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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Absorption Resonance Energy Transfer between Organic Dyes (Cumarin and Rohdamain ) Wajeha Abdle Diam
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

The spectral properties absorption of two laser dyes types, C480 and R610, the mixture was investigated. These types  of laser dyes  belong to Coumarinoids  and  Xanthenes  family were dissolved  using  ethanol  as solvent to prepare samples with range of ratios (1:1,  1:2,  1:3 and 1:4)  from  Cumarin  480 (C48) to Rohdamin 610 (R610) concentered in (10-410-5,10-6) M/L at room temperature. The achieved results pointed out an increase in the absorption intensities with the increasing of the concentration of the day type R610 from 10-6 and 10-5 to 10-4   M/L.the same thing for C480which are absorved in agreement with Beer-Lambert law and the finished results Pointed that  the absorption peak was moved toward the short wavelengths (BLUE SHIFT) when increasing the ratioconcentration.  Keywords: Dye laser, Fluorescence resonance energy transfer, Silica gel matrices. Absorption spectrum.
Discovery of Potential Inhibitors against Mainprotease of Sars Cov2 from Centella Asiatica by in Silico Study Kavitha K; Mohan S; Umarani G; Soundara Rajan D K; Subra Manian S; Sakila Ban U S
Journal of Global Pharma Technology Volume 13 Issue 04 (2021) April 2021
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Abstract

Centella asiatica encompass be utilize towards healing a set of affliction of humans. Legendary mechanism exemplify to its existence of plenteous genetic activities. In this explore revise be projected to make out the phytoderived antiviral moieties from Centella asiatica against Covid-19 Mpro protein as well as comprehend the Insilico study foundation of molecular activity and during in current examine five isolate molecules in Centella asiatica retrieve as of the PubMed database and be subjected towards docking investigation. Dock analysis were done by using Auto dock vina and PyRx software and followed by admet SAR in addition to pkCSM servers, were used for analyse the drug-likeness prediction. Among 5 Phyto-Molecules, 4 moieties of Centella asiatica are very probable aligned with the Mpro protein of Sars Co V 2. Further, the selected Phyto-molecules on the natural source strength launch consistent prescription and bear frontage discovery. Acknowledged beat molecules could be further in use for in vitro, in vivo evaluation and to investigate their efficiency opposed to COVID-19. Keywords: SARS Co V-2, Main Protease, Centella asiatica, Insilico study, Drug likeness.
A First Record and Developmental Stages of an Exotic Species Cochlicellabarbara (Linnaeus, 1758) (Gastropoda-Cochicellidae) in Iraq Baghdad Maysaloon Lafta Al-Doori
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

The aim of this study is to highlight this species of gastropoda Cochlicellabarbara( Linnaeus, 1758), which is recorded for the first time in Iraq, which is an exotic animal in this country. It is a terrestrial Molluscan, the study for three months (February, March and April) 2017. In garden houses in Baghdad Al-Karkh, we studied the development stages from the egg to the adult, they lay a hundred of eggs in about (15-20) eggs in each gelatinous sac, the shell with 7 whorls and about 10 mm in length.Keywords: Mollusca, Gastropoda, First recorded, Cochlicellidae, Cochlicellabarbara.
Genotyping of Helicobacter Pylori Isolated From Iraqi Patient with Upper Gastrointestinal Disease Aseel H. Al-Sabary
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

H. pyloriis one of the most frequent pathogen infected about half of the world population, despite that most infections are asymptomatic; some infections can develop chronic gastritis, peptic ulcer and gastric cancer. The aims of the study are the molecular detection of H. pylori and the main virulence factors association with clinical outcome of H. pylori infection. This study was start from February to September 2016, ninety two cases of H. pylori infections were detect in patients admitted to Medical Marjan City in Babylon -Iraq. The study display the high frequencies of H. pylori were observed for chronic gastritis, which h constituted 88% while low frequencies were 3.3% for gastric cancer whereas 8.7% for duodenal ulcer. Moreover, identification of H. pylori by PCR technique was performed on all gastric biopsy and ure C as well as ure genes were used as markers for confirmatory diagnosis of H. pylori through using specific primers of PCR technique. The result showed that, 84.8% and 73.9% of H. pylori were positive respectively for both genes. In additions, cag A gene was investigated in all H. pylori isolates. The result showed that65 (70.6%) was positive for PCR amplification of cag A gene whereas 56 (60.8%) was positive for PCR amplification of cag E gene. The frequency of the vac a gene found in the present study was 68.5% (63/92).It was concluded that the molecular detection of H. pylori genotype is important tool to determine pathogen city of H. pylori.Keywords: Helicobacter pylori, Gastric biopsy, Gastric diseases, Ure A gene, Ure C gene, Virulence genes. 
Probiotic Drugs Impact on the Innate Immunity Factors Oksana Nikolaeva
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Probiotics are the drugs containing living microorganisms related to normal physiological intestinal flora. Recently probiotic drugs are made based on microorganisms’ pp. Bifidobacterium, Lactobacterium, apathogenic strains pp. Streptococcus, Enterococcus, acquired from the humans and animals’ gastrointestinal tract. These microorganisms have a certain impact on the innate immunity factors, interacting with the lymphoid intestinal system. The studies were aimed at examination of the probiotic drugs impact on the innate immunity factors. 60 newborn calves of black-motley breed and 60 piglets of large white breed of 45-day weaning became the object of the study. Blood draw of newborn calves and weaned piglets for immunological studies was performed before the study and then on the 10th, 20th and 30th day of the study. When examining the innate immunity factors there were defined such factors as lysozyme activity in blood serum, blood serum bactericidal factors value and phagocytosis system factors. It was stated that the animals treated with the probiotic drugs based on L. plаntаrum 8P-А3 and synbiotic drugs based on L. plаntаrum 8P-А3 as well as on the medicinal plant materials have the innate immune factors activated with age.Key words: L. plаntаrum 8P-А3, innate immunity, Chеlidоnium mаjus L., Bеrbеris vulgаris, blood phagocytic activity.
Determination of lactic acid bacteria isolated from the gastrointestinal tract of Bali cattle with potential probiotic role Dewa Made Sukrama; I Wayan Suardana
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Bali cattle is known as pioneer’ cattle resulted by their high ability to adapt in poor quality of feed so that was assumed for finding the specific species of lactic acid bacteria.  The study aimed to investigate the potency of lactic acid bacteria isolated from the gastrointestinal tract of Bali’ cattle as a candidate for new probiotic. Fifteen isolates of lactic acid bacteria isolated from 15 intestinal tracts of Bali cattle were grown on the specific medium deMan Rogosa Sharpe (MRS) broth followed by Gram staining, catalase test, the formation of CO2 gas, and antimicrobial activities against Bacillus cereus. The result of this study confirmed 15 isolates were Gram-positive bacteria, and 14 out of 15 isolates were categorized as homofermentative. Probiotic potency test showed 11 out of 15 isolates were tolerant against lower pH (pH 2, 4 and 6), and also resistant to bile acid with NaDC concentration 0.2, 0.4, and 0.6 mM.  Identification of isolate using API 50CH test kit found 4 out of 5 isolates as Lactobacillus sp. and the remainder as Lactococcus sp. The study concluded isolates of lactic acid bacteria isolated from the gastrointestinal tract of Bali cattle showed potential as a probiotic candidate.
Giant Cell Tumor of the Right Distal Radius Campanacci Iii Treated with Wide Excision and Space Filler Using Prefabricated Polymethyl Methacrylate (Pmma) Bone Cement: A Case Report Magetsari R
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

ABSTRACT Background: Giant cell tumor of bone (GCT) is the most common benign aggressive primary bone tumor (metastatic rate less than 5% of cases). The hallmark appearance of GCT is an expansile lesion which is centrally radiolucent with formation of a thin neocortex at the border of the lesion (epiphysis and metaphysis). Campanacci grade is the classification system for giant cell tumors. Grade I tumors are confined within the cortex, grade II expand to cortex, and grade III perforating cortex with higher incidence of recurrence and transformation into malignancy. Functional outcome of the wrist joint was evaluated using Mayo wrist score (pain intensity, functional status, range of movement, and grip strength).Case Report: A 39 years old male presented lump in his right wrist joint since 6 months ago. The patient complained of decreasing range of motions and palpable mass that increase progressively over time. Slight pain was also felt around the wrist joint. He sought traditional (masseuse) therapy for the last 6 months, but the complaint persisted. He then underwent operation (tumor excision and augmented graft) in our institution. The graft was made from PMMA bone cement and designed identically similar to distal part of the patient’s radius. Histopathologic analysis was consistent with Giant cell tumor. We evaluated patient’s functional outcome using Mayo wrist score, with satisfactory result.Discussion : Most common method of replacing distal part of radius after excision of GCT was grafting using proximal fibula or ceramic prosthesis. There has never been a published clinical trial of using PMMA as a space filler. Nonetheless we used prefabricated PMMA bone cement based graft to mimic the bone in order to prevent the risk of recurrence and to achieve good functional outcome. We took the measurement of the patient’s left radius using X-ray as a model, then fabricate the PMMA bone cement in the Anatomy laboratory according to the model’s measurement. Although it’s not a popular method, but after 6 months of follow up satisfactory functional outcome was achieved (Mayo wrist score) and without sign of recurrence or metastatic.Conclusion: After excision of the GCT, prefabricated PMMA bone cement could be considered as one alternative of space-filling material to achieve good functional outcome.Keywords : Giant cell tumor, Radius, Excision, Bone Cement, Polymethyl Methacrylate, Graft
An Integrated Approach to the Treatment of Severe Psoriasis: A Clinical Case Lyudmila Smirnova
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Psoriasis is a disease of autoimmune origin, affecting not only the skin, but also the internal organs of a person. Currently, many methods of treating psoriasis are in use, which vary in effectiveness. The aim of this work is to analyze the results of complex physiotherapeutic and pharmacological treatment of a patient with severe psoriasis in comparison with the initial failed treatment with traditional pharmacological methods. The therapy was carried out in 2018-2019 (observation by a rheumatologist at the place of residence), after treatment that was unsuccessfully carried out in 2016 at the Institute of Rheumatology (Federal State Budget Scientific Institution "Scientific Research Institute of Rheumatology named after VA Nasonova") with an incorrect diagnosis of rheumatoid arthritis. In the secondary complex therapy, the following treatment methods were used: a) antihistamines (Chloropyramine 1.0 IM in the evening for 22 days, Chloropyramine 1 tablet 2 times a day in the morning, 18 days for the day); b) Methotrexate 15 mg IM once a week; c) hepatoprotector (heptor 400 mg 1 tablet 1 time per day-22 days); d) Folic acid 0.1 mg 2t 2 pd -6 days; e) Desensitizing therapy (200 ml of 0.9% Sodium Chloride-20 days); f) Local therapy (Komfoderm; Salicyl-dermatol ointment-22 days); g) Physiotherapeutic methods. With complex treatment, the trunk skin showed rashes regression, up to residual hyperpigmentation. The rash regression was 50% in the form of a decrease in the brightness of erythema in the palms, a decrease in peeling and the number of papular elements. Similar processes occurred on the skin of the feet, but with the preservation of large-plate peeling. A detailed literature analysis of known methods of treatment of psoriasis, with a comparison of new and traditional methods was performed. In recent years, the treatment of psoriasis has become more focused on targeted biological drugs. New methods of treatment not only demonstrate optimistic results, but also lead to a deeper understanding of the immunopathogenetic pathways of psoriasis, identifying new potential targets for therapeutic intervention and diagnosis. Our comprehensive approach has allowed us to establish one of the ways to achieve effective treatment.Key words: Psoriasis, Pharmacology, Symmetry, Paradoxical reaction, Physiotherapy, Papules, Rashes, peeling of the skin.
Analyzing the Ways to Improve Personnel Management in the Pharmaceutical Industry of Kazakhstan Kairat Zhakipbekov
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The analysis of foreign and Kazakh literature that addressed the problem of finding ways to improve personnel management in the pharmaceutical industry showed that such factors as intensifying competition on the world market, complication of the internal and external environments of the pharmaceutical industry, and discrepancies between the actual conditions and the demands of the pharmaceutical labor market necessitated the search for new ways of improving the effectiveness of modern pharmaceutical organizations, the cornerstone in which is the human factor. Modern approaches to personnel management and trends in the improvement of personnel management in the pharmaceutical industry of Kazakhstan were analyzed; the profile of an average pharmacist was built: a woman (75.3%) aged 36-55 (52.3%), with 26-30 years of work experience (32.3%) and higher education in pharmacy (77.2%). Sociological studies discovered the following problems: the need for innovations in personnel management in the pharmaceutical industry, which should be aimed at the professional and personal development of each individual in particular and the entire pharmaceutical team in general; the need for an algorithm of consistent performance appraisal of pharmacists  and an algorithm of planning and progress of the professional career of a pharmacist; personnel departments require recommendations regarding methods for improving the organization of personnel management, with a view to continuously improving the skills of pharmaceutical personnel. A textbook for the postgraduate occupational training of pharmacists titled Communication Skills was drafted and implemented in the learning process of a higher educational institution.Keywords: Appraisal, Communication skills pharmacy, Reserve, Personnel management, Social and psychological climate.
Different Parameters Influencing to Extraction and Drying of Anthocyanin Powder from Magenta (Peristrophe Roxburghiana) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Leaves of magenta (Peristrophe roxburghiana) have a good source of anthocyanin. They have potential health benefits for human consumption. Objective of the present study to examine various aspects affecting to anthocyanin extraction including blanching, solvent, solvent: solid, extraction time and temperature under ultrasound, carrier and temperature for drying. Optimal results were clearly shown that the panda leaves should be blanched under 95oC in 10 seconds; extraction should be conducted by ethanol 90%, ethanol: solid (2.0:1.0), 60oC, 8 minutes; vaccum drying should be executed at 60oC with the support of carrier (0.5 maltodextrin: 0.5 gelatin: 1.0 magenta fluid). Ultrasonic had positive effect on anthocyanin extraction and this method could be utilized to optain the most anthocyanin powder.Keywords: Magenta, Anthocyanin, Ultrasonic, Blanching, Solvent, Extraction, Carrier, Drying.

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