratracheal. Rats were randomly divided into six groups control (K1), rats infected with M tuberculosis H37rv  only (K2), and rats infected with M tuberculosis H37rv and then treated with INH 100,200, 300 and 400 mg/kg body weight/ day (P1, P2, P3 and P4, respectivelyAfter administration of 4 weeks of therapy, the rats were sacrificed and the right lung  tissue was  collected to measured the levels of TNF α and IL 10 by using  ELISA. Results  The mean level of TNF α was found in the lowest P2 group compared to the treatment group (P1, P3 and P4) and the control was 24.16pg/ml. The  level of  IL 10 was found in the lowest P2 group compared to the treatment group (P1, P3 and P4) and the control was 232.75pg/ml. Ethanolic extract of mangosteen peel has a significant effect on decreasing levels of TNF α with a value of P = 0.000 <0.005 and IL 10 with a value of p = 0.001 <0.005.  Conclusion  Ethanolic extract of mangosteen peel is effective in reducing levels of TNF α and IL10 in adjuvant tuberculosis therapy, especially at doses of 200mg/kgbw/day, in smaller or larger doses there is an increased possibility of interaction between INH  and the active substances in the extract. Therefore further studies are needed to find the cause.Keywords: M.tuberculosis, Mangosten, TNFα, IL10.
Study of the Prescription and Effectiveness of Combinations of Medicines in the Treatment of Arterial Hypertension Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 05 (2020) May 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Almost half of the world's adult population suffers from cardiovascular diseases: arterial hypertension, coronary heart disease, arrhythmias and others. Because of timely treatment of patients life is prolonged, its quality improves, severe complications decrease: cerebral haemorrhage, myocardial infarction. An increase in blood pressure leads to a decrease in life expectancy. For people with the highest blood pressure, this becomes threatening. Purpose: Determination of the structure of prescriptions by doctors of different combinations of medicines for the treatment of arterial hypertension and their use by patients, as well as to study the effectiveness of combined medicines in the monotherapy of the treatment performed. Materials and methods: The following methods were used: content analysis of medical case-records. Data processing was performed using statistical and mathematical methods and graphical analysis. Results: There were identified some differences in the prescriptions of different groups of medicine combinations for the treatment of arterial hypertension and the most prescribed medicine combinations in monotherapy. Conclusions: As a result of the study, it was found that the most prescribed combination in the treatment of arterial hypertension is a combination of three-component medicines. Keywords: Arterial hypertension; Antihypertensive medicines; Pharmacoepidemiological study.
The Effects of Hydroalcoholic Extract of Devil's Claw on Serum Levels of Obestatin and Body Weight in Male Rats Hossein Kargar Jahromi
Journal of Global Pharma Technology .
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Abstract

Introduction previous studies have referred to the moderating effect of devil's claw on appetite process. Obestatin is a peptide with 23 amino acids secreted from parietal cells of gastric mucosa. This hormone inhibits food intake and body weight reduces. This study was conducted to study the effects of hydroalcoholic extract of devil's claw on serum levels of obestatin and body weight in male ratsMethod In this experimental study, 40 male Wistar rats with an average weight of 180-200 g were randomly divided into 5 groups of 8 animals (control, testator, and the experimental groups receiving the hydroalcoholic extract of devil's claw in concentrations of 150, 300 and 600 mm g per kg of body weight). Hydroalcoholic extract of devil's claw (HAEDC) was administered to animals in gavage for 28 consecutive days. One day after the last injection, the rats were weighed, and after getting blood samples and separation of serum, obestatin concentration was measured using ELISA kits for rats. Data analysis was performed using ANOVA with SPSS 21 and Duncan's test.Results 300 and 600 mg/kg of HAEDC significantly increase serum levels of obestatin and reduce body weight compared to the control group (p<0.05).Conclusion HAEDC reduces body weight by increasing secretion of obestatin that restrains the appetite.Keywords: devil's claw, Obestatin, Body weight, Rat.
New Approaches for Preparation of Silver nanoparticles using Quince Plant Extract as Antibacterial Agents Rana A. K. Al-Refaia
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Nanoparticles have been considered as one of the emerging and promising platforms to solve the problem of antibacterial resistance. The uses of plants in synthesis of nanoparticles are new method as its cheap, environmental friendly and easily synthesis. In this paper silver nanoparticles were prepared using the Quince extract to inhibit the viability of some species of bacteria, because of their unique properties and conspicuous therapeutic potential in treating a variety of diseases. UV/visible, SEM and IR spectroscopy have been used to identify the presence of AgNPs. The in vitro test which was used to evaluate the potency of nanoparticles as antibacterial agents, two different types of bacteria (E coli and Staphylococcus) has been tested against the Quince extract and AgNPs produced from the extract. The overall results shown that the more than 80-90% of both types of bacteria are non-resistant and eliminated compared with untreated bacteria. Thus quince extract is a good biomaterial for the synthesis of AgNPs as antibacterial agents.
Effect of Edible Coating and Storage to Shelf Life of Orange Fruit during Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Orange fruit has high moisture content and nutrient composition make this fruit more susceptible to sofening, browning, or color change and microbial contaminations. It rapidly deteriorates during handling, transport and storage. Edible coatings are widely used for extension of shelf life of fruits and vegetables by reduction of moisture loss and gas exchange as well as reduction of the physiological disorders. The objective of the present study was to identify the effect of different CMC concentrations (1%, 2%, 3%, 4%, 5%) and storage temperature (8 o C, 12 o C, 16 o C, 20 o C) to the weight loss, firmness, total soluble sugar and ascorbic acid in orange fruits during preservation. Moreover, shelf life (0 day, 7 days, 14 days, 21 days and 28 days) of orange fruit in storage also clarified. Results demonstrated that CMC 4% and storage temperature 8 o C could maintain orange fruit quality for 28 days without any deterioration.Keywords: Edible Coating, Orange Fruit, Shelf Life
Modeling of the Effect of Socio-Economic Factors on the Accessibility of Medical and Pharmaceutical Care to the Population (on the Example of Sudan) Ievtushenko Olena M
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Introduction. The availability of pharmaceutical care is closely connected with the health care system and may be influenced by many factors. The heterogeneity of factors determines the need for their ranking and selection, determining the degree of their mutual influence on each other and on the level of morbidity in the country. The purpose. The aim of the study was the modeling of the availability of medical and pharmaceutical care (for example, Sudan). Materials & Methods. For the analysis, the following factors were selected: share of the state’s population in the total population of Sudan, share of the state’s area, share of doctors in the total employed population of Sudan, territorial accessibility of medical care, growth rates of the pharmacy network in the state, territorial accessibility of pharmaceutical care, share of expenditures on medicines in the subsistence minimum of Sudanese. To determine the degree of influence of these factors on the incidence rate, correlation and regression analysis was used; the models obtained were tested for adequacy, including the normal distribution of residuals. Research results and discussion. As a result of the study, a number of models were obtained, of which the optimal one was chosen according to the corrected coefficient of determination. It was revealed that the main accessibility factors affecting the incidence of infectious diseases are the territorial accessibility of pharmaceutical care, the share of drug costs in the subsistence minimum of Sudanese, and the growth rate of the pharmacy chain. Conclusions. In accordance with the proposed model, it is possible to determine not only the level of morbidity, but also to simulate the level of accessibility of pharmaceutical care to the population of a separate municipality, to develop, based on the analysis performed, certain organizational, administrative or legislative measures.Keywords: Pharmacy, Accessibility, Medical care, Pharmaceutical care, Modeling, African countries, Sudan.
Correlation of Myeloperoxidase Activity with Malondealdehyde Levels in Iraqi Patients with Coronary Artery Diseases Saba Z. Hussein
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Background and Objective: Coronary Artery Disease (CAD) is one of the largest cause of mortality worldwide. The majority of CAD is caused by atherosclerosis, which is the main pathophysiological process underlying of CAD. The purpose of the current study was to investigate the role of myeloperoxidase (MPO) activity in coronary artery disease besides to its relationship with malondealdehyde levels, Athrogenic Index of Plasma (AIP) value and its association with the risk of future evolution of CAD in sera of Iraqi patients. Methods: Two main groups were included in this study; 60 patients (35male&25female) with coronary artery disease, and 40 (23male& 17female) apparently healthy controls comparable for age were enrolled in the current study. The blood samples were obtained for measurements of MPO activity, lipid profile, MDA levels and AIP value; for all participants. Results: The obtained results showed that there was a significant increases in serum MPO activity and MDA levels in coronary artery disease (46.35 ± 5.13 U/L) and (6.44 ± 1.32 nmol/ml) as compared with the control (29.12 ± 4.88 U/L) and (2.75 ± 0.43 nmol/ml), respectively. Meanwhile a highly significant increase in AIP value in CAD patients group in comparison to control group (0.36 ± 0.08, 0.076 ± 0.04),  respectively. The activity of MPO was significantly correlated with MDA levels (r=0.751, p=0.000) and AIP value (r=0.762, p=0.000). Conclusion: According to the obtained results, MPO activity, levels of MDA and AIP value were elevated in patients with CAD. It can be concluded that higher MPO activity and its correlation with high MDA levels and AIP value may be associated with complications of CAD in the Iraqi patients.Keywords: Coronary Artery Diseases, Myelopreoxidase, Lipid peroxidation, Atherogenic Index of Plasma.
Melittin Inhibits Cell Growth, Alters the Cell Cycle Profile and Induces Apoptosis in Hela Cells Makkasau Plasay
Journal of Global Pharma Technology .
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Abstract

Conventional treatments for cancer are expensively and have serious side effect. Non-conventional natural treatments have gained acceptance because of minimal or no side effect, easy to find, but little scientific evidence exists. One of the anticancer candidates is melittin. Melittin is a venom protein isolated from bee venom. Presented here is the first reported effect of melittin on cell growth, cell cycle profile and apoptosis necrosis in HeLa cell line. The results show the melittin induce necrotic cell in dose dependent manner, but the IC25 shows the highest effect on apoptotic cell. All doses, IC10, IC25 and IC50 can inhibit G0/G1 on mitotic cell. Finally, the results may indicate the melittin potent to develop as anticancer drug.Keywords: Melittin, Cell growth, Cycle cell, Death.
Synthesis, Characterization with Studying Physical Properties by Free Radical Polymerization of Some New Resins Starting from 5-Styryl-1, 3, 4-Thiadiazol-2-amine Iman Mehdi Mohammed Hasan
Journal of Global Pharma Technology .
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Abstract

Starting from  5-styryl-1,3,4-thiadiazol-2-amine[1], a variety  of Schiff  bases [2-6] prepared,   Schiff base derivatives which containing heterocyclic rings  have been synthesized [7-11]  as monomers .Then  addition  reaction( free radical polymerization)  for monomers by using AIBN as initiator in (50-70) C0  obtaining [12-16] resins .  All proposed structure were supported by FTIR,  solubility ,softening points , and some derivatives evaluated by 1H-NMR  ,Elemental analysis , thermal analysis (TGA,DSC), X-Ray diffraction.Keywords:  Schiff bases, Derivatives with heterocyclic rings as monomers.
Assessment Knowledge of Pregnant Women about Gestational Diabetes in Primary Health Care Centers at Al Nassiriya City/Iraq Doaa Sami Rashash
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The American Diabetes Association (ADM) certified that the Gestational Diabetes Mellitus (GDM) was separated any grade of the intolerance of glucose with a nonset or fist recognition at the time of pregnancy. Objectives: The study aims at assessing the knowledge of pregnant women of Gestational Diabetes Mellitus (GDM), which includes screening importance, risk factors and post- partum follow-up. Methodology: A sample of 50 women was selected from primary health care centers in Nasiriyah. The data was collected by interviewing women. The questionnaire was designed and consisted of demographic components and variables and risk factors that contribute to gestational diabetes to pregnant women. The validity and reliability of the questionnaire was determined by conducting a pilot study. Statistical and statistical procedures were used to analyze the data. Results: The study results showed that most of them ranging from age (21-25) years and the highest proportion of them graduated from primary school and less, most of them housewives with enough to some extent. There were statistically important variances between the knowledge of pregnant women about gestational diabetes and demographic data at a value of p less than 0.05. Recommendations:  Visit prenatal clinics until late pregnancy, meaning that there is little chance to educate illness on GDM and how they can help prevent it. While doctors are proactively trying to change this, the results of this study suggest that continuing education is necessary to improve awareness of GDM, and early prenatal education is likely to be important and that the Department of Health is setting up workshops on pregnancy. Nurses midwives at primary health care centerKeywords: Assessment, Knowledge, Pregnant, Gestational Diabetes Mellitus.

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