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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis and Characterization of Some New Derivatives Starting from (4, 4'-diaminophenoxy) Ethane Containing Diazonium Groups Iftikhar Ahmed Hussein
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The diazonium salts are highly reactive compounds. They are used as intermediate in different reactions. The diazonium salt [C2] was synthesized and reacted upon with (Acetyl acetone, ethyl acetoacetate, salicyladehyde) to produce [C3-C5].Then reacted [C3, C4] with hydrazine hydrate 80% due to [C6,C7]  . Then reacted [C5] with (Methyldopa and Atenolol) as drugs obtained [C8, C9].The prepared derivatives were identified by infrared spectra, 1HNMR, and physical properties.Keywords: Azo compounds, Heterocyclic rings, Schiff bases.
A Validated Stability Indicating RP-HPLC Method Development for Platelet Aggregation Inhibitor Ticagrelor in Bulk and Tablet Formulation Kirtimaya Mishra
Journal of Global Pharma Technology Volume 11 Issue 12 (2019) December 2019
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Abstract

A stability-indicating Reverse Phase-HPLC technique for the quantification of Ticagrelor (TCG) in pharmaceuticals was developed and validated. Chromatography was done on Phenomenex Luna C18 5μm (250 mm×4.6 mm) analytical column with acetonitrile: methanol: water in 40:30:30% v/v/v ratio as mobile phase and 0.9 ml/min as a flow rate. TCG was detected at 280 nm UV-wavelength maximum. In this present research work developed technique was validated over 20-150μg/ml linear concentration range for TCG. This method was accepted with linearity coefficient value of 0.99 and the percentage recovery was found to be 99.3%. This method was shown with LOD and LOQ findings of 0.53μg/ml and 1.61μg/ml respectively. The drug was degraded in acid and alkaline medium and the percentage degradation values were 3.10 % and 4.54 % respectively. There was no degradation of drug when wide open to neutral, UV, thermal, sun-light and oxidative conditions. Drug was undergoing degradation when exposed to acid and alkaline conditions.Keywords: Ticagrelor, Reproducible, Degradation, Oxidative conditions.
Genotoxicity of Ciprofloxacin in Bone Marrow Stem Cells of Mice Infected with Uropathogenic E. coli Muthana Ibrahim Maleek
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Background and Objectives: Ciprofloxacin is an antibiotic used for the treatment of uropathogenic Escherichia coli (UPEC) infections. It is intended in this study to investigate the genotoxic effects of ciprofloxacin on bone marrow stem cells of mice prior to and after infection with E. coli.  Method: Two groups of mice were injected intraperitoneally every 8 hours with 9.5 mg/kg Ciprofloxacin; the first was for 24 hours and the other was for 5 days. Similarly, two other groups of mice were injected with 0.5 ml (1.5×108 cfu/ml) E. coli and treated with ciprofloxacin for 5 days. Microscopic slides were prepared from bone marrow of treated mice and genotoxicity was assessed by counting the number of chromosomes aberrations (CAs), mitotic index (MI) and micronucleus (MN). Results and Interpretation: Significant increase in the number of CAs, a decrease in MI and insignificant change in number of MN were seen in mice infected with E. coli and treated for 5 days with ciprofloxacin. However, no change in the values of these aberrations was observed in mice treated for 24 hours. It is believed that the effects of Ciprofloxacin on DNA in combination with the accumulated effects of E. coli toxins were responsible for the observed DNA damages. Conclusion: The use of ciprofloxacin for the treatment of E. coli infection may increase genotoxicity in bone marrow stem cells, which produces significant DNA damage.  Keywords: Ciprofloxacin, E. coli, Stem cells, Mitotic index, Chromosomal aberrations, Micronuclei.
Structural, Morphological and Optical Properties of Mg: ZnS Nanoparticle for Future Contribution in Different Biological Uses Jinan A. Abd
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The wet chemical co- precipitation technique has been used to prepare magnesium doped zinc sulfide nanocrystal powder at room temperature for future contribution in technological and biological applications. The crystal structural, morphology, optical properties, and the emission spectrum of the powder were characterized by x-ray diffraction (XRD), atomic force microscopy (AFM), UV-VIS spectrophotometer, and photoluminescence (PL) spectra. The analysis of XRD diffraction indicated that the powder had cubic zincblende structure and the calculated value of crystallite size was (15.9 nm) for the preferential orientation diffraction peak (111). The calculated energy gap of the Mg:ZnS nanoparticles was ( 3.87 eV) from absorbance spectrum. The PL spectrum of the nanoparticle confirmed two peaks located on (367 nm) and (485 nm).
Rationality and Prescribing Pattern of Antimicrobials on Female Lower Genital Tract Infection in a Tertiary Care Hospital of Odisha Ginia Agasti; Rasmita Jena; Dipti rani Rath; Trupti Rekha Swain; Goutam Ghosh; Durga Madhab Kar
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions for the treatment of female lower genital tract infection and its validation of rational use in a tertiary care hospital of Odisha. Methods: The current prospective investigation was carried out in outpatient department of Obstetrics and Gynaecology department at a tertiary care hospital over a period of six months.   A suitable data collection was carried out from female lower genital tract infection patients who were of 11-55 years of age group. Results: The study result found that most commonly prescribed antimicrobials were antifungal (azoles derivatives) and its combination with other antimicrobials. The other antimicrobials include, topical (8.4%)/single antimicrobial oral (2.8%)/ combination (intravaginal as well as oral- 50%) followed by other antimicrobials like linozolid (4.8%). Our study reveals that, antifungal agents are the most common antimicrobial drugs prescribed on the basis of laboratory diagnosis report, which revealed that, staphylococcal infection in majority of the patients (42%). Conclusion: Hence, present study shall definitely provide a small initiative towards control of emergence of antibacterial resistance, its side effects and cost of therapy worldwide.Keywords: Prescribing pattern, Antimicrobials, Lower genital tract infection, Tertiary care hospital.
Brown, White and Blue Bagging in Special Pharmacy: An Emerging Trend to Minimize Medication Error Sharad Chand
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Advancement in the sector of specialized pharmacy evolved a new concept of bagging system beyond the scope of traditional pharmacy service. Managed care organizations (MCOs) bring up the healthcare system in the network where the services are made available for the betterment of treatment and secure documentation system for reimbursement. Certain models namely brown bagging, white bagging, and blue bagging system are promising models for this system. These models generally cover expensive and high-risk medication to minimize the wastage and related drug related problems. In these models, all the prescribed medications reach to the health professionals, which meticulously review all the medications before its administration. This potential system has several advantages over the conventional pharmacy practices, despite several advantages many associated risk and disadvantages are equally challenging. But it can be concluded that benefits are outweighing the risk associated with these models, which may have more impact on patient wellbeing. Hence, this system of special pharmacy service can be recommended in the scope of hospital pharmacy and pharmacy practice.
The Characteristic of Congenital Fetal Anomalies at Sanglah Birth Defect Integrated Center (SIDIC), Sanglah General Hospital, Bali Indonesia Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction. Congenital anomalies are among the cause of neonatal morbidity and mortality. The aim of this study was to measure the occurrence of congenital fetal anomalies and explored the distribution of specific anomaly at SIDIC (Sanglah Birth Defect Integrated Center), Sanglah General Hospital Bali, Indonesia. Method. The study was a descriptive study of congenital anomalies who were screened at Maternal-Fetal Medicine Division outpatient clinic and who were delivered at Sanglah General Hospital Bali, Indonesia during the period January 2017-December 2018. Result. During two years study period, there were 109 pregnant women who gave birth to 118 babies with congenital anomalies. The system most involved were Gastrointestinal System 21.2% and Central Nervous System 21.2%. The majority of mother (70.6%) was at 20-35 years old. Regarding the gestational age, the majority accounting for 38.5% were at 28 - 34 weeks. Conclusion. In this descriptive study, the incidence of congenital anomalies most involving gastrointestinal system and Central Nervous system. Advanced in the knowledge of congenital anomalies could be important for better prevention. The preventive strategies such as preconception counselling, focused antenatal care, and care to optimized women’s health should be implemented. Keywords: Congenital anomalies, SIDIC, Fetal anomalies.
Nurses' Attitude Toward Mental Illness in DhiQar, Iraq Ahmed Hassan Hussein
Journal of Global Pharma Technology .
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Abstract

Stigma against mentally ill patients is highly prevalent among nurses. High rates authoritarianism and social restrictiveness, low rates of benevolence and community mental health ideology were noticed among nurses. Recommendations: These findings raise the importance of learning the nursing students and nurses about the stigma and the right attitudes towards mentally ill patients. Future studies need to be inclusive of larger samples and need to study other aspects of the problem like the etiology and impact on patients.Keywords: Nurses, Attitude, Mental illness
RP-HPLC Method Development and Validation for the Estimation of Methylcobalamin in Bulk BS Muddukrishna
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

The subsequent artefact entail of extremely subtle and informal Reversed phase HPLC (RP-HPLC) technique for approximation ofMethylcobalamin in large quantity. Shimadzu LC-20-AD(Kyoto, Japan), with auto sampler and (PDA/UV) detector was used for the separation of Methylcobalamin.C18 Hypersil BDS (5.0 micron,150 x 4.6mm) column was aimed at the separation and mobile phase(MP) comprising of(55:45 v/v) Methanol:o-phosphoric acid 0.02%v/v pH 2.3 was cast-offby keeping the rate offlow1 ml/minalong the effluents supervised on 223nm. linearity is undeviating having line equationf(x) =4.87512e-006*x-0.702284 with correlation coefficient(R2) of 0.997. Theprocessremained precise with 0.5% RSD(intra-day precision)&(Inter-day precision) is 0.43%. The LOD & LOQ was0.1499μg/ml and 0.4542μg/ml respectively.The establishedprocess wasvalidated forlinearity,system suitability,precision, and robustness; henceforthverifies in order that this one is exceedinglyrelevantto approximate Methylcobalamin in routine analysis.Methods name: Estimation of Methylcobalaminby HPLC.Keywords: Methylcobalamin, Reverse phase hplc (RP-HPLC), Validation and chromatography.
Biosynthesis of Copper Oxide Nanoparticles using Starch of Maize and It’s Antimicrobial Activity against Opportunistic Pathogens Mouruj A. Al-Aubydi
Journal of Global Pharma Technology .
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Abstract

Copper oxide nanoparticles were synthesized by thermal green synthesis method using basically starch of maize, CuSO4.5H2O, with an abundance quantity of ammonia solution as stabilizing and alkalinity agent, the reaction was completed at 200 ͦC. The formation of black solution was represented the creation of CuO nanoparticles. Finally, after precipitation, washing by deionized water and ethanol and drying, CuO nanoparticles are obtained as black powder. The synthesized copper oxide nanoparticles were characterized via various techniques, included ultraviolet –visible (UV-visible) spectrophotometry, X-ray diffraction (XRD), fourier transform infrared spectroscopy analysis(FTIR) and transmission electron microscopy (TEM).All the analysis showed that the nanoparticles were very constant, pure, globular shape as well as average crystallite measure is 9.8nm. The particles diameter size was ranging from 47.41nm to 109.49nm. However, the average distribution (d50) is71.17nm.Antibacterial CuO nanoparticles activity of different concentrations were tested against four strains of pathogenic Gram-negative  bacteria Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Gram-positive bacteria Staphylococcus aureus. The results showed that different concentration of CuO nanoparticles have been significant increasing effect in inhibiting of a bacterial growth compared with the control for both types of bacterial isolates. Also,it was found that all isolates appeared high level of resistance against most usable antimicrobial agents, while these resistance were decreased in case of combination with CuO NPs. Thus there is a synergistic effect between CuO NPs and antimicrobial agents. Keywords: Copper oxide nanoparticles, X-ray diffraction, Starch, Antibacterial activity.

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