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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis and Characterization of the Ligand (S, S'-Bis (Benzo [d] Oxazol-2-yl) 2, 2'-((Methylenebis (4, 1 Phenylene)) Bis (Azanediyl)) Diethanethioate (BMPAE) and it's Complexes with Some Transition Metals Ions Tariq Hussein Mgheer
Journal of Global Pharma Technology .
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Abstract

This study involved synthesis of ligand (S,S'-bis (benzo[d]oxazol-2-yl) 2,2'-((methylenebis(4,1-phenylene))bis(azanediyl))diethanethioate(BMPAE)by reaction in two steps. The first involved reaction between 2-Mercaptobenzoxazole with chloroacetyl chloride to get S-benzo[d]oxazol-2-yl 2-chloroethanethioate(compound-1).The second step reaction (compound-1) with 4,4'-Methylenedianiline to form S,S'-bis(benzo[d]oxazol-2-yl)2,2'-((methylenebis(4,1phenylene))bis(azanediyl))diethanethioate (BMPAE) .This ligand was characterized by melting point, FTIR,1H NMR , 13C-NMR  and elemental analysis. New chelating complexes were prepared from reaction ligand (BMPAE) with transition metal salts of Co (II), Cu (II), Cd (II), Ag (I), and Hg (II).The structures of these complexes were identified by FT-IR and UV-Vis spectra molar conductivity, melting points, elemental analysis, atomic absorption and magnetic susceptibility measurements. The FTIR spectra clearly show new bands, which were not found in ligand spectrum, while many other bands observed changes in shape, position and in intensity which are explained by the coordination with metal ions. All complexes showed tetrahedral geometry structures except Co (II), Cu (II) complexes are octahedral.Keywords: Heterocyclic, 2-Mercaptobenzoxazole, Benzoxazole complexes, Transition metal complexes.
Association of Plasma Neutrophil Elastase and Interleukin 1 Beta Levels with Metabolic Syndrome in Obese Premenopausal Women Moushira Zaki
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Introduction: Metabolic syndrome (MS) is the state of chronic low grade inflammation. Plasma neutrophil elastase (NE) might be a critical marker associated with several choric diseases. However, relation of NE, interleukin 1 beta (IL-1β) and MS and its complications in Egyptian obese women has not been yet investigated. The aim of this study is to determine the relationship between levels of NE, IL-1β with MS and metabolic components in obese premenopausal women. Methods: This cross-sectional study was conducted on 150 obese women with MS and 150 non obese healthy women matched in age. Inflammatory markers including NE and IL-1β were measured by ELISA. Blood pressure (BP), blood glucose, lipid profile and insulin sensitivity were studied. Insulin resistance was assessed by the homeostasis assessment model (HOMAIR) and insulin sensitivity by quantitative insulin sensitivity. Body fat % was assessed by Body composition analyzer. Results: MS patients showed significant higher levels of NE, IL-1β, fasting insulin, glucose and HOMA-IR and markers of serum lipid parameters (increase of triglycerides, low density lipoprotein, total cholesterol and decrease of high density lipoprotein), elevated levels of SBP and DBP than non obese controls. In addition, significant positive correlations were observed between NE and metabolic components of MS. Partial correlations revealed significant positive relation between NE, IL-1β and HOMAIR, body fat % in obese MS cases after adjustment of BMI and age. Conclusion: NE and IL-1β and body fat % are elevated in obese women with MS, suggesting their critical role in MS complications in obese Egyptian women and emphasized that these biomarkers might be used as good indicators for severity of the disease.Keywords: Metabolic syndrome, Interleukin 1 beta, Neutrophil elastase, Insulin sensitivity.
Rheumatoid Factor Isotypes in a Sample of Iraqi Rheumatoid Arthritis Patients Raghad Hassan Hussein
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Rheumatoid arthritis is a chronic inflammatory disease with an autoimmune origin. This disease primarily involves the small joints with subsequent systemic involvement. Rheumatoid factor is one of several biomarkers that characterize this disease. The prevalence of rheumatoid arthritis has increased in Iraq in recent decades. This study aimed to investigate the level of three RF isotypes in a sample of Rheumatoid arthritis patients. The study involved 100 Iraqi rheumatoid arthritis patients aged 5-72 years. The mean age for the patients included in the study was a 41.04 ±14.25 year with the majority of patients (42%) being in the age group 40-59 years. A highly significant difference in the prevalence of rheumatoid arthritis was found between female (82%) and male (18%) patients included in the study (p<0.01). Qualitative estimation of RF isotypes showed that the highest positivity was for RF-IgG (42%) followed by RF-IgA (29%) and RF-IgM (28%).Quantitative estimation of RF-isotypes showed that the mean value for serum IgA, IgG and IgM in patients included in this study was 41.04 U/ml, 39.6 U/ml and 48.6 U/ml respectively. An interrelation was found between RF-IgG and RF-IgM titers (r=0.54). The results of this study confirm the importance of measuring multiple RF isotypes in rheumatoid arthritis patients.Keywords: Rheumatoid arthritis, Rheumatoid factor isotypes, RF-IgM.
Estimation Free Cyanide on the Sites Exposed of Organisms Mortality in Sura River /November 2018 Reyam Naji Ajmi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Inductively coupled plasma mass spectrometry   (ICP-MS) and high-performance liquid chromatography hyphenated were used cyanide determination. Samples preparation, digestion, and extraction efficiency. Analytical methods for the determination of total acute toxicity of cyanide at temperatures from 4- 24 and dissolved oxygen 6.1±0.4 mg/L on different stages of five basic sites of Euphrates rivers water were more sensitive at lower temperatures. Results have been obtained from analysis of water samples with recoveries of 88.1% to 100 % and Relative Standard Deviations (RSD) of <0.05 %. This study proves the potential application of the newly developed method for the analysis of free cyanide in river waters while the study time we could not get any kind of fish especially after the mortality in November 2018.Keywords:  Hydrogen Cyanide, Euphrates, River water.
Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine Ali A. Mahmood
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Cytosine is used to synthesize several derivatives of Schiff base when reacted with some aldehydes which are refluxed by using ethanol as a solvent and non solvent with adomestic microwave (Compounds A1-A4). These products of the Schiff base are treated first with chloroacetyl chloride to synthesize four-membered heterocycles (Compounds B1-B4). After that, they treated with hydroxyl acetic acid to synthesize five-membered heterocyclic (Compounds C1-C4). In the third step, the products are used to react with amaleic acid anhydride to produce seven-membered heterocyclic (Compound D1-D4). The antioxidant activity of the compounds (A1-A4) and two of the compounds (B1, B3), (C1, C3) and (D1, D3) in different concentrations of (100, 200, 300, 400 and 500 mg/ml) are tested with 1, 2-Di Phenyl-2-Picryl Hydrazyl (DPPH) for scavenging a radical activity. Finally, these compounds are diagnosed by several technical devices such as IR, proton1HN.M.R and13C N.M.R. spectroscopy.Keywords: Synthesis; Cytosine; Schiff Base;
Sample of Genetic Map as to Assess Some Physical and Motion Capabilities and Attack Skills in Epee for the Female Students Based on the Physical Types Mohammed Jasim Ahmed Al-Yasiri
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

As the matter  is concerned with  the physical   and motion capabilities  and  attack skills performance in epee  in fencing  for female students   of college of physical education  and sport sciences  / Baghdad University  relied on physical types,  the current study comes as to  assess these capabilities  objectively  based on  scientific steps  and procedures.  The assessment does not go beyond the use of grades and standard scales in samples that concerned with the comprehensive assessment for all female students via showing their profile only for personification and address. In order to achieve this purpose and other goals that concerned with the differences in capabilities, the two researchers have tried to make field tests   regarding these capabilities and other of offensive skills performances in Epee.  They have carried out tests on 60 female students based on the physical types. When they got   data statistically addressed, then they offered and analyzed these data according to the known methodology as to know the differences and its reality in the already researched capabilities. The conclusion has indicated that there are not statistically differences among the vocabularies of the research according to the physical types in capabilities and researched skills. All results  achieved  for the sample of the research  have been  distributed in a just method  and helping in constructing  the schedule  concerning with the  grades  and standard scales  that , in return,  have helped   in making process of assessment  by using  the method of side map (profile) or genetic map.Keywords: Assessment sample, Genetic Map, Capabilities, Advance and leap from the definite position.
Technical Variables Affecting to the Production of Dried Herb Tea from Callisia Fragrans Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

C. fragrans is a herbaceous plant with small white fragrant flowers and waxy leaves. C. fragrans leaves contain biologically active components such as flavonoids, neutral glycol-and phospholipids and fatty-acids.The aim of this work was to evaluate the effect of blanching, drying and preservation on the free radical scavenging activity and total phenolic content of dried Callisia fragrans. By examining on different variables of the blanching, drying; the highest phenolic and antioxidant activity inside the dried Callisia fragrans could be achieved by blanching within 10 seconds, at 95oC in the presence of citric acid 4%; size of Callisia fragrans 2.0 cm; drying at 50oC by heat pump dryer until the final moisture content 6.5%. The dried Callisia fragrans may be stable for 12 months in PET/AL/PE bag at 25oC without any deterioration. The study was of great importance to generate information about the blanching and drying process in preserving herb quality and bioactivity by avoiding the degradation of metabolites.Keywords: Callisia Fragrans, Blanching, Citric acid, Drying, Phenolic, antioxidant.
Application of H-Point Standard Addition Method in Kinetic-Spectrophotometric Determination of Phenylephrine in Nasal Drops and Tetracycline in Capsule Faeza H. Zankanah
Journal of Global Pharma Technology Volume 11 Issue 05.
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A new simultaneous spectrophotometric-kinetic method was developed to determine phenylephrine (PHEN) and tetracycline (TETR) via H-point standard addition method (HPSAM). The proposed procedures rely on the measurements of the difference in the rate of charge-transfer (CT) reaction between each of PHEN and TETR as electron donors with p-Bromanil (p-Br) as an electron acceptor. Different experimental factors which affect the extent of the complex formation were investigated by monitoring the value of absorbance at 446 nm. Time pair of 50 -100 sec was selected and employed, among different examined pairs since it results in the highest accuracy for HPSAM-plot. Linear calibration graphs in the concentration ranges of 10.0-40.0 and 10.0–50.0 mg/L were obtained for PHEN and TETR, respectively and the proposed method was applied successfully in the determination of PHEN and TETR in their pure form and in commercial formulations.Keywords: Spectrophotometry, Kinetic H-point standard addition method, Phenylephrine, Tetracycline, Simultaneous analysis.
The Effect of Intracanal Medicament Using Calcium Hydroxide in Root Canal Infection Toward MMP-9, TIMP-1 and EGF Level in Apical Lesion: a Literature Review Ni Kadek Eka Widiadnyani
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Root canal infection is one of periodontitis spectrum that started by dental caries process. There are many bacteria causing root canal infections, mainly obligate anaerobe bacteria. Root canal infection can form apical lesions resulted from the interaction between bacteria and inflammatory cells. The apical lesion can be causing degradation of the extracellular matrix in the root canal system. Collagen degradation is the main characteristic of the apical lesion, which degradation process mediated by pro-inflammatory cells. One of them is a matrix metalloproteinase (MMP) mainly MMP Type-9 (MMP-9). Besides MMP, tissue inhibitor of MMP (TIMP) and epidermal growth factor (EGF) also play a role as MMP regulators. Root canal treatment with intracanal medicament needed to fix dental tissue destruction. There are many intracanal medicaments available, which is calcium hydroxide mostly used in dental therapy. Calcium hydroxide has an antibacterial effect and can be lowering inflammatory cells number. In apical lesion, immune-inflammatory response happened which inflammatory cells play an important role in extracellular matrix degradation. Studies showed that intracanal medicament using calcium hydroxide proven lowering inflammatory cells levels such as MMP-9, TIMP-1 and EGF. This review will have further discussion about calcium hydroxide mechanism in reducing MMP-9, TIMP, and EGF levels in the apical lesion. Keywords: Root canal infection, Intracanal medicament, MMP-9, TIMP-1, EGF.
Cardio Protective Effect of Neuregillin-1 against Cardio Toxicity Induced by Trastuzumab in Adult Mice Yousuf Qays Majeed
Journal of Global Pharma Technology .
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Objective: This work will be carried out to investigate the potential therapeutic effect of  Neuregulin-1 against cardio toxicity induced by trastuzumab in male mice Materials and Methods:  Forty five adult male and female mice (weighing 35-50 gm) were divided into 3 groups randomly, each group contains 15 animals, group A which received distilled water as control by using intraperitoneal injection (IP) route for 10 days group B, received Trastuzumab as 6 mg/kg/day by using intraperitoneal injection route for 10 days while group C, received Neuregulin-1 (2.5 mg/day/animal) just before the administration of Trastuzumab (6mg/kg/day) given by IP route for 10 days. The significance of difference was tested by using ANOVA followed by Tukey test. Statistical significance depends on the P<0.05. Results: Cardiac troponin I concentration was significantly elevated in the trastuzumab group when compared with the control group; while, concentration has been significantly lower in the group C when compared with the trastuzumab group. While, results of total antioxidant capacity had significantly higher in the group B and group C in compare with control group. Conclusion: Neuregulin-1 can be used as a cardio protective in cardiac complications of cancer treatment by its ability to attenuate the cardio toxic effect of trastuzumab by significantly lowering cardiac troponin I concentrations. Keywords: Neuregillin-1, Cardio toxicity, Trastuzumab, Cardiac troponins.

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