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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effectiveness of Chitosan-Based Edible Coating on Wax Jambu (Syzygium samarangense) N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Chitosan is a biodegradable material derived from chitin. It is used in agriculture industry. It has an antifungal property. Cinnamic acid is known as the agent of antimicrobial. Cinnamic acid is rarely used in single coating but tend to be used in combination coating. Coating is used to protect the food and conserve their shelf life. Wax jambu (Syzygium samarangense) fruits have a thin red skin and are delicate; they need to be picked by hand twice a week and handled with care. The fruits of S. samarangense are also having several medicinal properties they are highly perishable under post-harvest condition. This problem is an obstacle to the production of wax jambu for export. Objective of this study focused on the effectiveness of chitosan-based as edible coating on wax jambu (Syzygium samarangense) to extend its product’s shelf life. Results showed that wax jambu (Syzygium samarangense) was coated by 1.5% chitosan and 3.5 mM cinnamid acid which were appropriated to extend its shelf life for 10 days under ambient condition. Chitosan coatings can be used for storage of highly perishable fruits as it had showed increase in the shelf life of wax jambu. Chitosan ensures to slow down senescence by preventing respiration and transpiration.Keywords: Chitosan, Cinnamid acid, Coating, Shelf life, Syzygium samarangense.
Expression of Adipocyte Binding Protein-2 (AP-2) on the Adipogenic Differentiation of Mesenchymal Stem Cell after Pulsed Electromagnetic Field (PEMF) Exposure Umiatin U
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Obesity is a health condition that can cause serious health problems in developing countries such as Indonesia and still a major health concern worldwide. Obesity increasing the risk of a number of pathological disorders including certain cancers, heart disease, stroke, and diabetes. It has been reported that Pulsed Electromagnetic Field (PEMF) have an inhibitory effect on adipogenesis of MSCs. However, it is not clear if this effect is direct or indirect. Various genes are involved in the development of obesity include adipocyte binding protein 2 (AP-2) which is associated with inflammation and the metabolic syndrome. In the present study, we investigated the effect of PEMF exposure with frequency 75 Hz and magnetic field 2 mT on the adipogenic differentiation of mesenchymal stem cells (MSCs). In the present study we used the MSCs second passage. The cells were stimulated by PEMF of 75 Hz/2mT for 14 days 10 in/day. The relative expression of AP-2 was measured on days 2, 4, 7 and 14 by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) method. The PEMF significantly inhibited adipogenic differentiation by down regulating the expression of AP-2 on days 2, 4 and 7. This result indicated that PEMF exposure may have potent effect to inhibit adipogenic differentiation. Keywords: Pulsed electromagnetic field, Adipogenic, Mesenchymal Stem Cells, AP-2
ISOLATION OF ACTIVE COMPOUND FROM ZINGIBER PURPUREUM ROXB. USING BIOASSAY GUIDED FRACTINATION METHOD FOR WIDR COLON ADENOCARCINOMA CELL LINE rollando rollando
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Zingiber purpureum Roxb. was a plant that has the potential to be developed as a chemotherapy agent. Bioassay guided fractination aims to examine the anticancer activity of n-hexane, ethyl acetate, and methanol fractions from ethanolic extract of bangle plant rhizome to colon cancer cell type WiDr and Vero cells. The apoptotic test and modulating cell cycle were observed by flow cytometry method. Isolation process of the most active fraction. The pure isolates obtained were identified by structures with structural elucidation using ultraviolet, 1D-NMR, 2D-NMR and liquid chromatography-mass spectrometer. Obtained 2,3-dihydro-5-hydroxy-7-methoxy-2-phenylchromen-4-one compound of ethyl acetate fraction number 21. With a value of CC50 to a WiDr cell of 11.24 ± 3.44 μg/mL and 342.22 ± 4.98 μg/mL to Vero cells.
Association of Different Body Mass Index with Vitamin D Receptor Gene in Females with Deficiency of Vitamin D Maha F. Smaism
Journal of Global Pharma Technology .
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Abstract

Background: Obesity is one of the well spread chronic condition that is affecting health and it is connected to many fatal chronic diseases like cardiovascular disease, diabetes mellitus and cancers. Vitamin D is shown to has a role in the pathogen city of obesity, and the Vitamin D receptor (VDR) gene polymorphism is shown to affect the obesity phenotypes like body mass index (BMI).Objective: is to assess the association between different variants of vitamin D receptor gene and the BMI in females with deficiency of vitamin D. Methods and Materials:  The study was conducted with the participation of 170      females who are having low vitamin D levels. The single nucleotide polymorphism Taq in the vitamin D receptor gene was detected by PCR-RFLP. Vitamin D level in the serum was measured by ELISA technique. Result: This study is resulted in that there is a positive correlation between the BMI and different biochemical measurements like the level of vitamin D(p < 0.001), calcium level [ both free Ca(p=0.01) and total Ca(p= 0.002)], urea level (p < 0.001), and bilirubin level (p < 0.001). It is also resulted in finding a positive correlation between the BMI and the genotype of the vitamin D receptor, as it is noticed that 44.7% of the patients who are carrying the TT genotype, while only 40.0% of the patients who are carrying the CC genotype. Conclusion From the result   the study show significantly negative correlation between Vitamin D and BMI that means the vitamin D deficiency could relate with increase BMI ,Also there is significantly negative correlation between vitamin D and cholesterol ,as well as this study indicate that significantly decrease of total bilirubin  with increasing BMI increased. From the results of genetic study for vitamin D receptor gene study, can conclude that the T allele is positively correlated to the obesity represented by the BMI, and that could lead to the conclusion that females who are having the TT genotype are of higher probability to get high  BMI and obesity. 
Surveillance and Monitoring Brucellosis at Denpasar Veterinary Center Working Area in the 2016 Suharsono H
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: The situation of Brucellosis in the working area of the Denpasar Veterinary Center (BBVet) varies between provinces. The provinces of Bali and NTB have been declared free of Brucellosis. However, specifically in NTT, only Sumba Island was declared free of Brucellosis. The situation of Brucellosis in NTT Province, on the island of Timor, Belu Regency and TTU is a heavily infected area of brucellosis with a prevalence of > 2%, while other islands have an unknown prevalence. One Brucellosis reactor found in Ende District in 2006. Continuous surveillance was carried out as an early detection step to keep the area free. Objectives: Brucellosis and monitor the possibility of entry/emergence of new reactors in the region, and to determine the prevalence of Brucellosis in areas that are not yet free of Brucellosis. Methodology: The samples tested were samples received by the BBVet Denpasar Bacteriology laboratory during 2016. The samples were tested using the Rose Bengal Plate Test (RBPT) method if positive continued with the Complement Fixation Test (CFT) test. Results: A positive sample of CFT expressed as a Brucellosis reactor. The test results of 4,602 serum samples from Bali Province and 2,504 serum samples from NTB Province were all negative for Brucella antibodies. Whereas serum samples from NTT Province were 1,533 samples, three positive samples were CUC brucellosis; namely, two (2) positive samples from 175 serum samples came from Malacca District and one (1) positive sample from 73 serum samples came from North Central Timor District ( TTU). Whereas samples from the districts of Alor, Ende, Lembata, Manggarai, West Manggarai, East Manggarai, Nagekeo, Ngada, RotenDao, Southwest Sumba, West Sumba, East Sumba, East Timor Tengah (TTS), and Kupang City, Conclusion: all negative. Based on these data it can be concluded that the Provinces of Bali and NTB are still free of Brucellosis.Keywords: Brucellosis, BPT, CFT, Bali, NTB. NTT.
Evaluation of In-vitro free Radical Scavenging Potential of Whole Plant of Pupalia Lappacea Juss (L) P. Veeramani
Journal of Global Pharma Technology Volume 10 Issue 12 (2018) December 2018
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Abstract

The study was designed to examine the in vitro antioxidant activities of ethanolic extract of whole plant of Pupalia lappacea. The antioxidant activity was evaluated by DPPH radical scavenging, Nitric Oxide Scavenging and Iron chelating activity with reference standard Rutin, Ascorbic acid and EDTA respectively content was estimated.  Our results indicate that ethanolic extract of Pupalia lappacea has IC50 value of 510 μg/ml, 410 μg/ml, 310 μg/ml of DPPH, nitric oxide, and iron chelating activity respectively. So, the in-vitro studies clearly showed that the ethanolic extract of Pupalia lappacea has a significant antioxidant activity. These in-vitro assays wise that this plant extract is the best root of natural antioxidant; these are very supportive in the progress of preventing different types of oxidative stresses.Keywords: Pupalia lappacea, DPPH assay, Nitric oxide radical scavenging, Iron chelating activity.
Pattern and Characteristic of Sports Related Injury in Emergency Department Sardjito Hospital Andreas Wahyu Wicaksono
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective. Sport activites have been encouraged to everyone due to its benefits to the physical fitness, improving the endurance, and has psychological good impacts. But, sport activites also carries risk of injury to the body. Sports-related injuries are not an uncommon cause of ED visit. The aim of this study was to identify the pattern and characterize emergency department (ED) visits that result from sports-related injuries across the Sardjito Hospital.Methods. The study took place retrospectively observational study over a period of two years from January 2014 to December 2015 and included people 3 years of age or over. Any patient presenting with an injury attributable to participation in organised sport had their details and phone number noted in the medical record form by the orthopaedic resident. The patient medical record were analysed retrospectively. Demographic trends, pattern and characterstic for each patient were recorded.Results. A total of 133 elligible patients were enrolled to this study, 98 were male with the mean of age was 17.5. The most common type of sport that cause of injury was cycling (22.6%), followed by running (21.8%) and then football (17.3%). The majority of the patient sustained upper extremity injury (75.9%). 108 patients sustained fracture, 15 dislocation, and 10 soft tissue injury. There was statistical differences between type of injury as compared with age group (p = 0,000), the age group of <10 years old, 11-20 years old, 31-40 years old and >40 years old suffered more fracture than dislocation and soft tissue injury. There was statistical differences between type of injury as compared with injured extremity (p = 0.03), the injury mostly affected superior extremity, but there was no statistical difference between type of injury as compared with type of sports, gender and side of injury (left or right) (p > 0.05). Conclussions. Sports can cause musculoskeletal injuries, good preparation must be taken to avoid severe injury. High percentage of upper extremity injury and lower extremity injury, the specific type and location of injuries of each sport should be known by health professionals.Keyword: sport injury, emergency department, age group, gender, location and types of injuries
Effectiveness of Pitaya Pulp Incorporated to Wheat Flour in Bread Making Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

 AbstractThere has a trend towards the consumption of functional foods beneficial for human health.  Bread is one of the most important staple foods in the world.  Pitaya pulp is a rich source of nutrition like carbohydrate, pectin, crude fibre, vitamin and minerals. It also contains a great amount of phytochemical constituents like phenolics, flavonoids. It would be of functional benefit if wheat flour could be substituted by pitaya pulp to utilize anthocyanin pigment in adherent as natural valuable colorant in bread-making. We have attempted in the application of composite flour through the incorporation of pitaya pulp into wheat flour to improve nutritional quality of bread. In this study, pitaya pulp was utilized to substitute refined wheat flour in bread-making doughs at 3.5%, 5.0%, 6.5%, 8.0%, 9.5% substitution levels. Various variables of texture firmness (g), specific loaf volume (cm3/g), water activity (aw), rancidity (meq O2/kg fat), total phenolic (mg GAE/ 100g), total flavonoid (mg GE/ 100g) and sensory characteristics of bread were carefully observed. The substituted bread-making with 8.0% pitaya pulp had the improved firmness, rich in total phenolics and flavonoids but low in rancidity. During 7 days of storage in OPP/LLDPE pouch at ambient temperature, the physico-chemical, microbial and sensory characteristics of bread still satisfied to acceptable level.Keywords: Bread, Pitaya, Firmness, Specific loaf volume, Water activity, Phenolic, Flavonoid, Rancidity.
Bioactive Compounds From Marrubium vulgare L. based on in vitro antioxidant Activity Shamil Ismail Neamah; Ismail Ahmed Sarhan; Oqba NAFIA Al-Shay
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

Marrubium vulgare L. (Lamiaceae) used in the world a viable source of medically important. Six compounds included: flavonoids, triterpenoids, and phenolic acid, they were isolated from the leaf extract by methanolic solvent and were determined as luteolin-7-O-β-glucopyranoside (1), apigenin-7-O-β-glucopyranoside (2), oleanolic acid (3), β-sitosterol (4) luteolin-7-O-rutinoside (5), and rosmarinic acid (6). In the MTT assay, compounds 1-6 at 250 µg/mL concentration gave an absorbance value of 0.524, 0.455, 0.187, 0.088, 0.0362, and 0.241, respectively. The significant LPO inhibitory of the purifications afforded compounds 1, 2, and 5 by 66, 84, and 89 at 100 µg/mL concentration, respectively. 
The Effect of an Innovative Device to Perform the Sitting Test from Lying Down to Students Applying for Admission to the College of Physical Education and Sports Science Mohamed Abdulrahman Mohamed
Journal of Global Pharma Technology .
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Abstract

The main purpose of any test must contain and include all the specifications of the good test, relying on the scientific basis for the test itself. As you know, scientific progress has a clear effect on the consideration of the requirements of the good test, including the provision of effort, time and cost, it is one of the tests for acceptance of applicants to accept Physical Education and Physical Sciences Test the sitting of the bowel as one of the fitness tests. Through the follow-up of the researchers for this test it was found that it takes a lot of time and effort as well as the cadre of the work. Each group of testers comprises at least (10) elements which require (10) of the faculty members for the purpose of keeping and fixing the feet of the laboratory and also to calculate the number of the gift for each laboratory and this requires a large number of teachers and teachers who are also in the original also have other tests are done as if all skills (plane - basket - foot ... etc). The sit-down test of students applying for admission to the Faculty of Physical Education and Sports Science takes a lot of effort, time and cost through the number of staff required to conduct the test to hold the testers and calculate the number of times the test is conducted. The aim of the research is to design an innovative device and know its effect in conducting the sit-down test. It is assumed that the innovative device has the effect of conducting and achieving the sit-down test, taking into account the saving of effort, time and accuracy in performance.Keywords: Innovative device, Sitting test, Admission, Physical Education and Sports Science.

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