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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Efficacy of Hydraulic Pressure Sinus Lift VS osteotome Lift via Crestal Approach Utilizing Sinus Endoscopy (Randomized Clinical Study) Aseel Hamid Madab
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Rehabilitation of posterior maxilla is compromised by deficient residual bone height. Sinus lift procedure can be performed by either lateral or crestal approach. Crestal approach had many advantages in comparison with the lateral approach. Hydraulic pressure devices for sinus membrane elevation have demonstrated a low risk of sinus membrane perforation as well as ease of application. Endoscopic surgery has change the philosophy and practice of modern implant surgery in all aspects, it give rise to minimally invasive surgery procedures based on the ability to visualize sinus membrane perforation and to operate in an optimum manner. Assessing and evaluating the efficacy of osung sinus lift kit and the presence of maxillary sinus membrane perforation with the use of endoscopy, were the aim of this present study, thirty patients in rolled in this study with mean age of 46.86 years divided into 2 groups: group A (Osung) the hydraulic pressure technique and group B (osteotome) the conventional osteotome technique. For each patient, orthopantomography and cone beam computed tomography were recommended, an endoscope used intraoperatively in each case to assess the presence of shniedrian membrane perforation, 51.9% (27 cases) were managed by osung procedure for sinus lift, while 48.1% (25 cases) were managed by osteotome sinus lift, the perforation of sinus membrane occurred in (7.7%) in both groups. The use of endoscope is simple and quick for direct visualization of the Schneider membrane, maxillary sinus floor elevation using Osung water lift system kit is a predictable procedure with a low perforation rate. Keywords: Crestal approach, Endoscopy, Hydraulic pressure, Shniederian membrane perforation. Introduction
The Physical Exercise Program during Post-Surgery Rehabilitation of Elderly Patients Diagnosed with Thrombophlebitis of the Lower Limbs in Jordanian Hospitals Mutasem Abdel Wahhab Khalaf Al-Soub
Journal of Global Pharma Technology .
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Abstract

Deep vein thrombosis (DVT) or thrombophlebitis is frequently found in human limb veins and it is is a manifestation of venous thromboembolism (VTE). Thrombosis is a process of intravital blood clot formation inside blood vessels. This may be lethal. The mortality rate associated with this disease is higher than that of many extremely dangerous disorders. In most countries, statistical figures provided by healthcare systems regarding thrombosis patients are high. Aim of the study is checking the physical exercise program efficiency designed for post-surgery rehabilitation of elderly patients diagnosed with lower-limb thrombophlebitis in Jordanian hospitals. Research methodology was based on theoretical analysis and scientific and methodical literature, pedagogical observation, medical and biological research methods, as well as on statistical methods. The studied group was formed by elderly patients diagnosed with lower-limb thrombophlebitis. They underwent surgery and were sent to restore with a one-year (2014-2015) rehabilitation program in the Physiotherapy Department of the AL-Karak State Hospital (Jordan). The patients were in the age of 55-60 years. Before doing exercises, patients have not been feeling pain or distress. The rehabilitation program was applied for 30 minutes three times per week. Each session was attended by four patients. Results were processed by means of mathematical statistics and by calculating significant differences with the Student’s t-test. We have substantiated the use of a physical exercise program designed for post-surgery rehabilitation of elderly patients with thrombophlebitis of the lower limbs. This paper provides a research on bodily exercise program efficiency during one-year rehabilitation period of elderly patients, who underwent surgical management of lower-limb thrombophlebitis. The program has improved a number of patient characteristics: body weight, blood pressure, heart rate, physical condition index, the adaptive capacity of cardiovascular system.Keywords: Diagnosis, Thrombophlebitis, Physical Rehabilitation, Exercise, Elderly Patients.
COMPARISON THE ANTIHYPERTENSIVE AND ANTIOXIDANT POTENTIAL BETWEEN YOUNG MAHOGANY SEEDS EXTRACT WITH MATURE MAHOGANY SEEDS EXTRACT IN RATS WITH HYPERTENSION I Wayan Putu Sutirta Yasa; Putu Astawa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Mahogany seeds have been used in the community as an antihypertensive and antioxidant. Antihypertensive and antioxidant efficacy of mature mahogany seeds has been proven in hypertensive rats. The purpose of this study was to compare the antihypertensive and antioxidant effect of mature mahogany seeds extract with young mahogany seeds extract. This study is a laboratory experimental design with pre-test and post-test design control groups, with Wistar rats as samples. Thirty rats were divided into 5 groups, each group consist of 6 rats. The control group was given saline every day as a rat model of hypertension. 1-4 treatment groups were each given NaCl and water extract of young mahogany seeds for treatment 1, the ethanol extract of young mahogany seeds as treatment 2, water extract of mature mahogany seeds as treatment 3 and ethanol extract of mature mahogany seeds as treatments 4. Dosages of extract mahogany seeds is 100 mg / head / day for 4 weeks. Before treatment, evaluation of rat blood pressure with special sphygmomanometer was held, and examination of blood MDA as a pre-test data. Further evaluation of MDA and SOD blood pressure are at the end of the study. The data were tested by ANOVA to see the difference between the groups. The results showed a decrease in blood pressure and levels of MDA were significant in all treatments (p <0.05) compared with control as well as an increase in SOD were significantly (p <0.05). The ethanol extract of mature mahogany seeds showed the most excellent antihypertensive and antioxidant properties (p <0.05). From these results, it can be concluded that the ethanol extract of mature mahogany seeds is better than young mahogany seeds extract as an antihypertensive and antioxidant in hypertensive rats.Keywords – antioxidants, hypertensive rats, mature and young mahogany seeds
Comparison between Low Flow and High Flow Sevoflurane Isocapnic Technique to Achieve Early Recovery after Surgery (ERAS) Adinda Putra Pradhana
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective. The purpose of this study was to compare recovery time between low flow and high flow sevoflurane isocapnic anesthesia techniques, as well as the total consumption of sevoflurane.Design. This study was an observational single-blind randomized trialSetting. Operating room.Patients. Total 40 patients from both gender, 18 to 60 years old, BMI 18.5-29.99 kg/m2 with physical status ASA I or II, that scheduled for elective surgery under general anesthesia approximately between 3-5 hours were selected for this study.Intervention. Selected patients divided randomly into two groups (n=20 each). First group was given low flow sevoflurane, delivered with initial flow 6 L/min until MAC 0.9 or expiration level of sevoflurane 2.2 vol% then reduced flow to 0.5 L/min; second group with high flow technique  4L/min after induction.Measurement. The duration of operation, duration of anesthesia, time reaching of BIS 75, eye-opening with command, extubation, moving into the recovery room and when reaching Modified Aldrete score 10.Main Results: Based on statistics, sample characteristics, hemodynamic conditions, length of anesthesia and number of fentanyl were not significantly different. There was a significant difference on post anesthesia recovery time between low flow and high flow anesthesia time BIS 75: 1.7 (± 0.801) vs 7.05 (± 3.956), p<0.001, eye-opening time: 5.45 (± 3.82) vs. 14.86 (± 7.945 ), p<0.001, extubation time: 5.8 (± 2.783) vs. 15.29 (± 8.776), p<0.001, moving into recovery room: 15.35 (± 5.133) vs. 23.52 (± 12.213), p=0.021, time reaching modified aldrete 10: 8.95 (± 4.211) vs. 29 (± 18,091), p<0.001).Conclusion: Recovery time after general anesthesia using low flow sevoflurane isocapnic anesthesia technique is faster than the high flow anesthesia technique with less sevoflurane consumption.
The Ratio of Runx-2 and Osterix in Tension Area of Orthodontic Tooth Movements on Days 7 and 14 after Giving Mangostin I Ketut Sudiana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Orthodontic relapse is the return of the tooth to the first position after being treated with an orthodontic appliance. Bone density in tension area of orthodontic in new bone formation (apposition) is critical in orthodontic treatment to prevent relapse so that orthodontic treatment can be achieved optimally through runt-related transcription factor 2 (Runx-2) and Osterix evaluation. This study aims to determine the role of Runx-2 and Osterix ratio in the tension area of orthodontic tooth movement after Mangostin administration. Material and Methods: An experimental laboratory study was conducted among 30 male Wistar rats were divided into several groups. The K1 was a negative control group (K-) without treatment, K2 was a positive control group (K +) given orthodontic mechanical strength and observed for 7 days, and K3 was a positive control group, given orthodontic mechanical strength and was observed for 14 days. In addition, K4 was a treatment group (P) given orthodontic mechanical strength and were observed for 7 days, and K5 was the treatment group (P) given orthodontic mechanical strength and were observed for 14 days. Data were tabulated and analyzed using SPSS version 17 for Windows. Results: Mangostin administration is significantly increasing the expression of Runx-2 (8.3±0.4 ng/mL), Osterix (4.7 ± 1.8 ng/mL), and bone formation (1:3.23 vs. 1:1.23) in the tension area of the treatment group (P<0.05) after 14 days. The Osterix levels were also suggest a significantly higher among groups from K1 (0.2 ± 0.2 ng/mL), K2 (1.1 ± 0.2 ng/mL), K3 (1.4 ± 0.3 ng/mL), K4 (1.3 ± 0.6 ng/mL), and K5 (4.7 ± 1.8 ng/mL) (P<0.05). The ratio of Osterix (1:3.23) seemed to be higher in treatment groups, whereas Runk2 ratio was slightly lower compared with control groups (1:1.23).Conclusion: The administration of Mangostin can increase the expression of Runx-2 and Osterix in the area tension of orthodontic tooth movement on day 14.Keywords: Mangostin, Runx-2, Osterix, Tension area, Tooth movement.
Synthesis, Characterisation and Pharmacological Screening of Macro Cyclic Vanadium (IV) Complexes Vijay Kumar
Journal of Global Pharma Technology Volume 10 Issue 10 (2018) October 2018
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Abstract

The coordination chemistry has wide applications in different fields. The arrangement of stable buildings with great natural applications is additionally testing these days. The strength of the buildings depends just on Ligands. The cyclic ring has greater steadiness when contrasted with other polydentate ligands. Vanadium can consolidate with macrocyclicligands. The nearness think about includes amalgamation and portrayal of three diverse full scale cyclic ligands by utilizing ethylene diamine and perchloric corrosive. Planning of vanadium edifices do by blending of VOSO4.H2O and integrated ligands. These buildings were described utilizing UV – Visible spectroscopy, FT-IR. Included with these electrochemical investigations of the building and cyclic voltammetry a technique. Anti microbial examination has been completed.
The Relation of Angiotensin Converting Enzyme-1 Gene with Angiotensin II and Plasminogen Activator Inhibitor in Myocardial Infarction Maha F. Smaism
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

One of the very important causes of mortality worldwide is myocardial infarction (MI). Angiotensin converting enzyme-1 (ACE-1) gene plays a principal role in converting of angiotensin-I (ANG I) to angiotensin II (ANG II).  ANG II plays necessary role in promoting of hypertension, furthermore due to the improvement of cardiovascular disease, myocardial infarction. Plasminogen activator inhibitor-1(PAI-1) play a function in modulating intravascular thrombosis, impaired fibrinolytic linked to a high level of  (PAI-1).The aim of the study is to evaluate the role of ACE-1polymorphism in level of ANG II, and the relation between plasminogen activator inhibitor-1concentration and ANG II in (MI) and hypertension patients. The study includes (100) males: 25 control, 75 patient groups, the patient group subdivided into {25  hypertensive patients for 10 years (group A), 25 hypertensive patients for 20 years(group B), 25 patients with MI+ hypertension ( group C)}, ages between (50-60 years) and BMI (18.5-24.9).The results show: There is significantly increased of ANG II, PAI-1, TG, Total cholesterol(TC), LDL-c and VLDL-c concentration, while significantly decreased of serum HDL-c in all groups of patients compared with the control group. The result observed significantly increase of ACE-1 deletion –deletion (DD)in  group  (C)  (88%) compared with the control group (44%), while there were no significantly increased in groups (A,B) compared with control group, also the result showed ACE-1 (DD) genotype was (66%), insertion-deletion (ID) genotype was (34%) and ACE insertion-insertion( II )genotype was (0%) in all study groups. And there was a positive correlation between angiotensin II and plasminogen activator inhibitor-1 in all patient groups. Conclusion: The (DD) genotype of the Angiotensin converting enzyme-1 (ACE-1) polymorphism was the most frequent among Babylon patients with myocardial infarction. This suggests that Babylon individuals with the (DD) genotype might be at high risk for myocardial infarction .Furthermore, D allele of the ACE I polymorphism might confer increased risk for MI. plasminogen activator inhibitor 1(PAI-1) may consider as a risk factor of myocardial infarction. And there was a positive correlation between angiotensin II and plasminogen activator inhibitor-1 in all patient groups. Therefore DD genotype be lead to an increase of PAI-1level.Keywords: Myocardial infarction, Angiotensin converting enzyme-1, Plasminogen activator inhibitor-1, Angiotensin II.
Distance of Apical Constriction to the Apical Foramen in Extracted Lower First Premolar Teeth Assisted by Per Apical Radio-graph in Kerbala City Sameer Hatem Abdul Haleem
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The purpose of this study was to investigate the measurement of the site of apical constriction in the lower first premolar teeth of radio-graphically in Kerbala AL-Mukadissa samples of patients who's attending to the dental clinic for orthodontic treatment,62 lower premolar teeth were examined radio-graphically for the size of the apical constriction, all these teeth were sound and caries free, these teeth examined radio graphically for detection of the apical constriction and the radiographic apex by using size 20 K file inside the root canal  and the difference between the two were calculated as a measurement for the apical constriction size, the size of apical constriction was found 0.4-1.5mm, the man was found = 0.864 mm for the whole sample.Keywords:  Apical foramen, Apical constrictions, Per-apical radiograph.
Synthesis, Spectral and Antibacterial Studies of New 1-(4-Antipyrine azo)-2-hydroxy-3, 6-Disulphonic Acid Sodium Salt with Group IIB Metal ions Alyaa Khider Abba
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

A series of IIB group metal complexes have been synthesized from new azo ligand derived from 4-amino-antipyrine and 2-hydroxy-3, 6-disulphonic acid sodium salt. The structural features have been done on the basis of metal content C.H.N analysis, molar conductance measurement, FT-IR, UV-Vis and HNMR spectral studies. The natures of the prepared complexes were studied according to the Jobs method and Mole ratio method after fixing the optimum condition of pH and concentration. Beers low obeyed over a concentration range (1×10-4 -3×10-4) M .The stability constant of the complexes and Gibbs free energy have been conformed. The antibacterial studies were also studies.Keywords: azo dye, 4-aminoantipyrine, Spectral studies, Antibacterial studies.
Stunting Determinants Among Indonesian Children Aged 0-59 Month: Evidence From Indonesian Family Life Survey (IFLS) 2014/2015 Eka Mishbahatul Marah Has
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study aimed to analyze the determinants of stunting among children aged 0-59 months old in Indonesia. A cross-sectional survey by using data from the Indonesian Family Life Survey period 2014/2015 (IFLS-5) was conducted, which focused on the household with children aged 0-59 months old (n=3623). Ordinal regression test showed that determinants of stunting among children aged 0-59 months old, consist of children aged <6 and 6-23 months old; male; low birth weight; underweight mother; normal height mother; poor household; and ever had antenatal care. Integrated intervention address children, mother, and health service factors associated with stunting is needed.Keywords: Children, Indonesian family life survey, Stunting.

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