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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Evaluation of CD4 and CD8 in Patients Infected with Genital Wart Caused by Human Papilloma Virus in Babylon Province/Iraq Nisreen Kaddim Radi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Genital warts it’s a skin projection due to human papilloma virus infection (HPV) .Thirty skin lesion and sera were collected from patient (females) infected with genital warts that visit dermatological department of medical Moran city. Twenty sera was collected from healthy person used as control group.  The diagnosis of viral infectionwas achieved by dermatologist (specialist) and by using IgG anti HPV ELISA kit to detect papilloma virus in human serum, and ELISA testwas used to evaluate the level of CD4 and CD8 at patient with genital warts. The result demonstrates that:- 99% of samples dedicate positive for IgG anti HPV. Immunological study revealed that  :- decrease the ratio of CD4/CD8 at patient with genital wart( ratioCD4/CD8:-0.1), decrease in CD4 level at patient infected with genital warts compared with control group .CD8 increased at patient with genital warts compared with control group. There is significant differences between patient and control group, p value ≤ 0 .05.Keywords: HPV, Genital wart, CD4, CD8, Koliocyte.
The Effect of a Variety of Anaerobic Exercises on the Ability and Anaerobic Capacity and Rapid Individual Attack of Young Players in Handball Reza Talib Hilail
Journal of Global Pharma Technology .
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Abstract

The importance of research lies in the preparation of a variety of anaerobic exercises and their impact on anaerobic ability and capacity that directly participate in the performance of the individual handball rapid attack of young players. The problem of research: focused on the lack of use of trainers for the various anaerobic exercises based on the overlap in energy production systems, there is a weakness in the use of anaerobic exercises.It is necessary to study the effect of the various anaerobic exercises on the basis of the proper scientific connection between science and science. And training in order to achieve the desired objectives of the training process.The objective of the research is to:Preparing a variety of anaerobic exercises in handball.To recognize the effect of the various anaerobic exercises on the anaerobic ability and capacity and individual quick attack of young players in handball.The research hypotheses included the following:The various anaerobic exercises have an impact on the anaerobic ability and capacity and individual quick attack of young players in handball.There is a preference for influencing the various anaerobic exercises in the anaerobic ability and capacity and individual rapid attack of young players in handball between the experimental and control groups in the posttest tests and for the benefit of the experimental group.As for the research methodology and field procedures:The researchers used the experimental method to solve the research problem. The research community was identified by 16 young Kufa youth handball players and they were divided into two groups (experimental and control) equally by random method (drawing method). After preparing the training curriculum the pilot group underwent training on the use of a variety of anaerobic exercises, while the control group used the usual training method for the trainer. After eight weeks, the tests were carried out. And then the data using appropriate statistical methods address.As for the most important conclusions and recommendations, the most important conclusions were the following:Various anaerobic exercises have helped to develop anaerobic capacity.The various anaerobic exercises have helped to develop anaerobic capacity.The development of anaerobic capacity and anaerobic capacity has been positively reflected on the development of individual rapid handball attack.Keywords: Anaerobic exercises, Ability, Anaerobic capacity, Rapid individual and handball.
Effectiveness of Drying Methods to Callisia Fragrans Tea Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Herbal tea is a polyherbal formulation of different medicinal plants that is a rich source of antioxidant. Tea manufacturing processes can greatly affect the oxidation of tea polyphenols. Callisia fragrans is an herbaceous plant with small white fragrant flowers and waxy leaves. Its leaves are used for treatment of different skin diseases, burns and join disorders owing to its biologically active flavonoids, neutral glycol and phospholipids and fatty-acid. In order to better utilization of Callisia fragrans was functional herbal tea, the effect of different drying methods such as sun drying, microwave drying and oven drying to the total phenolic, total flavonoid and antioxidant capacity was investigated. Results revealed that microwave drying was the best option to stabilize the valuable components in this plant during drying.Keywords: Callisia fragrans, Total phenolic, Total flavonoid, Antioxidant, Drying, Herbal.
Anti-Tuberculosis Therapy: International, State, and Regional Pharmaceutical Care Policy Egor Vadimovich Grebenev
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

Today, pulmonary tuberculosis is a disease, which potentially threatens the whole humanity. Therefore, prompt actions should be taken. Tuberculosis is still the main threat to the global community. In this article, we investigated anti-tuberculosis therapy in an international, state and regional perspective. We have studied the use of combined therapy in treating tuberculosis patients. Thus, combining several anti-tuberculosis drugs in chemotherapy is deemed effective nowadays. We evaluated the drug supply for tuberculosis patients in regions and found out that patients have to take medicines constantly at all stages of anti-tuberculosis therapy. When analyzing the outcomes of cases of treatment of patients with tuberculosis and methods of increasing its effectiveness, we showed that insufficient adherence to treatment, as well as its insufficient control, provide almost half (44.6%) of unfavorable outcomes. Thus, it is necessary to develop methods and methods to motivate patients to comply with the recommendations of doctors. Keywords: Tuberculosis, Tuberculosis infection, Tuberculosis morbidity, TB services, Primary course of chemotherapy.
Evaluation of Risk Factors affects Length of Hospitalization in Patients with Transient Ischemic Attack or Ischemic Stroke Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Introduction: Cerebral artery diseases are the most prevalent neural disorder leading to serious diseases and death. Stroke is the third cause of death in the U.S. and is the most prevalent neurological disabling disease. This study aims to evaluate the influential factors of the duration of hospital stay in transient ischemic attack (TIA) or ischemic stroke   patients. Method of study This is re retrospective study. The population of study consists of all patients diagnosed as TIA or ischemic stroke who admitted in the neurology department of Urmia Imam Khomeini hospital from August, 2014 to August 2015. Data was collected from the cases’ records and analyzed using SPSS 22.\0 results A total number of 349 TIA and ischemic stroke cases was included in the study of whom, 322 (95.1%) and 17 (4.9%) cases were diagnosed and studied as ischemic stroke and TIA cases, respectively. In 258 cases (73.9%), the involved area was anterior circulation while in 91 cases (26.1%), it was posterior circulation. Considering relevant risk factors, hypertension with 212 cases (60.7%) was the most frequent risk factor followed by past medical history of stroke in 115 cases (33%), congestive heart failure in 113 cases (32.4%), diabetes mellitus in 86 cases (24.4%) and smoking in 72 cases (20.6%), respectively. Conclusion: According to our results, AF rhythm and anterior circulation involvement apparently affects the duration of hospital stay and increases it. This agrees with medicinal literature where AF has been introduced as a risk factor for cerebral embolic diseases and can be considered as a cause of TIA or ischemic stroke.  Keywords: Duration of hospital stay, Ischemic brain stroke, TIA.
Gene Polymorphism of Vitamin D Receptor (VDR) in Iraqi Population Khulood K. Hasan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Vitamin D receptor (VDR) gene has several variants.The distribution of these polymorphisms may vary among different ethnic groups therefore in this paper; we seek to determine population frequencies of selected VDR polymorphisms (FokI rs2228570 and TaqI rs731236) in the healthy Iraqi population. Genotyping for two VDR single nucleotide polymorphism were performed for a total of sixty healthy individuals using Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP). For FokI polymorphism, genotypes frequencies were 70%, 26.6% and 3.3% for FF, Ff and ff respectively and 50%, 45 % and 5% for TT, Tt and tt genotype for TaqI polymorphism respectively. As for the Allelic frequencies, the readings were 83.3 % opposed to 16.6 % for F and f alleles and 72.5 % opposed to 27.5 % for T and t alleles. In addition, the pattern regarding distribution of FokI and TaqI genotypes and alleles in the Iraqi Arab population was different from other ethnic groups. VDR polymorphisms data distribution among the healthy population in this work can be capitalized to investigate possible associations of VDR gene with different diseases. Further, anthropological comparisons can be attained using the same data set.Keywords: Vitamin D receptor, VDR polymorphism, VDR SNPs.
Effect of Prebiotic Plus Xylanase Enzymes in Reduced-Energy High Wheat Midd Diets on Broilers Subjected to Bursa Vaccine and Clostridium Perfringens Challenge under Heat Stress Y. J. Jameel
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

This study was designed to evaluate the effect of chronic heat stress (CHS) and pathogen challenge on broilers fed reduced energy, high wheat Midd (WM) diets with or without a mixture of yeast cell wall (YCW) and xylanase enzyme (XE) on performance, carcass fat percentage and the evaluation of diet and meat cost. Two hundred forty (1- day old) chicks (Ross 308) were distributed within 2 Petersime battery brooder units (48 pens: 5 birds per pen). For this experiment, treatments were assigned as an incomplete randomized block design with 6 treatments arranged as a factorial 3 × 2 with 3 levels of energy (3000, 2900, and 2800) and 2 treatments with or without supplementing mixture of (YCW 250 ppm plus XE 25/mg per ton) were used. Chronic heat stress CHS was induced by setting the HVAC system at 36± 2ºC from day one until the end of the study (day 24). Birds were vaccinated with a commercial IBD vaccine via eye drop at 10 days of age, followed by Clostridium perfringens challenge on day 16 and 17 of the study by 3/mL oral gavages 106 cfu/ml. Results revealed that the body weight (BW), body weight gain (BW gain), Productivity Index (PI), and feed conversion ratio (FCR) of chicks fed low energy (2800 Kcal with YCW and XE; PVL) then (2900 Kcal with YCW and XE; PL) respectively, were improved numerically but not significantly (P˃0.05) at days 10, 16, 21, and 24 as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE. Also, no significant differences were found by dual energy X-ray absorptiometry (DEXA scan) among the treated groups, but % fat of birds fed low energy (2800 Kcal plus YCW and XE; PVL) were decreased (P˃0.05) as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE). However, average cost of the feed and meat were lower of treatment administration diet have 2800, and 2900 Kcal as compared with 3000 Kcal diets. In conclusion, reduced energy diets did not affect under HS may be low energy decrease heat increment. Chicks fed low energy with or without YCW and XE led to enhance performance and lower carcass fatpercentage. In addition, low energy diet led to lower the cost of diets and meat. Keywords: Broiler, performance, reduced energy, heat stress, xylanase, prebiotics.
Epidemiological Study of Toxoplasmosis in Patients with Renal Failure form Kirkuk City /Iraq Sadia Shahab Hamad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The present study was aimed to estimate Toxoplasma gondii occurrence among immunocompromised patients Renal Failure (RF) patients in Kirkuk city / Iraq. A total of 71 sera were drown from renal failure patients attending to dialysis unit of Kirkuk general Hospital and 48 individuals having a normal immune system as healthy control. The serological were tested for toxoplasma antibodies using four types of test. Result of Latex Agglutination Test indicated that out of 71 sera examined 41(57.7%) were positive and 22(45.8%) for control group, without significant differences between them.                                                     The overall rate of Toxoplasmosis in (RF) patients using Modified Latex Agglutination Test (2-ME) was 25(35.21%), 12(25%) for patients & control group respectively, the differences between them was statistically significant. While Rapid test-Cassette showed 14(19.72%), 0(0%) for IgG, IgM for patients group comparing with control group 5(10.4%), 0(0%), for IgG, IgM respectively with significant differences. Using ELISA test (30.9%), (16.6%) of the sera were seropositive for anti- toxoplasma antibodies IgG while (2.82%), (6.25%)  for patients & control group sera were positive for anti- toxoplasma antibodies IgM moreover common infection was1(1.41%), 3(6.25%).Relationship between toxoplasma antibody distribution with patient age was significant  and the high rate was (75%), (25%) in the age group 71-81 year for IgG, IgM respectively .The infection rate in female was higher than those in male (40.63%), (23.08%),(3.1%),(2.56%) for female &male in  IgG, IgM respectively without significant.           Considered patients residency acute & chronic infection were higher recorder among patients from urban area and the rate was (36.3%),(26.3%) than rural area patients (6%),(0%) without significant, and the results of non-officer showed higher rate than officer by (33.8%),(3.08%)  for IgG, IgM with statistically significant differences.Keyword:    Toxoplasma Gondii, Renal Failure Patients,
Ferrimagnetism in the Mean-field Approximation of a Mixed Spin Ising Nanowire System Hadey K. Mohamad
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

A ferrimagnetic mixed spin square Blume-Capel Ising nanowire system consists of spin-1 core and spin-3/2 outer shell has been investigated. The general formula for the temperature dependence of the equilibrium magnetization of the system is presented. The ferrimagnetic core-shell nanosystem shows a compensation point when the exchange interactions are changed at various values of the single-ion anisotropies of shell sublattices and core ones, respectively. So, one can examine interesting phenomena are compensation behaviors and the free energy of the nanosystem, where these phenomena found that the mixed-spin square Blume-Capel Ising nanosystem which is being considered has two spin compensation temperatures in the range of ,  when , for two different values of core anisotropy for sublattices of atoms A, , and , respectively.
EPSTEIN BARR VIRUS AND CYTOMEGALOVIRUS CORRELATION WITH ORAL SQUAMOUS CELL CARCINOMA PATIENTS BY USING IN SITU HYBRIDIZATION METHOD IN THE CITY OF BAGHDAD. Zaid A Saeed; Noor Al-Huda Ali A.H. Saeed; Samar Abdul Raheem Al-Gharrawi
Journal of Global Pharma Technology .
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Abstract

Worldwide, the most prevalent cancer related deaths, poses one of the most risk cancers globally in many countries, is the oral cancer. There are some important factors associated with many human cancers, for example viral agents, which are involved in the spread of tumors, including the Oral Squamous Cell Carcinoma.So, this study was resolved to determine the relationship between Epstein Barr Virus and Cytomegalovirus with some Iraqi patients who suffer from Oral Squamous Cell Carcinoma by using In Situ Hybridization Technique, related to their age, gender, site distribution, histological grade and the tumor stage.According to sixty OSCC biopsies randomly collected during the period between July 2015 and September 2016, EBV was detected in (71.6 %) 43 out of 60 patients, whereas CMV was detected in (36.6 %) 22 out of 60 patients, the mean age was 38 years old and ranged between ( 27-72) years old, male to female ratio was (1.3 : 1) with 34 men and 26 women, most of the cases were tongue SCC 39, followed by gingiva 13 and 8 were at the floor of the mouth. Histological grades involved were 37 well differentiated, 5 were moderately differentiated and 18 were poorly differentiated. Staging of the tumor included 43 patients who fell in stage I and II, while the rest 17 patients fell in stage III and IV. Regarding to the positive results, EBV correlates in highly significant association with each of (age, gender, grading, tumor stage and site distribution at p<0.01), also CMV correlates with each aspect mentioned above in highly significant association at p<0.05. 

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