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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Correlation of Serum Dynorphin /KOR System with Serum IL-6 and IL-10 in Major Depressive Disorder Hussein Kadhem Al-Hakeim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A case-control study was applied to improve if there is a relation between endogenous opioid dynorhpin (Dyn) and its receptor KOR with serum interleukin-6 (IL-6) and interleukin-10 (IL-10) among MDD patients versus a group of apparently healthy subjects.  The study included 60 depressed pretreatment male patients and 30 (age and gender matched) controls. The serum Dyn, KOR, IL-6 and IL-10 levels were measured and the relation between these factors was obtained in addition to comparison of these factors between MDD patients and control group. Each parameter was determined by using ELISA technique. The comparison between both groups indicated a significance increase (p<0.05) in Dyn, IL-6 and IL-10 in MDD group comparing with controls. Whereas KOR didn’t show any significant difference. The correlation results indicated that there was no correlation between the two systems (endogenous opioid and immune systems). The conclusion of the study is that there was no relation between Dyn/KOR with inflammatory marker IL-6 and IL-10. This finding indicates that there is no effect of endogenous dyn on the immune function.
Jet Lag, Stress, and Behavioural Changes of Daily Living on Umrah Pilgrims from Indonesia Eko Mulyadi
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction:Umrah is an Islamic pilgrimage to Mecca that can be undertaken at any time of the year the Umrah pilgrims who depart from Indonesia to Saudi Arabia has air travel for 10 hours, this study aims to observe the phenomena umrah pilgrim from Indonesia conducted in Indonesia and Saudi Arabia with a long time of 18 days. Method:This study involved 14 participants who perform umrah pilgrims, by using interview technique and direct observation. Research design used a qualitative study with a phenomenological approach. Results:The result of the study showed that pilgrims experience jet lag, also stressed. Disturbance sleep. and behavioral change of daily living. Although umrah (pilgrims) is a spiritual activity, but the implementation made the pilgrims stressed, long flight up to 10 hours with boarding matter, visa examination, made the pilgrims stressed. Conclusion:Umrah pilgrims who experience stress will affect their physical condition. Where physical conditions will affect other biological conditions. including its ability to worship.Keywords: Jet Lag Syndrome, Umrah pilgrims, Stress.
Evaluate the Factors Associated with the Choice of Cesarean Section among Pregnant Women Rasool Gharaaghaji
Journal of Global Pharma Technology .
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Abstract

Introduction Caesarean section is usually limited to factors that vaginal delivery is not possible or associated with the serious risks to the fetus and mother. So, it is expected a few specific indications forces are an delivery, and the rates do not exceed certain limits. But in our country today, the cesarean rate is reported to be more than acceptable. The aim of this study was to evaluate the social, cultural and demographic factors associated with the choice of delivery method. Methods the population of pregnant women was in cities and villages around Uremia city and the intended sample sizewas299 for pregnant women of which171wereurbanand 128 were rural. Sampling was in classification. Using question naire, data was collected and data was analyzed by SPSS software and logistic regression and Pearson Chi-Square. Results Inferential multi variate statistics and findings indica tea significant association between maternal education and the mother's age and father's occupation and child birth with choosing cesarean, but there was no significant relationship between the place of residence (urbanorrural), father's education, mother's occupation, father's occupation, father's age, wanted and unwanted babies and sex with choosing cesarean. The variables, maternal education, maternal age and rating childbirth were entered. According to the importance of place of residence variable its correlation with mode of delivery was confirmed using the Chi-square test. Conclusion Maternal education, maternal age, parental occupation, rating childbirth andplace of residence (urbanorrural) variables was the most important factors in choosing cesarean section. So, it is necessary to organize training workshops form others with high education and young age that are experiencing their first pregnancy, to reduce cesarean section cost.Keywords: Pregnant women, Cesarean section, vaginal delivery.
The Comparison of the Strength of the Arm Muscle between the Conventional Basket Ball Training and the Training Using the Medicine Ball Ida Ayu Kade Arisanthi Dewi
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The training for athletes in the basketball sports must have the excellent biomotor skills, especially in the components of the strength of the arm muscle to be able to do the passing and shooting with the maximum movement. The basketball game uses three main elements namely passing and catching, dribling, and shooting. Until now, the training technique in order to maximize the function of the arm muscle is carried out by loading sand in the body weighing 0.5 kg. This training technique is felt to be uncomfortable when moving, thus another technique is needed to perfect it, namely the training with the medicine ball. This research is a quasi-experimental study using the randomized pre and posttest control group design. The results show that the comparison of athlete's arm muscle strength levels using the conventional training technique with the medicine ball in a row, with the result of 21.45 : 42.3, i.e., there is an increase in the strength of the arm muscle by 49.29% in the medicine ball training. The training by using the medicine ball is an exercise plan using a 1.7-kg medicine ball which can improve the conventional training method.
The Effects of Varieties Sources of Omega- 3 Fatty Acids on Diabetic Male Rats Eman A. Al-Rekabi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The aim of the present study was to investigate the effects of varieties sources of omega-3 on blood parameters, lipid profile and liver enzymes in diabetic male rats. Fish oil and flaxseed oil were used and the animals were maintained with (0.5ml/animal/day). The results indicated that the treatment of diabetic male rats with fish oil and flaxseed oil caused a significant increase (P<0.05) in Hb and PCV and caused a significant decrease (P<0.05) in WBC in compared with diabetic male rats. The results showed a significant decrease in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and liver enzymes, whereas it explained a significant increase in high density lipoprotein (HDL) of  diabetic male rats treated with fish oil and flaxseed oil when compared with diabetic male rats. The study suggested that fish oil and flaxseed oil especially may be as antidiabetic.Keywords: Diabetic male rats; Omega-3; Fish Oil; Flaxseed Oil; Blood parameters; Lipid profile; Liver enzyme.
Study UV-Visible and FTIR Characterization of ZnPc Dye using Double Solvent Ban Mazin Alshabander
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The effects of dissolving zinc phthalocyanine (ZnPc) in two solvents, (N, N-dimethylformamide (DMF)/water, dimethylsulphoxide (DMSO)/water, tetrahydrofuran (THF)/water), on the absorption spectra and infrared spectra were studied using (UV–Vis) spectroscopy and FTIR spectrophotometer. Solvents affected on the photochemical and photophysical properties of ZnPc complexes. The noticed trend inside the difference of Q-band position with solvent was occasionally attributed to solvent parameters comprising aromaticity, arrange power, polarity, and refractive index. UV-V spectra analysis showed non-proof of aggregation in sol as a display throught great unperturbed phthelocyanine Q band. zinc phthalocyanine emerge absorption spectra with duo essential band electron the Q band with a generality (685, 675 and 680) nm separately as well as Soret B band with an extreme of (340, 340 and 350) nm separately. Farthest potential aggregation included method is such the H-aggregation because of rise shift energy of absorption spectrum as well as provided information via the potential electrostatic allocation onto molecule zinc phthalocyanine . FTIR results showed that elevate include peaks belongs to ZnPc with the alteration in the present of the two solvent furthermore little shift toward low energy existed. Keyword: Double solvent, Metal-Phthalocyanine dye, Energy bandgap.
Antimicrobial and Bacteriological Study for Men Patients with Respiratory Disorder Diseases Hasanain Khaleel Shareef
Journal of Global Pharma Technology .
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Abstract

The current study aimed to designation and investigation for bacteria in the respiratory secretions 40 sputum samples form men patients which found after laboratory examination 40 samples infected with pathogenic bacteria in respiratory disorder diseases patients infected with lung cancer and pneumonia , the results included of Gram Positive Bacteria isolated  were: Staphylococcus epidermidis  had the most presence with 24 (60%) , followed by Streptococcus pyogenes with 5 (12. 5%) , followed by 3(7. 5%) for Staphylococcus aureus ,and about Streptococcus pneumonia represented the lowest percentage 2(2.5%) ,while the Gram Negative Bacteria isolated from sputum were : Klebsiella spp.  and Escherichia coli have the same percentage had the equal presence with2(5% ),while Mycobacterium tuberculosis with 2(5% ),also the study had been included the determination of the antibiotic effected of ( Key: AMC=Augmenting/Amoxicillin, E=Erythromycin, CIP=Ciprofloxacin, AZM= Azithromycin ,CN=Gentamycin, CRO=Ceftriaxone, AM=Ampicillin , P=Penicillin ) on bacterial pathogen isolates from respiratory disorder diseases, they were found: resistance to Azithromycin, Augmenting/Amoxicillin, Ciprofloxacin, Ampicillin and Penicillin were showed by most for bacteria, while most isolated have been found to be sensitive to Gentamycin with Ceftriaxone. Mycobacterium tuberculosis and Streptococcus pneumoniae species showed resistance to most of antibiotics, Kellbesilla spp.  showed resistance to most of antibiotic agents except Ceftriaxone while Streptococcus pyogenes which isolates displayed sensitive for most antibiotics except for Augmenting/Amoxicillin, Ampicillin and Penicillin. Generality of the isolates were Escherichia coli showed best sensitivity to Gentamycin just but resistance for all antibiotics in the study, Staphylococcus epidermidis had to be sensitive for Augmenting/Amoxicillin, Gentamycin and Ceftriaxone which Staphylococcus aureus had to be sensitive for antibiotics agents Gentamycin and ceftriaxone. Conclusions: The respiratory disorder diseases are a serious problem and healthy issue in any community that might refer to elevation diseases of males than females. Also the most common bacteria accompanying in (Lung cancer, pneumonia) are Staphylococcus epidermidis, Streptococcus pyogenes and Staphylococcus aureus respectively from patients in Babylon province. Although the proper antibiotics had been used were the Gentamycin and Ceftriaxone which give high sensitivity for studied bacterial species.Keywords: Respiratory; Disorder; Diseases; Lung; Cancer; Pneumonia; Respiratory; Allergic; Antibiotic.
TRICHOMONIASIS AMONG PREGNANT WOMEN IN DENPASAR CITY, BALI, INDONESIA Luh Seri Ani; IGA Sri Darmayani
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Objective: This study aimed to investigate the incidence of T. vaginalis infection among pregnant women in the city of Denpasar, Bali, Indonesia and the associated factors. Methods: There were 376 pregnant women who participated in this study. Study participants were selected using cluster sampling method. These pregnant women were then interviewed and tested for T. Vaginalis infection (microscopic and culture). Results: Infection of T. vaginalis was found in 7.4% of the pregnant women. The infection is most likely to be found in pregnant women who have a lower education level, middle-class status and a history of STIs. It is also most likely if they never had any vaginal douching before if they have intercourse ≥3 times per week, use sitting toilets and use river water as their main water source. Type of toilet used, the practice of vaginal douching, and condom usage show a significant association with trichomoniasis among pregnant women (p values were 0.001, 0.002 and 0.000 respectively). Conclusion: Early detection of sexually transmitted infections (STIs), especially T. vaginalis infection, should be performed during prenatal care to avoid the negative effects on pregnancy.Keywords - pregnancy, STI, vaginal trichomoniasis
Genetic Polymorphism of IL-4 Gene as Risk Factors for Patients Suffering from House Dust and Storage Mites Allergy Suaad Almas. Brakhas
Journal of Global Pharma Technology .
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Abstract

The study was design to show and shed light on the Association between IL-4 Gene polymorphism with allergic Rhinitis and Asthma in patient suffering from House Dust and Storage Mite allergy that diagnosed by Skin Prick test forHouse Dust Mites (HDM) Dermatophagoidespteronys sinus, (D.p), Dermatophagoides farina (D.f) and Intradermal skin test for Storage mites Glycyphagusdomesticus   with detected of IL-4 level in serum by ELISA, IL-4 Gene polymorphism (RFLP-PCR), and Total IgE level. A highly significant difference in IL-4 level and totaling E level between allergic asthma, allergic rhinitis and control. In HDM allergy The C allele showed a significant increased polymorphism in Asthma patients (43.33%) and rhinitis patients (40.00%) compared to controls (33.33%). CC genotype was observed to have a significant increased frequency in patients compared to controls while CTand TT genotype frequencies were significantly decreasedin patients compared to controls, increased risk of asthma might be associated with CC genotype, while the genotypes CT and TT are thought to havea protective effect from asthma. Season of mites allergy have major role for disease, the positive Skin Prick test for Dermatophagoidespteronys sinus, (D. p) (46.67%), Dermatophagoides farina (D.f) (70.00%) increased in winter (55.00%) while Glycyphagusdomesticus positive Intradermal skin test (47.67%) increased in autumn. Genetic polymorphism and environmental factors play major role for House dust and Storage Mite mite’s allergy.Keywords: House Dust Mites (HDM), Storage Mites, Serum IL-4, Serum Total IgE, Gene polymorphism IL-4, Allergic Rhinitis and Asthma.
Determination of Residual Monomer in Heat Cured of Acrylic Resin Denture Base Material after strengthening it with Titanium Nanotubes Sahar Abdulrazzaq Naji
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objectives: The objective of this introductory study was to investigate, for the first time, the impacts of incorporation of titanium nanotubes to polymethyl methacrylate (PMMA) on the remaining monomer content of the  of PMMA denture base. Methods: Forty-five specimens of heat polymerizing acrylic resin were prepared according to ISO 20795-1:2013. Divided into three groups (n=15) Methyl methacrylate was mixed with 0% (control), 2.5 weight %, and 5 weight % titanium dioxide nanotubes. TiO2 nanotubes were prepared using alkaline hydrothermal process. Gas Chromatography analyses GC-MS was used as an analytical monitoring method to quantify the remaining monomer in the cured samples. Data  were analyzed using ANOVA and Tukey's test (p < 0.05). Results: residual monomer content significantly reduced in both modified groups with TiO2 nanotubes 2.5and 5w% (0.0783,0.1407, %) respectively) compared with the unmodified group (0.1567%). Conclusion: supporting of acrylic cured acrylic denture base with TiO2 nanotubes reduces the residual monomer content significantly, which improves the physical, chemical and biological properties of the acrylic denture base material.Keywords: Acrylic resin; GC-MS; Methyl methacrylate; Residual monomer; TiO2 Nanotubes.

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