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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Live Healthy Be Free from Anxiety and Stress Mainul Haque
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Live, Healthy, Anxiety, Stress.
Acoustic-Assited Osmotic Dehydration of Dried Pumpkin Jam Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Acoustic drying accelerates the mass transfer rate during dehydration. Osmotic dehydration has recently gained a significant interest. It consists of immersing the material to be dried in a hypertonic solution. Acoustic-assisted osmotic dehydration, have been implemented as an alternative pretreatment associated to drying procedures. This study focused on the synergistic effect of osmotic and acoustic dehydration in the dried pumpkin jam production. Our results revealed that pumpkin slices should be soaked in 40% sugar and then dried by convective drier for 4 hours under assistance of ultrasonic wave at frequency 37 kHz in power 500 W. From this combination, the dried pumpkin jam would be obtained with the safe moisture content and high beta-caroten retention.Keywords: Pumpkin, Acoustic, Osmotic, Drying, Jam, Beta-caroten.
Comparative Study for Photocatalytic Degradation of Bromo Phenol Blue by Some Nanoparticales Semiconductors Amer Muosa Juda
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

In this study, a comparison of different types of nanocatalyst such as zinc oxide nanoparticles, copper oxide nanoparticles and magnesium oxide nanoparticles on the photocatalytic activity efficiency of Bromo Phenol blue dye. Heterogeneous photocatalytic method was utilized; it was approved out by using UV (A) as light source. Some factors influence on the rate of the photocatalytic degradation of each catalyst were studied and compared and selected the most efficient nanocatalyst. The results of many factors, (such as weight of catalyst, primary dye concentration, pH of aqueous solution, and temperature) , shows that the photodecolorization and degradation is a pseudo-first order reaction giving to the Langmuir-Hinshelwood relationship. The experiments were carried out by varying weight of catalyst (0.02–0.07 g), initial concentration of dye (50–30ppm ) , pH solution  (1-11), and temperature range(298-313)K. The optimum conditions were approximated as: pH 3 when use ZnO NPs and pH = 5 when using both of CuO NPs and MgO NPs, catalyst amount of 0.06 g,0.05,  and 0.03g for ZnO NPs, CuO NPs and MgO NPs respectively. The degradation extents of 92.85%, 65.16% and 74.18% with ZnO NPs, CuO NPs and MgO, respectively obtained for BPB during 20 min irradiation and 30ppm dye concentration. The degradation extent was monitored by UV–vis spectroscopy. The Photocdecolorazation and degradation extent was observed increase with high temperature. Arrhenius plot shows that the Ea is equal to (29.7±1, and 18.54±1, 13.9±1) kJ mol-1 by using ZnO, CuO and MgO NPs respectively. The thermodynamic parameters of the photocatalytic degradation of BPB, like Ea, ΔH*, ΔS*and ΔG*showed the efficiency of the process. The most efficient nanocatalyst ZnO NPs>MgO NPs>CuO NPs
A Comparative Study for The Alcoholic Extract Effect of Ajwa Dates (Phoenix Dactylifera L) in Protection of the Hepatic and Renal Tissues from Toxicity Induced by Aspergillus Niger in Albino Rats Alaa Abdul Ali Al-Khafaf
Journal of Global Pharma Technology Volume 09 Issue 11
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The plant extracts and their chemical components have a long history as antifungal agents to control the growth of isolations that released toxins and for this reason, they were used in the bio techniques as a preservative due to increased fungal resistance to the fungal antibiotics. The study aimed to evaluate the efficiency of the alcoholic and aqueous extracts for Ajwa dates in inhibiting the production of Ochratoxin A from Aspergillus Niger, and study the possible protective effect of these extracts on the tissues of vital organs such as liver and kidneys against the toxicity that induced by Ochratoxin A. The analysis results of the chromatography methods (HPLC, TLC) showed an influence of these two extracts on the production of Ochratoxin A, and the full inhibitory impact for the production of this type of fungal toxin was in the two concentrations ( 25, 20 mg / mL) by using the medium of Yeast Extract Sucrose (YES). The present study did not find any significant differences (P˃0.05) between the activity of aqueous and alcoholic extract in Ochratoxin A inhibition. The present study performed in the animal house of Biology department/Faculty of Education for Girls, twenty laboratory male rats of Sprague-Dawley strain were divided into four equal groups, the first group of animals (control) was orally administrated with normal saline solution (0,9%),the second group was orally given alcoholic extract of Ajwa dates at the concentration of (1) mg/kg, while the third group was orally treated with Ochratoxin A at the concentration of (289) μg /kg ,with regard to the last group was orally received alcoholic extract of Ajwa dates (1) mg/kg + Ochratoxin A (289) μg /kg respectively, the treatment of all animals was once daily for five days a week. During this study the body weight as well as the relative weights of liver and kidneys for rats were recorded, also the effectiveness of some hepatic enzymes (Aspartate amino transferase AST, Alanine amino transferase ALT and Alkaline phosphatase ALP) was estimated, in addition to the other biochemical parameters such as urea and creatinine levels, also the study was comprised the preparation of histological sections for liver and kidneys. The statistical analysis results of the current study were revealed ,Ochratoxin A caused a significant decrease (P˂0.05) in the body weight at the group of rats that treated with it when compared with the other experimental groups ,contrary to that, the Ochratoxin A showed a significant increase (P˂0.05) in the relative weights of liver and kidneys ,effectiveness of hepatic enzymes AST,ALT , ALP, levels of urea and creatinine at the male rats were submitted to this type of mycotoxin compared to the other groups of study. In relation with the microscopic examination of liver and kidney sections for the laboratory animals that treated with Ochratoxin A, several patho-histological changes were noted as compared with the other groups. From the results of this study can be concluded that the alcoholic extract of Ajwa dates was ameliorated the functional performance of both liver and kidneys through its preservative properties to protect the tissues of those organs from the nephrotoxicity and hepatotoxicity that induced by Ochratoxin A. Keywords: Ochratoxin A, Ajwa dates, Patho-histological effects, Biochemical properties
Nurses’ Perception of The Implementation of Patient Safety in the Inpatient Ward of a Teaching Hospital Setiawan Setiawan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Patient safety is a complex system to prevent injuries caused by mistakes and it allows the nurse to consider taking action or not to deal with the problem of patient safety. The purpose of this study was to explore the nurses’ perceptions of the implementation of patient safety in the inpatient ward of a teaching hospital. A qualitative study was used. The sample consisted of 20 nurses who were involved in a focus group discussion for 70 minutes. The data was analyzed using content analysis as guided by Collaizi. This research found 5 themes that included events almost causing harm to the patients during shifts, obstacles related to reporting events, information about events that should be reported, primary concerns regarding patient safety and habits done to reduce the risk of making mistakes. The implementation of patient safety still needs to be improved due to the lack of perception among the nurses. Patient safety occupies an important position in the health services provided and it plays an important role in the perception of the nurse.Keywords: Inpatient ward, Nurse perception, Patient safety.
Association of IL-1α (-889) and TNF-α (-309) Gene Polymorphisms with Chronic Periodontitis in Hilla City Doaa H. Hassan
Journal of Global Pharma Technology .
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Abstract

Background: Periodontitis is a infectious disease leading to the destruction of periodontium including periodontal ligament and adjacent alveolar bone induced by periodontal pathogens biofilm. Materials and Methods: A total of 90 patients, 50 with chronic periodontitis (CP) and 40 normal subjects0referring to the clinic of collage of Dentistry, Babylon University, Hilla City, Iraq, were evaluated, TNF-α and IL-1α genotyping was performed by PCR)and analyzed by polyacrylamide gel. Results: polymorphism of  IL­1α (-889) and TNFα(-308), The results showed that there was no (significant) allele frequency) difference between(patients and)control groups. Conclusion: The current study suggest that there is no association between IL­1α (-889) and TNF-α 308 polymorphism and chronic periodontitis in this population.Keywords: Periodontitis, IL­1α (-889), TNF-α 308, Genetic Polymorphism, PCR.
E-CADHERIN-A SURROGATE MARKER AND ITS RELATION TO OTHER BIOMARKERS IN EARLY STAGES OF DIABETIC NEPHROPATHY IN EASTERN PROVINCE OF SAUDI ARABIAN POPULATION Moattar Raza Rizvi
Journal of Global Pharma Technology Volume 08 Issue 10: (2016) October 2016
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Background: At present, it is very arduous to reliably envisage which, and when, diabetic patients will developnephropathy and progress to kidney failure. Therefore, preventing diabetic nephropathy or delaying the disease progression bysearching for novel biomarkers is very important. Objective: Determination of diagnostic and prognostic significance of solubleE-cadherin (sE-cadherin) and cystatin C as novel biomarkers of diabetic nephropathy in type 2 diabetic (T2D) Saudi patients.Patients and Methods: Type 2 diabetic patients (n=50) with urinary albumin excretions (UAE) > 300 mg/day (n=16)macroalbuminuria, between 30-300 mg/day (n=14) microalbuminuria and without urinary albumin excretions (UAE < 30 mg/24h) (n=20) normoalbuminuria and 15 controls were enrolled in the study. sE-cadherin, Serum Cystatin C, beta2-microglobulin,urinary microalbumin levels, and creatinine clearances were determined in all groups. Results: There was significant increasein the values of fasting blood sugar(FBS), serum creatinine, NAG, b-microglobulin, Hb1Ac in different groups. There was nosignificant change of Hb1Ac and serum creatinine between diabetic mellitus (DM) with normalbuminuria and diabeticnephropathy with microalbuminuria. The diabetic control and DM group presented with no significant change in E-cadherin(p=ns), however there was significant change of E-cadherin between DM with normoalbuminuria and diabetic nephropathy withmicroalbuminuria (p<0,001) and diabetic nephropathy with macroalbuminuria. Serum creatinine, FBS, cystatin C and Hb1Acwere known predictors of E-cadherin as extracted from regression model [Y(E-cadherin)= -1792.2+ 0.51(S.Creatinine)+0.47(FBS)+0.30(Cystatin C)-0.24(HbA1c)]. Cystatin C was significantly increased in DM as compared to diabetic control (p<0,001),however there was no change between DM normoalbuminuria and diabetic nephropathy microalbuminuria (p=ns). Furtherthere was significant increase in the values of Cystatin C in diabetic nephropathy with macroalbuminuria as compared todiabetic nephropathy with microalbuminuria and normoalbuminuria. Linear regression model of cystatin showed only Ecadherinand b-microglobulin as independent variables [Y (cystatin C) = 0.301+0.559(E-cadherin) + 0.363(β-microglobulin)].Conclusion: In conclusion, this study demonstrated that E-cadherin and cystatin C might play an important role in thedevelopment of early diabetic nephropathy and their measurement might become a useful and noninvasive marker thancreatinine or β2-MG for early incipient diabetic nephropathy as well as for the evaluation of renal involvement of T2D patients.
Reduce the Pollution of Some Heavy Elements in Agricultural Soil by Biological Treatment of Certain types of Algae Ibtisam Fareed Ali Karm
Journal of Global Pharma Technology .
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Abstract

Many researches on soil contamination had been done but few solutions were offered. This research focused on the use of some microorganisms as an alternative ways for remediation environmental pollution to reduce the concentration of five heavy elements that were tested Pb, Cd, Cr, Ni and Cu. Therefore, this research was conducted in order to find out the effect of mixed algae culture from two important microalgae (Oscillatoria sp. and Chlorella sp. ) that were locally isolate and cultivated easily under lablotary conditions to give a biomass production , a laboratory experiment was done for 12  samples of contaminated soil with heavy metals. Testing the bioactivity of remediation take three weeks, a significant difference were recorded in some data treatments, others show no significant, in general all concentrations of heavy metals were degreased after using the mixed algae culture that chosen for its wide ability for cleaning or removing the pollutants from agriculture soils. Keywords:  Mixed algae culture, Agriculture soils, Heavy metals, Bioremediation. 
Optimum Condition for Peroxidase Activity in Crude Extract of Loranthus europaeus Shaema Saadon Fadel
Journal of Global Pharma Technology Volume 11 Issue 07
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In this study peroxidase was extracted from fruit part of Loranthus europaeus then peroxidase activity was detected and optimized. Optimum conditions for the activity of crude peroxidase were studied. Results showed maximum activity of peroxidase was achieved 0.5125U/ml when the enzyme was incubated with 1mM of 4-aminoantipyrine at 40 oC  for 10 minutes in the presence of 0.2M of potassium phosphate buffer solution at PH7.Keywords: Loranthus europaeus, Peroxidase, enzyme activity.
The Modern State and Historical Aspects of Homeopathy as a Scientific and Educational Discipline in Ukraine Olena Olexandrivna Gaidukova; Svitlana Valentynivna Oliinyk; Evgen Yakovych Nikolenko; Kira Vitaliivna Vovk; Olha Olexandrivna Vlasenko
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The problem-targeted analysis of the modern homeopathy structure is carried out. The state of the modern regulatory and legal framework concerning regulation of the homeopathic method of treatment as the basis of the legal mechanism in state management of this branch is analyzed. The historical aspects of homeopathy are generalized, the analysis of homeopathic doctors’ activity legal regulation in Ukraine is carried out, and also issues of their education are covered. The results of scientific achievements are presented and their role in the formation of the evidence base for the homeopathic method of treatment is outlined. The problems of homeopathic medicine, pharmacy and science are covered. Key words: homeopathy, data of scientific literature, legal regulation, homeopaths, pharmacological studies.

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