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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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A Review of the Literature: The Situation of Continuing Nursing Education in Iran Mohsen Shahriari
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

Background:  Continuing nursing education is one of the ways of improving the quality of patient care. So, the evaluation of these programs will be very important.  The present study has been designed and implemented with the aim of investigating the situation of continuing nursing education in Iran. Materials and methods: This study was a narrative review in a matrix approach that has been done by studying 16 articles in English and Persian. The search was performed in SID, IRANMEDEX, PUBMED, PREQUEST, CINHAL and Google Scholar data bases. Articles’ screening was performed in 4 stages. Results: In 3 areas of needs’ assessment and planning, implementation of continuing education plans and overall evaluation of programs, these studies evaluated their research environments. Most studies estimated general continuing nursing education in moderate level. Conclusions: Making changes in three areas of planning, implementation and evaluation with the participation of nurses seems to be necessary. Keywords: Continuing Education, Nurses, Review Study, Iran
Different Ferroxidases Activities in Sera and Saliva of Iraqi Patients with β-thalassemia Major Muhtada Ali
Journal of Global Pharma Technology .
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Abstract

Background and aim: β-thalassemia is the most common recessive hemoglobin disease, caused by defective in normal hemoglobin β-globin chain production. It results in large number of red blood cells being destroyed, which leads to anemia. We conducted this study to investigate the different ferroxidases activities in sera and saliva samples of these patients. Materials and methods: Serum and saliva specimens were collected from 91 males, 51 of them were β-thalassemia major patients, aged 11 to 26 years (mean= 15.28 ± 4.45 years) and 40 of them were age and gender-matched healthy controls. Results: The obtained results were as follows: in sera samples the activity and the specific activity of: total ferroxidase, and non-ceruloplasmin ferroxidase, were highly significantly decreased (P<0.001), with a significant increase in the activity and specific activity of ceruloplasmin ferroxidase (p<0.05) were found in the patients compared with the control. Meantime the results in saliva of the patients group, showed a none-significant increase (p>0.05) in the activity of non-ceruloplasmin ferroxidase and the specific activity of total ferroxidase in comparison with that of the control group, this was accompanied with none significant increase in ceruloplasmin activity and specific activity (p>0.05). Conclusion: According to our results, it can be suggested that the reduction in ferroxidase activities other than ceruloplasmin ones contributes in the oxidative stress that was measured previously in β-thalassemia patients. Furthermore, saliva cannot be served as an alternative diagnostic fluid for this disease instead of serum as far as the present study measured parameters are concerned.Key words: Ferroxidase, Thalassemia, Deferasirox, Ceruloplasmin.
Preparation and Characterization of (PMMA-PVC-MWCNTs) Nanocomposite for EMI Shielding Application Hatam Mohsin Shareef
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The (PVC-PMMA-MWCNTs) nanocomposites have prepared by Solution cast technique with different concentrations of CNTs (0, 0.5, 1, 1.5, 2, 2.5), casted in a clean glass plate. The structures of nanocomposites have been studied. The structural properties include Fourier Transform infrared spectroscopy (FTIR), scanning electron microscope (SEM). The effect of  radar in the range (8-12) GHZ  on (PVC-PMMA-MWCNTs) nanocomposite films, were studied as applications for shielding from Electromagnetic Interference (EMI), and has been noticed that the shielding effectiveness increases with the increase of concentration of MWCNTs.Keywords: Blend polymer, Cast method, MWCNTs, PMMA, PVC.
In Vitro Evaluation of Antibacterial Activity from Nephelium lappaceum L. Leaf Ethanolic Extract and Fraction against Some Foodborne Pathogens Imam Adi Wicaksono; Raden Bayu Indradi; Danni Ramdhani; Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Fooborne pathogens are causing foodborne illness with significant effects on human health. Some of the most common foodborne bacteria that cause foodborne illness are Bacillus cereus and Shigella dysenteriae. Nephelium lappaceum L. is known to have antibacterial potential because of these plants have secondary metabolites such as flavonoid and polyphenols. The ethanolic extract and fractions of Nephelium lappaceum L. was investigated for antibacterial activities including determine of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against foodborne pathogens. The extraction of N. lappaceum L. was done by maceration method with 70% ethanol and fractionationed by liquid-liquid extraction to obtain ethyl acetate, water, and n-hexane fractions. Secondary metabolite content and profile determination of N. lappaceum L. was done by phytochemical screening and thin layer chromatography. The antibacterial activities were determined using the agar diffusion method, MIC and MBC value determined by dilution method using the test tube. The results showed that the ethanolic extract, ethyl acetate fraction and water fraction of N. lappaceum L. had antibacterial activity against Bacillus cereus isolate and Shigella dysenteriae bacteria. The value of MIC and MBC of the extract in the concentration range between 0.08%(w/v) – 0.15%(w/v) against B. cereus isolate and 2.5%(w/v) – 5%(w/v) against S. dysenteriae, which the ethyl acetate fraction in concentration range between 0.04%(w/v) - 0.08%(w/v) against B. cereus isolate and 1.25%(w/v) – 2.50%(w/v) against S. dysenteriae bacteria. The ethyl acetate fraction is the most active fraction because it had the best activity, MIC and MBC values when compared to the results against both of test bacteria.
Cytotoxic Activity of 2- iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) Acetate from Sterculia Quadrifida R.Br Ethyl Acetate Fraction Rollando Rollando
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Faloak (Sterculia quadrifida R.Br) was used empirically as a traditional medicinal plant. The information of the active compounds contained in the faloak bark was not specifically published. This study aims to determine the active compounds contained in the fraction of ethyl acetate of faloak bark which has cytotoxic effect on breast cancer cell type T47D. Extraction method use maceration, isolation compound using gradient isolation method, structural elucidation using information from IR, H-NMR, C-NMR and LC-MS. Cytotoxic activity test on breast cancer cell line T47D using MTT method. The result show the isolate compound was 2-iminoethyl 2- (1-hydroxypentan-2-yl) phenyl) acetate with IC50 value on T47D breast cancer cell 7, 12 μg/mL and with selectivity index value was 47, 53.Keywords: Sterculia quadrifida R.Br, 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) acetate, T47D.
PASSAGE INFLUENCE ON THE AGING PROFILE AFTER SUCCESSIVE CRYOPRESERVATION OF BONE MARROW MESENCHYMAL STEM CELLS Ismail Hadisoebroto Dilogo; Starifulkani Arif; Jeanne Adiwinata Pawitan; Ria Anggraeni; Yogi Ismail Gani
Journal of Global Pharma Technology Volume. 9 Issue 6
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Abstract

Objective: Bone marrow mesenchymal stem cells are promising in cell therapy but the low frequency of this subpopulation necessitates their in vitro expansion and cryopreservation prior to clinical use. The aim of this study was to analyze the passage effect on the aging profile of previously successive cryopreserved bone marrow mesenchymal stem cells.  Methods: The samples of this in-vitro observational analytic study (April - September 2016) were iliac crest bone marrow mesenchymal stem cells that were cryopreserved in passage one and a second group was cryopreserved after being subcultured. It was obtained from UPT TK Sel Punca RSCM-FKUI. Samples were analyzed for each passage in terms of cell size, viability, population doubling time (PDT), and percentage of senescent cells by ANOVA test and independent t-test for the inter-cryopreservation group.Results: The remarkable manifestation of senescence appeared at passage six in both cryopreserved groups, but tend to appear earlier in the twice cryopreservation group. The senescent positive cell size became bigger along with the increasing number of passage. There were significant differences in PDT, 30% confluent cell size, viability, in passage six between the two cryopreservation groups (p<0.001, p<0.001, p=0.022), respectively, but no significant difference in percentage of senescent cells (p= 0.052). The cells became senescent in P6 in both groups (P=0.000).Conclusion: The onset of senescence of bone marrow mesenchymal stem cells was in passage six, while PDT, cell size and viability differ significantly due to successive cryopreservation.
Quantification of Porphyromonas gingivalis in Plaque of Severe Chronic Periodontitis Patients Associated with Interleukin-12 Serum Level Using Real-Time Polymerase Chain Reaction Ghasaq A. Abdulwahab
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Periodontitis is a multifactorial polymicrobial infection in which the bacteria play a fundamental role in its initiation and progression. Porphyromonas gingivalis has been implicated as a major etiological agent causing tooth loss. Aim of the study: This study was carried out for molecular identification and quantification of Porphyromonas gingivalis in subgingival plaque samples of severe chronic periodontitis (CP) patients and healthy controls and its association with interleukine-12 serum levels. Materials and Methods: Fifty one CP patients and 45 healthy controls with age ranged from (30-50) years old, were recruited. Periodontal status was assessed based on plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL). Real time-Polymerase chain reaction-SYBR green technique was used to quantify Porphyromonas gingivalis from extracted DNA of dental plaque samples, while enzyme-linked immunosorbent assay (ELISA) was carried out to estimate the serum level of interleukin-12. Results: The present finding revealed that Porphyromonas gingivalis count was higher in the patients compared to the healthy controls and positively associated with all clinical parameters.  As well significant increase of interleukin-12 serum level was found to be associated with severe chronic periodontitis. Interestingly, positive significant correlation between bacterial count and serum interlukin-12 level was noticed. Conclusion: A quantitative real time-polymerase chain reaction is sensitive and efficient method which permits to study specific organisms and their role in periodontal disease pathogenesis. The results of this study confirmed the earlier finding of Porphyromonas gingivalis present in significantly higher levels in CP patients. The positive association between bacterial count and interlukin-12 appear to be indicative of interactive relationship and may play a crucial role in pathogenesis of CP.Keywords: Periodontitis, Porphyromonas gingivalis, Real time-polymerase chain reaction, Interlukin-12, SYBR green.
Synthesis and Antibacterial Activities of New 2-Mercapto-Imidazoline-4-one Derivatives Sahar Abdullah Kadham
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

New 2-mercapto-imidazoline-4-one Derivatives comprising 1, 3-thiazoline, Schiff's bases, pyrazole, pyrimidine and γ - lactam moieties are reported. Compound1was synthesized by the reaction of thiourea with Chloro acetyl chloride, compounds 2a - dwere converted into thioester 3a - d Compounds contains pyrazole 5a - h and pyrimidine 6a - hweresynthesized by the reaction of hydrazine hydrate and thiourea with compounds 4a – h respectively Compounds 3a-d and 8a – d were converted into a variety of derivatives. All structural of compounds have been confirmed by FTIR, 1HNMR and mass spectra and tested for invitro antibacterial activity against Escherichia coli, Staphylococcus aurous and Proteus mirabbilisby.Keywords: imidazoline-4-one, 1, 3-thiazoline, Schiff's bases, Pyrazole, Pyrimidine  and γ – lactam.
Physicochemical Analysis of Nephelium Lappaceum Seed Fat and its Application in Topical Formulations Gouri Kumar Dash
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
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Abstract

Nephelium lappaceum L. (Family- Sapindaceae), popularly known as ‘Rambutan’, is well known for its edible fruits with delicious taste and flavour in Southeast Asia. The fruits are deseeded during processing in the canning industry and considered as a waste by-product. The seeds contain good amount of fatty material and has been claimed to be a source of natural edible fat. The objective of the study was to report the physicochemical parameters of the seed fat together with formulation of few topical preparations such as creams and lotions containing the seed fat that would offer new prototype formulations containing natural ingredients. The physicochemical analysis of the seed fat such as melting point, saponification value, acid value, ester value and peroxide value were studied. The GC-MS analysis of the seed fat was carried out to find its chemical composition. Further, two topical preparations such as creams and lotions were prepared using the seed fat and evaluated using standard recommended procedures. The seed fat was compatible to be used as an ingredient in the bases of creams or lotions. Keywords: N. lappaceum seed fat, Physicochemical analysis, GC-MS analysis, Topical formulations
Pulmonary Function Test among Asymptomatic Male's Smokers and Non-smokers: A Community Study in Denpasar City, Bali I Made Muliarta
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Smoking chronically affects lung function, The effect and severity changes differ between individuals. It is estimated that six million adults and ~100,000 adolescents died each year from tobacco-related health issues. Active smoking by healthy adults has been reported to cause declines in lung function. These differences between cigarette smokers and non-smokers are in direct proportion to the quantity of smoking. Study-related factor associated with pulmonary function in Indonesia, especially in Bali still limited. Aim: This study aims to examine the factor that may be associated with pulmonary function among smokers and non-smokers in Denpasar. All participants were males. Method: This is an analytical study using a case-control method conducted in Denpasar City represented by 592 male respondents. Data collection is done through interviews with structured questionnaires. Demographic data, occupation, residence, body mass index, smoking habit, spirometry examination were documented. Data were analyzed using SPSS IBM 25.0 with univariate and bivariate analysis. Results: Spirometry examination showed 0.2% respondent had obstructive lung disease, 8.3% had restrictive lung disease, and 0.3% combines. This study found the association between smoking status and impaired lung with p-value <0.0001 (3.334 (CI95% 1.898-7.204). Association between pack years above 1.9 also significant with p-value <0.05 4.020 (CI95% 2.638-8.558). Conclusion: A significant association was found between the status of smoking and lungfunction parameters. Pack years also affect towards lung function parameter, especially FEV1%. Keywords: Smoking status, Packyears, Spirometry, Pulmonary functions.

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