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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Auto-antibodies Profile in Children Infected with Visceral Leishmaniasis Entsar Jabbar Saheb
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Visceral leishmaniasis (VL) is a parasitic infection caused by an intracellular growth of Leishmania spp. in macrophage cells. The autoimmune disorder is a condition takes place when the immune system produces antibodies which incorrectly attacked its own body tissues. VL has been involved as an effect or on the autoimmune aspect. This study was conducted to identify the auto antibodies profile in patients infected with VL.  The presences of auto antibodies in 21 Iraqi children infected with VL were tested for laboratory autoimmune aspect. The highest percentage of seropositive in Leishmania patients was observed for anti-ds DNA, anti-Mi-2, anti-Ku and anti-PCNA antibodies (90.5%, 90.5% , 90.5% and 61.9%) respectively, while the lowest percentage was recorded for anti-Histone, anti-R0(RPP), anti-SS-A/Ro 52, anti-Scl 70, anti-Jo-1 antibodies (4.8%) while the auto antibodies (anti-SmD1, anti-SS-A/Ro-60, anti-SS-B/La, anti-CENP, anti-U1snRNP, anti-AMA M2, anti-PM/Scl) showed different profiles in Leishmania patients. These results provide evidence that VL can have an effective role in the production of the auto antibodies.Keywords: Children, Leishmania spp, Visceral leishmaniasis, Auto antibodies.
Measurement of Pollution with Heavy Metals in Water and Sediment Dalmage Lake-Middle of Iraq Esraa A. Elewi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The current study aims at determining the quality of the water and the sediments of the Dalmage Lake in terms of pollution. Where some physical characteristics and concentrations of some heavy elements were measured by three different stations from Dalmage Lake which is located in middle of Iraq between Qadisiyah and Al-Kut provinces, from September 2017 to January 2018 . The studied properties included temperature, pH, electrical conductivity and measurement of concentrations of heavy metals (cadmium, lead, copper, cobalt and iron) in the water and sediments of the Dalmage Lake. The results of the study showed that the temperature of the air is compatible with the temperature of water in all stations of the study where the temperature of air between (18 - 35.3)0c and water temperature (12-25)0c. The electric conductivity was recorded between (9.89 - 16.81) ms/cm and the pH values ranged from (7, 72 - 8, 16). As for the concentrations of heavy elements in the water of Dalmage Lake, the study showed that the cadmium concentration ranged between (0.034 - 0.082), lead (0,041 - 0,753), copper (0.039-0,354) Cobalt (0.050 - 0.189) and iron (0.405 - 0.490) mg / L. While in the sediment of Dalmage Lake the pH values (7, 41 - 8, 09) were the electrical conductivity (12.97 - 17.13) ms/cm and the concentrations of heavy metals were recorded for cadmium (0,093-0,010), lead (1,202 - 1,708), copper (0,180 -), Cobalt (0.157-0.521) and Iron (35,170 - 115,971) mg/L. The study showed that the water of Dalmage Lake has a basic character. This corresponds to the Iraqi water which is characterized by basal quality. The electrical conductivity is high because the water of the lake is sality, and the study showed an increase in concentration of heavy elements, this means that the lake is polluted by its because of incompatibility with values of WHO and local standards .Keywords: Pollution, Dalmage Lake, Heavy Metals, Sediment.
Evaluate Toxic Effect of Bisphenol A on Kidney of Male Mice and Mitigation Its Effect by Green Tea Extract Aamer. M. Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Bisphenol A is a substance for the synthesis variety of plastics, primarily epoxy resins and polycarbonates. Bisphenol can have severe effects on the type and might contribute to gradual cumulative renal injury over a lifetime. This study object to estimate toxic effect of bisphenol A on type of male mice also mitigation toxic effect of bisphenol A by using extract green tea. Healthy adult male albino laboratory mice (Mus musculus) treated for two doses of bisphenol a (20 mg/kg and 40 mg/kg body weight per day) for thirty days and green tea extract was co-administration orally as antioxidant. Bio-chemical parameter of serum creatinine and blood urea was calculated as indicator of kidney function. groups treated with bisphenol A showed increased in serum creatinine and blood urea also histopathological of kidney showed significant damage in groups that treated with bisphenol A whereas groups that treated with bisphenol A and co-administration  green tea extract showed mitigation toxic effect of bisphenol  A due to role of green tea as anti-oxidant compound.Keywords:  Evaluate, Bisphenol A, Green Tea, Antioxidant compound.
Synthesis, Physiochemical and Thermal Study of Some Transition Metal Complexes with Chelating Ligand and Study their Theoretical Treatments Israa H. Ibraheem
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Complexes of Cr+3, Ni+2 and Cu+2 with the ligand 2-(p- nitrobenzoyl) thiobenzimidazol) (L) were prepared and characterized by FT-IR  ,UV-Visible, TG analysis ,Atomic absorption spectroscopy , Molar conductivity and magnetic moments measurements .The general formula has been suggested for all the prepared complexes [Cr(L)2Cl2]Cl.4H2O, [Ni(L)2(H2O)2]Cl2.2H2O and [Cu(L)2(H2O)2]Cl2.2C2H5OH to be an octahedral geometry. A theoretical treatment of these compounds in gas phase was done using HyperChem.8.7 program. Semi –empirical PM3 method was performed to evaluate the ∆H° ƒ, ∆ Eb and ∆ET for all compounds, also vibration frequencies, electronic spectra and electrostatic potential HOMO and LUMO energies for the ligand was estimated to determine the reactive position for this ligand .Keywords: Physiochemical study, Transition metal ion, octahedral structure, Theoretical study.
THE INHALATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND ITS PHARMACEUTICAL STUDIES C Kumaresan
Journal of Global Pharma Technology Volume 08 Issue 09: (2016) September 2016
Publisher : Journal of Global Pharma Technology

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Abstract

The aerosols such as gas borne suspension of solid or liquid particles are used for therapeutic applications of lung and other systemic diseases. These inhaled pharmaceutical aerosols deliver drug (active pharmaceutical ingredient) to the alveolar region to the blood in the capillaries. The injectable drugs are significantly administered by inhalation. There are so many drug delivery systems of inhaled pharmaceuticals are available. The metered dose inhaler, dry powder inhaler and nebulizers drug delivery systems are most famous. The development of suitable drug delivery system of inhaled pharmaceuticals for new drugs is very simple at this modern times technology. This review deals about inhaled pharmaceutical aerosols and its studies including particle size and adhesive forces of aerosol particles.Keywords: Dry powder inhaler, pharmaceutical inhalation, drug delivery, lung
Synthesis and Characterization of Some New Oxazol, Thiozol, Oxazolidinone Derivatives from Quinazoline Nagham Majid Abdulhassan
Journal of Global Pharma Technology .
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Abstract

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2, 3-disubstituted-4(3H) quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, cyclization with ethyl chloro acetate and 4-phenyl-phenacyl bromid moiety afforded final compounds. The structures of compounds were confirmed by F IR, 1HNMR and.Keywords: Anthranilic acid, 4(3H)-Quinazolinone, Synthesis.
Synthesis, Spectroscopic Characterization, and Biological Evaluation of Some Transition Metal Complexes from C16H19N3O3S Ligand Sura K. Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A first series of transition metal complexes were synthesized from the ligand Methyl -6- [2-(benzyl ideneamino) -2- (4-hydroxyphenyl) acetamido]-2, 2-dimethyl -5-oxo-1-thia 4-azabicyclo [3.2.0] heptane-3-carboxylate with appropriative metal salts. The complexes were characterized by spectral methods such as FTIR, Uv-Visible, and Atomic absorption as well as some physical properties, molar conductivity and magnetic moment measurements. The results showed that the proposed structures of these complexes are Octahedral, except Co II is a tetrahedral geometry. The biological activities of these complexes were studied using two types of bacteria (Staphylococcus aures, Echerchia coli) in addition to Candical albicans c. albicans that gave results a good activity than the free ligand.
Teenager’s Thought is Related to Self-Control in Safe Smartphone Use During the Covid-19 Pandemic Rizki Fitryasari; Rr Dian Tristiana; Ah Yusuf
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: The use of smartphones in the Covid-19 pandemic era is an inevitable phenomenon, including for teenager who participated in online learning. The inability to control themselves independently in using smartphone-based devices is a risk factor for gadget addiction. This study aimed to analyze the relationship between teenagers' thoughts and self-control in safe smartphone use in the Covid-19 pandemic era. Methods: This study was a descriptive correlation design based on a cross-sectional approach. The population was teenagers aged 11-18 years in Surabaya, Indonesia who had participated in online learning during the Covid-19 pandemic. The purposive sampling was conducted and gained 185 respondents. The study variables were teenagers' thoughts and self-control in using smartphones. The instrument used was a questionnaire and the data were analyzed using the Spearmen Rank test. Results: The statistical test results showed that a good thought of teenagers was related to high self-control in using a smartphone (p = 0.000, r =0.371). Conclusion: The teenager’s thought in smartphone usage was formed based on benefits, barrier, beliefs, and the consequences of online learning activities. The teenagers’ awareness will lead to a good self-control for limiting the smartphones usage independently. Further research should be focused on the development of a safe smartphone usage guidance that can assist teens to be able to use the smartphone safely.
Investigating the Relationship between Organizational Memory and Management of Organizational Conflicts in Chaharmahal and Bakhtiari Social Security Staff Meisam Jamalzadeh
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Human resources, the most important and valuable factor, are from different sources of organization and conflict is a phenomenon that has positive and negative effects on the performance of individuals and organizations. The ability to deal with the conflict and its management is of a great importance to the success of the managers of the organizations. Therefore, the purpose of this study is to investigate the relationship between organizational memory and management of organizational conflicts among Chaharmahal and Bakhtiari social security staff. The research method is descriptive and survey method. The statistical population of this research includes all employees of Chaharmahal and Bakhtiari social security and the sample is 150 with Cochran formula. For measuring the variables, a researcher-made organizational memory questionnaire and Stefan Robbins organizational conflict management questionnaire were used. The reliability of the questionnaires was calculated using Cronbach's alpha method and validity of the questionnaire is confirmed by content method. Pearson correlation coefficient was used to analyze the data using SPSS 19 software. The results showed that there is a significant positive correlation between 5 components of organizational memory (personal skills, mental models, organization structure, data retrieval and information recording) and management of organizational conflicts among Chaharmahal and Bakhtiari social security staffs.Keywords: Organizational memory, Management of organizational conflicts, Social security organization.
The Role of In-service Training Courses to Improve the Effectiveness of Human Resources in Anticipation of Zabol University of Medical Sciences Mohammad Ghasemi
Journal of Global Pharma Technology .
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Abstract

Nowadays, increasing the efficiency of organizations depends upon the enhancement of efficiency of human resources. Eenhancing the efficiency of human resources in order to do things successfully, also depends on training, expansion of knowledge and skill as well as developing desirable behaviors. This study aimed at investigating the impact of training programs of development plan and promotion on the improvement of employees’ effectiveness. Participant s of the study includes 550 of the personnel of Zabol University of Medical Sciences. A researcher-made questionnaire was used as the research instrument which was designed based on Likert model. It is to be mentioned that the validity of the questionnaire was confirmed by expert supervisors and reliability was examined and approved through applying Cronbach alfa. Data analysis was done through applying SPSS, Kolmogorov-Smirnov, Pearson simple and multiple regression along with descriptive methods to test research variables. The results of the study indicated that training programs of development plan and promotion have significant impact on the improvement of employees’ effectiveness and its components such as job identifying, responsibility, management ability, and improvement of mutual relations.Keywords:  Effectiveness, Job identifying, Employees’ responsibility, Management ability, Improvement of mutual relations.

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