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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Structural Conformational Study of Isoflavon Derivatives in Soybean Using Semi empirical Methods Yuyun Yuniati
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Isoflavon was falconoid group which was a polifenolic compound. As a member of flavonoid groups, isoflavon was a bioactive compound that contains phenolic group reported to have an  ability as antioxidant and prevent free radical damage through two mechanism. The mechanism are donating hydrogen ions and directly acting as a free radical scavenger. One of the seed plants which contain isoflavon was soybean. Isoflavon derivatives in soybean are biochanin a, genistein, daidzein, equol, formononetin, dan glycitein. The compounds can be applied in medical and pharmaceutical. Generally the is of lavon derivatives in soy bean have been conducted to anti-allergic, antioxidant, dan anti cholesterol. These studies based on optimization and structural conformational to support QSAR and Molecular docking studies. In this study, semiempirical AM1 method was used for optimization all the structure. The distance of two nearby atoms affect the structure stability and the strain energy because the lower the strain energy, the more stable that compound The most stable structure for biochanin a, genwastein, daidzein, glycitein, formononetin was 40o while the most stable structure for equol was 280o.Keywords: Conformation, Derivatives, Energy, Isoflavon, Soybean.
Relationship between Vitamin C and Parathyroid Hormone and Insulin Resistance Associated with Obesity Ali Mojed Al-Dhmoshy
Journal of Global Pharma Technology .
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Abstract

Objective: To show the association between parathyroid hormone and obesity and to determine the relationship between vitamin C and insulin resistance with obesity. Background Obesity is representing a global epidemic that affecting more than 1.9 billion adults in 2014, 18 years and older, were overweight. Of these over 600 million were obese. Many causes have been implicated for developing obesity such as: environmental, hereditary, medical disease like endocrine disorders furthermore, some medication like antipsychotic drugs and steroids. Obese people are at high risk to develop much complication such as diabetes, hypertension, atherosclerosis, joints problems, cancers especially hormone dependent, respiratory problems and others. Material and methods: Eighty-eight people were in cladding this study visiting Merman medical city from December 2015 to June 2016.A 40 normal non-obese , and 48 obese, The overall mean age of patients and controls was 34.48±9.83 and 28.78±6.96  years old, respectively. They were classified according to body mass index after measuring their weight, height, The be line Questionnaire was done for all patients and control for diagnosis excluded disease and any treatment that effect on obesity. The investigation was done and include fasting blood glucose, Calcium , Phosphate, HOMA IR, Vitamin C, Then hormonal testing : parathyroid hormone, insulin hormone, c-peptide . Results: There is a significantly higher difference (p value ≤ 0.05) between case and control groups concerning education, gender. Regarding investigation there is significantly higher difference (p value ≤ 0.05) between case and control groups in parameters of fasting blood glucose, HOMA IR, but all the investigations were within normal acceptable clinical range. Whereas, in regard to the hormonal parameters:- parathyroid hormone : There is significant difference between case and control (p value ≤ 0.05) , While no significant difference (p value ˃ 0.05) in percentage between case and control for insulin hormone . While significant difference  in C-peptide. Conclusion: The results of this study support the evidence that obesity associated with parathyroid hormone. Furthermore obese patients have a tendency toward higher serum PTH, there does not appear to bea resistance to PTH in the obese based on the similar serum calcium-PTH curve between obese and no obese. Hyperparathyroidism also can cause obesity. Vitamin C has   responsible effect in preventing of obesity by antioxidant role.Keywords: Obesity, Vitamin C, Ascorbic acid, Parathyroid hormone, Hyperparathyroidism, Insulin resistance. 
Enhance the Terahertz Wave by Varying the Laser Beam Intensity via Relativistic Plasma Bashair A. Abdul Khudher
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In this work, the use of 14CO2">  laser and high intensity at the wavelength 10.6 14μm">  with Gaussian beam shape. This research focuses on the derivation of the equation which represents interaction between laser and plasma parameters in to states paraxial and nonparaxial in the case of self-focusing .The interaction of the laser with longitudinal magneto plasma occurs. The relation between the laser beam width and normalized distance parameters for three types intensities (0.9, 0.8, 0.7) self-focusing were studied. Then the best result self-focusing obtained at high intensity and at the lowest intensity, the self-focusing become weak .In nonparaxial beam the self-focusing been very weak and the best state at in high intensity and then at least intensity there no self-focusing exist .The THz radiation in case of paraxial beam is appear clearly with clean peaks (high resolution) so that the best at the power full self-focusing, either case nonparaxial beam obtained on the semi-stability phenomena. These results were studied and discussion.Keywords: Relativistic nonlinearity, Magneto plasma, Non paraxial, Terahertz radiation, Laser density, Self-focusing.
Ni (II) and Cd (II) Complexes Derivatives from Heterocyclic Schiff Base; Synthesis, Spectroscopic and Biological Studies Fawzi Y. Waddai
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Ni and Cd complexes of new Schiff base derived from 5-Amino-2-phenyl-2,4-dihydro-pyrazol-3-one with 4-chlorobenzalaldehyde (A) , 2-Hydroxy-benzalaldehyde (B) and 4-Hydroxy-benzaldehyde (C) have been prepared and characterized by elemental analysis ,molar conductivity measurements, FTIR, UV-vis, 1HNMR, mass spectrometer and magnetic susceptibility. Analytical data revealed that six complexes were a distorted tetrahedral geometry and exhibited (1:1) metal: ligand ratio. The biological activity for the three ligands and its complexes were studied.
Anti-brain Cancer Activity of New (N, O) Bidentate Schiff Base Ligand and its Metal Ion Complexes Hayder Muneam A.M.
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Anti-brain cancer activity was studied by treated it with new bidentate Schiff base ligand and its metal ion complexes. The ligand 2-(((Z)-1-(4-(((E)-4-(dimethyl amino) benzylidene) amino) phenyl) ethylidene) amino) phenol and its metal ion complexes have been characterized by using FT-IR, UV. visable, 1H-NMR,13C-NMR, mass spectroscopy, thermal analysis, (CHN) analysis, atomic absorption, magnetic susceptibility and molar conductivity. The octahedral geometry was suggested for all the synthesized complexes with the bidentate ligand in (1:2) mole ratio of metal: ligand. The M (II) complexes were having neutral nature while the Fe(III) was an electrical according to the magnetic susceptibility. Copper ion complex has been shown a good anti-brain cancer activity than other complexes and the ligand.Keywords: Schiff base, Anti-brain cancer, Metal ion complexes, Bidentate ligand.   
Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms Derived from Nalidixic Acid and 4-Aminoantipyrine and Metal Complexes and Evaluation of their Biological Activity Hawraa K. Salloom
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this study, a novel Schiff base (E)-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)-1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid [HL] was synthesized from nalidixic acid 4-Aminoantipyrine and its metal complexes for metal ions M=VO, Mn, Co, Ni, Cu, Zn, Pd and Pt in ethanol and acetic acid  with mole ratio (M:L) (1:2). All complexes have general composition [VO (L)(SO4)] H2O, [Mn(L)2], [Co(L)2] H2O, [Ni(L)2] H2O, [Cu(L)2] H2O, [Zn(L)2].H2O, [Pd(KL)2] and [Pt(KL)Cl2] Cl2 where L- =C23H22N5O3. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV Vis, 1HNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against one type of bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry accept [[VO (L)(SO4)] H2O] square pyramidel geometry and [Pd (KL) 2] Square planer geometry. The value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligand and starting material.Keywords: Nalidixic Acid, 4-Aminoantipyrine, Metal complexes, Biological activity.Introduction
COMPARISON OF THREE DIFFERENT CONFIGURATION POSTERIOR INSTRUMENTATION OF SYNBONE® BONE MODEL OF ADOLESCENT IDIOPTAHIC SCOLIOSIS LENKE 1: IN VITRO TEST OF BIOMECHANICAL S. Dohar Tobing; Hendar Nugrahaedi Priambodo
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

Introduction. Biomechanical construction test of posterior instrumentation for scoliosis correction is needed to evaluate reliability and instrumentation performance. Latest biomechanical testing have validated bone model as a suitable substitute. Low pedicle screw density can correct without significant complication. This study compared biomechanics of three posterior instrumentations: Bilateral Pedicle Screw (BPS), pedicle screw on proximal end, apex, distal end concave side (PAD), and PAD with sublaminar wire the concave side (PAD+SW).Method. Three groups of vertebral model of Scoliosis Lenke I Synbone® is equipped with configurations of 15 samples posterior instrumentations divided into three groups of BPS, PAD, PAD+SW. Each of the static test is given axial force gradually from 50N, 100N, 150N, and 200N using Tensilon® AMD RTF-1310 from Japan, with dial indicator Mitutoyo, Japan. Total displacement were measured for each groups. Stiffness were also analyzed using load-displacement ratio.Results. BPS as the current gold standard showed minimal displacement, followed by BPS, PAD and PAD+SAW for 50N (p<0.001), 100N (p<0.001), and 200N (p<0.001) force, and was not significant for 150N (p=0.086). There was also significant difference between the stiffness of BPS, PAD and PAD+SW for 50N (p=0.002), 100N (p<0.001), 150N (p<0.001) and 200N (p<0.001)Conclusion. For biomechanical testing with static test, type of posterior instrumentations showed significance relationship with displacement and stiffness. BPS groups were more rigid compared to PAD+SW and PAD. Low density of pedicle screw resulted in the decrease of stiffness and posterior instrumentation sublaminar wire addition significantly added the strength.Keywords: Posterior instrumentation, adolescent idiopathic scoliosis, Lenke I, In Vitro
Oil Active Fractions of Nigella Sativa and Their Activity Against Brest Cancer Cell Line MCF-7 Taif H. Al-Ameedy
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: Seeds of Nigella sativa have been used as spice and food preservative, also these seeds have been used to promote health and fight disease especially in the Middle East. The aime of this study is to evaluate the effect of partially purified oil fractions extracted from Nigella sativa purified oil fractions against breast cancer cell line. Methods: The oil of black seed was extracted with 96% ethanol and partially purified by adsorption chromatographically using silica gel column with different solvents depending on the polarity of N.sativa compositions. Subsequently the resulted fractions (hexne, chloroform, ethyl acetate, acetone, ethanol, methanol and water fractions) were tested as anticancer against breast cancer cell line Michigan cancer foundation-7 (MCF-7)  and compare with the human hepatic cell lineWRL 68 as a normal cell line. Results: The most effective oil fraction for killing MCF-7 cell  was hexane with IC5087.52µg/ml, followed ethyl acetate and ethanol fraction the cytotoxicity against WRL68 were  significantly (P≤ 0.0001) less than for MCF7 and it was 203.1µg/ml and 218.3µg/ml respectively. Whereas the rest fractions including chloroform, acetone, methanol and water fractions had slightly anticancer activity. Conclusion: The black seed oil contain effective compounds act as antitumor agents and their were had no activity against normal cell, so we can use a chemotherapy drugs after perform another detailed research for other activities and study the chamical structure to modify for increase their anticancer activity. Keywords: Nigella sativa, Oil seeds, Anticancer activity, Medicinal plants.
Radon Concentration Measurements and Physiochemical Parameters of Sawa Lake Water-Samawa City, South of Iraq Ahmed Augab Sharrad
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Radon concentration measurements were carried out for 85 water samples collected from Sawa Lake in Samawa city, Southern part of Iraq, in order to obtain the levels of radon concentration in this area and for enhancing the national radon survey. For the measurements, a continuous radon monitoring detector (RAD7) was used. The period of assessment was two months (from December, 1st  2018 to February, 1st  2019) during the winter season. Radon activity concentrations were ranged from (0.111 Bq/l) to (0.965 Bq/l), while the average value was (0.396 Bq/l), the annual effective dose (AED) of inhalation was estimated from the measured radon concentrations and is found to be ranged from (0.080784 µSvy-1) to (0.917136 µSvy-1) with a mean value of (0.325764 µSv/y). Physiochemical parameters such as pH, EC, TDS, resistivity, and turbidity were determined samples and the correlation between these parameters and radon concentrations was conducted. The results have revealed that the radon concentration and the associated annual effective dose does not pose any kind of health hazard to the population and tourists, and were found to be well within the reference levels as reported in the ICRP 2000.Keywords: Radon, Sawa Lake, Samawa City, Physiochemical Parameters, RAD7Detector.
Treatment of Childhood and Adolescent Depression with Physical Rehabilitation Olga Taranina
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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One of the effective methods of treating depression in children and adolescents is exercising. The aim of the research is to study the effectiveness of physical activity in the treatment of psychogenic depression in children and adolescents. The sampling contained 90 children and adolescents (age 11-15 years) suffering from psychogenic depression, they were divided into 2 groups: group 1 (control group) – 45 children undergoing psychotherapy for 8 weeks; group 2 (study group) – 45 children who, in addition to psychotherapy, were treated with a complex of physical exercises 1 hour a day 4 times a week for 8 weeks. The main methods of the study were clinical-anamnestic and clinical-psychopathological methods, analysis of medical history and lifestyle data, anthropometry methods, laboratory and instrumental diagnostics, mathematical statistics methods. At the end of the 8th week of treatment, HAM-D score level of depression significantly decreased by 2.27 times (p

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