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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Assessment of IL17BR Serum Concentration in Females with benign & Malignant Breast Tumors Haider Abed Ali Alshawi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Breast cancer is one of the most dangerous and most common malignancies  among women in the world, which affects different age groups of women, IL-17 plays an important role in chronic inflammation and cancer, Serum IL-17BR concentration which useful in early diagnosis and staging of breast tumors.  The aim of the study was to evaluate of IL-17BR serum concentrations in patients with benign and malignant breast tumors and study the relation between the above parameter and breast cancer development. The study population was composed of 120 samples 24 patients with recently diagnosed breast carcinoma, 6 patients with repetitive carcinoma, 40 patients with benign breast tumor (fibroadenoma) and 50 normal apparently health woman as a control.ELISA technique was applied for estimation of IL-17BR levels in patients as well as apparently healthy volunteers of women. The results revealed the mean age of malignant breast females was 52.8 ± 12.3 (Mean ± SD), while it was 26.9 ± 8.3 years for women with benign tumor with highly significant difference (P<0.001), IL-17BR level was determined and found that was a highly significant difference in its level among benign breast females subjects (72.48 Ng/ μL) and healthy control (50.87 Ng/ μL) P< 0.001), no significant difference in the mean of sIL-17BR level among the different patients‘ groups (49.83, 64.33 Ng/ μL) for recurrent and primary breast cancer respectively. Estimation of IL-17BR level showed significant elevation of the concentration among the sera of recurrent breast cancer in comparison with other groups which perhaps regarded as a prognostic marker.Keywords: IL-17BR, Fibro adenoma, Breast cancer, Carcinoma, ELISA.
Certain Blood Lipid Profile and Immunological Alterations Accompanied Vascular Inflammation in Hypertensive Patients Lamees M. Al-Janabi
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The current study was conducted to examine certain blood biochemical and immunological changes associated with high blood pressure in hypertensive patients. Hundred blood samples were collected from normal and hypertensive people, at Al-Hussein teaching Hospital, for assessment of Fatty lipids such as total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein as well as the study of IL-1β and TNF-α genes expression levels. The results of hypertensive patients showed significant increase of T. Cholesterol , TG and LDL and significant decrease of HDL, whereas the molecular analysis revealed significant increase in the expression ranks of both IL-1ß and TNF-ɑ genes in comparison with normal people. In conclusion, hypertension could be accompanied by lipidemia and decreased immunity.Keywords: Hypertension, Lipid profile, Immunity IL-1β, TNF-α.
Evaluation of Aggressive Behaviour Management in PICU (Psychiatric Intensive Care Unit): A Focus Group Study Ah. Yusuf
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: PICU is a Psychiatric Intensive Care Unit. PICU is a service aimed at mental health clients in conditions of psychiatric crisis. PICU is a combination of psychiatric emergency services and intensive services, which can be held in psychiatric hospitals or psychiatric units in general hospitals. Purpose: This study is on evaluating aggressive problem management at PICU. Methods: This research was designed with a qualitative approach using focus group discussion. The total number of participants was 12 nurses. Data was collected using a focus group and analyzed using standard software NVIVO 12 Plus. This research was conducted from January to March 2020. Respondents consisted of Head of the room, Head of the nurses' team, Managing Nurse, and Supervisor. Results: This research was conducted to explore the experience of nurses in dealing with business class patients in commercial medical escorts. The results of this study found 3 themes, namely: rules are not systematic, injuries due to restrain are still high, nurses' competencies are not evenly distributed. Conclusion: several themes and sub-themes support nurses in treating aggressive client behavior. Besides, nurses must standardize services to improve patient and family satisfaction. Keywords: Aggressive behavior, Mental Disorder, Nurses, PICU.
Pain Assessment for Adult Patients Admitted to Coronary Care Units in Al - hilla Teaching Hospitals, Babylon – Iraq Amina Abd Al Hassan Jabur
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Pain considered as a significant problem for critically ill patients, pain assessment is essential toreach optimal level of quality of care. Nurses play a critical role in managing and alleviating acute pain amongcritically ill adult patients. Objectives: To assess the level of pain of critically ill adult patients who wereadmitted to the coronary care units in Al-hilla teaching hospitals. Methodology: A descriptive cross-sectionalstudy design selected to assess pain for critically ill patients who were admitted to coronary care units in Al-hilla teaching hospitals was conducted from October 2016 through August 2017. Non-probability (purposive)sample consisted of 92 patients selected, structured questionnaire which consist five parts were prepared inorder to collect the data. The statistical package version 22 was used to analyze the data. Results: Malepatients were predominated, the majority age group of participants were (41 to 65) years constituted 62%most of them were married with low level of education, regarding smoking habit 52% of them were smokers.High proportion of patients 83.7% had frequent bouts of pain while 35.9% were suffering from persistent pain;the most associated symptom with pain was drowsiness (77.2%). About two third of the participants preferredto use medications to control their pain, according to McGill questionnaire the mean score of pain intensity forthe study sample was severe (2.50). Conclusion: Pain still unresolved problem among adult patients admittedto the coronary care units in Al hilla teaching hospitals who recorded severe pain, which accompanied withassociated symptoms such as drowsiness. Recommendation: There is a need for focused continuouseducation and training program to important the health personnel&#39;s practice and knowledge regarding painassessment and management.Keywords: Pain Assessment, Adults Patients, Critical care units, McGill Pain Questionnaire.
Creating Srs Document with Combination of Scenario_Based Teqniques and web_Based Teqniques Azita Soltanian Bojnord
Journal of Global Pharma Technology Volume 08 Issue 02
Publisher : Journal of Global Pharma Technology

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Abstract

Requirements and user interface specifications are often elicited and specified separately, in most cases.The errors in requirements gathering and software specification phases lead to project failure and costlymistakes during software development. Likewise a bad user interface lessens the quality of software.WEBSTEUIR is a support tool to help the developers and users in user interface requirement elicitationand specification. The approach used in WEBSTEUIR is to elicit user interface requirements from UMLinteraction diagrams in order to generate SRS which include user interface requirements and have to bewell understood and well presented to the developers and end-users and also provide easy way to extractmain functionalities, features, and user interface of the software. Description of our approach to softwareuser interface requirements specification and an overview of WEBSTEUIR's design concepts are presentedin the paper, together with examples of the tool's use, a comparison with related work and pointers tofuture.
Production of Pickled Mustard Greens (Brassica Juncea) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Mustard greens are fresh during the harvesting season but perishable under the prevailing conditions of temperature and humidity as well as lack of adequate storage facilities. An alternative way of preserving surplus mustard greens could be fermented to pickle products. Preservation of the mustard green by fermentation can eliminate the undesired taste and improve flavor of the vegetable. Therefore we explored a lactic fermentation from mustard greens by focusing on the effect of different parameters such as blanching time and temperature as pre-treatment, salt concentration, fermentation time to physicochemical, microbial and sensory characteristics of pickled mustard greens. Experimental results revealed that blanching raw mustard green in water heated at 95oC in 10 seconds, 6% salt in 12 days of fermentation was appropriated to get a pleasant pickled mustard greens quality. Mustard greens pickles are considered as one of the health supplements.Keywords: Mustard greens, Lactic fermentation, Salt, blanching, Physicochemical, Microbial, Sensory.
Can Maternal Age at Menopause Predict Daughters Antimullerian Hormone in Babylon? Hanan Abduljabbar Al-Taee
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: daughter fertility potential is possibly related to her mother fertility and age at menopause. This study aims to determine any relationship between maternal age at natural menopause with anti mullerian hormone of mid reproductive age daughters. Design: questionnaire survey and blood sample of women attending gynecology clinic in Babylon\ Iraq from June 2014 - July 2018 .Subjects and Methods: this cross sectional study, collected questionnaire data from 106 (N=106) mother daughter pairs who fulfilled the study inclusion criteria out of a random population. For this analysis, young women (daughters) between the ages of 16 and 35 years, who provided a blood sample for anti mullerian hormone and their mother’s age at natural menopause were selected. Assessment of relationship between maternal age at menopause and their counterpart daughter anti mullerian hormone was done. Result: Person correlation for association of mother age at natural menopause with daughter anti mullerian hormone shows insignificant association. Conclusion: our selected mother-daughter pairs show no association between maternal age at natural menopause and serum anti mullerian hormone level.Keywords: Maternal menopause, Anti mullerian hormone (AMH), Fertility, Mid reproductive age women.
Survey about Shape Detection Ahmed Brisam
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

The simplifying original shoreline of vector data into direction-line is the source of picture of baselines of the shape detection. Applying standard algorithms of vector data confining, such as the Douglas-Peucker algorithm, to analyze the real shoreline within direction-line, disregards the specific elements of a guarantee of general marine interests .To solve this problem, this research suggested an improved Douglas-Peucker algorithm. First, determine the curved vertices of the original shoreline as a choice set of points; later filter division points from curved vertices based on corner and length; ultimately, separate the data into different parts in order to complete the Douglas-Peucker algorithm, and compare the threshold of each part to efficiently select specialty points and protect shape detection. This research uses Python language to carry out the algorithm design, and openCV2. The results show that, compared with the Douglas-Peucker algorithm, the improved Douglas-Peucker algorithm improves how detect the contours, and shape detection, and the accuracy of curve simplification also fixed.
Study Electronic Properties of Adsorption of CO and H2S Gas Molecules on the Surface of Fullerene and Heterofulleren as a Gas Sensor for Environmental Protection of Organic and Pharmaceutical Material Hussam Shoab Mohmmed
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of this research paper is to study two properties of fullerene molecules.The first are electronic properties of heterofullerene C58Cl2 using Density Functional Theory (DFT). The geometrical structures, electronic properties, of the doped of fullerene molecules were studied systematically and compared with the pristine fullerene C60. A series of dodecahedral functionalized derivatives have been studied at the functional B3LYP and basis set 6- 31G (dip) level of density functional theory (DFT). The relative and formation energies of compounds, occupancy, the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), the (LUMO -HOMO) energy gap (Egap) were calculated. The adsorption behavior of the CO and H2S on the surface of Fullerene is studied by DFT. The chemical potential or Fermi energy for Fullerene (C58Cl2) and gas molecules have been systematically explored. The adsorption energy values of gas molecule are short. So, the sensor will possess short recovery times. Our results indicate that larger values of EHOMO for adsorption CO and H2S fullerene C60 at site (a) is (-6.234 and -6.163 ) eV, show that a propensity of the molecule to donate electrons and smaller value ELUMO for fullerene C60  at site (a) is (-3.365 and -3.295) eV, these values show that a propensity of the molecule to accepter electrons and smaller values of Eads of C58Cl2 at site (b) is (-0.465 and -0.463) these values show that a propensity of the molecule used as a sensor.Keywords: Fullerene, Gas adsorption, density functional theory, HOMO and LUMO.
The Implementation of Controlling in Nursing Care Management Regarding Ventilator-Associated Pneumonia Bundles on Post Heart Surgery Patient in Intensive Care Unit Nursalam .
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Control in the nursing care management for Ventilator-Associated Pneumonia (VAP) bundles of post-cardiac surgery patients is related to using predetermined standards and actions taken to correct mismatches between standards and actual performance. The purpose of this study was to apply the identification of controls in the nursing care unit to the VAP collection in the intensive care unit. Design research using quasi-experiments before and after with the control group. The population in this study was nurses invited to pediatric Intensive Care Unit (ICU). The number of samples was 32 people, divided into two groups consisting of intervention and control, taken by purposive sampling technique and General Linear Model Repeat Measure (GLM-RM) analysis method.  The results of this study were analyzed by the dependent t-test. Dependent t-test results obtained in the average VAP bundle before the intervention were 3.3462 and after the intervention were 3.8362 with an average change of 0.41707 andp-value (0,000) < (0.05).The application of controls in the nursing care management to the VAP bundle in accordance with the Standard Operational Procedure (SOP) emphasizes better accountability in providing nursing care to patients who are fitted with work safety and improves the actual performance of officers. Implement the control of a part of a continuous improvement strategy in quality control of special health services in relation to pneumatic infections installed in mechanical facilities in the Intensive Care Unit.Keywords: Controlling, Nursing Care Management, VAP Bundles

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