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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Antimicrobial Resistance Patterns and Extended Spectrum Beta-Lactamases Producing MRSA Isolated From Wounds and Burns of Iraqi Patients Issraa Hamza Yassin
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A total of 160 samples included 61 wounds samples and 99 burns samples were collected from Baghdad province hospitals. All samples were cultured on blood agar and mannitol salt agar plates to isolate     S. aureus bacteria. Results showed that rate of S. aureus isolates was 59% of wounds samples and 82.8% of burns samples. MRSA rate of S.aureus wounds and burns isolates was 58.3% and 93.9% respectively. Antibiotic susceptibility test showed that there was no resistance (0%) in ciprofloxacin, vancomycin and imipenem for all isolates, low levels of resistance were recorded for several antibiotics: trimethoprim 5%, rifampin 7.5%, chloramphenicol 7.5%, gentamicin 7.5%, levofloxacin 10% and cefotaxime 17.5%. High and moderate levels of resistance were recorded against cefepime with 82.5%, cefoxitin with 61%, piperacillin with 42.5%, ceftazidime with 27.5%, azithromycin with 25% and amoxicillin/clavilonicacid with 2.5%. 29 different patterns of resistance to 15 different antibiotics were observed as resistance profiles. High rate of 58% of total MRSA isolates was ESBLs producing isolates.
Possibility of Herbal Tea Production from Corn Silk (Zea mays) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Corn silk is usually discarded as waste. It has a great medicinal importance due to the presence of valuable bioactive phytochemical compounds. It’s believed to be nontoxic and safe for human. Among various parts of corn, the corn silk is a rich source of antioxidant components and possesses strong antioxidant potential. It could be utilized as herbal tea like a healthy beverage. Objective of this study focused on the effect of blanching temperature and time; vacuum drying temperature and pressure to anthocyanin (mg/L), flavonoid (µg RE/g) and overall acceptance (sensory score) of the dried corn silk tea. Results showed that corn silk should be blanched in hot water 95oC at 10 seconds in the present of CaCl2 1.5% and then being dried by vacuum dryer at 45oC, -0.8 bar for 4 hours to get the final moisture content 8% available for preservation. It’s considered as a suitable raw material for production of functional food.Keywords: Corn silk, Blanching, Vacuum drying, Herbal tea, Anthocyanin, Flavonoid.
Identification and Prioritization of Effective Factors on Increasing the Short-Term E-Learning Systems’ Effectiveness in University Jihad in Khorasan Razavi Abdolali Keshtegar
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

In the present era, computer and subsequently internet are ones of the main human inventions which led to some great changes in human life that has caused a virtual world and an incentive for universities in order to invest in e-Learning section. But what that makes the importance of discussion clear is making attempt to succeed in using e-learning system and checking these systems’ success rate and unsuccessful attempt for implementing e-learning will cause loss of capital. This research was conducted with the purpose of identifying and ranking the effective elements on increasing the effectiveness of short-term e-learning systems in university Jihad in Khorasan Razavi. Therefore, the components and indicators of e-learning systems’ effectiveness assessment were suggested according to previous studies, then, a questionnaire was provided to the e-Learning learners of the of University Jihad Education Deputy of Mashhad with the aim of identifying the components of measuring the effective factors of e-Learning systems in order to assess the validity and appropriateness of the proposed components and indicators. Collected data of questionnaire was processed by software SPSS and one-sample t-test and Pearson correlation coefficient test have been used to analyze data. Six components were finalized with 26 indicators. The main components respectively include: 1- school characteristic. 2- Information quality.3- Quality of system and infrastructure. 4- Service quality. 5- Support factors. 6- Comprehensive characteristics.Keywords: E-Learning system, E-Learning’s assessment components.
Impact of Pharmacokinetic Parameters Modifications of Tamsulosin Hydrochloride Controlled Release Pellets Palanisamy Vishnu
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities. There are so many oral delivery systems in that one of the advance techniques is Pellatization. Tamsulosin  controlled  release pellets prepared by pellatization method that the Tamsulosin is coated on inert suger spheres by using non perial seeds as a binder solutions and Hydroxypropylmethylcellose, Ethyl cellose, Eudragit, Triethyl citrate coating agents used for controlled release action. The prepared pellets were evaluated for Moisture content, Acid resistance Assay, and In-vitro drug release study. All the formulation exhibited assay, Moisture content with in the range given in USP. Dissolution studies revealed that formulations containing Eudragit 0.287gms coating agent Hydroxypropylmethylcellose, 0.00312gm of ethyl cellose 0.138gm Showed 100% of drug release, at the 8th hour. The concentration of coating agents Hydroxtpropylmethycellose and Ethyl cellose had an effect on in-vitro drug release had the same drug release profile when compare with US dissolution parameters, and innovator drug release. Thus, the pellets apart from fulfilling all official and other specifications and exhibited higher rate of drug release.
The Role of Mobile Phones in the Transmission of Methicillin-Resistant Staphylococcus aureus (MRSA) among the Students and Staff of the College of Health and Medical Technology/ Kufa in Najaf, Iraq Oday Mitib Hadi
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: During every phone call the mobile phone, come into close contact with strongly contaminated human body areas with hands to hands, and hands to other areas like mouth, nose, and ears [10]. Mobile phones touch faces, ears, lips, and hands of different users thus they may be serves as reservoirs of different pathogens [11].  This study was designed to determine the role of the mobile phones in the transmission of methicillin-resistance Staph. aureus. Methodology: The cross-sectional study was done in the college of health and medical technology/ Kufa- Najaf- Iraq. Three hundred swab samples from mobile phones were collected from the students and staff of the college from November- 2015- February-2016 and divided into three groups categorized according to the site of collection (from the mobile phones) as follows: earpiece, keypad or touch screen, and mouthpiece. All samples were cultured, and the resulting isolates were identified and subjected to antimicrobial susceptibility test by standard procedures (Kirby-Bauer method).Methicillin-resistant Staph. aureus was detected by using polymerase chain reaction (PCR) based on mecA gene.   Results: Keypad or touch screen was occupied the highest percentage (58.74%) of bacterial contamination among other regions i. e. earpiece (26.7%) and mouthpiece (14.83%).Coagulase-negative Staph. aureus was predominant (41.83%) bacterial genus among other Gram-positive genera. Other Gram-positive bacteria had different ratios; there were 28.37%, 19.71%, 8.65%, 0.96% and 0.048 for Micrococcus spp., Bacillus spp. Methicillin-sensitive Staph. aureus (MSSA), Methicillin-resistant Staph. aureus (MRSA), and Enterococcus faecalis, respectively. On the other hand, Gram-negative bacteria gave different percentages, ranging from 53.57% for E. coli to 3.57% for Salmonella spp. Molecular detection was revealed the presence of mecA gene in only two isolates of Staph. aureus. Conclusion: Mobile phones may serve as vehicles of transmission of methicillin-resistance Staph. aureus.Keywords: Mobile phones, Methicillin Resistant Staph. aureus,  Meca gene.
Chemical Quality Attributes of Refrigerated Mudskipper (Pseudapocryptes elongatus) under Vaccum and Modified Atmosphere Packaging Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Modified atmosphere and vacuum packaging were believed as emerging innovative technologies for food preservation. They changed food environment by withdrawing O2 or replacing the atmosphere inside the package by a mixture of gases. Mudskipper (Pseudapocryptes elongatus) has huge potential for coastal aquaculture development and is an alternative to shrimp farming in the Mekong Delta. Mudskipper fishes were refrigerated and stored at 4oC for 21 days under vacuum and modified atmosphere packaging. These samples were analyzed the changes of major chemical parameters such as total volatile base (TVB-N, mg TVB/g), trimethylamine (TMA, mg TMA/g), thiobarbituric acid-reactive substances (TBARS, mg malondialdehyde/kg) during preservation. Results revealed that vacuum packaging could maintain chemical quality attributes for 15 days; meanwhile modified atmosphere packaging could extend the chemical quality indicators for 20 days. It’s obviously presumed that modified atmosphere packaging should be an alternative technology for seafood storage. Keywords: Mudskipper, Vacuum, Modified atmosphere packaging, Total volatile base, Trimethylamine, thiobarbituric acid-reactive substances.
Study the Optical Properties of Fluorescein Sodium Dye Doped in Polymer Polyvinyl Alcohol Khawla J. Tahir
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

In this research, the linear and non-linear optical properties for laser dye fluorescein sodium in solvent Ethanol doped with polymer polyvinyl alcohol (PVA) at different concentrations (1x10-4,5x10-4,1x10-3,5x10-3,1×10-2,5x10-2) M were studied. Z-scan technique was used to determine the nonlinear optical properties like the refractive index (n2) and the absorption coefficient (β) at wavelength 532nm CW frequency doubling Nd-YAG laser. The results showing the nonlinear absorption coefficient (β) changes between saturated absorption and two-photon absorption of certain concentration while the refractive non-linear coefficient (n2) of film samples changes between positive (self-focusing) and negative (self-defocusing). The quantum efficiency has been calculated for the same above concentrations (87%, 83%, 76%, 73%, 70%, 67%) respectively.Keywords: Linear and non-linear optical properties, Fluorescein Sodium dye, Z-scan technique, fluorescence quantum efficiency.
In Vitro Antibacterial Activity of Essential oil and Ethanolic Extract of Ajowan (Carum Copticum) against some Food-Borne Pathogens Alireza Mohammadzadeh
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

The present study aimed at evaluating the in vitro antibacterial activity of essential oil and ethanolic extract of ajowan (Carum copticum) against some food-borne pathogens.The micro-dilution method was used to study the antibacterial activity of ajowan (Carum copticum) essential oil and ethanolic extracts against some food-borne pathogens (Bacillus cereus, Staphylococcus aureus, Salmonella typhimurium and Escherichia coli ). The ethanolic leaf extract of ajowan against Salmonella typhimurium strain showed the best antibacterial activity, with the lowest minimal inhibitory concentration (MIC) of 50 mg ml-1 and MBC was 100 mg ml-1 for this bacterium and the results of essential oil on all bacteria tested showed that gram-negative bacteria were sensitively. MIC and MBC of essential oil for Salmonella typhimurium were 16 and 32 mg ml-1 respectively and MIC for Escherichia coli was 32 mg ml-1. According to results, the essential oil and ethanolic extract of this plant has antibacterial activity and therefore it could be used as a natural preservative ingredient in food and/or pharmaceutical industries.Keywords: ajowan (Carum copticum), essential oil, ethanolic extract, antibacterial activity 
Molecular Identification of Tomato Yellow Leaf Curl Virus and its Whitefly Vector (Bemisiatabaci) Aqeel N. Al-Abedy
Journal of Global Pharma Technology .
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Abstract

This study was conducted in the Plant Virology Laboratory of Plant Protection Department at College of Agriculture-Karbala University to isolate and identify three viral isolates, which isolated from diseased tomato (Solanumlycopersicum L.) plants grown in farms of the desert region in Najaf, Karbala, and AL-Muthanna provinces in Iraq. In addition, this study also aimed at identifying the biotype of whitefly (B. tabaci) in 10 different locations in Najaf, Babylon, and Karbala. Identification of TYLCV and white flies was done on the basis of the PCR technique and determining the nucleotide sequences of the PCR-amplified products.   Results, obtained from the PCR amplification and analysis of nucleotide sequences of the amplified products of the viral isolatesusing BLAST (Basic Local Alignment Search Tool), showed that the three isolates belong to Tomato yellow leaf curl virus (TYLCV). Comparison of the nucleotide sequences generated from the identified TYLCV isolates with the nucleotide sequences deposited at the National Center for Biotechnology Information (NCBl) revealed that the identified TYLCV isolates (A1MA, A2MA, and A3MA) were not previously recorded at NCBI. Therefore; these identified sequences have been deposited and recorded in GenBank database (NCBI) under the accession numbers: KT961703, KU145132, and KT961704, respectively. From the analysis of the mitochondrial cytochrome oxidize I (mtCO I) sequence of B. tabaci using BLAST program, results indicated that the biotype B whitefly is the only biotype prevalent in sampling region and none of the collected whitefly samples contains either the Q biotype or any other whitefly biotype. 
Determination of Cefotaxime Sodium in Drugs via the use of Six Source of White LEDs Coupled with One Solar Cell as a Detector using CFI Analyser Marwah A. Kadhim Al-Banaa
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A direct method is described for the determination of cefotaxime sodium in drugs and pure formulations using six LEDs for turbidimtric measurements and one solar cell as a detector. The method is based on formation of a red-brown precipitate produce via the reaction between cefotaxime sodium with Ce(IV) sulfate at acidic medium. Under the optimum established conditions, the linear range of 0.001-0.3mmol/L along with r of 0.9975, limit of detection (LOD) 35.81ng/sample and precision expressed as relative standard deviation for eight replication measurements at 0.07 and 0.25mmol/L less than 1% were obtained for cefotaxime sodium. The method was successfully applied for the estimation of cefotaxime sodium in three drugs. The newly method using the standard additions procedure and the results have shown that no significant difference between the two methods using ANOVA one way test.Keywords: Cefotaxime sodium, Flow injection analysis, Turbidity.

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