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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Iron Status, Malondialdehyde, and Nitric oxide Levels in Iraqi Infertile Women with IgG Seropositive Toxoplasma Gondii Nada A Kadhim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The purpose of this study is to highlight the levels of IgG toxoplasma gondii (T. gondii) in infertile Iraqi women and its effect on iron status, malondialdehyde (MDA), and nitric oxide (NO). In order to do this, four groups were included in this study, infertile women with seropositive IgG T. gondii group (PP, n=25), infertile women with seronegative IgG T. gondii group (NP, n=25), healthy fertile women with seropositive IgG T. gondii as control group (PC, n=15) and healthy fertile women with seronegative IgG T. gondii as control group (NC, n= 15). All of the samples were tested as seronegative of IgM T. gondii. The results were as followes: Infertile women (PP) group have a significant levels of seropositive IgG T. gondii than fertile women (PC) group (P=0.008), while both (NC & NP) groups have seronegative IgG T. gondii. Serum iron and Hb concentration have been found to be with no significant differences (p>0.05), while significant increases were found in (TIBC, UIBC, transferrin and saturation of transferrin, p<0.001) in (NP vs. NC) group and (PP vs. PC) group, Also in (PP vs. NP) group and (PC vs.NC) group. The levels of malondialdehyde in serum of (NP & PP) were higher than (NC&PC) groups respectively. No remarkable changes were observed of (NC) group compared to (PC) group but a significant increase in MDA serum levels in PP group as compared to NP group, p<0.05. In addition to that levels of NO showed significant alterations in serum of infertile groups (NP & PP) as compared to that of their control groups (NC & PC) respectively (p<0.05), while no significant variation in sera of both (NP & NC) groups compared to (PP & PC) groups.Keywords: Toxoplasmosis, Infertility, Iron, Lipid peroxidation, Nitric oxide.
Synthesis, Characterization and Study of Electrical Properties of Some New Aromatic Polyester Basma. J. Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

This research discloses the synthesis of various polyester resins, the polyesters containing homoring aromatic and others heterocyclic were synthesized by the condensation polymerization of suitable monomers (which are containing variety function groups in different structures) with phthalic anhydride. The main objective is synthesis of new polyester with keeping a reasonable electrical insulating behavior. The structural of polymer was characterized by Fourier Transform infra-red spectroscopy FTIR and HNMR. The dielectric constant (real ε' and imaginary parts ε") and AC conductivity (σAC) for all the polyester samples are studied by varying the frequency (30, 50, 70, 90, 120, 300, 500Hz and 1KHZ) at 25⁰C. Indeed, study of the electrical behavior of various polyesters revealed that the cross-linked polyesters presents higher insulating behavior at room temperature than linear polymers. Thermo gravimetric analysis (TGA) and differential scanning calorimetry (DSC) were employed to study the thermal stability for these polymers.Keywords: Aromatic polyester, Condensation polymerization, Heterocyclic, Phthalic anhydride, Thermal stability.
Human Herpesvirus-6 in Relapsing Remitting Multiple Sclerosis Ansam W
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. HHV-6 has been implicated in the pathology of relapsing Remitting MS. Objective: Study the relation between HHV-6 viremia and relapsing remitting MS. Methods: A case-control study conducted on MS patients. fifty blood samples were collected from relapsing-remitting MS patients-thirty samples from the patients at the time of remission and twenty samples from the patients at the time of relapse and fifty blood samples from apparently healthy controls. Viral DNA extracted from plasma samples, and then, HHV-6 DNA detected and measured by quantitative real-time PCR. Anti HHV-6 IgG and IgM  antibodies measured by ELISA. Results: HHV-6 was detected in 22% (11/50) of MS patients, in 45% (9/20) of relapsing patients and 6.77% (2/30) in remission, while none of the controls was positive for the virus, (P=0.0013) (OR=11.45, P=0.045) (RR=2.9, P= 0.0003). IgG was positive in 48% (24/50) of MS patients and 56% (28/50) of the controls, (P=0.42). While IgM was positive in only 4% (2/50) of MS patients in the relapsing group, (P=0.49).Conclusion: HHV-6 could have a role in the pathology of relapses in MS patients and high viral load might be an indicator of relapse.Keywords: Relapsing-remitting MS, HHV-6, Real time PCR, IgG, IgM. 
Comparison the Effect of Ewe and Goat Colostrum Extracts on the Hematological and Biochemical Profiles: Rat as a Model Afrah Sabeeh Mhyson
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study was generated to provide information about the hematological and biochemical changes affected by exposing female rats to colostrum extracts of ewes and goats. As a start, 30 female rats were classified randomly into 3 groups (10 rats/each). The experiment was lasted for 30 days. Until the end of the experiment, a group received ewe colostrum extract (ECE) as 0.1ml orally/daily, another group was given goat colostrum extract (GCE) at 0.1ml orally/daily, the control group (C) was provided with normal saline at 0.1ml orally/daily. After the experiment was done, sacrificing of the tested animals was performed, and blood-based samples were obtained. These blood samples were tested for changes in the blood profiles using certain features such as RBCs counting, hemoglobin (Hb) level, packed cell volume (PCV), WBC counting, glucose (Glu) level, cholesterol (Ch) level, triglycerides (TAG), alkaline phosphatase (AP), alanine transferase (ALT), basophils (B%), eosinophils (E%), monocyte (M%), lymphocyte (L%), and neutrophils (N%). The results recognized significant (p<0.05) effects of the extracts on the RBCs, Hb, PCV, Glu, Ch, and TAG when compared with those in the C group. Furthermore, no significant (p>0.05) differences were provided from such effects on the WBCs, AP, and the ALT when compared with those in the C group. There were significant (p<0.05) effects of the extracts on the L% when compared with that in the C group. However, no significant (p>0.05) differences were provided from such effects on the B%, E%, M%, and N% when compared with those in the C group. No differences were noticed from these effects between both extracts on all those parameters. The study provides very important data about the effects of ewe and goat colostrum extracts on the hematological and biochemical characteristics in female rats that could be further used as supportive information for future studies.Keywords: Blood, Biochemical, Colostrum, Ewe, Goat, Parameters, Rat.
The Effect of Some Chemical Materials against Virulence Factors of Candida Ssp Isolated from UTI Patients Fatima Abdul Hussein Mejbel
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

During the period from September 2016 to December 2017, a total of 135 urine samples were collected from urinary tract infection patients attending to AL-Zahraa Hospital in AL-Najaf Governorate. The present study was conducted to isolate and identify Candida spp. isolated from urinary tract infection patients by different methods including direct examination , laboratory culture ,  biochemical test and by modern techniques (Api Candida kit) and determine the virulence factors phenotypic to Candida spp which involved (bio film formation, phospholipase and germ tube).The percentage of females to males was as following , female (84) 62.2 % (21) infected and male (51) 37.8% (1) infected with all age categories. The results in this study are explain that is some Candida spp. such as C. albicans, have high susceptible to eugenole follow by phenol and umbellulone. The efficiency of some chemical substances such as (eugenole, umbellulone, and phenol) was evaluated to inhibit the growth of Candida ssp as well as some virulence factors such as bio film formation, germ tube and phospholipase which were studied in this research. Statistically analysis results have been significance difference between the results of the substance concentrations and the concentrations of the different other substances.
The Emotional Sensitivity of University Student's Girls to the Practices and Non-practices of Sport Hind Salem Tayeh
Journal of Global Pharma Technology .
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Abstract

Their current research problem has focused on trying to answer the following question: Does exercise affect the emotional sensitivity of students in Iraqi universities? The objective of the study was to identify the level and fields of emotional sensitivity of both female students and non-sports practices, and to identify the differences between the level and fields of emotional sensitivity in both female and non-sports students. The researchers hypothesized the following: Of the emotional sensitivity between female students and non-practices of sport, and there are significant differences between the results of the negative field of emotional sensitivity between female students and non-practices of sport, there are differences of statistical significance between NTA The researchers used descriptive research method in the method of comparative studies on a sample of students of the third stage of the Faculty of Physical Education and Sports Sciences at the University of Baghdad (practices) for sport and the third phase students of the Faculty of Management and Economics at Mustansiriya University (Non-practices) for the sport, the number of (60) students who are 21 years of age in each of the two kidneys persisted for the academic year 2017/2018 by (30) students to exercise sports, and (30) non-sports student, Their stages of rain (SPSS). The researchers concluded that the level of emotional sensitivity in both the practices and non-practices of the sport was clear, that the level of emotional sensitivity in the practices was More than non-sports practices, female students need practices and practices to guide psychological counseling to reduce the level of emotional feeling they have, to recommend that researchers should pay attention to the measurement of emotional sensitivity to university students B Each league, interest in providing the educational atmosphere dominated by harmony and tolerance for students of Physical Education and Sports Science, it is necessary to work to enable the teaching staff in the faculties of Physical Education and Sports Science members to provide educational and psychological counseling programs and provide students with the state of love.Keywords: Emotional sensitivity, Practices and non-practices of sport.
Various Technical Aspects in Herbal Tea Production from Alisma Plantago-Aquatica Leaf N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Alisma plantago-aquatica is abundant weed on thinned crops of rice. A. plantago-aquatica is resistant to flood, but being very susceptible to shade; therefore the thickened rice crops shade the weeds and detain their growth. Leaves green; lower ones only sessile, widely linear, and swimming; the other ones aerial, long-petiolate; their plates big, ovoid or widely ovoid, with cordate base usually, with pointed apex. The use of medicinal herbs as a source of antioxidants is significant because they are often utilized to heal chronic diseases. Objective of this study focused on the effectiveness of blanching temperature and time; oven drying temperature and storage condition to total phenolics (mg/g), total flavonoids (mg/g), ferric reducing/antioxidant power (FRAP, mg/g), radical-scavenging activity (DPPH, mg/mL) of the dried Alisma plantago-aquatica tea. Results showed that Alisma plantago-aquatica should be treated in hot water at 95oC within 8 seconds in the present of citric acid 1.0% and then being dried by drying oven at 45oC until 7.5% moisture. The final herbal tea could be preserved under vacuum in aluminum bag at 28oC to maintain total phenolics, total flavonoids, antioxidant power and radical-scavenging activity for 12 months.Keywords: Alisma plantago-aquatica, Phenolic, Flavonoid, Herbal, FRAP, DPPH, Blanching, Drying.
Anredera Cordifolia Leaves Sub-fraction as Anti Hyperlipidemia R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This study aimed to evaluate the anti-hyperlipidemic properties of the sub-fraction of the Binahong (Madeira vine, Anredera cordifolia) extract in male Wistar rats. The rats were given high-fat food every day for 3 months and pure cholesterol on weeks 0, 3, 7, and 11. Furthermore, Ethyl acetate sub-fraction of binahong leaves with 0, 12 mg/kg BW, and 0, 24 mg/kg BW doses were given orally for 3 weeks and observed for lipid profile on day 21. The result showed that sub-fractions of Madeira vine leaves decreased in triglyceride, cholesterol, and low-density lipoprotein (LDL) levels and did not influence the high-density lipoprotein level (HDL). Meanwhile, statin decreased total triglyceride, cholesterol, and the LDL level, and increased the HDL level. It concluded that Madeira vine sub-fraction with 0, 24 mg/kg BW dose presented improved results in the lipoprotein profile. Keywords: Binahong, Madeira vine, Anredera cordifolia, hyperlipidemia, ethyl acetate fraction
The Impact of Iron Deficiency Anemia on Histomorphological Features of Placenta and the New Born Infants Rafah Hady Lateef Al-Mamouri
Journal of Global Pharma Technology .
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Abstract

 Iron deficiency anemia during pregnancy is  mutual heamatological disorder that happens in pregnancy, it affects maternal blood , leading to hypoxia, which cause changes in the structure of the placenta . Aim of study to explore the changes occurres both   in gross morphology and in histology of the placenta in anemic mothers. Methods: A fifty placentas were taken from mothers (full term) delivered at hospital constituted the material for the  present study. Full term placenta  was collected with case history and investigated after delivery of fetus. Two cm pieces were removed from both anemic and normal  group of placenta fixed in 10% formalin and used for processing and staining.  The microscopic study revealed histomorphological abnormalities as increased capillaries per villas, thickening of capillary basement membrane , trophoblastic basement  membrane, cytotrophoplastic proliferation,syncytial knots and fibrosis. All these changes occurred maintaining sufficient efficiency of placenta, to fulfill demand of oxgen in the fetus.Key words: anemia, histology, placenta,pregnancy.
Investigating the Architectural Structure and Decorations of Aligholi Agha School Mosque in Isfahan Mohieddin Aghadavoudi
Journal of Global Pharma Technology Volume 08 Issue 01
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Abstract

School mosques, as places where the science and worship are blended, have a particular position in Safavid era Isfahan’s style of architecture; and, the study and recognition of such places is of a great importance in terms of their associated architectural structure and decorations. Among these, Aligholi Agha School-Mosque as the most important building in Aligholi Agha urban collection should be recounted as one of the aforementioned buildings featuring prominent points regarding the structure and decoration which is the significant theme dealt with in the format of the current research paper. Thus, the most important question raised herein is that what are Aligholi Agha school mosque characteristic architectural structure and decoration features? The present study is based on a descriptive-analytical method and the information has been collected based on field observations and library research. Also, the findings have been analyzed based on quantitative methods. The results of the current study confirm that Aligholi Agha blended structure, while being small in its dimensions, encompasses distinct decorations and inscriptions turning it into a tiny treasure of the Safavid Era treasure. Among the most important of these decorations and ornamentations are the embossed tiles embedded with geometrical and plant-like carvings on the façade and the sceneries bestowed upon the interior spaces. Also, there are diverse inscriptions made via seven-color techniques and mosaic and stone carvings by taking advantage of buildings’ Kufi style of writing and Nasta’alygh calligraphy bearing contents such as the representation of Holy Quran’s Ayat and Hadith, compliments and praising king Sultan Hussein, information about the construction and an introduction on the personality of Aligholi Agha as the founder of the building.Keywords: Safavid era architecture, structure, decorations, Aligholi Agha school mosque

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