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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Vitamin C (L-Ascorbic Acid) Degradation Kinetics during Simultaneous Infrared Dry-Blanching and Dehydration of Apple Slices with Intermittent Heating Method Hassan Sabbaghi
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Vitamin C (L-Ascorbic Acid) is the most important vitamin in nutritional terms. The polyphenols existing in apple exhibit the highest antioxidant rates hence the preservation of apples’ nutritional quality during the heating process is of a great importance. Simultaneous infrared dry blanching and dehydration (SIRDBD) based on intermittent heating method is a novel process during which the temperature is kept constant. The present study investigated the effect of irradiation temperature and the product’s thickness on polyphenol oxidase (the enzymatic browning agent) and Vitamin C degradation. For this purpose, apple slices, in different thicknesses, namely 5mm, 9mm and 13 mm, and diameter of 20 mm were prepared. Irradiation was carried out in three surface temperatures, i.e. 70, 75 and 80°C. The temperature of product center was recorded during processing. The enzymatic activity of polyphenol oxidase (PPO) and ascorbic acid content were assessed in various 2 min and 30 min intervals, respectively. Vitamin C degradation kinetics was studied. The results indicated that the enzyme degradation time was significantly lower in 80°C (P<0.05). At the time of blanching sufficiency, the center temperatures for apple slices with thicknesses of 5mm, 9mm and 13mm were 64.4, 61.7 and 60.8°C, respectively. The vitamin’s degradation kinetic constant (k) was found significantly increased with the increase in temperature or thickness (P<0.05). With the increase in thickness, the vitamin degradation was more dependent on temperature elevation (higher activation energies or Ea). Vitamin C contents were very close at the beginning of the process in different temperatures. Therefore, the high-temperature short-time approach (HTST) can, meanwhile accelerating the enzymatic inactivation, preserve the nutritional quality of the products.Keywords: Vitamin C, Blanching, Infrared, Polyphenol oxidase.
Evaluation of Medical Error Status in Various Wards of Shohadaye Ashayer Hospital, Khorramabad, Iran Reza Masoudi
Journal of Global Pharma Technology Volume 08 Issue 10: (2016) October 2016
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Abstract

Medical errors are known as the most important challenges that healthcare systems in all countries areencountered to them. To provide security and safety for patient is one of the major items in the health care systems. Confessing medical errors imposed on patient and education system is found to be an important aspect of medical ethics and care in turn lowers incidence of errors. Given the importance of identifying and reporting occurred medical errors, the present research aimed to assess medical errors in hospital wards of Shohadaye Ashayer Hospital Khorramabad so that findings of this research can inspire us to incorporate medical errors as a very important subject in the curriculum of medical students and finally physicians can do best examination and treatment with minimal or no errors and inaccuracies. The present research is descriptive in nature which lasted from April to March 2015. Statistical population (subjects) included employees and supervisors, nurses, staffs, lab safety facilitator, pharmacy safety facilitator, surgery room personnel, equipment and personnel in the hospital wards, including the emergency department, men surgery, women surgery, operating room, orthopedics, internal medicine ward, neurology, laboratory room, surgery, infectious, ophthalmic, reception, pharmacy and CCU hospital in Shohadaye Ashayer Hospital- Khorramabad. Keywords: Medical Error, Shohadaye - Ashayer Hospital, Khorramabad, Iran.
Vitamin D Status and its Association with Homocysteine, Insulin and Insulin Resistance among Type II Diabetes Mellitus in Iraqi Patients Luay Qasim Abdulhameed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The study aimed to assess vitamin D level and its impact on homocysteine, fasting blood glucose,Glycated hemoglobin, insulin and insulin resistance. The study conducted in Baqubah city, Diyala province, Iraq. Study period from September 2017 to June2018. Totally123samples, (78) samples of patients type II with mean age (54.75±1.11), and (45) samples with mean age (37.24±0.79) as control group. Vitamin D, homocysteine, fasting blood glucose (FBG), Glycated hemoglobin (HbA1C), insulin and insulin resistance (HOMO-IR) were measured. Results indicated presence of significant higher (p ≤ 0.001) in fasting blood glucose, glycated hemoglobin, insulin, insulin resistance and homocysteine among diabetic patients type II compared to control. Whereas, vitamin D was significant lower (P<0.001) in diabetic patients type II compared to control. In addition vitamin D level was inversely correlation (P<0.01) with fasting blood glucose, glycated hemoglobin. Moreover, it was inversely correlation (P<0.001) with insulin, insulin resistance and homocysteine.The study concluded thatvitamin D was inversely correlation with all variables in current study and it has important effect on these variables through several mechanisms at level gene expression in diabetic patients.  Keywords: Diabetes mellitus,Vitamin D, Homocysteine,Insulin, Insulin resistance.
Incorrect Use of Antibiotics Asmaa Khalid Salman
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present study aims to determine the information about the safe and appropriate antibiotic which can be utilized among the undergraduate students of medical and dental colleges. The formula that was applied in the current study was an integrated self-administration approach. We found that dental students were more aware of the instructions provided by the doctor. They resorted to specialized assistance from healthcare professionals. Nevertheless, the observed difference between males and females in the medical profession in this study was significant where the females were more aware of self-medication compared to males. Furthermore, The findings of this research provide evidence about the self-medication prevalence. There was a sudden increase in the misuse of antibiotics other than being used for medicinal purposes. In dealing with this challenge, relevant healthcare bodies can play an important role in ensuring that self-medication is curbed through effective regulatory mechanisms. At the same time,  they can offer information about the proper use of medications and various kinds of prescriptions.Keywords: Self-medication, Dental students, Antibiotic resistance.
Differences in the Effectiveness of SRQ (Self Reporting Questionnaire) and HRQLQ (Health-Related Quality of Life Questionnaire) with Malamoi Dialect for Early Detection of Mental Disorders Symptoms in Aimas District Residents of Sorong District in 2019 Butet Agustarika; Panel Situmorang
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Early detection tools for mental disorders can be one of the tools to overcome mental health problems in Indonesia, where there are still many patients with mental disorders who gets an incorrect diagnosis. This study aims to obtain the results of the analysis of differences in the effectiveness of the SRQ and HRQLQ questionnaires in the Aimas District residents of Sorong regency, with the characteristics of the respondents for each questionnaire respectively most are lazy (57.5% and 70%), with elementary school education (50% and 40%) and have jobs as laborers/farmers/fishermen (62.5%). Based on the result of data analysis correlation of Detection of Mental Disorders Symptoms with Question Type, it was concluded that there was a significant difference between the detection of mental disorders using the SRQ and HRQLQ questionnaires, with SRQ effectiveness levels higher than HRQLQ (SRQ's mean rank is 47.50 and HRQLQ at 33.50). Keywords: Self-reporting Questionnaire, Health-related Quality of Life Questionnaire, Mental Health, Malamoi Dialect.
HOXB 13 Gene Single Nucleotides Polymorphisms as an Early Molecular Marker for Prostate Cancer Hasanain Ali Shubbar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

New single nucleotide polymorphisms in Hoxb13 gene has a related with prostate cancer and may be considered as early molecular marker and SNPs are located in gene promoters, exons, intronsas well as 5'- and 3'- un translated regions. The study investigation the association between single nucleotide polymorphisms and prostate patients Materials and Methods: 75 prostate cancer patients, 75 prostate benign and 81 healthy were included. A conventional PCR technique was used to defect variable region of HOXB13 gene by using specific primer pairs synthesized targeting certain region of exon one and two in the HOXB13. The DNA sequencing results for 134 samples were analyzed and aligned using NCBI nucleotide alignment tool, BLAST n (Basic Local Alignment Search Tool) in which DNA sequence obtained in this study were compared with human reference HOXB13 gene sequence. Results showed for HOXB13 gene deletion T located in 48728612 region complement (promoter region), substitution C >T Rs 8556 (exon 1 region), deletion A 48727109 region complement (intron region) and substitution G >A region complement.
Assessing the Rate of Social Phobia among Infertile Women Mohsen Hojat
Journal of Global Pharma Technology .
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Abstract

Introduction although social phobia is considered mainly as behavioral disorder in the field of clinical psychology, it entails by social factors and in consequences that can be followed in the fields of social sciences and social psychology. Infertile women implicate in social phobia disorder; therefore, this study is designed to put into effect the rate of social phobia among infertile women. Materials and Methods The present study is a descriptive-analytical. It is carried out on 210 infertile women in Jahrom and Yazd. Utilized tool is SPIN questionnaire that its validity and reliability are confirmed. Data collection is inquired by educated group, and it is analyzed by software SPSS: 16. Findings Results indicate that infertile women implicate a high rate of social phobia, and there is significant relationship between social phobia and education, religiosity, and social support (p<0.05).  Conclusion Due to high rate of social phobia among infertile women, it is recommended to consider social phobia and its increasing and decreasing variables, along with mental advisory and physical examination in fertility treatment clinics.Keywords: Social phobia, Religiosity, Social support, Socio-economic status, Infertility, Women.
A Case Report on Diabetic Ketoacidosis in Children Keerthana Chandrasekar; Diya C; Vignesh Kumar K
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Abstract

Abstract:Introduction: Diabetic Ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycaemia, ketonemia and acidosis. It oocurs as a complication of diabetes that results in accumulation of ketone bodies and acidosis in large quantities in the blood. It occurs as a result of a complication of Type 1 Diabetes Mellitus (T1DM) and rarely in Type 2 Diabetes Mellitus (T2DM) in children and adult.Presentation of the case: A 10 year old female child had the complaint of polyuria and polydipsia and within 2 weeks her weight has reduced to 10 kg; she also had itching, burning sensation during micturition and history of vomiting 2 episodes. She was diagnosed as T1DM with DKA and was treated with Intravenous Fluids, cefotaxime, ranitidine and insulin. She was re-admitted with complaints of fever, cough, headache and vomiting for which she was managed symptomatically and discharged.Conclusion: DKA is found to be common; hence early diagnosis and proper education and public awareness should be initiated.Key Words: Diabetic Ketoacidosis, Children, Polydipsia, Polyuria, Type 1 Diabetes Mellitus 
Synthesis, Characterization and Biological Activity of New Ester Containing Azo Group Derived From 2-Amino-1, 3, 4-Thiadiazoline Derivatives Ammar H. Al-Dujaili
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

New azo compounds derived from 2-amino-1,3,4-thiadiazolines were synthesized. The cyclization reaction of thiosemicarbazones [I]a,b with the acetic anhydride lead to formation of 1,3,4-thiadiazoline compounds [II]a,b. Compounds[II]a,b were converted to 2-amino-1,3,4- thiadiazolines [III]a,b by hydrolysis of amide group using hydrazine hydrate. The new azo compounds [IV]a,b were synthesized via converted  the amino group of [III]a,b to diazonium salt, follow by the reaction with 4-hydroxyphenol. Finally the ester compounds [V]a-f was synthesized from the reaction of azo compounds with suitable carboxylic acid chloride. The synthesized compounds were characterized by elemental analysis, FTIR, 1HNMR and mass spectroscopy. All these compounds were evaluated for antibacterial activity against Staphylococcus aureus, Bacillius Subtilis, Escherichia coli and Pseudomonas aeruginosa by disk diffusion method and for antifungal activity against Aspergillus niger in Sabouraudʼs dextrose agar medium. Amoxicillin and fluconazole were used as standard drugs for Gram positive, Gram negative and antifungal activity, respectively. Most of the compounds have shown significant antibacterial and antifungal activity when compared with the standard antimicrobial agents.Keywords: 1, 3, 4-Thiadiazoline; Ester compounds; Azo compounds; Antibacterial activity; Antifungal activity; Disk diffusion.
The Risk of Bone, Joint and Inflammatory Bowel Disorders in Patients Treated with Angiotensin-Converting Enzyme Inhibitor Drugs Firas Fadhil Alyaseen
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objective: the aim of this study is to describe the adverse effects and disorders of angiotensin-converting enzyme inhibitor drugs treatment in patients with various cardiac diseases who prescribed those treatments. It also evaluates the risk of angiotensin-converting enzyme inhibitor drugs on long term therapy of patients.  Subjects and methods: this cross-sectional study was carried out in Al Hussein-teaching hospital at Al Nasiriya city, south of Iraq. The research started at November 2016 until April 2017. Eighty one patients (52) males and (29) females], age (34-77 years) were enrolled in this study. All of the patients were diagnosed with cardiac diseases by specialist doctors and currently on angiotensin-converting enzyme inhibitor drugs for long term therapy. The data collected from patients through a questionnaire list designed and developed for this study. The list concerned with the disorders and drugs-related data in addition to the patients' general data. The collected results were analyzed in order to construct tables, figures and other necessary research requirements.  Results and conclusions: in this study, most of the cases are treated with angiotensin-converting enzyme inhibitor drugs for hypertension (97.5%), and captopril represents the most popular of them (52 %). The most common significant results among the disorders associated with angiotensin-converting enzyme inhibitor treatment in patients were osteoporotic back pain (79 %), osteoarthritic joint pain (87.65 %), and gastrointestinal disorders like constipation, abdominal pain and chest pain were (66.7%), (53%), and (56.8%) respectively.Keywords: Bone, Joint, Inflammatory Bowel Disorders, Angiotensin.

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