cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 52   53   54   55   56 
Detection of Resistance Mutations in Chronic Hepatitis B Patients Using Antiviral Drugs in Iraq Abeer Ali Marhoon
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this study, it is aimed to determine the mutations responsible for drug resistance in patients with chronic hepatitis B virus (HBV) infection received/receiving antiviral treatment at our hospital and to examine the patients in terms of the treatment applied and their HBV-DNA levels. One hundred and eighty-one samples taken from patients diagnosed with chronic hepatitis B infection and follow them between February 2017 till January 2018 at Hepatology and Gastroenterology Teaching Hospital and Central Public Health Laboratory in Baghdad were studied with reverse hybridization principle-based INNO-LiPA HBV DR v2 method and the results were evaluated retrospectively. Mutation was determined in 80 samples (44.1%). and a decrease in DNA level was observed in 101 patients. In INNO LipA reverse hybridization the rtL80V/I mutation was highly frequency among patients 76/80(95%) and followed by rtS202GCI (75%), rtM204V/I/S (72.5%) and rtM250V/I/L (72.5%), rtA194T (67.5%), rtL180M (63.75%), rtT184SCGA (58.75%), rtT184ILFM (31.25%), rtN236T (25%), rtA181T/V (17.5%) and rtV173L (12.5%). This mutation was point mutations a result occurs substitution one nucleotide to another, causing antiviral drugs resistance.  Since a limited number of mutations can be examined via INNO LiPA method, it is concluded that different mutation patterns causing drug resistance cannot be determined and it will be beneficial to use an additional method such as sequencing that enables to determine these genes. Additionally, as a result of treatment failure due to drug resistance, if the treatment will be continued with a novel drug that is not used before, it is considered that the possibility of the presence of mutations causing a resistance against this antiviral should not be neglected.
Antifungal Activity of Alkaloid and Flavonoid Extracted from Curcuma longa Zeena G. Faisal
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The present study investigates the use of agar well diffusion method and the inhibitory effect of Alkloids and flavonoids againist some pathogenic fungi. The statistical analysis of the results  showed of the inhibitory effect of Alkaloids extracted from  Curcuma longa on the growth of fusarium and penicillium, there are significant differences below the level of probability (P<0.05) between the inhibitory effectiveness of Alkaloids extracted from  Curcuma longa of the studied  species, compared with the standard antifungal (Itraconazole), Alkaloids extract of the Curcuma longa gave higher inhibition  impact compared with the inhibitory effect of antifungal (Itraconazole) at the concentration 98% .The inhibitory percentage showed the  effect of Flavonoids extract of Curcuma longa in growth of fusarium and penicillium, that there are significant differences below the level of probability (P<0.05) between  the inhibitory effectiveness of the extract Flavonoids and the fungal genera compared with the standard antifungal (Itraconazole),. Showed Flavonoids is less inhibitory effect of inhibitory effect of Itraconazole antifungal at all concentrations of Flavonoids extracts. The inhibitory effect of Flavonoids extract of Curcuma longa at concentration 99% (22, 25,) mm to fungal species (fusarium and penicillium) respectively.
Effectiveness of Lactic Fermentation and Convective Dehydration to Antioxidant Characteristics of Plumeria Flower Tea Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.746 KB)

Abstract

Fermentation is believed as one of the oldest and most useful approach to maintain or improve phytochemical values. Convective drying is an economical and versatile dehydration method commonly applied in food and herb production. Plumeria flower contains a large number of phytochemical constituents and pharmacological activities. The benefits of plumeria flowers can be enhanced remarkably by processing it into a probiotic tea through lactic fermentation and convective dehydration.  Lactic acid bacteria are able to accelerate the production of polyphenolic compounds as well as to improve antioxidant capability in this valuable herbal tea. This study penetrated on the utilization of lactic fermentation by Lactobacillus acidophilus culture in different innoculation ratio (0.05%, 0.1%, 0.15%, 0.20%, 0.25%) at the loading cell 109 cfu/g on plumeria flower during 37oC in 24 hours. Relying on bioconversion mechanism, we can obtain higher amount of active ingredients in the fermented tea. This study also emphasized on the convective drying temperature (45oC, 50oC, 55oC, 60oC, 65oC) in maintaining the active components inside plumeria flower tea during dehydration to safe mode (6.5% moisture). We noticed that the Lactobacillus acidophilus culture innoculation 0.20% (109cfu/g) and convective drying temperature 55oC were appropriate for plumeria flower tea production. From this production, consumers have better chance to use one kind of novel herbal tea from plumeria flower.Keywords: Plumeria flower, Lactobacillus acidophilus, Lactic fermentation, Convective dehydration, herbal tea.
Molecular Identification of Phlebotominae Sand Flies (Diptera: Psychodidae) in Al-Diwaniyah Region/Iraq Hadi M.H. Al-Mayali
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this study, the  Polymerase chain reaction technique (PCR)  and morphological identification were used in identification of sand flies ,the vectors of leishmaniasisin diseases  in Al-Diwaniyah region for the first time in Iraq,  Morphological  identification  showed presence three different species of sand flies, two belong to Phlebotomusgenus it P.papatasiand P. sergenti and one belong to Sergentomiya genus it S. sintoni. It has been observed that the most species density was the genus P. papatasi (53.09%) followed by the S.sentoni species (28.54%) then  P. sergenti (18.35%). Molecular identification through detection of the   Mitochondrial cytochrome b gene DNA (Cytbgene)   and molecular length output 575base pairs (bp) of species P.papatasi and a molecular length 325 bp of the species of P.sergenti While the species S. sintoni was excluded because it is one of the species that tend to feed on the blood of animals and rarely found indoor and there no indication of its relationship to leishmaniasisin disease in human. Molecular identification results for extracted DNA samples of 2250 sand flies females by PCR method showed two species of sand flies are P.papatasi and  P.Sergenti, P. papatasi species The PCR amplified products showed bands of molecular weights 325 and 575 base pair . Analysis of individual sequences belonging to P. papatasispecies and P.sergenti.Keywords: Molecular identification Phlebotomus, Sand flies, Al-Diwaniyah Iraq.
Pharmacokinetic Modification of Controlled Release Tablets of Antihypertensive Drug Palanisamy Vishnu
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The objective of the study was to pharmacokinetic modification of controlled release tablets  of Isradipine tablets designed to provide 24 hours drug release profile using varying proportion of Eudragit L – 100 and HPMC Phthalate; Lactose monohydrate as matrix-forming material. The prepared matrix tablets showed satisfactory physicochemical properties where drug content was 99.19 % to 103.78 %, thickness was 3.23 mm to 3.36 mm, hardness was 3.37±0.13 to 3.51±0.20 kg/cm2 , friability was less than 1% and % weight variation was within the standard pharmacopoeial limits of ±10% of the weight. Mathematical analysis of the release kinetics of the optimized formulation (F15) was best fitted in zero order kinetics (R2 = 0.982). The dissolution profiles of formulation FI4 and innovator product in multi media were compared in Phosphate buffer pH 6.8.Several kinetic models respectively. The stability data reveals that the FI4 showed a negligible change in drug content thickness, weight variation, hardness, friability and in vitro drug release for three months according to ICH guidelines.
Virulence Factors of Uropathogenic Escherichia coli in Diabetic Patients of Al-Muthanna Province Elaf Lateef Neamah Al-Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.948 KB)

Abstract

Background and aims: There are evidences that patients with diabetes have an increased risk of asymptomatic bacteriuria and urinary tract infections (UTIs). UTIs are the most common bacterial infection in diabetic patients. The present study aimed to describe the characteristics of E. coli of Al-Muthanna province patients with urinary tract infection by identifying the virulence genes (FimH, Pap and HlyA). Material and methods: The study population included 240 diabetic and non-diabetic patients with UTIs as well the healthy control, Urine and blood sample was collected at Al Hussein Educational Hospital, between October 2017 to July 2018. Serum sample were collected and stored for immunological tests. Standard protocol was followed to isolate and identify organism and the data were analyzed using Microsoft Excel 2013. Results: Of the total 240, The results  of the study  were  41 (33.3%)  isolates  of  Diabetes  patients (DM group), 42(34.1%) isolates of Non-Diabetes  patients (ND group) with  urinary pathogenic  E. coli (UPEC)  and selected 40 (32.5%) of control group.  The age  duration of  46-61  years  were  most prevalence  of  UPEC  infections either  DM group  (56.1%) or  ND group (35.7%)  while  the gender  factor was shown significantly in DM and ND females (78.1% and 97.6% respectively ) compare to  males.  Twenty two  (53.7%) of diabetes urban  community  were  found to have UPEC infections while the rural infected  population were 19 (46.3%),  Non-diabetes  group  were recoded  17 (40.5%) , 25 (59.5%) positive cases of UPEC in urban  and rural  communities respectively. Fimbriae  severity virulence  genes of  DNA (fimH , pap) and  alpha-hemolysis  gene (HlyA)  of  were  extracted  of  83  UPEC isolates,  it was  then  identified  using the PCR amplification technique. The results  of molecular  diagnosis  shown that fimH was  detected  in  78%  in DM  patients  had  higher  than of  ND  patients (57%) of UPEC strains while the  percent of  Pap and HlyA were (31.7%, 12.2%) in DM patients compare to  ND patients  (Pap /38.1%)  and  (HlyA /7.1%)  of  UPEC  strains  respectively. Conclusion: UTIs are frequent in diabetic patients. For the reason of the great proportion of asymptomatic forms among diabetic patients, the urine culture should be performed in all hospitalized patients with diabetes.
Plasma Diagnostics of Low Pressure Helium Glow Discharges at Different Working Voltages Hanaa E. Jasim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (472.324 KB)

Abstract

In addition to measurements of, the neutral gas temperature, the electron density and electron temperature plays a vital role in a low-pressure helium plasma characterization and processes. For instance, in biological and mass spectroscopy applications .In this paper, low pressure plasma of helium gas was generated between a flat planar anode and cathode electrodes. A cylindrical probe was constructed and employed to analyze plasma parameters of a structure discharging glow in a negative glow region. Electrons and ions currents of helium plasma have been measured at different discharges voltages and currents. Langmuir probe results at working pressure of 0.5 mbar indicate the electron temperature decreases and density increases as applied voltage increases which can be traced to the fact that electrons collide more frequently with plasma species. Keywords: Plasma diagnostics; Helium gas; Glow discharge; Langmuir probe.
Effect of Vitamin D3 Supplementations on FEV1 and FVC in Patients with Non-small cell Lung Cancer Dhaferah Jaafar Abd
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The current study was conducted at the Middle Euphrates Center for tumors from December 2015 to July 2016 on 90 subjects, thirty healthy person were saved as a control group (G1), and the other group with 60 patients with lung cancer (LC) were subdivided into two subgroup (30 / group), group (G2 was not administered and group G3 was administered) with 1000 IU of vitamin D3) cholicalciferol). In the base line of study, vitamin D concentration and some of lung functions like Forced Vital Capacity (FVC), and Forced Expiratory Volume in the First second (FEV1) were measured for all groups. Then group G3 orally administered 1000 IU of  vitamin D3  for 63 days  then  groups of patients (G2 and G3) were exposed intravenous to 3 doses of Cisplatine 75mg/m2 and Gemcitabin  1gm/m2 for 63day (1dose/ 21 day) , then vitamin D and FVC and FEV1were measured. The results of this study showed a significant decrease (P ˂0 .01) in the level of vitamin D (8.6 ± 2.95 and 7.99 ± 3.08) ng / ml in the two groups of patients at the beginning study, vitamin D increased significantly (P ˂ 0.01) to 18.4 ± 5.8 ng / ml in group administrated with vitamin D when compared to the vitamin D in the beginning of study in the same group and group which was not administered with vitamin D.  The values of both FVC and FEV1 maintained their level close to the control values in the vitamin D administrated group (G3). It was being concluded that vitamin D 3 improved lung functions.
A Comparative Analysis of the Current Performance of University Deputies and Main Functions of Management Abbasali Karimi
Journal of Global Pharma Technology Volume 09 Issue 02
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: the organizations are established for the realization of the certain goals and the level of achieving to these goals depends on performance of organization. The Organization's performance quality depends on main performance of organization management, while managers mainly perform their main tasks (planning, organizing, leading, and controlling). Evidence suggests that the failure of any organization in achieving its mission and vision is a serious issue. Lack of attention to main functions of management among the usual programs of managers is one of the major reasons for this failure. The aim of this study was to compare the current performance of the medical science university deputies with the main functions of management. This study was a cross-sectional research, which its population included educational, health, cultural, student, support, food and medicine deputies of Yasuj medical science university in the years 2010-2011. Deputies trained on recording the current performance and main functions of management collected data required to study. In this process, a researcher-developed tool was used, which includes the type of activity, time spent on each activity and its method. The validity of this tool was determined by using the opinions of experts and its reliability was determined by Cronbach's alpha (0.84). These activities were recorded during the entire week of one year and one day per week. Then, data inserted in forms were coded by researchers and they were analyzed after entering to SPSS software. The results showed that almost 90% of activities of university deputies were consistent with their written organizational functions. However, 47 percent of all recorded activities were among the main functions of management: planning with 17%, organizing with 16%, leading with 9%, and controlling with about 5%. In other words, about 53%time of deputies at their account ability location belonged to activities apart from the basic functions of management. the prerequisite for the dynamics of the organization, and to achieve goals focus on the main management functions. According to the findings of this study, it seems firstly that designing organizational structure (including the hierarchy, description of duties and functions, conditions) needs to serious reviewing and revising so that description of functions and duties notified to them to be in line with main functions of the management and it does not include merely the usual performance. Secondly, with an inadequate focus on the core functions of management by managers, health sector that has special sensitivity in society is deprived of optimal guidance and achieving to organizational goals will be very difficult.Keywords: Management, performance, Health sector, Planning, organizing, University Deputies.
Association of Chicken PMEL17 Gene Polymorphism with Coat Colour Trait in Iraqinative Chicken Mostafa Sadeghi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

PMEL17 gene encodes a transmembrane protein called pre-melanosomal protein 17 or PMEL17. PMEL17 is responsible for the production of eumelanin and is present in the melanosome. The aim of this study was to investigate the genetic diversity of the partial coding regions of the PMEL17 gene and its association with coat colour in Iraqinative chicken.Furthermore, the possible impact of amino acid substitutions on effected the mutations in physicochemical properties and structure of the PMEL17 protein was investigated. Blood samples from 95 Iraqinative chickens were collected to extract DNA and the 594-bp fragment of the PMEL17 gene was amplified and then DNA sequencing method was adopted for single nucleotide polymorphism (SNP) discovering and genotyping. Sequence analysis showed that a 9 bp deletion polymorphism (GGTGCCCAG/-) at chicken PMEL17 gene. The allele frequency of this mutation is 0.84 and 0.16 for the wild allele and the mutant allele, respectively.This mutation created an early codon stop in the PMEL17 protein. The isoelectric point, net charge and hydrophobic index have significant changes by this deletion polymorphism.The association analysis showed that no significant differences between different genotypes and coat colour (p> 0.05).Key words: PMEL17 gene, Chicken, DNA sequencing, Deletion, Protein physicochemical.

Page 54 of 244 | Total Record : 2439

 52   53   54   55   56 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue