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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Bioequivalence Study of Morphine Hydrochloride Oral Solution versus Immediate Release Tablets Geliya Gildeeva; Andrey Belostotsky; Ekaterina Ezhova; Vladimir Yurkov
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Comparative study of bioequivalence and safety of Morphine Hydrochloride 2 mg/ml oral solution (T) and Morphine Hydrochloride 10 mg immediate release film-coated tablets (R) after single dose administration (1 ampoule 5 ml, 2 mg/ml / 1 tablet 10 mg) by healthy subjects under fasting conditions. Methods: Open-label, single dose, 2-period crossover, randomized design study in 42 healthy subjects under fasting conditions. Test product: Morphine Hydrochloride 2 mg/ml oral solution (FSUE «Moscow Endocrine Plant», Russia) was compared with the reference product Morphine Hydrochloride 10 mg Immediate Release Tablets (FSUE «Moscow Endocrine Plant», Russia) under fasting conditions. The statistical method is testing for Cmax, AUC0-t and AUC0-∞. Bioequivalence study was based upon the 90% confidence interval (90% CI) for the test and reference geometric mean ratio. Bioequivalence was to be assumed if 90% CI fell within the recommended acceptance interval 80%; 125%.Results:Forty-two subjects completed the study. Both Morphine T and Morphine R exhibited peak plasma Morphine concentrations of ~13 ng/ml. 90% CIs of the ln-transformed values of Morphine AUC0-t and Cmax were within 80% to 125% range for bioequivalence. The most common adverse events were anemia and headache. These data show that, in these subjects, Morphine T was bioequivalent to Morphine R, a treatment for pain with well-established efficacy and safety profiles.
Description of Personal Factors, Information and Attitudes of Young Women in Early Marriage Dwi Purwanti
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Early marriages are marriages conducted by 18 year olds, who physically, physiologically and psychologically are not yet prepared to take on the responsibilities of marriage, if they are done it can disturb reproductive health. Adolescent problems are a very complex problem ranging from a large number to problems surrounding adolescent reproductive health. Methods: This research is a descriptive quantitative research. The population of this research is all female adolescent of 60 people. The sampling technique was simple random sampling, with a sample size of 30 adolescent female. The variables of this research are personal, information and attitudes. The data collection tool uses a questionnaire, to measure the personal dimension and the dimension of information. Data analysis using descriptive statistics in the form of frequency distribution and central tendency. Presentation of research data in the form of table and textual data. Results: The results of the research on personal factors in adolescent female were 23 (76.7%) women with good personalities, 30 (100%) women with good life values, 23 (76.7%) women with sufficient emotions, and 23 (76.7%) women with good intelligence as much as 21 (70%). Personal factors consisting of dimensions of personality, life values, emotions and intelligence in adolescent female, are 23 (76.7%) women with good personalities, 30 (100%) women with good life values, young women with good emotions. enough as much as 23 (76.7%) and the group of women with good intelligence as much as 21 (70%). The Attitude Toward The Behavioral (Attitude) factor of 28 (93.3%) young women with good beliefs about early marriage and 28 (93.3%) women who have good consequences. Discussion and Conclusion: Three factors in the survey to examine the background of early marriage in ramaja are the personal dimension, the information dimension and the attitude dimension. The description of the results of the three-factor study shows that the numbers need to be taken into account and need to be used as a basis for follow-up in reducing the rate of early marriage among adolescent female.The recommendations offered based on this research are necessary Health care providers should consider a multidimensional approach to supporting and empowering these vulnerable girls. Keywords: Early Marriage, Personal, Information, Attitude.
A review on the physico-chemical properties of solvent influencing the solubility of drugs Vamshi Krishna Tippavajhala
Journal of Global Pharma Technology Volume 09 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

As the bioavailability of drugs from liquid orals mainly depends on their solubility in the given solvent system, it is considered as one of the important parameters for assessing the absorption of drugs into the systemic circulation. Because of this, lot of emphasis has been given to the various factors affecting the solubility of drugs. One among these factors is the physico-chemical properties of the solvent. In this context, the present review article details various physico-chemical properties of the solvent that can influence the solubility of drugs and thereby affecting their bioavailability. Study of these factors helps a researcher in the selection of a solvent system with an optimal solubility of the drug that can lead to an improved bioavailability.Keywords: Solubility, Physico-chemical properties of solvent.
Synergistic Combination of Chitosan and Cinnamid Acid as Edible Coating to Extend Self-life of Acelora Cherry (Malpighia emarginata) Fruit N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Chitosan is edible coating which is a safe, biodegradable and non-toxic substance derived from chitin shells of crustaceans. It’s considered as an antifungal agent that can control postharvest diseases. Cinnamic acid is a plant-derived soluble compound that impedes microbial growth. Acerola cherry (Malpighia emarginata) fruit is well known as one of the richest natural sources of ascorbic acid as well as its high concentration of health-relevant phytochemicals. It has a red color and highly perishable at complete maturity, resulting in serious quality losses during post-harvest. Purpose of this research demonstrated the efficacy of chitosan combined with cinnamid acid as edible coating to extend self-life of acelora cherry fruit. Finding results revealed that chitosan 1.5% + 2 mM cinnamid acid was appropriate to limit weight loss; maintain firmness, chlorophyll, and vitamin C content effectively. Microbial safety was also monitored on treated samples during 8 days of storage at ambient temperature. The combination of chitosan and cinnamic acid provides synergistic effect as a semi-permeable barrier to delay the respiration rate.Keywords: Acelora cherry, Chitosan, Cinnamid acid, Coating, Weight loss, Firmness, Chlorophyll, vitamin C.
Role of Estrogen in the Oxidation Process in Postmenopausal Osteoporosis Elaf Mahmood Shihab
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Introduction: Bone exerts important functions in the body, such as locomotion, support and protection of soft tissues, calcium and phosphate storage, and harboring of bone marrow. Osteoporosis is a common metabolic bone disease characterized by reduced bone mass, micro architectural deterioration of bone tissue, and an increased risk of fragility fracture. After menopause, the period of time after a woman has experienced 12 consecutive months without menstruation called postmenopausal period. Estrogen showed to be the most important sex steroid in preventing osteoporosis in women, so estrogens modulate bone growth and turnover in vivo. Total antioxidant capacity (TAC) is the measure of the amount of free radicals scavenged by a test solution, being used to evaluate the antioxidant capacity of biological samples. Estrogens are steroid hormones that have been shown to affect numerous tissues, including reproductive tissues (such as the breast, endometrium, and vagina) and the skeletal, cardiovascular, and central nervous systems(11).The aim of the study was to evaluate the effect of estrogen therapy on the level of total antioxidant capacity  in serum of postmenopausal osteoporotic women. Materials and Methods: Randomized, single blind clinical trial carried out at the Rheumatology outpatients department of Baghdad Teaching Hospital / Medical City Complex in Baghdad, Iraq from the 10th of Jan to the 12th of June 2016.The study was carried out on 24 postmenopausal women, with  amenorrhea for  more than 12 consecutive months. Venous blood samples (10 ml) were drawn from each patient by venipuncture .Blood samples were taken from participants at day zero of treatment as baseline and after 90 days of treatment to obtain serum for measurement of total antioxidant capacity .Total Antioxidant Capacity (TAC) Bio Assay TM Elisa Kit manufactured by US Biological. The manufacturer instructions were strictly adhered during the laboratory procedure. Results: A total of 24 osteoporosis woman patients were enrolled in this study and they consisted of two studied groups: Group A:12 postmenopausal osteoporotic women were treated by conjugated equine  estrogens tablet  0.625mg (PREMARIN ®) once daily for 90 days.  Group B:12 postmenopausal osteoporotic women were treated by placebo one capsule (filled with starch) daily for 90 days and served as a control group. The mean age of the patients was 56.3 ± 6.14 (range:47 – 65). The mean Body Mass Index (BMI) of the participants was 26.86 ± 2.1 (range: 22.3 – 29.4) kg/m2. On the other hand, the comparison of mean age and BMI across the two studied groups revealed no statistically significant differences, (P>0.05) .Statistics had shown that there was no significant changes between pre and post treatment in Group A or B with baseline increase from (476.35 ± 112.79) to (484.11 ± 117.67) and (471.87 ± 165.59) to (472.78 ± 184.12) respectively ( P value > 0.05).Conclusion: daily dose of 0.625 mg of estrogen therapy for 90 days duration was not proven to be effective in lowering the oxidation level following menopause in osteoporotic women.Keywords: Estrogen, Postmenopausal osteoporosis, Antioxidant.
Thermal Properties of Epoxy Resins and Phenol Formaldehyde Component with Differential on the Mixing Ratios and Reinforced by Nanoparticles Mustafa Ahmed Rajab
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The research aims to study the mechanical properties (tensile strength, hardness, Impact) and thermal properties of epoxy resin and phenol formaldehyde by varying the mixing and strengthening ratios of the nanoparticles. First: (the effect of different mixing ratios between epoxy resins and phenol formaldehyde), and secondly: (nanoparticles containing both magnesium oxide and zirconium oxide) on both mechanical and thermal properties.Keywords: Mechanical and Thermal Properties, Composite Material, Mixing ratios.    
Shigella Flexneri Ghost Cells as a Vaccine with Correct Surface Antigens Orooba Meteab Faja
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Increasing interest was shown in the last five years concerning preparation of the microbial ghosts including the bacterial cells as a vaccination method by using the newly-introduced protocol, the sponge-like protocol. The current study is concerned with preparing Shigella flexneri cell ghosts (SFGs) for generating vaccine against the intestinal infection caused by S. flexneri to minimize the incidence of watery and dysentery diarrhea among people. SFGs were successfully produced in vitro with and their surface antigens were evaluated with specific antibodies. The oral vaccination with SFGs through a challenge test proved that both of (O) and (H) antigens in rat sera were confirmed after treatment with SFGs. The agglutination test showed correct in vitro and in vivo antigen-antibody binding. That demonstrated the validity of SFGs in rat immunization against viable S. flexneri. This study is the first in showing the feasibility of SFGs as a vaccine and in different immunological applications such as the preparation of the adjuvants and the antibodies, the production of the diagnostic kits and experiments aimed to study the surface antigens of S. flexneri. This study is an important process for establishing proper SFGs for different immunological directed applications.Keywords: Ghost cells, Shigella flexneri.
Analytical Method Development for Sacubitril and Valsartan in Combined Pharmaceutical Dosage Forms by RP-HPLC S. Aparna
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The Present work was to develop a simple, fast, accurate, precise, reproducible, Reverse Phase High Performance Liquid Chromatographic Method for simultaneous estimation of Valsartan and Sacubitrilin pure drug form. Chromatographic separation was done using Terrosil C18 column having dimension of (100 mm x 4.6 mm) having particle size of 5.0 µm, with mobile phase consisting of Phosphate buffer (KH2PO4 and K2HPO4) pH 3 ±0.02 pH adjusted with ortho phosphoric acid and Acetonitrile (25:75 %v/v), flow rate was adjusted to 0.8 ml/min and detection wavelength at 254nm. The retention times of Valsartan and Sacubitril was found to be 2.589 and 3.711mins.  The no. of theoretical plates is 4456, 582.and the tailing factor is 1.4, 1.3.Keywords: Valsartan, Sacubitril, RP-HPLC, Method development.
Study of Medical and Biological Properties of Zinc Lysinate-Riboflavinate Qasim Shakir Kadhim
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Biomedical houses about the Zinc-lysinitroboflavinate a new colloidal chelate structure over zinc address microelement are investigated within the case on the work. Intragastric ruler of a hundred mg/kg regarding zinc lysinate-riboflavinate in imitation of experimental animals does no longer cause signs regarding toxicological effects. Toxicological tests on zinc lysinate-riboflavinate have been conducted outdoors over the basis concerning the department about remedy and pharmacology regarding the Faculty regarding Veterinary Medicine on StSAU. The give phase arrangement about zinc lysinate-riboflavinate aqueous solutions was once investigated with the aid of the method over photon-correlation spectroscopy within the laboratories about the branch on technological know-how over Nanomaterials (NCFU, Engineering Institute).Keyword: Zinc-lysinitroboflavinate, biomedical properties, toxicological effects.
Dermatoglyphics and Type 2 Diabetes Mellitus: Review Falah S. Al-Fartusie
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Study of epidermal ridges on the skin covers the palmar and plantar surface of hands and soles, and is known as Dermatoglyphics (also known as fingerprints). Dermatoglyphics patterns are genetically determined and are affected by environmental factors in the uterus. After their formation, they remain stable, unchanged, and are not affected by postnatal environment or age. Dermatoglyphics can serve as a reliable marker of individual identification, as they can be a morphological trait, and a mirror to explain genetic and environmental factors in the first trimester of pregnancy. Diabetes is a chronic disease with serious complications if not managed well. In fact, 90% of diabetics are type 2 diabetes mellitus, multifactorial metabolic syndrome. T2DM will not be diagnosed until the long-term complications. Early diagnosis and treatment are very important to prevent long-term complications of the disease (such as retinopathy, neuropathy, nephropathy), and predicting people with high risk of T2DM can be useful in preventing disease and complications. In this review, we will discuss dermatoglyphics, and the main results of researchers who studied Dermatoglyphics for T2DM patients.Keywords: Dermatoglyphics, T2DM, Arch, Loop, Whorl, Ridge count.

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