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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Burnout Incidence during Online Lectures in Medical Students in Udayana University during the Covid-19 Pandemic Agung Wiwiek Indrayani
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease that caused by SARS-CoV-2 with new cases and mortality rates that are increasing recently. Due to inadequate of health facilities in Indonesia and the absence of a COVID-19 vaccine, some actions are required to reduce the spread of the virus, such as physical distancing. In educational aspect, conventional learning system are replaced by online learning system. This kind of system may cause burnout in medical students. The aim of the study was to describe the burnout incidence during online lectures in medical students in Udayana University during the Covid-19 pandemic. Materials and Methods: A cross sectional study with 175 medical students in Udayana Univerity class of 2018 and 2019 was conducted in this study. The data were collected via google form which includes informed consent and questionnaire which contains burnout scale. Univariate and bivariate analysis through chi-square test was conducted in this study. Results: According to univariate analysis, there was 75.4% students were experienced moderate burnout, 4.9% students were experienced high burnout, and 9.7% were experienced low burnout. Based on chi-square results (p
Fatty Liver and Liver Malondialdehyde Expression in Severe Malnourished Wistar Rats that given Virgin Coconut oil Compared to Corn Oil in World Health Organization Formula I Gusti Ayu Putu Eka Pratiwi; Soetjiningsih .; I N. Mantik Astawa; I Gusti Ayu Trisna Windiani; I Gede Ngurah Harry Wijaya Surya
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Objective: There is a lack of antioxidant in severe malnutrition, and it may lead to increase oxidative stress. Fatty liver is one of severe malnutrition (SM) cardinal features. Virgin coconut oil (VCO) contains high antioxidant capacity and medium chain triglyceride. It is supposed to improve those problems. Methods: Posttest only control group design study was done to observe whether VCO could decrease fatty liver and liver malondialdehyde (MDA) expression in 38 male wistar rat with SM. The rats were divided into two group which were VCO Group (Group A) and Control Group (corn oil (Group B)). They were given feeding World Health Organization (WHO) Formula for SM (Formula 75 and Formula 100) that contained VCO or corn oil. After being SM, this formula was fed until 28 days. In the 29th day, they were sacrificed, and liver samples were obtained for fatty liver analysis and MDA expression. Results: Fatty liver was less in Group A (mean 13.74 cell in 5 view field (SD 1.32) than Group B (mean 20.74 cell in 5 view field (SD 2.01), and it was statistically significant (p=0.000). Cut off point for determining low and high liver MDA expression based on o ROC curve were <2.9% (low) and ≥2.9% (high). Low MDA expression (<2.9%) was higher in Group A than Group B (p <0.05). Conclusions: This study found less fatty liver and low liver MDA expression in severe malnourished rat given VCO than corn oil.  Keywords: Virgin coconut oil, Fatty liver, Malondialdehyde, Severe malnutrition.
Study the Antibacterial and Antibiofilm Activity of Purified Exopolysaccharides (EPSs) from Lactobacillus acidophilus Against Bacteria Isolated from Burn Wounds Noor Naeem Khwen
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The current study was investigated the antibacterial and antibiofilm activity potential of purified Exopolysaccharides (EPSs) from lactobacillus acidophilus against bacteria isolated from patients with Burn wounds that showed some resistance to antibiotics, the results of isolation and identification were showed the predominant bacteria was S. aureus 90% followed by P.aeruginosa 80%, B.subtilis 60%, S.hominis 50%, E coli 40%, P.mirabilis 40%, E.feacalis 40%. Furthermore some isolates were sensitive to ciprofloxacin, P.aeruginosa 37.5%, S. hominis 100%, B. subtilis 16.6%, E.feacalis 50%, P.mirabilis 100%, However the other isolates showed sensitivity to Tetracycline such as S.aureus 44.4 %, E.coli 100%, B. subtilis 100 %. While Azithromycin and Novobiocin, Ampicillin, Cefotaxime, Erythromycin, Imipenem, Doxycycline were showed no effect toward isolates .Meanwhile Chloromphenicol, Amoxicillin /clavulanic acid, Gentamicin showed intermediate effects toward isolates. In addition EPSs showed a positive antibacterial activity against the isolates with different concentrations and the highest value recorded in 500 mg/ml concentration in each isolates but in 200mg/ml concentration in some isolates showed no inhibition zones. Finally anti biofilm activity of EPSs, the study noticed   EPSs showed more effective against biofilm formation withing 24 hr  more than  performed biofilm of isolates (after 24 hr). Furthermore MIC of antibiotic showed more effective  than MIC of EPSs in biofilm assay, but both MIC of antibiotic and EPSs were decreased the strength of biofim of isolates from strong biofilm and  moderate biofilm  formation to weak biofilm formation. The study was revealed depended on obtained results, purified EPSs from Lactobacillus acidophilus had antibacterial and antibiofilm activities against some bacteria isolated from burn wounds showed some resistance to antibiotics.Keywords: Extraction of Exopolysaccharides from lactobacillus acidophilus, Antibacteria, Antibiofilm activity of EPS, Burn wounds. 
The Physiology of Motor Rhythm to the Arm of Performance and its Relationship with Accuracy of the Shooting in Handball Nabhan Hamid Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The aim of the study was to study the relationship between the physiology of the motor rhythm and the accuracy of the shooting in the handball. This was done by studying some of the wave changes resulting from the work of the muscles involved in the movement of the arm related to the skill of the shooting in the handball, Electromyography (EMG), which includes (peak, time and space). The study included (15) young players. Electromyography)EMG) tests were carried out in a special form that was developed to classify the data and then processed statistically to reach the results of which were reached to reach the most important conclusions, which include: Through what was shown from the results we note that there is a strong correlation between the summit variable relationship of triceps brachial in the two parts lateral and medial with the shooting in the hand ball accuracy as this variable gives the fact contraction of muscle and the ability of the muscle to continue performance without fatigue, but for the This means that there is a delay in the speed of the response required to achieve the best accuracy shooting, and this requires a greater concentration in the reaction speed and response exercises because of the significant impact in increasing the precision accuracy variable to achieve advanced results.Keywords: Physiology, Motor rhythm and handball.
Synthesis and Characterization of [1-phenyl-3-naphthoyl-2-thiourea] and Its Metal Complexes with [Co (II), Ni (II), Cu (II), Zn (II), and Cd (II)] ions and Study Antibacterial Activity and Corrosion Inhibitor Basim Ibrahim Al-Abdaly
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The formation of Co (II), Ni (II), Cu (II), Zn (II) and Cd (II)-complexes (C1-C5) respectively were studies with new thiourea ligand [1-phenyl-3-naphthoyl-2-thiourea] from 2-naphthoic acid in three steps. The suggested structures of the ligand and its complexes have been determined   by using C.H.N.S analyzer, thermal analysis, FT-IR, U.V-Visible, 1HNMR, 13CNMR, conductivity measurement, magnetic susceptibility, and atomic absorption. According to these studies, the ligand coordinates as  a bidentate with metal ions through  oxygen atom of  carbonyl, and  sulfur atom of thione  and the ratio of  metal to ligand (M:L) as (1:2) and all the complexes were octahedral structures except copper-complex was distorted octahedral structureKeywords: Thiourea ligand, antibacterial activity, Corrosion inhibitor.
Evaluation of IL-27 Concentration in a Miscarriages Woman Infected with Toxoplasma gondii Raad Ajam Sayal Al. Jorany
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Toxoplasmosis is one of the most common zoonotic pathogens worldwide; Immune response against this parasite was affected by synthesis of specific interleukins like IL-27. The major objectives of this study detection of prevalence expression of IL-27 among ninety-six miscarriages women were tested; forty-eight of them was with miscarriages due to toxoplasmosis and forty-eight apparently healthy pregnant women (with out of any miscarriages) were enrolled as a control group in Najaf governorate. Methodology: Descriptive case-control, purposive (probability) sample among ninety six miscarriages women were tested, attending in Central Health Laboratory .The data collected from January 2019 to September 2019. The concentration level of IL-27 in miscarriages women was measured  by ELISA technique according to many parameters such as age, occupation, residence and number of miscarriages. The result indicated that the concentration of IL-27 was elevated in women with one or two miscarriages. The high concentration of IL-27 in infected miscarriages women with age group (20-24), (25-29).There was no significant differences in study groups according to occupation and there were differences in IL-27 concentration levels according to residency. It was demonstrated that the high concentration of IL-27 was appear in rural infected miscarriages women and low in urban miscarriages women with toxoplasmosis, results were analyzed by using statistical methods (Levene test, ANOVA test, t test). Conclusion:  Interleukins (IL-27) play a significant role in immunity against infection with Toxoplasma gondii. Recommendation: Further studies are recommended to know the concentration of IL-27 among miscarriages women to be one of an important laboratory tests in the induction of immune response against this type of infection.Keywords: Interleukins IL-27, Toxoplasma gondii, Miscarriages women.
Effect of Physicochemical Factors on Cyanobacteria Biodiversity in Some Agricultural Soil of Al-Diwaniyah City during Spring Period Haider A. Alghanmi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The present study investigated the effect of some physicochemical factors on the biodiversity of Cyanobacteria In the agricultural soils of some areas in the city of Diwaniyah, where six areas are selected: Ghammas, Al-Shamiya, Al-Saniya, Afak, Al-Daghara, Al-sadeer with five farms per region during spring, Physical and chemical factors of the soil range between 21-23.5 °C and pH between 7.72-7.33, electrical conductivity between 233.8-3072  μs/cm, salinity between 0.268-1.730%, Nitrate between 7.46-20.0400 ppm, and phosphate between 1.340-5.260 ppm while the soil texture, the percentage of sand ranges between 12.08-15.68%, the Silt between 50.112-53.216%, and the clay between 34.208 -35.5%, the organic matter is between 3.350-6.202%, potassium 23-57ppm, calcium between 125.2-1320 ppm, magnesium between 51.46-557 ppm, and sodium between 1.3040-12.3580 ppm. Cyanobacteria species identified in this study are about 26 species. The dominant species of cyanobacteria represented by Oscillatoria sp. with percentage 50% followed by Phormidium sp.19.230%, then Chroococcus sp. and Spirulina sp. 7.692%, Finally, Gleocapsa sp., Microcoleus, sp. and Shizothrixsp. Reach to 3.864%. Some species of Cyanobacteria record in all soil areas like Oscillatoria acuta, O. Laetevirens, O. tenuis, Phormidium anomala, and P. pachydermiticum. The lowest number of Cyanobacteria is 2 in Afak and in Al-Sanyia and the highest number is 8 in Gammas. The Shannon Diversity index values of ranged between 2.350-2.685. While Simpson index Diversity values range between 0.935-0.960 in Afak and Ghamm as, respectively. The results of the statistical analysis showed significant differences and a positive, negative correlation between physicochemical factors and to the cyanobacteria numbers of some agricultural areas at p<0.05.Keywords: Cyanobacteria, Biodiversity, Soil, Physicochemical factors, Spring.
The Effect of Papain Enzyme Against Collagen Density in Keloid Tissue Culture Herman Y. L. Wihastyoko
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: Papain enzyme in Papaya sap has the ability to increase collagen degradation, thus, it can be used for the treatment of keloid. Therefore, the aim of this study was to determine the effect of this enzyme on keloid tissue. Methods: Randomized Controlled Trial Post-Test Only Design using ten human keloid tissues was applied in this research. Each of the tissue was divided into four treatment groups. The histological preparation was conducted by Masson’s trichrome staining. All of the samples were observed using a microscope. The collagen density was determined through the use of Olyvia software. The hydroxyproline level was measured by total collagen kit assay using a spectrophotometer. All the results were analyzed using a one-way ANOVA test. Result and Discussion: The mean value of collagen density in group K = 193,273+4,099; P1 = 188,765±3,598; P2 = 187,217±2,839; and P3 = 185.143±2.871. The results of statistical tests (p <0.05) on collagen density mean value showed that there is a significant difference between groups K, P1, P2, and P3. The mean value of hydroxyproline levels in group K = 268.5±69.43; P1 = 389,1±43,58; P2 = 454.8±85.81; and P3 = 559.8±167.57. The results of statistical tests (p<0.05) on hydroxyproline groups also showed a significantly difference in the groups. Conclusion: The papain enzyme can decrease the collagen density in keloid tissue culture.Keywords: Collagen density, hydroxyproline, keloid, papain enzyme
Study of Lipids Profile Levels in Patients with Hypothyroidism in Al-Muthanna Province Duaa Hamad Hamza
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The objective of this study was to investigate the changes that occurred on lipids profile levels of patients with hypothyroidism in al-muthanna province. The current study is carried out in the ‘specialized center of endocrinology and diabetes’ in Al- Muthanna province. The study included 200 individuals (100 patients with hypothyroidism and 100 controls).The patients and control divided to three groups according to ages. The ages were between (20-49) years. The results show a significant increase at(P<0.05) in ( Total cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low density lipoproteins (VLDL) levels of patients comparing with control group in all age groups .In this study concluded that hyperlipidemia is associated with hypothyroidism. These enhance the risk for development of atherosclerosis and coronary artery disease.Keywords: Hypothyroidism, Total cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, Very low density lipoproteins.
Neuropathy in Vitamin Deficiency Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Neuropathy is a disorder of the motor nerves, sensory disorders and also autonomic and tendon reflexes. The Neuropathy that occurs can be caused by systemic diseases (diabetes, hypothyroidism), drugs, infections and also vitamin deficiencies. Vitamins are organic components with a high level of potential. Vitamins themselves are classified into 2 which are air soluble and fat-soluble, for fat-soluble vitamins, there are vitamins A, D, E, K and for vitamin B complex including vitamins that are soluble in air. Vitamin B plays an important role as a co-factor or co-enzyme in various metabolic processes in the body. A continuous lack of vitamins will cause damage to the peripheral nervous system so that symptoms of neuropathy appear. Deficiency of vitamin E and vitamin B can cause damage to the nervous system and neuropathy occurs. Vitamin B which has several kinds, such as B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantonetate), B6 (pyridoxine), B7 (biotin), B9 (folate) and B12 (cobalamin) where this B vitamin has a neurotrophic function. Vitamin B cannot be produced by mammals, so we can get this vitamin through food and supplementation. Vitamins themselves function to maintain the body's physiological functions and also maintain optimal health. Keyword: Neuropathy, Vitamin, Thiamine, Cobalamin, Pyridoxine.

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