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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Improve Flour Quality by use Oxidized Agent during Tempering of Local Wheat Sakena Taha Hasan
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The Objective of this study was examined the effect of Oxidized Agent (hydrogen peroxide) added to temper water in order modify the quality of the local wheat flour. Chemical properties (protein, ash) and wet, dry gluten, gluten index and color. Rheological properties were measured by the farinograph, amylograph. Bread quality (Specific volume, Sensory evaluation). The hydrogen peroxide was added at three different levels (0, 0.01, 0.03%) to temper water wheat. Addition of hydrogen peroxide during tempering water wheat led to no significant increase in protein, ash, color and wet, dry gluten contained, but led to significant increase in gluten index. Addition hydrogen peroxide led to no significant increase on farinograph parameters. No significant effect on begin of gelatinization and viscosity temperature but there is significant positive effect on peak of viscosity curve. Significant positive effect on dough and bread quality, improved dough process Specific volume, crust color, symmetry of form, taste and chew ability. The optimal dose of hydrogen peroxide is (0.03%).Keywords: Hydrogen peroxide, Tempering, Local wheat, Dough rheology, Gluten, bread.
Synthesis and Identification of New Macrocyclic Ligand and Study its Pharmaceutical Properties as Anti-bacterial Reagent by Using Molecular Docking Study Ali M. Mohamed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The macrocyclic ligand (5, 7, 12, 14-tetraisobutyl-5, 12-dimethyl -1, 4, 8, 11-tetraazacyclotetradeca-7, 14-diene) was prepared by the reaction between ethylene diamine and 4-methyl pentan-2-one with the help of the perchloric acid as a precipitant reagent. It characterized by FTIR, 1HNMR and UV –Visible techniques. The prepared macrocyclic ligand combine with protein by the application of molecular docking study and it compared with a well-known and standard drug which is gentamycin. The results indicated that the recorded compound is very effective against the toxic bacteria on its cell area and may be in the future become an effective treatment regent by conduct further studies.Keywords: Macrocyclic ligand, Molecular Docking, Gentamycin, Staphylococcus aureus.
Synthesis and Characterization of Some Oxazepine Compounds from 2- Amino Thiazole Zainab Muhsin Bdaiwi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

A chains of new heterocyclic oxazepin compounds contain thiazole ring were Produced via two steps, the first step comprising condensation of 2- amino thiazol and various aldehydes, (3- hydroxy benzaldhyede, 4- nitro benzaldhyede, 4- chloro benzaldhyede and 4-dimethylamino benzaldhyede), and second step formation oxazepin as sevene membred ring compounds, by cycloreaction of these Schiff bases and (pathalic, malic anhydride) in tolune as solvent. These compounds were established via melting point, FTIR, HNMR, C13NMR spactra. Keywords: 2 amino thiazol, oxazepin heterocyclic, Schiff base.
The Role of IL-6 and TGF-β1 in Iraqi Women with Recurrent Abortion Roua Jamal Abdulkhaliq
Journal of Global Pharma Technology .
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Abstract

The alteration in the cytokines stability synthesis by Thelper1 cells with a rise of interleukin 6 (IL-6) and Thelper2 cells with the increase of TGF-β1 secretion is measured critical for retaining of usual pregnancy and increased risk of recurrent spontaneous abortion (RSA). This study was designed to measure some cytokines and affect these cytokines in the case of recurrent spontaneous abortion and healthy pregnant. Blood samples were collected from 210 women 180 women with the recurrent pregnancy loss (three or more abortions), and 30 women with normal pregnancy to three or more birth and without a previous abortion in the first trimester Based on clinical examination and diagnostic laboratory findings for TORCH of ELISA examination measured serum levels of immunoglobulin (IgM and IgG (for Toxoplasmosis, cytomegalovirus, herpes, and rubella in normal pregnant and in aborted women. Depending on the results of the test, the patients were divided into four groups: group one included 30 women with recurrent abortion with seronegative for TORCH test was (23.8%), group two recurrent aborted with seropositive for anti-toxoplasma antibodies was (20.9%), group three included recurrent abortion suffering from infected with different causes such as (cytomegalovirus, Rubella or Herpes) ratio was (41%). while group four women with a healthy pregnancy promise as a control group was (% 14.3). Then taking thirty serum samples of women from the first and second group with recurrent abortion and compared with control group then measured serum levels of pro-inflammatory cytokines Interleukin-6 (IL-6) and anti-inflammatory marker Tumor growth factor-beta1 (TGF-β1). The results presented that the serum levels of (IL-6) were highest in group1 and 2 (474.50 pg/ml and 629.60 pg/ml) respectively compared with control group (247.03 pg/ml), there was a significant difference. While TGF-β1 was the highest level in group1 (217.63 pg/ml) followed by group 2 (171.06 pg/ml) then control group (109.97 pg/ml) with the significant difference between three groups. The results indicated that the serum levels of pro-inflammatory and anti-inflammatory marker found with high level in recurrent abortion compared with healthy pregnant.
The Effect of Iron Addition on the Magnetic Properties of Nano Particles Made from Cerium-Cobalt Composition by the Co-Precipitation Method SJ Hosseini
Journal of Global Pharma Technology Volume 08 Issue 02
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Abstract

We have produced nanoparticles made fromco-precipitation-induced cerium-cobalt composition with 4:1 ratio. The results of the curve VSM represent the weak ferromagnetic properties of this compound at room temperature. But VSM curve shows an increase in ferromagnetism in this compound by eliminating (removing) the amount of oxygen, the mixture at 300 ° C under pressure of an atmosphere from H2 gas. In this compound, this property can be attributed to new created phases such as Co with hexagonal structure and properties of super paramagnetic and so can be due to the presence of Ce with Cubic structure in its ferromagnetic phase. By adding iron to the compound and production of new nanoparticles, XRD spectra shows that in addition to not changing the previous phases  and with Cubic structures, two new phases  and have been created with the same Cubic structure. The results of VSM curve represent the enhancement of ferromagnetism property of these nanoparticles which is caused by the presence of two new phases of iron and cobalt ferrite.
Effect of Frying And Storage on the Quality and Shelf Life of Fried Sweet Potato (Ipomoea Batatas) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Sweet potato is the seventh most important crop in terms of global production. Sweet potatoes are rich in antioxidants, such as phytophenolics and carotenoids which also provide distinct flesh colours. The high perishability of sweet potato roots during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. Consumers are increasingly health conscious and trends are moving toward foods with low oil content. This research has been focused on different parameters of drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and carotenoid; extending product shelf life during packaging and preservation. Results revealed that frying 2.0 cm of sweet potato chip in soybean oil heating at 150oC in 2 minutes was appropriated. Fried sweet potato chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried sweet potato products. Frying of sweet potato bars is carried out to convert the roots to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Sweet potato chip, Frying, Shelf life, Carotenoid, Flavonoid, Vaccum.
Morphometric Assessment of the Cerebellum of the Pre-implanted albino Rats Embryos after Maternal Exposure to AgNPs Israa Hassan Ali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Cerebellum (cb) is the most important and sensitive part of the central nervous system (CNS) after cerebrum. The exposure to any infection during embryogenesis produces abnormalities in the cerebellum function and morphology that effect on behavioral of offspring later. In the present study we used 30 mature female pregnant albino rats divided in to three groups, each group contain 10 females: G1 was considered the control group received D.W only, while G2 group treated orally with (2mg/kg /day) suspension of silver nanoparticles (AgNPs) and G3 group treated orally with (20mg/kg/day) AgNPs. The embryos retrieved in different embryonic days from ED12 to ED21. In this study morphometric analysis was measured in the developing albino rats cerebellum after maternal exposure to two concentrations of AgNPs from pre- implantation period until delivery . we measured the morphometric parameters  (area, perimeter, anterior-posterior diameter APD and transverse diameter TD) of the selected embryonic days; ED12,ED15,ED18, and ED21 and retrieved the embryos from these days. The morphometric results in the control group(G1) showed that increased significantly (P≤ 0.05) in the area of the developing cerebellum from ED12 until reach the optimal level in the end of gestation at ED21 (14.0815mm2 to 18.969 mm2 respectively), perimeter (9.804 mm2 to 16.267 mm2) and TD (52.6308µm to 431.6 µm),while the APD value was increased significantly (P≤ 0.05) at ED12 and ED15 only (367.0041 µm, 454.011 µm )respectively but the orientation growth of the cerebellum decreased significantly (P≤ 0.05) at the later stage of the development at ED18 and ED21(364.48 µm, 225µm) respectively. In the present research both  concentrations of the AgNPs (2mg and 20 mg/kg/ B.Wt) showed changes in the dimensions of the developing cerebellum cortex according to the studied morphometric parameters; in the 2 mg/kg/ B.Wt, the area of the developing cerebellum cortex was increased significantly (P≤0.05) from ED12 (47.437mm 2) and reached to maximum growth at ED18 (130.220 mm2), while it is growth inhibited at ED21( 68.909 mm2) compared to control group, the values of the developing cerebellum cortex perimeter increased significantly (P≤0.05) from ED12 until ED15 (0.964 mm 2, 2.548 mm 2)  respectively compared to control group; TD values of the developing cerebellum cortex increased significantly (P≤0.05) from ED12 until ED15 also (259.341 µm,436.203 µm) respectively compared to control group. While the APD of the developing cerebellum cortex was decreased significantly (P≤0.05) during late development of the cortex at ED18 and ED21(330.415 µm, 131.5 µm) respectively as in the control group. In G3 group which treated with 20mg/kg/ B.Wt concentration of AgNPs, the similar results of area were showed as in the lower concentration, area of the developing cortex increased significantly (P≤0.05) from ED12(80.11mm 2) and reached to maximum growth at ED18(140.56 mm2) and lower after that. the values of the developing cerebellum cortex perimeter increased significantly (P≤0.05) from ED12 until ED15 (0.256 mm2, 0.543 mm2)  respectively compared to control group; while in the APD and TD values the effect of the higher concentration of the AgNPs was more effect on these dimensions; APD values decreased significantly (P≤0.05) at ED15 (360.48 µm ) and not reach to the complete growth, also in TD values decreased at ED15 (400.5744 µm) and do not reach to maximum growth at end embryonic development compared to the embryonic development timing in the control group.Keywords:  AgNPs, Pre-implantation, Cerebellum, ED, Albino rats.
Evaluation the Effect of Growth Regulators and Explants Source on Micro Propagation of Moringa Oleifera In Vitro Huda E. Mahood
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

The present study describes a procedure for indirect regeneration of Moringa oleifera using leaves and stems as explants derived from in vitro germinated seedlings grown on Murashige and Skoog (MS) medium supplemented with different concentrations of auxin and cytokinins. The best callus induction was observed on MS medium containing 1.5 mg.L-1Indole-3-butyric acid (IBA) with 1.5 mg.L-16-benzylaminopurin (BAP) on stem explants .However, when callus was transferred onto a maintenance  medium supplemented with different concentrations of IBA (0.0, 1.0, 1.5, 2.0 or 2.5) mg.L-1and BAP (0.0, 1.0, 1.5, 2.0 or 2.5) mg.L-1, for increasing  callus mass, the combination of  1.5 mg.L-1  IBA with 1.0 mg.L-1 BAP resulted in best response in increasing callus fresh weight. A high shoot proliferation percentage was achieved at the combination 1.0 mg.L-1Kinetin (Kin) with 0.4 mg.L-1Naphthalene acetic acid (NAA) recorded (90%).The rooting percentage was 100% for shoots regenerated from callus cultures when MS medium was supplemented with 2.0 mg.L-1 IBA .After acclimatization, 80% of plants were able to survive.Keywords: Moringa oleifera, Indirect organogenesis, Explants, In vitro, Callus.
High Expression F2-Isoprostan (F2-IsoP), High Sterol Regulatory Element Binding Protein-2 (SREBP-2) and Low 2-Methoxyestradiol (2-ME) On Placenta Tissue as a Risk Factor of Pre-Eclampsia Jaya Kusuma AAN; Suwiyoga K; Mantik AN; Sukrama DM
Journal of Global Pharma Technology Volume 09 Issue 09
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Abstract

To date, pre-eclampsia (PE) still a problem of Maternal Fetal Medicine related to high incidence, maternal and neonatal morbidity and mortality. Pre-eclampsia is caused by pregnancy; however, the mechanism has not been established so it is still a disease of theories. This relates to differences in treatment, resulting in different ways of prevention and output of PE itself. Recently, the role of F2-IsoP ,SREBP-2 and 2-ME was suspected to be very important in the mechanism of the PE. Meanwhile, the placenta acts as a source regulatory protein production, so that the material of this study was taken from placental tissue. The study objective was to prove the high F2I-soP, high SREBP-2 and low 2-ME expression in the placenta as risk factors for PE Case control study has been conducted in the department of obstetrics and gynecology Sanglah Hospital with 62 samples in 2015. The case group consisted of 31 mothers with PE and control groups consisted of 31 non-PE mother. The study material is a placental tissue. F2-IsoP and SREBP-2 expression study was performed using immunohistochemistry and 2-ME with ELISA techniques in Pathobiology Laboratory Faculty of Veterinary Medicine Udayana University. Data were analyzed with chi square test and discriminant using SPSS. The statistical test results are presented in tabular form and narrative. In this study, it was found that high expression of F2-IsoP increased the risk of PE  4 times higher (OR = 4.44; 95% CI = 1.53 to 12.94; p = 0.005) ; high expression of SREBP-2 increased the risk of PE 8 times higher  (OR = 8.19, CI95% = 2,311 to 29.073; p = 0.001) and low expression of 2-ME increased the risk of PE 5 times higher (OR = 5.23; CI95% = 1.75 to 15.55; p = 0.002). On the discriminant test, we obtained contributing risk factor for the occurrence of PE were SREBP-2, F2Isop and 2-ME (p = 0.002) respectively. Conclusion, high F2-IsoP expression, high SREBP-2 expression and low 2-ME expression in placenta were risk factors for PE. The most dominant risk factor of PE mechanism was SREBP-2.Keywords: Pre-eclampsia, F2-Isoprostane, Sterol Regulatory Element Binding Protein-2, 2-Methoxyestradiol.
Comparison Of Ethanol Emulgel Extract Activity Of Duku Fruit Peels (Lansium domesticum Corr) With Tranexamic Acid As A Skin Lightener Lusi Nurdianti
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

ABSTRACT Objective : Emulgel which has the potential for skin lightener is a medical cosmetic preparation used to inhibit the formation of melanin pigments so that it can brighten the skin. The purpose of this study was to determine the effect of concentration variations of duku (Lansium domesticum Corr.) peel waste extracts on the evaluation results of preparations, the level of irritation to rabbits, and an increase in brightness on human skin compared with emulgel containing tranexamic acid. A dermatoscopic test is used to look at the imaging of the skin surface after the use of an emulgel. Material and Method : In this study, concentration variations of ethanol extract from duku peel waste of 10%, 15% and 20% were used. Result : The test results obtained that all formulas meet the requirements of organoleptic test, pH, homogeneity, dispersibility, and centrifugation test. Irritation test with the Draize method obtained all formulas do not irritate. The results of testing the increase in skin brightness on emulgel preparations showed that F1 (16.67%), F2 (33.33%), F3 (60%), F4 (60%). Conclusion : Increasing the brightness of emulgel preparations containing 20% ethanol extract of duku peel is comparable to 4% tranexamic acid.Keywords: Tyrosinase, Lightening cream, Duku fruit Peel, Tranexamic acid.

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